公开(公告)号：US20200377604A1

公开(公告)日：2020-12-03

申请号：US16872974

申请日：2020-05-12

Applicant: Genentech, Inc.

Inventor： J. Michael Elliott ,  Justin Scheer

IPC: C07K16/28 ,  C07K16/24 ,  C07K16/46

Abstract: Described herein are Fc variants and methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins). Heteromultimeric proteins may be capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.

公开(公告)号：US10544198B2

公开(公告)日：2020-01-28

申请号：US15454662

申请日：2017-03-09

Applicant: Genentech, Inc.

Inventor： Justin Scheer ,  Wenjun Ouyang ,  Richard Vandlen ,  Philip E. Hass ,  Eric Gary Stefanich ,  Xiaoting Wang ,  Ganesh A. Kolumam ,  Wyne P. Lee

IPC: C07K14/54 ,  C07K16/28 ,  A61K38/20 ,  A61K47/38 ,  A61K38/00

Abstract: The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.

公开(公告)号：US10323094B2

公开(公告)日：2019-06-18

申请号：US15184690

申请日：2016-06-16

Applicant: Genentech, Inc.

Inventor： Isidro Hotzel ,  Teemu T. Junttila ,  Ji Li ,  Justin Scheer ,  Danielle DiCara ,  Diego Ellerman ,  Christoph Spiess ,  Paul J. Carter

IPC: C07K16/00 ,  C12P21/08 ,  A61K39/395 ,  A61K39/40 ,  A61K39/42 ,  C07K16/28 ,  A61K45/06 ,  C07K16/30 ,  G01N33/574 ,  A61K47/68 ,  A61K39/00

Abstract: The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g., FcRH5 T cell-dependent bispecific (TDB) antibodies), and methods of using the same.

公开(公告)号：US09815880B2

公开(公告)日：2017-11-14

申请号：US15217790

申请日：2016-07-22

Applicant: Genentech, Inc.

Inventor： Justin Scheer ,  Wenjun Ouyang ,  Richard Vandlen ,  Philip E. Hass ,  Eric Gary Stefanich ,  Xiaoting Wang

IPC: A61K38/20 ,  C07K14/54 ,  C07K16/28 ,  A61K47/38 ,  A61K38/00

CPC classification number: C07K14/54 ,  A61K38/00 ,  A61K38/20 ,  A61K47/38 ,  C07K16/2866 ,  C07K2319/30

Abstract: The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.