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21.发明授权公开(公告)号：US07824394B2
公开(公告)日：2010-11-02
申请号：US11098030
申请日：2005-04-01
申请人： Dieter Manstein
发明人： Dieter Manstein
IPC分类号： A61B18/18
CPC分类号： A61B18/1477 , A61B5/4893 , A61B18/18 , A61B2018/00005 , A61B2018/0016 , A61B2018/0019 , A61B2018/00452 , A61B2018/143 , A61B2018/2005 , A61B2018/2211 , A61M5/158 , A61M2202/048
摘要： The present invention provides improved methods and apparatus for skin treatment and tissue remodeling. The apparatus includes an array of needles that penetrate the skin and serve as electrodes to deliver radio frequency current or other electrical or optical energy into the tissue being treated, causing thermal damage in controlled patterns. The damaged regions promote beneficial results such as uniform skin tightening by stimulation of wound healing and collagen growth.
摘要翻译： 本发明提供了用于皮肤治疗和组织重塑的改进的方法和装置。 该装置包括穿透皮肤并用作电极的针阵列，以将射频电流或其他电或光能量输送到被处理的组织中，从而导致受控模式的热损伤。 受损区域通过刺激伤口愈合和胶原生长促进有益效果，例如均匀的皮肤收缩。
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22.发明授权Methods and devices for selective disruption of fatty tissue by controlled cooling 有权通过受控冷却选择性破坏脂肪组织的方法和装置公开(公告)号：US07367341B2
公开(公告)日：2008-05-06
申请号：US10391221
申请日：2003-03-17
IPC分类号： A61B19/00
CPC分类号： A61F7/00 , A61B5/415 , A61B5/6804 , A61B18/02 , A61B2018/0237 , A61B2018/0262 , A61F7/10 , A61F2007/0054 , A61F2007/0056 , A61F2007/0075 , A61F2007/0082 , A61F2007/0094 , A61F2007/0096 , A61F2007/0239 , A61F2007/029 , A61H23/00
摘要： The present invention relates to methods for use in the selective disruption of lipid-rich cells by controlled cooling. The present invention further relates to a device for use in carrying out the methods for selective disruption of lipid-rich cells by controlled cooling.
摘要翻译： 本发明涉及用于通过受控冷却选择性破坏富含脂质细胞的方法。 本发明还涉及一种用于实施通过受控冷却选择性破坏富含脂质细胞的方法的装置。
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公开(公告)号：US20080058784A1
公开(公告)日：2008-03-06
申请号：US11931232
申请日：2007-10-31
申请人： Dieter Manstein , R. Anderson
发明人： Dieter Manstein , R. Anderson
IPC分类号： A61B18/20
CPC分类号： A61B18/203 , A61B2018/00005 , A61B2018/00452 , A61B2018/0047 , A61B2018/208
摘要： The present invention provides improved methods and apparatus for skin treatment. The apparatus includes multiple sources of optical energy or several blades that are scanned along a region of skin to form micro-line patterns of damaged tissue. The micro-lines are small in at least one dimension, having a width of less than about 1 mm, and the wounded regions promote beneficial results by stimulation of wound healing and tissue remodeling.
摘要翻译： 本发明提供了用于皮肤治疗的改进方法和装置。 该装置包括沿着皮肤区域扫描的多个光能源或几个叶片，以形成受损组织的微线图案。 微细线在至少一个维度上是小的，具有小于约1mm的宽度，受伤的区域通过刺激伤口愈合和组织重塑来促进有益的结果。
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公开(公告)号：US20080009842A1
公开(公告)日：2008-01-10
申请号：US11760333
申请日：2007-06-08
申请人： Dieter Manstein , Richard Anderson
发明人： Dieter Manstein , Richard Anderson
IPC分类号： A61B18/18
CPC分类号： A61N7/02 , A61B18/20 , A61B18/203 , A61B2018/00452 , A61B2018/00458 , A61B2018/00476 , A61B2018/00904
摘要： A method and apparatus are provided for performing a therapeutic treatment on a patient's skin by concentrating applied radiation of at least one selected wavelength at a plurality of selected, three-dimensionally located, treatment portions, which treatment portions are within non-treatment portions. The ratio of treatment portions to the total volume may vary from 0.1% to 90%, but is preferably less than 50%. Various techniques, including wavelength, may be utilized to control the depth to which radiation is concentrated and suitable optical systems may be provided to concentrate applied radiation in parallel or in series for selected combinations of one or more treatment portions.
摘要翻译： 提供了一种方法和装置，用于通过在多个选定的三维位置的处理部分中浓缩至少一个所选波长的施加的辐射来对患者的皮肤进行治疗处理，该处理部分处于非处理部分内。 处理部分与总体积的比率可以在0.1％至90％之间变化，但优选小于50％。 可以使用包括波长在内的各种技术来控制辐射集中的深度，并且可以提供合适的光学系统以将施加的辐射平行或串联地选择一个或多个处理部分的组合。
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公开(公告)号：US20070264288A1
公开(公告)日：2007-11-15
申请号：US10599519
申请日：2005-04-01
申请人： Dieter Manstein
发明人： Dieter Manstein
CPC分类号： A61B18/1477 , A61B5/4893 , A61B18/18 , A61B2018/00005 , A61B2018/0016 , A61B2018/0019 , A61B2018/00452 , A61B2018/143 , A61B2018/2005 , A61B2018/2211 , A61M5/158 , A61M2202/048
摘要： The present invention encompasses methods that use heat and/or electromagnetic radiation for dermatological treatment and more particularly to a method that uses heat and/or electromagnetic radiation in combination with chromophores for fractional wounding and, in particular, discontinuous fractional damage of skin tissue.
摘要翻译： 本发明包括使用热和/或电磁辐射进行皮肤病学治疗的方法，更具体地涉及使用热和/或电磁辐射与发色团组合用于分数伤口，特别是皮肤组织的不连续分数损伤的方法。
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公开(公告)号：US20070239236A1
公开(公告)日：2007-10-11
申请号：US11733136
申请日：2007-04-09
申请人： Dieter Manstein
发明人： Dieter Manstein
IPC分类号： A61N5/06
CPC分类号： A61B18/203 , A61B2017/00176 , A61B2018/00005 , A61B2018/00452 , A61B2018/00458 , A61B2018/0047 , A61B2018/207
摘要： A method and apparatus are provided for treating dermatological conditions, in which a first beam of radiation is used to ablate a hole in skin tissue, and a second beam of radiation is directed into the hole and onto a region of skin tissue adjacent to and/or at the bottom of the hole. The first beam can be provided by an ablative laser such as a CO2 laser or an ER:YAG laser. The second beam can be provided by, e.g., an ablative laser operating at a lower peak power level than the first beam, a non-ablative laser, a flashlamp, a tungsten lamp, a diode or a diode array. A controlled amount of thermal damage can thereby be provided at a desired depth within the skin, using radiation sources that would be absorbed closer to the surface of the skin if an ablated hole were not present. Cooling and/or freezing of the skin prior to ablation can be provided to provide an analgesic effect and/or stabilize the tissue surrounding the ablated hole. The region of skin to be treated can optionally be pulled towards the radiation source using a vacuum to stretch and/or stabilize the skin tissue surrounding the volume to be ablated.
摘要翻译： 提供了一种用于治疗皮肤病学条件的方法和装置，其中使用第一辐射束来消除皮肤组织中的孔，并且将第二辐射束引导到所述孔中并附着到与所述皮肤组织相邻和/ 或在孔的底部。 第一束可以由诸如CO2激光器或ER：YAG激光器之类的烧蚀激光器来提供。 第二光束可以由例如以比第一光束低的峰值功率电平操作的烧蚀激光器，非消融激光器，闪光灯，钨灯，二极管或二极管阵列来提供。 因此，如果不存在烧蚀孔，则使用辐射源可以在皮肤内的期望深度处提供受控量的热损伤，所述辐射源将被吸收更接近皮肤表面。 可以提供在消融之前皮肤的冷却和/或冷冻以提供止痛效果和/或稳定消融孔周围的组织。 待处理的皮肤区域可以可选地使用真空拉向辐射源，以拉伸和/或稳定要消融的体积周围的皮肤组织。
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公开(公告)号：US20070073308A1
公开(公告)日：2007-03-29
申请号：US11599786
申请日：2006-11-15
CPC分类号： A61N7/02 , A61B18/20 , A61B18/203 , A61B2018/00452 , A61B2018/00458 , A61B2018/00476 , A61B2018/00904
摘要： A method and apparatus are provided for performing a therapeutic treatment on a patient's skin by concentrating applied radiation of at least one selected wavelength at a plurality of selected, three-dimensionally located, treatment portions, which treatment portions are within non-treatment portions. The ratio of treatment portions to the total volume may vary from 0.1% to 90%, but is preferably less than 50%. Various techniques, including wavelength, may be utilized to control the depth to which radiation is concentrated and suitable optical systems may be provided to concentrate applied radiation in parallel or in series for selected combinations of one or more treatment portions.
摘要翻译： 提供了一种方法和装置，用于通过在多个选定的三维位置的处理部分中浓缩至少一个所选波长的施加的辐射来对患者的皮肤进行治疗处理，该处理部分处于非处理部分内。 处理部分与总体积的比率可以在0.1％至90％之间变化，但优选小于50％。 可以使用包括波长在内的各种技术来控制辐射集中的深度，并且可以提供合适的光学系统以将施加的辐射平行或串联地选择一个或多个处理部分的组合。
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28.发明申请公开(公告)号：US20050222565A1
公开(公告)日：2005-10-06
申请号：US11098030
申请日：2005-04-01
申请人： Dieter Manstein
发明人： Dieter Manstein
CPC分类号： A61B18/1477 , A61B5/4893 , A61B18/18 , A61B2018/00005 , A61B2018/0016 , A61B2018/0019 , A61B2018/00452 , A61B2018/143 , A61B2018/2005 , A61B2018/2211 , A61M5/158 , A61M2202/048
摘要： The present invention provides improved methods and apparatus for skin treatment and tissue remodeling. The apparatus includes an array of needles that penetrate the skin and serve as electrodes to deliver radio frequency current or other electrical or optical energy into the tissue being treated, causing thermal damage in controlled patterns. The damaged regions promote beneficial results such as uniform skin tightening by stimulation of wound healing and collagen growth.
摘要翻译： 本发明提供了用于皮肤治疗和组织重塑的改进的方法和装置。 该装置包括穿透皮肤并用作电极的针阵列，以将射频电流或其他电或光能量输送到被处理的组织中，从而导致受控模式的热损伤。 受损区域通过刺激伤口愈合和胶原生长促进有益效果，例如均匀的皮肤收缩。
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公开(公告)号：US10278677B2
公开(公告)日：2019-05-07
申请号：US13982085
申请日：2012-01-27
申请人： William G. Austen , Dieter Manstein
发明人： William G. Austen , Dieter Manstein
摘要： Exemplary embodiments of an apparatus can be provided for obtaining portions or samples of tissue from a target region of a biological tissue. One or more needles can be provided that have a small internal diameter, e.g., about 1 mm or less, and the needles can be configured to extract the tissue portions when the needles are inserted into and withdrawn from the tissue. Windows and/or markings can be provided on the wall of the needles to facilitate access to the sample. The needles can be provided in an enclosure, and an actuator can be provided to direct the needles into the tissue and/or withdraw them. A plurality of tissue portions having known relative locations in the target region can be obtained, and extraction of the tissue portions can be well-tolerated by the tissue as compared with conventional punch biopsies or the like.
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公开(公告)号：US20190015153A1
公开(公告)日：2019-01-17
申请号：US16129128
申请日：2018-09-12
申请人： Dieter Manstein
发明人： Dieter Manstein
摘要： Exemplary embodiments of a method, device, and apparatus for positioning an apparatus on a location of a tissue. For example, a substantially rigid film over an area of tissue to be treated can be provided. The film can include a positioning arrangement that facilitates a particular spatial engagement with the apparatus. The exemplary method can further include applying a portion of the film to a portion of a surface of the tissue and positioning the apparatus at the location by the engagement of the film to the apparatus using the feature of the film.
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