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公开(公告)号:US20080090846A1
公开(公告)日:2008-04-17
申请号:US11956190
申请日:2007-12-13
申请人: Gary Bridger , Renato Skerlj , Al Kaller , Curtis Harwig , David Bogucki , Trevor Wilson , Jason Crawford , Ernest McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Smith , Rosaria Di Fluri
发明人: Gary Bridger , Renato Skerlj , Al Kaller , Curtis Harwig , David Bogucki , Trevor Wilson , Jason Crawford , Ernest McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Smith , Rosaria Di Fluri
IPC分类号: A61K31/436 , A61K31/47 , A61K31/506 , C07D215/38 , C07D401/14 , C07D491/052
CPC分类号: C07D213/38 , C07D213/65 , C07D213/81 , C07D215/40 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/04
摘要: Tertiary amines containing a multiplicity of heteroaromatic substituents are useful as chemokine receptor modulators.
摘要翻译: 含有多个杂芳族取代基的叔胺可用作趋化因子受体调节剂。
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公开(公告)号:US20060100240A1
公开(公告)日:2006-05-11
申请号:US11301725
申请日:2005-12-13
申请人: Gary Bridger , Ai Kaller , Curtis Harwig , Renato Skerlj , David Bogucki , Trevor Wilson , Jason Crawford , Ernest McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Smith , Maria Di Fluri
发明人: Gary Bridger , Ai Kaller , Curtis Harwig , Renato Skerlj , David Bogucki , Trevor Wilson , Jason Crawford , Ernest McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Smith , Maria Di Fluri
IPC分类号: A61K31/4709 , C07D403/02 , C07D403/14
CPC分类号: C07D401/14 , C07D235/14 , C07D401/12 , C07D403/12 , C07D471/04 , C07D471/06 , C07D491/04
摘要: The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
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公开(公告)号:US20050277670A1
公开(公告)日:2005-12-15
申请号:US11012002
申请日:2004-12-13
申请人: Yuanxi Zhou , Gary Bridger , Renato Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz , Maria Di Fluri , Siqiao Nan
发明人: Yuanxi Zhou , Gary Bridger , Renato Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz , Maria Di Fluri , Siqiao Nan
IPC分类号: A61K31/4545 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C12N20060101 , C07D43/02
CPC分类号: C07D401/14 , C07D401/12 , C07D413/14 , C07D417/14
摘要: The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
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公开(公告)号:US20070060591A1
公开(公告)日:2007-03-15
申请号:US11599066
申请日:2006-11-13
申请人: Gary Bridger , Eva Boehringer , Dominique Schols , Renato Skerlj , David Bogucki
发明人: Gary Bridger , Eva Boehringer , Dominique Schols , Renato Skerlj , David Bogucki
IPC分类号: A61K31/52 , A61K31/496 , A61K31/4439
CPC分类号: C07D401/12 , A61K31/33 , A61K31/4439 , A61K31/496 , A61K31/52 , C07D257/02 , C07D403/12 , C07D413/12 , C07D417/12 , Y02A50/411
摘要: The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV- or FIV-infected cells as well as other biological activity related to binding of ligands to chemokine receptors that mediate a number of mammalian embryonic developmental processes.
摘要翻译: 本发明涉及新的抗病毒化合物,药物组合物及其应用。 更具体地,本发明涉及在针对HIV或FIV感染的细胞的标准测试中具有活性的单环多胺的衍生物以及与介导多种哺乳动物胚胎发育过程的配体与趋化因子受体的结合相关的其它生物活性。
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公开(公告)号:US20050154005A1
公开(公告)日:2005-07-14
申请号:US10991944
申请日:2004-11-17
申请人: Gary Bridger , Eva Boehringer , Zhongren Wang , Dominique Schols , Renato Skerlj , David Bogucki
发明人: Gary Bridger , Eva Boehringer , Zhongren Wang , Dominique Schols , Renato Skerlj , David Bogucki
IPC分类号: A61K31/381 , A61K31/395 , A61K31/4178 , A61K31/4353 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/444 , A61K31/496 , A61K31/497 , A61K31/52 , A61K31/675 , A61P1/00 , A61P19/02 , A61P21/02 , A61P25/00 , A61P31/12 , A61P31/18 , A61P35/00 , C07D257/02 , C07D401/06 , C07D401/12 , C07D403/12 , C07D409/12 , C07D471/06 , C07D471/08 , C07D473/00 , C07D487/08 , A61K31/4745 , C07D487/14
CPC分类号: C07D473/00 , C04B35/632 , C07D257/02 , C07D401/06 , C07D401/12 , C07D403/12 , C07D409/12 , C07D471/06
摘要: The present invention is drawn to novel antiviral compounds, pharaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines wihich have activity in standard tests against HIV- or FIV-infected cells as well as other biological activity related to binding of ligands to chemokine receptors that mediate a number of mammalian embryonic developmental processes.
摘要翻译: 本发明涉及新型抗病毒化合物,药物组合物及其用途。 更具体地,本发明涉及在具有针对HIV或FIV感染细胞的标准测试中具有活性的单环多胺衍生物以及与介导多种哺乳动物胚胎发育过程的配体与趋化因子受体的结合相关的其它生物活性。
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公开(公告)号:US20060069129A1
公开(公告)日:2006-03-30
申请号:US11281296
申请日:2005-11-16
申请人: Gary Bridger , Eva Boehringer , Dominique Schols , Renato Skerlj , David Bogucki
发明人: Gary Bridger , Eva Boehringer , Dominique Schols , Renato Skerlj , David Bogucki
IPC分类号: A61K31/33
CPC分类号: C07D401/12 , A61K31/33 , A61K31/4439 , A61K31/496 , A61K31/52 , C07D257/02 , C07D403/12 , C07D413/12 , C07D417/12 , Y02A50/411
摘要: The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV- or FIV-infected cells as well as other biological activity related to binding of ligands to chemokine receptors that mediate a number of mammalian embryonic developmental processes.
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公开(公告)号:US07160872B2
公开(公告)日:2007-01-09
申请号:US10872735
申请日:2004-06-21
申请人: Gary Bridger , Eva Maria Boehringer , Zhongren Wang , Dominique Schols , Renato Skerlj , David Bogucki
发明人: Gary Bridger , Eva Maria Boehringer , Zhongren Wang , Dominique Schols , Renato Skerlj , David Bogucki
IPC分类号: A61K31/675 , A61K31/44 , A61K31/33 , A61P31/12 , C07D243/14
CPC分类号: C07D473/00 , C04B35/632 , C07D257/02 , C07D401/06 , C07D401/12 , C07D403/12 , C07D409/12 , C07D471/06
摘要: The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV-infected cells as well as other biological activity related to binding of ligands to chemokine receptors that mediate a number of mammalian embryonic developmental processes.
摘要翻译: 本发明涉及新的抗病毒化合物,药物组合物及其应用。 更具体地,本发明涉及在针对HIV感染细胞的标准测试中具有活性的单环多胺衍生物以及与介导多种哺乳动物胚胎发育过程的配体与趋化因子受体的结合相关的其它生物活性。
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公开(公告)号:US20050277668A1
公开(公告)日:2005-12-15
申请号:US11152589
申请日:2005-06-14
申请人: Yuanxi Zhou , Gary Bridger , Renato Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz
发明人: Yuanxi Zhou , Gary Bridger , Renato Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz
IPC分类号: A61K31/4545 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C12N20060101 , C07D41/14
CPC分类号: C07D417/14 , C07D401/12 , C07D401/14 , C07D413/14
摘要: The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
摘要翻译: 本发明涉及趋化因子受体结合化合物,药物组合物及其用途。 更具体地,本发明涉及趋化因子受体活性的调节剂,优选CCR5的调节剂。 这些化合物表现出对人体免疫缺陷病毒(HIV)感染靶细胞的保护作用。
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公开(公告)号:US07491735B2
公开(公告)日:2009-02-17
申请号:US11012002
申请日:2004-12-13
申请人: Yuanxi Zhou , Gary J. Bridger , Renato T. Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz , Maria R. Di Fluri , Siqiao Nan
发明人: Yuanxi Zhou , Gary J. Bridger , Renato T. Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz , Maria R. Di Fluri , Siqiao Nan
IPC分类号: A61K31/4468
CPC分类号: C07D401/14 , C07D401/12 , C07D413/14 , C07D417/14
摘要: The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
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公开(公告)号:US07498346B2
公开(公告)日:2009-03-03
申请号:US11152589
申请日:2005-06-14
申请人: Yuanxi Zhou , Gary J. Bridger , Renato T. Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz
发明人: Yuanxi Zhou , Gary J. Bridger , Renato T. Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz
IPC分类号: A61K31/4453 , C07D211/58
CPC分类号: C07D417/14 , C07D401/12 , C07D401/14 , C07D413/14
摘要: The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
摘要翻译: 本发明涉及趋化因子受体结合化合物,药物组合物及其用途。 更具体地,本发明涉及趋化因子受体活性的调节剂,优选CCR5的调节剂。 这些化合物表现出对人体免疫缺陷病毒(HIV)感染靶细胞的保护作用。
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