公开(公告)号：US20080067355A1

公开(公告)日：2008-03-20

申请号：US11441542

申请日：2006-05-25

Applicant: Gangqiang Li

Inventor： Gangqiang Li

IPC: H01J49/04

CPC classification number: H01J49/044

Abstract: A mass spectrometer sample input interface comprises a desolvation apparatus defining a desolvation pathway along which a desolvation gas flows, in a direction from upstream to downstream, the desolvation pathway having a desolvation pathway portion; and an ion pathway apparatus for defining an ion pathway for analyte solution droplets to follow, the ion pathway leading into the mass spectrometer, the ion pathway including an ion pathway portion that follows the desolvation pathway portion.

Abstract translation: 质谱仪样品输入界面包括去溶剂化装置，其定义了去溶剂化途径，去溶剂化气体沿着从上游到下游的方向从具有去溶剂化途径部分的去溶剂化途径流出; 以及离子通道装置，用于限定分析物溶液液滴的离子路径，通向质谱仪的离子通道，离子通路包括遵循去溶剂化途径部分的离子通路部分。

公开(公告)号：US20080067350A1

公开(公告)日：2008-03-20

申请号：US11442250

申请日：2006-05-30

Applicant: Gangqiang Li

Inventor： Gangqiang Li

IPC: H01J49/40

CPC classification number: G01N27/624

Abstract: A multi-channel high field asymmetric waveform ion mobility spectrometer (FAIMS) is provided. The apparatus provides for substantially simultaneous FAIMS analysis of plurality of ions from a single sample. The apparatus has a analyzer region comprising a hollow electrode, a plurality of plate electrodes positioned parallel to and distanced from the hollow electrode, a contact for applying an high voltage asymmetric waveform to the hollow electrode and a plurality of contacts for applying a compensation voltage to the plurality of plate electrodes. A method for substantially simultaneous FAIMS analysis of plurality of ions from a single sample is also provided.

公开(公告)号：US20070278398A1

公开(公告)日：2007-12-06

申请号：US11442232

申请日：2006-05-30

Applicant: Gangqiang Li

Inventor： Gangqiang Li

IPC: H01J49/40

CPC classification number: G01N27/624

Abstract: A high-field asymmetric waveform ion mobility spectrometer (FAIMS) with enhanced ion focusing is provided. The apparatus comprises an outer electrode with a central region and inner surface and an inner electrode disposed in the central region of the outer electrode. The inner and outer electrodes are positioned to form a non-uniform gap between the inner electrode and outer electrode inner surface. A method of using the apparatus to analyze ionized samples is also provided.

Abstract translation: 提供了具有增强的离子聚焦的高场非对称波形离子迁移谱仪（FAIMS）。 该装置包括具有中心区域和内表面的外部电极和设置在外部电极的中心区域中的内部电极。 内电极和外电极被定位成在内电极和外电极内表面之间形成不均匀的间隙。 还提供了使用该装置来分析电离样品的方法。

公开(公告)号：US07279681B2

公开(公告)日：2007-10-09

申请号：US11157906

申请日：2005-06-22

Applicant: Gangqiang Li ,  Alexander Mordehai

Inventor： Gangqiang Li ,  Alexander Mordehai

IPC: H01J49/42

CPC classification number: H01J49/424 ,  H01J49/4225 ,  H01J49/423

Abstract: An apparatus and method for correcting deviations in a quadrupole field in a quadrupole ion trap is provided. More specifically the invention provides for correction electrodes positioned in at least one primary quadrupole electrode and a method of using the correction electrodes to provide a field correction potential.

公开(公告)号：US06642516B1

公开(公告)日：2003-11-04

申请号：US10322955

申请日：2002-12-18

Applicant: Stuart C Hansen ,  Christian A. Le Cocq ,  Gangqiang Li ,  Scott W Corzine

Inventor： Stuart C Hansen ,  Christian A. Le Cocq ,  Gangqiang Li ,  Scott W Corzine

IPC: H01J4900

CPC classification number: H01J49/063 ,  H01J49/0059

Abstract: Mass spectometer system and method of use are disclosed. Briefly described, one embodiment of the mass spectrometry system, among others, includes a radio frequency multipole assembly, an inner structure, and a laser diode array system. The inner structure has an outside, an inside, and an opening. The inner structure substantially surrounds the radio frequency multipole assembly. The laser diode array system is disposed on the outside of the inner structure adjacent the side opening such that laser radiation emitted from the laser diode array system travels through the side opening.

Abstract translation: 公开了质谱仪系统和使用方法。 简而言之，质谱系统的一个实施方案包括射频多极组件，内部结构和激光二极管阵列系统。 内部结构具有外部，内部和开口。 内部结构基本上围绕射频多极组件。 激光二极管阵列系统设置在邻近侧面开口的内部结构的外侧，使得从激光二极管阵列系统发射的激光辐射穿过侧开口。

公开(公告)号：US5614711A

公开(公告)日：1997-03-25

申请号：US434931

申请日：1995-05-04

Applicant: Gangqiang Li ,  Gary M. Hieftje

Inventor： Gangqiang Li ,  Gary M. Hieftje

IPC: B01D59/44 ,  H01J49/40 ,  H01J49/00

CPC classification number: H01J49/40 ,  B01D59/44

Abstract: A novel, time-of-flight mass spectrometer for the qualitative and quantitative analysis of elemental, molecular, and isotopic chemical samples is provided which offers increased sensitivity, speed of analysis, resolving power, and signal-to-noise ratios than prior mass spectrometers by properly sampling and collimating an ion beam from a continuous ion source, decelerating said ion, forming ion packets from the continuous ion beam, storing said ion packets, extracting and accelerating the ion packets along a stable flight path, transversely compressing said packets, focusing ions of similar mass, and detecting the focused ion masses. The mass spectrometer includes an ion optics assembly and an analyzer disposed along a common axis coincident with a continuous beam of sampled ions. The relationship between the ion extractor and accelerator are such that ions of isomass are focused at at least one point in space in the analyzer along a narrow flight path so as to be either removed from the flight path or allowed to proceed and be detected at substantially the same time. The separate modulation and extraction steps, when coupled with the space-focusing and selected deflection of certain ionic species, results in higher sensitivity, greater analysis speed, higher resolving power, and improved signal-to-noise ratio than achieved in prior orthogonal or on-axis time-of-flight mass spectrometers. A novel method achieved by the apparatus is also disclosed.

Abstract translation: 提供了一种用于元素，分子和同位素化学样品的定性和定量分析的新型飞行时间质谱仪，其提供了比现有的质谱仪更高的灵敏度，分析速度，分辨率和信噪比 通过适当地对来自连续离子源的离子束进行采样和准直，使所述离子减速，从连续离子束形成离子包，存储所述离子包，沿着稳定的飞行路径提取和加速离子包，横向压缩所述包，聚焦 离子质量相似，并检测聚焦离子质量。 质谱仪包括离子光学组件和沿着与连续的取样离子束重合的共同轴设置的分析仪。 离子提取器和加速器之间的关系使得等离子体的离子沿着窄的飞行路径聚焦在分析仪中的空间中的至少一个点处，以便从飞行路径移除或允许进行并基本上被检测 同一时间。 单独的调制和提取步骤当与某些离子物质的空间聚焦和选择的偏转相结合时，导致比在先前的正交或在之前实现的更高的灵敏度，更高的分析速度，更高的分辨能力和改善的信噪比 -axis飞行时间质谱仪。 还公开了一种由该装置实现的新颖方法。

公开(公告)号：US20110127422A1

公开(公告)日：2011-06-02

申请号：US12627372

申请日：2009-11-30

Applicant: Stuart C. Hansen ,  Gangqiang Li

Inventor： Stuart C. Hansen ,  Gangqiang Li

IPC: H01J49/04 ,  H01J49/26

CPC classification number: H01J49/0404

Abstract: A mass spectrometer system an ion source configured to produce ions and a non-metallic capillary configured to receive at least a portion of the ions from the ion source. The capillary includes an elongated body and multiple bores traversing the elongated body in a longitudinal direction. The bores transport the received ions through the capillary toward a mass analyzer of the mass spectrometer system for detection.

Abstract translation: 质谱仪系统，被配置为产生离子的离子源和被配置为从离子源接收至少一部分离子的非金属毛细管。 毛细管包括细长主体和在纵向方向上穿过细长主体的多个孔。 孔将接收到的离子通过毛细管运送到质谱仪系统的质谱仪进行检测。

公开(公告)号：US07755040B2

公开(公告)日：2010-07-13

申请号：US11860263

申请日：2007-09-24

Applicant: Gangqiang Li ,  Alexander Mordehai

Inventor： Gangqiang Li ,  Alexander Mordehai

IPC: H01J49/00

CPC classification number: H01J49/425

Abstract: An electric field source for a mass spectrometer and a mass spectrometer are described.

Abstract translation: 描述了用于质谱仪和质谱仪的电场源。

公开(公告)号：US07534997B2

公开(公告)日：2009-05-19

申请号：US11441542

申请日：2006-05-25

Applicant: Gangqiang Li

Inventor： Gangqiang Li

IPC: H01J49/04

CPC classification number: H01J49/044

Abstract: A mass spectrometer sample input interface comprises a desolvation apparatus defining a desolvation pathway along which a desolvation gas flows, in a direction from upstream to downstream, the desolvation pathway having a desolvation pathway portion; and an ion pathway apparatus for defining an ion pathway for analyte solution droplets to follow, the ion pathway leading into the mass spectrometer, the ion pathway including an ion pathway portion that follows the desolvation pathway portion.

Abstract translation: 质谱仪样品输入界面包括去溶剂化装置，其定义了去溶剂化途径，去溶剂化气体沿着从上游到下游的方向从具有去溶剂化途径部分的去溶剂化途径流出; 以及离子通道装置，用于限定分析物溶液液滴的离子路径，通向质谱仪的离子通道，离子通路包括遵循去溶剂化途径部分的离子通路部分。

公开(公告)号：US07397028B2

公开(公告)日：2008-07-08

申请号：US11216884

申请日：2005-08-30

Applicant: Reid A. Brennen ,  Tom A van de Goor ,  Gangqiang Li ,  Kevin P. Killeen

Inventor： Reid A. Brennen ,  Tom A van de Goor ,  Gangqiang Li ,  Kevin P. Killeen

IPC: B01D59/44

CPC classification number: H01J49/10

Abstract: The invention described herein provides a mass spectrometry system, having an ion source including an ionization device for producing ions, a collection conduit adjacent to the ionization device for collecting ions produced by the ionization device, a first gas source for supplying gas to desolvate ions produced by the ionization device, a second gas source for supplying gas at a defined flow to the ionization region, and a detector downstream from the ion source for detecting ions produced by the ion source. The invention also provides an ion source including an ionization device for producing ions, a collection conduit adjacent to the ionization device for collecting ions produced by the ionization device, a first gas source for supplying gas to desolvate ions produced by the ionization device, and a second gas source for supplying gas at a defined flow to the ionization region. A method for producing analyte ions is also disclosed. The method includes producing analyte ions from an ionization device, directing a first heated gas toward the analyte ions to desolvate the analyte ions, and directing a second gas toward the analyte ions at a defined and continual flow rate.

Abstract translation: 本发明提供了一种质谱系统，其具有离子源，该离子源包括用于产生离子的离子化装置，与电离装置相邻的收集管，用于收集由离子化装置产生的离子;第一气体源，用于向产生的脱溶质离子供应气体 通过电离装置将用于以规定的流量供给到电离区域的气体的第二气体源和离子源下游的检测器，用于检测由离子源产生的离子。 本发明还提供了一种离子源，其包括用于产生离子的离子化装置，与离子化装置相邻的用于收集由离子化装置产生的离子的收集管，用于向离子化装置产生的脱溶质离子供给气体的第一气体源， 用于以限定的流量供应气体至电离区的第二气体源。 还公开了一种生产分析物离子的方法。 该方法包括从电离装置产生分析物离子，将第一加热气体引向分析物离子以使分析物离子脱溶质，并以限定和持续的流速将第二气体引向分析物离子。