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公开(公告)号:US11524300B2
公开(公告)日:2022-12-13
申请号:US16924966
申请日:2020-07-09
Applicant: GEN-PROBE INCORPORATED
Inventor: Christopher B. Davis , Norbert D. Hagen , James T. Tuggle
IPC: B03C1/28 , B01L3/00 , G01N35/00 , B03C1/033 , B65B3/04 , B03C1/12 , B03C1/14 , B01L9/00 , B25J11/00 , C12N15/10
Abstract: A method for performing a magnetic separation procedure that includes transporting a receptacle containing a fluid medium to a first location of a system, where the fluid medium contains both a sample material and a suspension of magnetically-responsive solid supports. At the first location, the fluid medium is exposed to a first magnetic field for a first dwell period, thereby isolating the solid supports within the receptacle, where no portion of the fluid medium is removed from the receptacle at the first location. The receptacle is then transported from the first location to a second location of the system, where the fluid medium is exposed to a second magnetic field for a second dwell period. Following the second dwell period, at least a portion of the fluid medium is removed from the receptacle. A suspension fluid is then dispensed into the receptacle, and the contents of the receptacle are agitated to suspend the solid supports within the suspension fluid.
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公开(公告)号:US10279351B2
公开(公告)日:2019-05-07
申请号:US14996339
申请日:2016-01-15
Applicant: GEN-PROBE INCORPORATED
Inventor: Christopher B. Davis , Norbert D. Hagen , James T. Tuggle
IPC: B03C1/28 , B01L3/00 , G01N35/00 , B03C1/033 , B65B3/04 , B03C1/12 , B03C1/14 , B01L9/00 , B25J11/00 , C12N15/10
Abstract: A system for separating an analyte from other components of a sample includes a receptacle holding station and a magnetic separation station. The receptacle holding station includes one or more stationary, permanent magnets positioned to apply a magnetic field to the contents of a receptacle held stationary within the receptacle holding station. The magnetic separation station includes one or more permanent magnets and is configured to perform a magnetic separation procedure on the contents of a receptacle transported from the receptacle holding station to the magnetic separation station. The magnetic separation procedure includes isolating an analyte immobilized on a magnetically-responsive solid support within the receptacle and removing other components of the sample from the receptacle. The magnetic separation station is configured to provide relative movement between the receptacle and the one or more permanent magnets after the receptacle is transported to the magnetic separation station.
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公开(公告)号:US12194468B2
公开(公告)日:2025-01-14
申请号:US18061995
申请日:2022-12-05
Applicant: GEN-PROBE INCORPORATED
Inventor: Christopher B. Davis , Norbert D. Hagen , James T. Tuggle
IPC: B01L3/00 , B01L9/00 , B03C1/033 , B03C1/12 , B03C1/14 , B03C1/28 , B25J11/00 , B65B3/04 , C12N15/10 , G01N35/00
Abstract: A method for performing a magnetic separation procedure that includes transporting a receptacle containing a fluid medium to a first location of a system, where the fluid medium contains both a sample material and a suspension of magnetically-responsive solid supports. At the first location, the fluid medium is exposed to a first magnetic field for a first dwell period, thereby isolating the solid supports within the receptacle, where no portion of the fluid medium is removed from the receptacle at the first location. The receptacle is then transported from the first location to a second location of the system, where the fluid medium is exposed to a second magnetic field for a second dwell period. Following the second dwell period, at least a portion of the fluid medium is removed from the receptacle. A suspension fluid is then dispensed into the receptacle, and the contents of the receptacle are agitated to suspend the solid supports within the suspension fluid.
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公开(公告)号:US11345946B2
公开(公告)日:2022-05-31
申请号:US15934339
申请日:2018-03-23
Applicant: GEN-PROBE INCORPORATED
Inventor: David Opalsky , David Buse , James T. Tuggle , Alexander Navarro , Patrick Sheehan
IPC: B01L3/00 , C12Q1/6806 , G01F23/263 , G01N35/04 , G01N35/10 , C12Q1/686
Abstract: A fluid container holder includes a body having a receptacle configured to receive a container. The body has a conductive outer surface for connection to an electrical ground or voltage source, and the holder is not formed solely of an electrically conductive metal. A fluid container handling assembly includes a drawer having a holder supporting a fluid container, and a frame supporting the holder. The frame is movable between a first position providing access to the holder and a second position positioning the holder within the instrument. The assembly also includes a first lock securing the holder to the frame when the frame is at the first frame position and unlocking the holder from the frame when the frame is at the second frame position. The assembly also includes a holder transporter configured to move the holder between a first holder position and a second holder position within the instrument.
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公开(公告)号:US09259732B2
公开(公告)日:2016-02-16
申请号:US14500584
申请日:2014-09-29
Applicant: GEN-PROBE INCORPORATED
Inventor: Christopher B. Davis , Norbert D. Hagen , James T. Tuggle
IPC: B03C1/12 , B01L3/00 , G01N35/00 , B03C1/033 , B03C1/28 , B65B3/04 , B03C1/14 , B01L9/00 , B25J11/00
CPC classification number: B01L3/52 , B01L3/561 , B01L9/52 , B01L2300/0609 , B01L2300/12 , B03C1/0332 , B03C1/12 , B03C1/14 , B03C1/28 , B03C1/286 , B03C1/288 , B03C2201/18 , B03C2201/26 , B25J11/00 , B65B3/04 , C12N15/1013 , G01N35/0098 , Y10T29/49815
Abstract: A system for separating an analyte from other components of a sample contained in a receptacle, where the system includes a receptacle holding station and a magnetic separation station. The receptacle holding station is configured to receive and hold a receptacle and includes one or more magnets positioned to apply a magnetic field to the contents of the receptacle. When present in the receptacle holding station, a receptacle remains stationary relative to the one or more magnets. The magnetic separation station includes one or more magnets and is constructed and arranged to perform a magnetic separation procedure on the contents of a receptacle transported from the receptacle holding station to the magnetic separation station by an automated receptacle transport. The magnetic separation procedure includes isolating an analyte immobilized on a magnetically-responsive solid support within the receptacle and removing other components of the sample from the receptacle. The magnetic separation station is configured to provide relative movement between the receptacle and the one or more magnets after the receptacle is transported to the magnetic separation station.
Abstract translation: 用于将分析物与包含在容器中的样品的其它组分分离的系统,其中所述系统包括容器保持站和磁分离站。 容器保持站被配置为容纳和保持插座,并且包括一个或多个定位成将磁场施加到容器的内容物上的磁体。 当存在于容器保持站中时,容器相对于一个或多个磁体保持静止。 磁分离站包括一个或多个磁体,并被构造和布置成对通过自动插座传送从容器保持站传送到磁分离站的容器的内容物执行磁分离程序。 磁分离程序包括将固定在磁反应性固体支持物上的分析物分离在容器内并从容器中除去样品的其它组分。 磁性分离台构造成在容器被传送到磁分离站之后,在容器和一个或多个磁体之间提供相对运动。
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