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公开(公告)号：US10691773B2
公开(公告)日：2020-06-23
申请号：US14984766
申请日：2015-12-30
Applicant: General Electric Company
Inventor： Nichole Lea Wood , Lynn Ann DeRose , Kunter Seref Akbay , Christopher Donald Johnson , Reginald Donovan Smith , Dolores Baksh
Abstract: The present disclosure relates to cell processing techniques. By way of example, a cell processing system may include a plurality of sample processing devices configured to process patient samples and a plurality of readers respectively associated with the plurality of sample processing devices, wherein each reader is configured to read information from tracking devices associated with respective patient samples. The system may also include a controller that uses information from the readers to provide an estimated completion time for a patient sample based on availability of the sample processing devices.
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公开(公告)号：US20200181572A1
公开(公告)日：2020-06-11
申请号：US16339077
申请日：2017-08-24
Applicant: General Electric Company
Inventor： Ernest William Kovacs , Anup Sood , Reginald Donovan Smith , Evelina Roxana Loghin , Padmaparna Chaudhuri , Vandana Keskar , Chrystal Mae Chadwick , Martin James Brown
IPC: C12N5/0783 , C07K16/28
Abstract: Provided herein are methods of activating immune cells. The method includes providing a population of immune cells and contacting the population of immune cells with a first agent and a second agent. The first agent includes an immune cell activator attached to a first binder moiety, and the second agent includes at least one capture oligomer. The at least one capture oligomer is capable of associating with the first binder moiety. Also provided are kits for activating immune cells.
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Patent Agency Ranking
公开(公告)号：US10465157B2
公开(公告)日：2019-11-05
申请号：US14462594
申请日：2014-08-19
Applicant: General Electric Company
Inventor： Chengkun Zhang , Kenneth Roger Conway , Donald Joseph Buckley , Eugene Pauling Boden , Weston Blaine Griffin , Anshika Bajaj , Reginald Donovan Smith , Zhipeng Zhang
Abstract: A sampling assembly configured to be coupled to a sample source is provided. The sampling assembly is configured to facilitate aseptic sampling at one or more instances in time. The sampling assembly includes a first conduit having a first port and a second port, where the first port is configured to be coupled to the sample source, and where the second port is configured to be hermetically sealed. The sampling assembly further includes a plurality of sub-conduits having corresponding sub-ports, where each of the plurality of sub-conduits is operatively coupled to the first conduit at respective connection points, and where each of the sub-ports is in fluidic communication with the first conduit. Moreover, the sampling assembly includes a plurality of sampling kits, where each sampling kit of the plurality of sampling kits is operatively connected to a respective sub-port of a corresponding sub-conduit.
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公开(公告)号：US20190105609A1
公开(公告)日：2019-04-11
申请号：US15726013
申请日：2017-10-05
Applicant: General Electric Company
Inventor： Chengkun Zhang , Kashan Ali Shaikh , Reginald Donovan Smith , Weston Blaine Griffin
Abstract: A disposable cell enrichment kit includes a crossflow filtration device configured to be disposed along a main loop pathway and to receive a process volume containing a biological sample and utilize crossflow filtration, via a micro-porous membrane, to retain a specific cell population in a retentate from the process volume and to remove a permeate including certain biological components from the process volume. The crossflow filtration device includes a laminated filtration unit that includes the micro-porous membrane, a first mating portion, a second mating portion, and a membrane support. The membrane support includes a first plurality of structural features that define a first plurality of openings, wherein the first plurality of structural features are coupled to the micro-porous membrane and provide support to the micro-porous membrane, and the first plurality of openings allow the permeate to flow through them after crossing the micro-porous membrane.
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公开(公告)号：US10190950B2
公开(公告)日：2019-01-29
申请号：US14529201
申请日：2014-10-31
Applicant: General Electric Company
Abstract: A semi-automated sampling assembly configured for aseptic sampling at one or more instances from a sample source having a biological inoculum is provided. The semi-automated sampling assembly includes a sampling conduit, a recovery conduit, one or more sampling kits, and a pumping device. The sampling conduit includes a first port and a second port, where the first port of the sampling conduit is configured to be operatively coupled to the sample source. Further, the recovery conduit includes a first port and a second port, where the first port of the recovery conduit is configured to be operatively coupled to the sample source. Also, the second port of the recovery conduit is operatively coupled to at least a portion of the sampling conduit. Moreover, the one or more sampling kits are operatively coupled to the sampling conduit, and the pumping device is operatively coupled to the sampling conduit.
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公开(公告)号：US09709549B2
公开(公告)日：2017-07-18
申请号：US14565142
申请日：2014-12-09
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Nichole Lea Wood , Reginald Donovan Smith , Hongyi Zhou , Liming Yu , Brian David Polizzotti , Peter D. Miller
IPC: G01N33/49 , A61M1/02 , B01D61/28 , B01D61/30 , B01D63/02 , C12N5/0789 , C12N5/0775 , G01N1/40
CPC classification number: G01N33/491 , A61M1/029 , B01D61/28 , B01D61/30 , B01D63/02 , B01D2313/18 , B01D2313/50 , C12N5/0647 , C12N5/0665 , G01N1/4077 , G01N2001/4083 , G01N2001/4088
Abstract: Method and systems, for processing biological material, that contain a biological material in a vessel; add an aggregating agent to the material in the vessel and allow the material to separate into two or more distinct submaterials; extract one or more of the submaterials from the vessel; automatically transport one or more of the submaterials remaining in the vessel to a filtration device; and collect a resulting target retentate into a target retentate receptacle.
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公开(公告)号：US20160252434A1
公开(公告)日：2016-09-01
申请号：US15149383
申请日：2016-05-09
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Reginald Donovan Smith , Patrick Joseph McCloskey
IPC: G01N1/34
CPC classification number: G01N1/34 , C12N5/0087 , C12N2500/50 , G01N33/491
Abstract: Provided herein are kit for providing a gamma sterilized aqueous dextran solution that increase the efficiency of blood separation by allowing the dextran solution to be sterilized by exposure to gamma radiation while maintaining sufficient molecular weight to act as a red blood cell aggregate. Also provided are methods of use.
Abstract translation: 本文提供了用于提供伽马灭菌的水性葡聚糖溶液的试剂盒，其通过使葡聚糖溶液通过暴露于γ辐射而消毒而提高血液分离的效率，同时保持足够的分子量用作红细胞聚集体。 还提供了使用方法。
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