公开(公告)号：US20120274637A1

公开(公告)日：2012-11-01

申请号：US13458555

申请日：2012-04-27

申请人： Vladimir Ivanov ,  Thomas Feldbauer ,  Alexey Pryakhin ,  Peter Kunath ,  Marek Strassenburg-Kleciak

发明人： Vladimir Ivanov ,  Thomas Feldbauer ,  Alexey Pryakhin ,  Peter Kunath ,  Marek Strassenburg-Kleciak

IPC分类号： G06T17/05

CPC分类号： G01C21/32 ,  G01C21/3638 ,  G06T9/001 ,  G06T17/05 ,  G06T17/20

摘要： A database for a navigation system has digital elevation model data defining a three-dimensional surface. The database stores, for plural tiles of a tiling, a first array including three-dimensional coordinates of vertices of plural triangulated irregular networks, TINS, for the respective tile, and a plurality of second arrays. Each second array respectively defines triangular faces of a TIN and includes a plurality of vertex indices of the vertices to define triangular faces of the respective TIN. A method of outputting a three-dimensional representation of a terrain and a method of generating the database are also described.

摘要翻译： 用于导航系统的数据库具有定义三维表面的数字高程模型数据。 数据库存储用于多个瓦片的瓦片，包括用于各个瓦片的多个三角形不规则网络TINS的顶点的三维坐标的第一阵列，以及多个第二阵列。 每个第二阵列分别定义TIN的三角形面，并且包括顶点的多个顶点索引以限定相应TIN的三角形面。 还描述了输出地形的三维表示的方法和生成数据库的方法。

公开(公告)号：US20120274633A1

公开(公告)日：2012-11-01

申请号：US13458428

申请日：2012-04-27

申请人： Vladimir Ivanov ,  Thomas Feldbauer ,  Alexey Pryakhin ,  Peter Kunath ,  Marek Strassenburg-Kleciak

发明人： Vladimir Ivanov ,  Thomas Feldbauer ,  Alexey Pryakhin ,  Peter Kunath ,  Marek Strassenburg-Kleciak

IPC分类号： G09G5/00 ,  G06T15/00

CPC分类号： G01C21/32 ,  G06F17/30241 ,  G06F17/30321 ,  G06T17/05 ,  G06T17/20

摘要： A navigation system has a database which stores index data for, respectively, a tile of a tiling. The index data includes, for each one of plural cells of a grid which is superimposed on the tile, respectively an identifier for each triangular face of a triangulated irregular network which at least partially overlaps with the respective cell. The plural cells of the grid are defined so as to cover the respective tile. A processing device of the navigation system is configured to use the index data to determine a triangular face on which a map feature having given lateral coordinates is located, in order to determine a height coordinate of the map feature.

摘要翻译： 导航系统具有数据库，该数据库分别存储分块的瓦片的索引数据。 索引数据对于叠加在瓦片上的网格的多个单元格中的每一个单独分别包括与相应单元至少部分重叠的三角形不规则网络的每个三角形面的标识符。 限定网格的多个单元以覆盖相应的瓦片。 导航系统的处理装置被配置为使用索引数据来确定具有给定横向坐标的地图特征位于其上的三角形面，以便确定地图特征的高度坐标。

公开(公告)号：US20110295012A1

公开(公告)日：2011-12-01

申请号：US13197226

申请日：2011-08-03

申请人： Kenneth Alan Simmen ,  Herman Augustinus De Kock ,  Pierre Jean-Marie Bernard Raboisson ,  Lili Hu ,  Abdellah Tahri ,  Dominque Louis Nestor Ghislai Surleraux ,  Karl Magnus Nilsson ,  Bengt Bertil Samuelsson ,  Asa Annica Kristina Rosenquist ,  Vladimir Ivanov ,  Michael Pelcman ,  Anna Karin Gertrud Linnea Belfrage ,  Per-Ola Mikael Johansson ,  Sandrine Marie Helene Vendeville

发明人： Kenneth Alan Simmen ,  Herman Augustinus De Kock ,  Pierre Jean-Marie Bernard Raboisson ,  Lili Hu ,  Abdellah Tahri ,  Dominque Louis Nestor Ghislai Surleraux ,  Karl Magnus Nilsson ,  Bengt Bertil Samuelsson ,  Asa Annica Kristina Rosenquist ,  Vladimir Ivanov ,  Michael Pelcman ,  Anna Karin Gertrud Linnea Belfrage ,  Per-Ola Mikael Johansson ,  Sandrine Marie Helene Vendeville

IPC分类号： C07D417/04 ,  C07C225/22 ,  C07D277/56

CPC分类号： C07D487/04 ,  A61K31/427 ,  A61K31/4709 ,  A61K31/7056 ,  A61K38/05 ,  A61K38/212 ,  A61K45/06 ,  A61K47/60 ,  C07D245/04 ,  C07D277/56 ,  C07D401/14 ,  C07D417/04 ,  C07D417/14 ,  C07K5/06139 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/389 ,  Y02A50/393

摘要： Inhibitors of HCV replication of formula (I) and the N-oxides, salts, and stereoisomers, wherein each dashed line represents an optional double bond; X is N, CH and where X bears a double bond it is C; R1 is —OR7 or —NH—SO2R8; R2 is hydrogen, and where X is C or CH, R2 may also be C1-6alkyl; R3 is hydrogen, C1-6alkyl, C1-6alkoxyC1-6alkyl, or C3-7cycloalkyl; R4 is aryl or Het; n is 3, 4, 5, or 6; R5 is halo, C1-6alkyl, hydroxy, C1-6alkoxy, phenyl, or Het; R6 is C1-6alkoxy or dimethylamino; R7 is hydrogen; aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het; R8 is aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het; aryl is phenyl optionally substituted with one, two or three substituents; Het is a 5 or 6 membered saturated, partially unsaturated or completely unsaturated heterocyclic ring containing 1 to 4 heteroatoms selected from nitrogen, oxygen and sulfur, and being optionally substituted with one, two or three substituents; pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I). Bioavailable combinations of the inhibitors of HCV of formula (I) with ritonavir are also provided.

摘要翻译： 式（I）的HCV复制抑制剂和N-氧化物，盐和立体异构体，其中每个虚线表示任选的双键; X为N，CH，X为双键，C为C; R1是-OR7或-NH-SO2R8; R2是氢，并且其中X是C或CH，R2也可以是C1-6烷基; R 3是氢，C 1-6烷基，C 1-6烷氧基C 1-6烷基或C 3-7环烷基; R4是芳基或Het; n为3,4,5或6; R 5为卤素，C 1-6烷基，羟基，C 1-6烷氧基，苯基或Het; R6是C1-6烷氧基或二甲基氨基; R7是氢; 芳基; Het; 任选被C 1-6烷基取代的C 3-7环烷基; 或任选被C 3-7环烷基，芳基或与Het取代的C 1-6烷基; R8是芳基; Het; 任选被C 1-6烷基取代的C 3-7环烷基; 或任选被C 3-7环烷基，芳基或与Het取代的C 1-6烷基; 芳基是任选被一个，两个或三个取代基取代的苯基; Het是含有1至4个选自氮，氧和硫的杂原子并且任选地被一个，两个或三个取代基取代的5或6元饱和，部分不饱和或完全不饱和的杂环。 含有化合物（I）的药物组合物和制备化合物（I）的方法。 还提供了式（I）的HCV抑制剂与利托那韦的生物可利用组合。

公开(公告)号：US20090281140A1

公开(公告)日：2009-11-12

申请号：US11632102

申请日：2006-07-28

申请人： Kenneth Alan Simmen ,  Herman Augustinus De Kock ,  Pierre Jean-Marie Bernard Raboisson ,  Lili Hu ,  Abdellah Tahri ,  Dominique Louis Nestor Ghislain Surleraux ,  Karl Magnus Nilsson ,  Bengt Bertil Samuelson ,  Åsa Annica Kristina Rosenquist ,  Vladimir Ivanov ,  Michael Pelcman ,  Anna Karin Gertrud Linnea Belfrage ,  Per-Ola Mikael Johansson ,  Sandrine Marie Helene Vendeville

发明人： Kenneth Alan Simmen ,  Herman Augustinus De Kock ,  Pierre Jean-Marie Bernard Raboisson ,  Lili Hu ,  Abdellah Tahri ,  Dominique Louis Nestor Ghislain Surleraux ,  Karl Magnus Nilsson ,  Bengt Bertil Samuelson ,  Åsa Annica Kristina Rosenquist ,  Vladimir Ivanov ,  Michael Pelcman ,  Anna Karin Gertrud Linnea Belfrage ,  Per-Ola Mikael Johansson ,  Sandrine Marie Helene Vendeville

IPC分类号： A61K31/4709 ,  C07D245/00 ,  A61P31/12

CPC分类号： C07D487/04 ,  A61K31/427 ,  A61K31/4709 ,  A61K31/7056 ,  A61K38/05 ,  A61K38/212 ,  A61K45/06 ,  A61K47/60 ,  C07D245/04 ,  C07D277/56 ,  C07D401/14 ,  C07D417/04 ,  C07D417/14 ,  C07K5/06139 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/389 ,  Y02A50/393

摘要： Inhibitors of HCV replication of formula (I) and the N-oxides, salts, and stereoisomers, wherein each dashed line represents an optional double bond; X is N, CH and where X bears a double bond it is C; R1 is —OR7, —NH—SO2R8; R2 is hydrogen, and where X is C or CH, R2 may also be C1-6alkyl; R3 is hydrogen, C1-6alkyl, C1-6alkoxyC1-6alkyl, C3-7cycloalkyl; R4 is aryl or Het; n is 3, 4, 5, or 6; R5 is halo, C1-6alkyl, hydroxy, C1-6alkoxy, phenyl, or Het; R6 is C1-6alkoxy, or dimethylamino; R7 is hydrogen; aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het; R8 is aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het; aryl is phenyl optionally substituted with one, two or three substituents; Het is a 5 or 6 membered saturated, partially unsaturated or completely unsaturated heterocyclic ring containing 1 to 4 heteroatoms selected from nitrogen, oxygen and sulfur, and being optionally substituted with one, two or three substituents; pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I). Bioavailable combinations of the inhibitors of HCV of formula (I) with ritonavir are also provided.

摘要翻译： 式（I）的HCV复制抑制剂和N-氧化物，盐和立体异构体，其中每个虚线表示任选的双键; X为N，CH，X为双键，C为C; R1是-OR7，-NH-SO2R8; R2是氢，并且其中X是C或CH，R2也可以是C1-6烷基; R 3是氢，C 1-6烷基，C 1-6烷氧基C 1-6烷基，C 3-7环烷基; R4是芳基或Het; n为3,4,5或6; R 5为卤素，C 1-6烷基，羟基，C 1-6烷氧基，苯基或Het; R6是C1-6烷氧基或二甲基氨基; R7是氢; 芳基; Het; 任选被C 1-6烷基取代的C 3-7环烷基; 或任选被C 3-7环烷基，芳基或与Het取代的C 1-6烷基; R8是芳基; Het; 任选被C 1-6烷基取代的C 3-7环烷基; 或任选被C 3-7环烷基，芳基或与Het取代的C 1-6烷基; 芳基是任选被一个，两个或三个取代基取代的苯基; Het是含有1至4个选自氮，氧和硫的杂原子并且任选地被一个，两个或三个取代基取代的5或6元饱和，部分不饱和或完全不饱和的杂环。 含有化合物（I）的药物组合物和制备化合物（I）的方法。 还提供了式（I）的HCV抑制剂与利托那韦的生物可利用组合。

公开(公告)号：US20060104974A1

公开(公告)日：2006-05-18

申请号：US09784950

申请日：2001-02-15

申请人： C. Davis ,  Russell Blacher ,  Jose Corvalan ,  Alan Culwell ,  Larry Green ,  Joanne Hales ,  Nancy Havrilla ,  Vladimir Ivanov ,  John Lipani ,  Qiang Liu ,  Richard Weber ,  Xiao-Dong Yang

发明人： C. Davis ,  Russell Blacher ,  Jose Corvalan ,  Alan Culwell ,  Larry Green ,  Joanne Hales ,  Nancy Havrilla ,  Vladimir Ivanov ,  John Lipani ,  Qiang Liu ,  Richard Weber ,  Xiao-Dong Yang

IPC分类号： A61K39/395 ,  C07K16/28

CPC分类号： C07K16/2803 ,  A61K2039/505 ,  C07K14/70596 ,  C07K16/2896 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/30

摘要： In accordance with the present invention, we have discovered that the molecule CD147 as expressed on certain cells, such as T-cells, B-cells, and/or monocytes, can be utilized for the treatment of a variety of diseases. In particular, we have demonstrated that antibodies that bind to CD147 and that result in the killing of such cells, for example, through the binding of complement, is efficacious in the treatment of diseases. Diseases in which such treatment appears efficacious include, without limitation: graft versus host disease (GVHD), organ transplant rejection diseases (including, without limitation, renal transplant, ocular transplant, and others), cancers (including, without limitation, cancers of the blood (i.e., leukemias and lymphomas), pancreatic, and others), autoimmune diseases, inflammatory diseases, and others.

摘要翻译： 根据本发明，我们发现在诸如T细胞，B细胞和/或单核细胞的某些细胞上表达的分子CD147可用于治疗各种疾病。 特别地，我们已经证明，结合CD147并导致这种细胞的杀伤，例如通过补体结合的抗体在治疗疾病中是有效的。 这种治疗显示有效的疾病包括但不限于：移植物抗宿主病（GVHD），器官移植排斥疾病（包括但不限于肾移植，眼部移植等），癌症（包括但不限于： 血液（即白血病和淋巴瘤），胰腺等），自身免疫疾病，炎性疾病等。

公开(公告)号：US20050144503A1

公开(公告)日：2005-06-30

申请号：US10783240

申请日：2004-02-20

申请人： Rohit Amarnath ,  Vladimir Ivanov

发明人： Rohit Amarnath ,  Vladimir Ivanov

IPC分类号： G05B19/418 ,  G06F11/00 ,  G06Q10/00

CPC分类号： G05B19/41865 ,  G05B2219/31449 ,  G06Q10/10 ,  Y02P90/20

摘要： A process automation system is described which includes a sense and response framework for receiving events in the process and initiating tasks in response to the received events. Execution of the scheduled tasks may in turn generate additional events that are received and responded to until all nodes in the flow have been completed.

摘要翻译： 描述了一种过程自动化系统，其包括用于在该过程中接收事件的响应和响应框架，并响应于接收的事件发起任务。 调度任务的执行可能反过来产生接收和响应的附加事件，直到流中的所有节点都已完成。

公开(公告)号：US09835462B2

公开(公告)日：2017-12-05

申请号：US13458428

申请日：2012-04-27

申请人： Vladimir Ivanov ,  Thomas Feldbauer ,  Alexey Pryakhin ,  Peter Kunath ,  Marek Strassenburg-Kleciak

发明人： Vladimir Ivanov ,  Thomas Feldbauer ,  Alexey Pryakhin ,  Peter Kunath ,  Marek Strassenburg-Kleciak

IPC分类号： G09G5/00 ,  G06T15/00 ,  G01C21/32 ,  G06F17/30 ,  G06T17/05 ,  G06T17/20

CPC分类号： G01C21/32 ,  G06F17/30241 ,  G06F17/30321 ,  G06T17/05 ,  G06T17/20

摘要： A navigation system has a database which stores index data for, respectively, a tile of a tiling. The index data includes, for each one of plural cells of a grid which is superimposed on the tile, respectively an identifier for each triangular face of a triangulated irregular network which at least partially overlaps with the respective cell. The plural cells of the grid are defined so as to cover the respective tile. A processing device of the navigation system is configured to use the index data to determine a triangular face on which a map feature having given lateral coordinates is located, in order to determine a height coordinate of the map feature.

公开(公告)号：US09441978B2

公开(公告)日：2016-09-13

申请号：US13458555

申请日：2012-04-27

申请人： Vladimir Ivanov ,  Thomas Feldbauer ,  Alexey Pryakhin ,  Peter Kunath ,  Marek Strassenburg-Kleciak

发明人： Vladimir Ivanov ,  Thomas Feldbauer ,  Alexey Pryakhin ,  Peter Kunath ,  Marek Strassenburg-Kleciak

IPC分类号： G06T17/05 ,  G01C21/32 ,  G01C21/36 ,  G06T17/20 ,  G06T9/00

CPC分类号： G01C21/32 ,  G01C21/3638 ,  G06T9/001 ,  G06T17/05 ,  G06T17/20

摘要： A database for a navigation system has digital elevation model data defining a three-dimensional surface. The database stores, for plural tiles of a tiling, a first array including three-dimensional coordinates of vertices of plural triangulated irregular networks, TINs, for the respective tile, and a plurality of second arrays. Each second array respectively defines triangular faces of a TIN and includes a plurality of vertex indices of the vertices to define triangular faces of the respective TIN. A method of outputting a three-dimensional representation of a terrain and a method of generating the database are also described.

摘要翻译： 用于导航系统的数据库具有定义三维表面的数字高程模型数据。 数据库存储用于多个瓦片的瓦片，包括用于各个瓦片的多个三角形不规则网络TIN的三维坐标的第一阵列，以及多个第二阵列。 每个第二阵列分别定义TIN的三角形面，并且包括顶点的多个顶点索引，以定义相应TIN的三角形面。 还描述了输出地形的三维表示的方法和生成数据库的方法。

公开(公告)号：US08862392B2

公开(公告)日：2014-10-14

申请号：US13426376

申请日：2012-03-21

申请人： Carsten-Christian Spindler ,  Vladimir Ivanov ,  Martin Fischer ,  Simon Schütz

发明人： Carsten-Christian Spindler ,  Vladimir Ivanov ,  Martin Fischer ,  Simon Schütz

IPC分类号： G01C21/00 ,  G01C21/36

CPC分类号： G01C21/3638

摘要： A navigation system includes a display for displaying at least a part of a digital map. A landmark detected within the digital map is displayed as a three-dimensional graphical object or a two-dimensional graphical object depending on a location of the landmark.

摘要翻译： 导航系统包括用于显示数字地图的至少一部分的显示器。 根据地标的位置，在数字地图内检测到的地标被显示为三维图形对象或二维图形对象。

公开(公告)号：US08725411B2

公开(公告)日：2014-05-13

申请号：US13571960

申请日：2012-08-10

申请人： Viktor Samokhin ,  Vladimir Ivanov ,  Martin Fischer ,  Carsten-Christian Spindler ,  Stavros Mitrakis

发明人： Viktor Samokhin ,  Vladimir Ivanov ,  Martin Fischer ,  Carsten-Christian Spindler ,  Stavros Mitrakis

IPC分类号： G01C21/00 ,  G06T15/00

CPC分类号： G01C21/3638 ,  G06T17/05 ,  G06T17/20 ,  G06T2210/04 ,  G09B29/007 ,  G09B29/106

摘要： The invention relates to system and method for generating a 3-dimensional representation of a tunnel. Road network data is provided having a plurality of road segments, at least one road segment being a tunnel road segment, including the information that said at least one road segment is a road segment located in a tunnel. The tunnel segment in the road network is identified, providing a geographical elevation map including elevation data of the geographical region in which the tunnel road segment is located, providing predefined patterns representing predefined parts of a 3-dimensional tunnel body, generating the 3-dimensional representation of the tunnel based on the tunnel road segment, the elevation map and the predefined patterns, and storing the 3-dimensional representation of the tunnel in connection with the road network as a 3-dimensional object which is located at the geographical position of the tunnel road segment.

摘要翻译： 本发明涉及用于产生隧道的三维表示的系统和方法。 道路网络数据被提供有多个路段，至少一个道路段是隧道路段，包括所述至少一个路段是位于隧道中的道路段的信息。 识别道路网络中的隧道段，提供包括隧道路段所在地理区域的高程数据的地理高程图，提供表示三维隧道主体的预定义部分的预定模式，产生三维 基于隧道路段的隧道的表示，高程图和预定义模式，并且将与道路网络相关的隧道的三维表示作为三维对象存储在位于 隧道路段。