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公开(公告)号:US07498346B2
公开(公告)日:2009-03-03
申请号:US11152589
申请日:2005-06-14
申请人: Yuanxi Zhou , Gary J. Bridger , Renato T. Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz
发明人: Yuanxi Zhou , Gary J. Bridger , Renato T. Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz
IPC分类号: A61K31/4453 , C07D211/58
CPC分类号: C07D417/14 , C07D401/12 , C07D401/14 , C07D413/14
摘要: The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
摘要翻译: 本发明涉及趋化因子受体结合化合物,药物组合物及其用途。 更具体地,本发明涉及趋化因子受体活性的调节剂,优选CCR5的调节剂。 这些化合物表现出对人体免疫缺陷病毒(HIV)感染靶细胞的保护作用。
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公开(公告)号:US07491735B2
公开(公告)日:2009-02-17
申请号:US11012002
申请日:2004-12-13
申请人: Yuanxi Zhou , Gary J. Bridger , Renato T. Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz , Maria R. Di Fluri , Siqiao Nan
发明人: Yuanxi Zhou , Gary J. Bridger , Renato T. Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz , Maria R. Di Fluri , Siqiao Nan
IPC分类号: A61K31/4468
CPC分类号: C07D401/14 , C07D401/12 , C07D413/14 , C07D417/14
摘要: The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
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公开(公告)号:US07790747B2
公开(公告)日:2010-09-07
申请号:US11453221
申请日:2006-06-14
申请人: Yuanxi Zhou , Elyse Bourque , Yongbao Zhu , Jonathan Langille , Markus Metz , Wen Yang , Ernest J. McEachern , Curtis Harwig , Ian R. Baird , Tong-Shuang Li , Renato T. Skerlj
发明人: Yuanxi Zhou , Elyse Bourque , Yongbao Zhu , Jonathan Langille , Markus Metz , Wen Yang , Ernest J. McEachern , Curtis Harwig , Ian R. Baird , Tong-Shuang Li , Renato T. Skerlj
IPC分类号: A61K31/4545 , C07D409/14
CPC分类号: C07D413/14 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要: The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
摘要翻译: 本发明涉及趋化因子受体结合化合物,药物组合物及其用途。 更具体地,本发明涉及趋化因子受体活性的调节剂,优选CCR5的调节剂。 这些化合物表现出对人体免疫缺陷病毒(HIV)感染靶细胞的保护作用。
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公开(公告)号:US20100298366A1
公开(公告)日:2010-11-25
申请号:US12851495
申请日:2010-08-05
申请人: Yuanxi ZHOU , Elyse Bourque , Yongbao Zhu , Jonathan Langille , Markus Metz , Wen Yang , Ernest J. Mceachern , Curtis Harwig , Ian R. Baird , Tong-Shuang Li , Renato T. Skerlj
发明人: Yuanxi ZHOU , Elyse Bourque , Yongbao Zhu , Jonathan Langille , Markus Metz , Wen Yang , Ernest J. Mceachern , Curtis Harwig , Ian R. Baird , Tong-Shuang Li , Renato T. Skerlj
IPC分类号: A61K31/4545 , C07D413/14 , C07D413/04 , C07D401/14 , A61K31/454 , A61K31/506 , A61P31/18
CPC分类号: C07D413/14 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要: The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
摘要翻译: 本发明涉及趋化因子受体结合化合物,药物组合物及其用途。 更具体地,本发明涉及趋化因子受体活性的调节剂,优选CCR5的调节剂。 这些化合物表现出对人体免疫缺陷病毒(HIV)感染靶细胞的保护作用。
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公开(公告)号:US20090099205A1
公开(公告)日:2009-04-16
申请号:US11453221
申请日:2006-06-14
申请人: Yuanxi Zhou , Elyse Bourque , Yongbao Zhu , Jonathan Langille , Markus Metz , Wen Yang , Ernest J. McEachern , Curtis Harwig , Ian R. Baird , Tong-Shuang Li , Renato T. Skerlj
发明人: Yuanxi Zhou , Elyse Bourque , Yongbao Zhu , Jonathan Langille , Markus Metz , Wen Yang , Ernest J. McEachern , Curtis Harwig , Ian R. Baird , Tong-Shuang Li , Renato T. Skerlj
IPC分类号: A61K31/506 , C07D403/12 , A61K31/4545 , C07D409/14 , C12N5/06
CPC分类号: C07D413/14 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要: The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
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公开(公告)号:US20050277668A1
公开(公告)日:2005-12-15
申请号:US11152589
申请日:2005-06-14
申请人: Yuanxi Zhou , Gary Bridger , Renato Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz
发明人: Yuanxi Zhou , Gary Bridger , Renato Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz
IPC分类号: A61K31/4545 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C12N20060101 , C07D41/14
CPC分类号: C07D417/14 , C07D401/12 , C07D401/14 , C07D413/14
摘要: The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
摘要翻译: 本发明涉及趋化因子受体结合化合物,药物组合物及其用途。 更具体地,本发明涉及趋化因子受体活性的调节剂,优选CCR5的调节剂。 这些化合物表现出对人体免疫缺陷病毒(HIV)感染靶细胞的保护作用。
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公开(公告)号:US20050277670A1
公开(公告)日:2005-12-15
申请号:US11012002
申请日:2004-12-13
申请人: Yuanxi Zhou , Gary Bridger , Renato Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz , Maria Di Fluri , Siqiao Nan
发明人: Yuanxi Zhou , Gary Bridger , Renato Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz , Maria Di Fluri , Siqiao Nan
IPC分类号: A61K31/4545 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C12N20060101 , C07D43/02
CPC分类号: C07D401/14 , C07D401/12 , C07D413/14 , C07D417/14
摘要: The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
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公开(公告)号:US20070066624A1
公开(公告)日:2007-03-22
申请号:US11505669
申请日:2006-08-16
申请人: Yuanxi Zhou , Elyse Bourque , Yongbao Zhu , Ernest McEachern , Curtis Harwig , Renato Skerlj , Gary Bridger , Tong-Shuang Li , Markus Metz
发明人: Yuanxi Zhou , Elyse Bourque , Yongbao Zhu , Ernest McEachern , Curtis Harwig , Renato Skerlj , Gary Bridger , Tong-Shuang Li , Markus Metz
IPC分类号: A61K31/496 , A61K31/454 , C07D403/14 , C07D403/04
CPC分类号: C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D493/08
摘要: The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR4 or CCR5. In one aspect, these compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
摘要翻译: 本发明涉及趋化因子受体结合化合物,药物组合物及其用途。 更具体地,本发明涉及趋化因子受体活性的调节剂,优选CCR4或CCR5的调节剂。 一方面,这些化合物表现出针对人类免疫缺陷病毒(HIV)感染靶细胞的保护作用。
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