公开(公告)号：US20250100999A1

公开(公告)日：2025-03-27

申请号：US18829547

申请日：2024-09-10

Applicant: Gilead Sciences, Inc.

Inventor： Kevin McCormack Allan ,  Amanda Lynn Vandehey ,  Gediminas Brizgys ,  Sachin Dhar ,  Ian James Doxsee ,  Alex Goldberg ,  Lars V. Heumann ,  Zilin Huang ,  Nathaniel Thomas Kadunce ,  Shahrokh Kazerani ,  Willard Lew ,  Vinh Xuan Ngo ,  Brian Michael O'Keefe ,  Trevor James Rainey ,  Benjamin James Roberts ,  Bing Shi ,  Dietrich P. Steinhuebel ,  Winston C. Tse ,  Anna Michelle Wagner ,  Xianghong Wang ,  Scott Alan Wolckenhauer ,  Chloe Yuyi Wong ,  Jennifer R. Zhang

IPC: C07D401/14 ,  C07C45/67 ,  C07C59/50 ,  C07D213/61 ,  C07D231/54 ,  C07D231/56 ,  C07D339/06 ,  C07D401/12 ,  C07D495/10

Abstract: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.

公开(公告)号：US20240101533A1

公开(公告)日：2024-03-28

申请号：US18205877

申请日：2023-06-05

Applicant: Gilead Sciences, Inc.

Inventor： Kevin McCormack Allan ,  Amanda Lynn Vandehey ,  Gediminas Brizgys ,  Sachin Dhar ,  Ian James Doxsee ,  Alex Goldberg ,  Lars V. Heumann ,  Zilin Huang ,  Nathaniel Thomas Kadunce ,  Shahrokh Kazerani ,  Willard Lew ,  Vinh Xuan Ngo ,  Brian Michael O`Keefe ,  Trevor James Rainey ,  Benjamin James Roberts ,  Bing Shi ,  Dietrich P. Steinhuebel ,  Winston C. Tse ,  Anna Michelle Wagner ,  Xianghong Wang ,  Scott Alan Wolckenhauer ,  Chloe Yuyi Wong ,  Jennifer R. Zhang

IPC: C07D401/14 ,  C07D401/12 ,  C07D495/10 ,  C07D339/06 ,  C07C59/50 ,  C07D231/56 ,  C07C45/67 ,  C07D213/61 ,  C07D231/54

CPC classification number: C07D401/14 ,  C07D401/12 ,  C07D495/10 ,  C07D339/06 ,  C07C59/50 ,  C07D231/56 ,  C07C45/673 ,  C07D213/61 ,  C07D231/54 ,  C07C2602/18

Abstract: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I:






or a co-crystal, solvate, salt or combination thereof.

公开(公告)号：US20240067629A1

公开(公告)日：2024-02-29

申请号：US18223169

申请日：2023-07-18

Applicant: Gilead Sciences, Inc.

Inventor： Gediminas Brizgys ,  Eda Canales ,  Chienhung Chou ,  Michael Graupe ,  Jiayao Li ,  Roland D. Saito ,  Scott D. Schroeder ,  Winston C. Tse ,  Qiaoyin Wu ,  Jennifer R. Zhang

IPC: C07D401/14 ,  A61P31/18 ,  C07D405/14 ,  C07D413/14

CPC classification number: C07D401/14 ,  A61P31/18 ,  C07D405/14 ,  C07D413/14

Abstract: The invention provides compounds having Formula (I):




or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising the same, processes for their preparation, and methods of treating and preventing HIV infection by their administration.

公开(公告)号：US11572362B2

公开(公告)日：2023-02-07

申请号：US16539753

申请日：2019-08-13

Applicant: Gilead Sciences, Inc.

Inventor： Stephen Ammann ,  Elizabeth M. Bacon ,  Gediminas Brizgys ,  Elbert Chin ,  Chienhung Chou ,  Jeromy J. Cottell ,  Marilyn Ndukwe ,  James G. Taylor ,  Nathan E. Wright ,  Zheng-Yu Yang ,  Sheila M. Zipfel

IPC: C07D487/04 ,  A61P29/00

Abstract: A compound of Formula (I): pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof are disclosed.

公开(公告)号：US20200369647A1

公开(公告)日：2020-11-26

申请号：US16869653

申请日：2020-05-08

Applicant: Gilead Sciences, Inc.

Inventor： Kevin McCormack Allan ,  Amanda Lynn Vandehey ,  Gediminas Brizgys ,  Sachin Dhar ,  Ian James Doxsee ,  Alex Goldberg ,  Lars V. Heumann ,  Zilin Huang ,  Nathaniel Thomas Kadunce ,  Shahrokh Kazerani ,  Willard Lew ,  Vinh Xuan Ngo ,  Brian Michael O`Keefe ,  Trevor James Rainey ,  Benjamin James Roberts ,  Bing Shi ,  Dietrich P. Steinhuebel ,  Winston C. Tse ,  Anna Michelle Wagner ,  Xianghong Wang ,  Scott Alan Wolckenhauer ,  Chloe Yuyi Wong ,  Jennifer R. Zhang

IPC: C07D401/14 ,  C07D401/12 ,  C07D495/10 ,  C07D339/06 ,  C07C59/50 ,  C07D231/56 ,  C07C45/67 ,  C07D213/61 ,  C07D231/54

Abstract: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.

公开(公告)号：US20180273508A1

公开(公告)日：2018-09-27

申请号：US15910083

申请日：2018-03-02

Applicant: Gilead Sciences, Inc.

Inventor： Gediminas Brizgys ,  Eda Canales ,  Chien-Hung Chou ,  Michael Graupe ,  Randall L. Halcomb ,  Yunfeng Eric Hu ,  Scott E. Lazerwith ,  John O. Link ,  Qi Liu ,  Yafan Lu ,  Roland D. Saito ,  Scott D. Schroeder ,  John R. Somoza ,  Winston C. Tse ,  Jennifer R. Zhang

IPC: C07D401/12 ,  C07D487/04 ,  A61K31/517 ,  A61K31/496 ,  A61K31/4725 ,  C07D491/052 ,  A61K31/4439 ,  A61K31/437 ,  A61K45/06 ,  A61K31/444 ,  A61K31/5377 ,  C07D401/14 ,  C07D403/14 ,  C07D471/04 ,  C07D401/04 ,  C07D417/14 ,  C07D413/14 ,  A61K31/506

CPC classification number: C07D401/12 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  A61K45/06 ,  C07D401/04 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/052

Abstract: Compounds of formula (I) or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.

公开(公告)号：US20180230157A1

公开(公告)日：2018-08-16

申请号：US15898095

申请日：2018-02-15

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Gediminas Brizgys ,  Elbert Chin ,  Cheinhung Chou ,  Jeromy J. Cottell ,  John O. Link ,  James G. Taylor ,  winston C. Tse ,  Nathan E. Wright ,  Zheng-Yu Yang ,  Jennifer R. Zhang ,  Sheila M. Zipfel

IPC: C07D487/04

CPC classification number: C07D487/04 ,  A61P29/00 ,  C07D453/00 ,  C07D519/00

Abstract: Provided is a compound of Formula (I) wherein the variable groups are defined herein.

公开(公告)号：US20180127388A1

公开(公告)日：2018-05-10

申请号：US15658818

申请日：2017-07-25

Applicant: Gilead Sciences, Inc.

Inventor： Kerim Babaoglu ,  Gediminas Brizgys ,  Jacob Y. Cha ,  Xiaowu Chen ,  Hongyan Guo ,  Randall L. Halcomb ,  Xiaochun Han ,  Richard Huang ,  Hongtao Liu ,  Ryan McFadden ,  Michael L. Mitchell ,  Yingmei Qi ,  Paul A. Roethle ,  Lianhong Xu ,  Hong Yang

IPC: C07D277/82 ,  C07D498/04 ,  A61K31/428 ,  C07D487/04 ,  C07D471/04 ,  C07D417/14 ,  C07D417/10 ,  C07D417/04 ,  C07D277/68 ,  C07D277/66 ,  A61K45/06 ,  A61K31/553 ,  A61K31/551 ,  A61K31/5383 ,  A61K31/538 ,  A61K31/5377 ,  A61K31/513 ,  A61K31/506 ,  A61K31/501 ,  A61K31/4985 ,  A61K31/497 ,  A61K31/496 ,  A61K31/4741 ,  A61K31/4709 ,  A61K31/454 ,  A61K31/444 ,  A61K31/4439 ,  A61K31/4375 ,  A61K31/437 ,  A61K31/436 ,  C07D491/06

CPC classification number: C07D277/82 ,  A61K31/428 ,  A61K31/436 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/4741 ,  A61K31/496 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/506 ,  A61K31/513 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/5383 ,  A61K31/551 ,  A61K31/553 ,  A61K45/06 ,  C07D277/66 ,  C07D277/68 ,  C07D417/04 ,  C07D417/10 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/06 ,  C07D498/04 ,  A61K2300/00

Abstract: Compounds disclosed herein including compounds of formula I′: and salts thereof are provided. Pharmaceutical compositions comprising compounds disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an HIV infection using compounds disclosed herein are also provided.

公开(公告)号：US09951043B2

公开(公告)日：2018-04-24

申请号：US14771779

申请日：2014-02-28

Applicant: Gilead Sciences, Inc.

Inventor： Gediminas Brizgys ,  Eda Canales ,  Chien-hung Chou ,  Michael Graupe ,  Randall L. Halcomb ,  Yunfeng Eric Hu ,  Scott E. Lazerwith ,  John O. Link ,  Qi Liu ,  Yafan Lu ,  Roland D. Saito ,  Scott D. Schroeder ,  John R. Somoza ,  Winston C. Tse ,  Jennifer R. Zhang

IPC: C07D401/12 ,  C07D401/04 ,  C07D487/04 ,  C07D413/14 ,  C07D491/052 ,  C07D417/14 ,  C07D401/14 ,  C07D471/04 ,  C07D403/14 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  A61K45/06

CPC classification number: C07D401/12 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  A61K45/06 ,  C07D401/04 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/052

Abstract: Compounds of formula (I) or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.

公开(公告)号：US20160152582A1

公开(公告)日：2016-06-02

申请号：US14741025

申请日：2015-06-16

Applicant: Gilead Sciences, Inc.

Inventor： Kerim Babaoglu ,  Gediminas Brizgys ,  Hongtao Liu ,  Ryan McFadden ,  Michael L. Mitchell ,  Yingmei Qi ,  Paul A. Roethle ,  Lianhong Xu ,  Hong Yang

IPC: C07D277/82 ,  A61K31/4741 ,  A61K45/06 ,  A61K31/428 ,  C07D277/68 ,  A61K31/437 ,  A61K31/4439 ,  C07D417/14 ,  A61K31/444 ,  A61K31/506 ,  A61K31/496 ,  C07D471/04 ,  C07D491/06 ,  C07D417/10

CPC classification number: C07D277/82 ,  A61K31/428 ,  A61K31/436 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/4741 ,  A61K31/496 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/506 ,  A61K31/513 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/5383 ,  A61K31/551 ,  A61K31/553 ,  A61K45/06 ,  C07D277/66 ,  C07D277/68 ,  C07D417/04 ,  C07D417/10 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/06 ,  C07D498/04 ,  A61K2300/00

Abstract: Compounds of formula I′: or salts thereof are provided. Pharmaceutical compositions comprising a compound of formula I′, processes for preparing compounds of formula I′, intermediates useful for preparing compounds of formula I′ and therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal are also provided.

Abstract translation: 提供式I'化合物或其盐。 包含式I'化合物的药物组合物，制备式I'化合物的方法，可用于制备式I'化合物的中间体和用于治疗HIV病毒增殖的治疗方法，治疗AIDS或延迟AIDS或ARC发作 还提供哺乳动物的症状。