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46 条记录 (耗时 0.028 秒)

    5-monoaryl as.-triazin-3-ones substituted in 2-position, and their use as medicaments
    24.
    发明授权
    5-monoaryl as.-triazin-3-ones substituted in 2-position, and their use as medicaments 失效
    2-取代的5-单芳基三嗪-3-酮及其作为药物的用途

    公开(公告)号：US4851411A

    公开(公告)日：1989-07-25

    申请号：US4169

    申请日：1987-01-15

    申请人： Guy Pitet ,  Henri Cousse ,  Antoine Stenger ,  Michel Briley ,  Philippe Chopin

    发明人： Guy Pitet ,  Henri Cousse ,  Antoine Stenger ,  Michel Briley ,  Philippe Chopin

    IPC分类号： A61K31/53 ,  A61P25/24 ,  A61P25/26 ,  C07D253/06 ,  C07D253/07 ,  C07D401/06 ,  C07D405/04 ,  C07D405/10 ,  C07D405/12 ,  C07D409/04

    CPC分类号： C07D253/06 ,  C07D253/07 ,  C07D401/06 ,  C07D405/10 ,  C07D405/12 ,  C07D409/04

    摘要： The present invention concerns new 5-monoaryl as.-triazin-3-ones substituted in 2-position, a method of preparing them, and their use as medicaments.The compounds according to the present invention have general formula (I) ##STR1## in which: the bond represented by a dashed line indicates the presence of an optional double bond;A represents a direct N--C bond, a straight or branched C.sub.1 to C.sub.5 alkylene, possibly substituted one or more times by --COOR' or by Ar;R represents --H, --OH, ##STR2## R' represents --H, --OH, straight or branched C.sub.1 to C.sub.7 alkyl, --NH.sub.2 ;Ar represents an aromatic ring having 5 or 6 members possibly containing a heteroatom such as O, N, S and possibly substituted one or more times by a radical selected from among --OH, C.sub.1 to C.sub.4 alkyl, C.sub.1 and C.sub.4 alkoxy, halogen, --CF.sub.3, acetonyloxy, ##STR3## and .gamma.-butyrolactone; as well as their pharmaceutically acceptable salts.

    摘要翻译： 本发明涉及2-位取代的新的5-单芳基三嗪-3-酮，其制备方法及其作为药物的用途。 根据本发明的化合物具有通式（I）其中：由虚线表示的键表示存在任选的双键; A表示直接的N-C键，直链或支链C1至C5亚烷基，可能被-COOR'或Ar取代一次或多次; R表示-H，-OH，R 3表示-H，-OH，直链或支链C 1 -C 7烷基，-NH 2; Ar表示具有5或6个可能含有杂原子如O，N，S的芳环，并且可能被选自-OH，C 1至C 4烷基，C 1和C 4烷氧基，卤素， CF 3，乙酰氧基，γ-丁内酯; 以及它们的药学上可接受的盐。

    2'-(Orthochlorobenzoyl)-4'-chloroglycylanilides
    25.
    发明授权
    2'-(Orthochlorobenzoyl)-4'-chloroglycylanilides 失效
    2' - （邻氯苯甲酰基）-4'-氯草酰苯胺

    公开(公告)号：US4476061A

    公开(公告)日：1984-10-09

    申请号：US409320

    申请日：1982-08-18

    申请人： Gilbert Mouzin ,  Henri Cousse ,  Antoine Stenger

    发明人： Gilbert Mouzin ,  Henri Cousse ,  Antoine Stenger

    IPC分类号： A61K31/165 ,  A61K31/535 ,  A61P21/02 ,  A61P25/18 ,  A61P25/20 ,  C07C231/12 ,  C07C237/04 ,  C07C237/06 ,  C07C275/38 ,  C07D295/15 ,  C07C103/737

    CPC分类号： C07D295/15 ,  Y10S514/96 ,  Y10S514/962 ,  Y10S514/966

    摘要： The present invention relates to 2'-(ortho-chlorobenzoyl)-4'-chloroglycylanilides, compositions thereof, and their use as medicaments, e.g., as anxiolytic agents.The compounds of the invention have the general formula I ##STR1## in which R represents hydrogen or alkyl,R.sub.1 and R.sub.2 may be identical or different and are selected from hydrogen, alkyl, hydroxyalkyl, alkenyl, and alkynyl, possibly substituted by alkyl, and cycloalkyl having three to six members, possibly substituted by alkyl, with the proviso that, when one of R.sub.1 and R.sub.2 represents hydrogen, the other is not lower alkyl or hydroxyalkyl; and with the further proviso that R.sub.1 and R.sub.2 may not simultaneously represent either hydrogen or lower-alkyl. R.sub.1 and R.sub.2 may furthermore form, with the nitrogen atom to which they are connected, a nitrogen heterocycle possibly containing a second heteroatom selected from oxygen and nitrogen.

    摘要翻译： 本发明涉及2' - （邻氯苯甲酰基）-4'-氯草酰苯胺，其组合物及其作为药物的用途，例如作为抗焦虑剂。 本发明的化合物具有通式I（I）其中R表示氢或烷基，R 1和R 2可以相同或不同，并且选自氢，烷基，羟基烷基，烯基和炔基，可能被 烷基和具有3至6个成员的环烷基，可能被烷基取代，条件是当R 1和R 2之一表示氢时，另一个不是低级烷基或羟烷基; 并且进一步的条件是R 1和R 2可以不同时表示氢或低级烷基。 R1和R2可以与它们所连接的氮原子形成可能含有选自氧和氮的第二杂原子的氮杂环。

    2-Benzoyl-4-nitroanilides and their use as medicaments
    26.
    再颁专利
    2-Benzoyl-4-nitroanilides and their use as medicaments 失效
    2-苯甲酰基-4-硝基酰苯胺及其作为药物的用途

    公开(公告)号：USRE31237E

    公开(公告)日：1983-05-10

    申请号：US350233

    申请日：1982-02-19

    申请人： Henri Cousse ,  Gilbert Mouzin

    发明人： Henri Cousse ,  Gilbert Mouzin

    IPC分类号： A61K31/165 ,  A61K31/535 ,  A61P25/20 ,  C07C237/04 ,  C07C237/06 ,  C07D295/15

    CPC分类号： C07D295/15

    摘要： New derivatives of 2-benzoyl-4-nitro anilides, their preparation and their use as medicaments.The new chemical derivatives of the invention have the general formula ##STR1## in which R represents a linear or branched alkyl group, an alkenyl group, a cycloalkyl group or a benzyl group,R.sub.1 represents a hydrogen atom, an alkyl group or a hydroxy alkyl group,R.sub.2 represents a hydroxy-alkyl, alkenyl or alkynyl group, possibly substituted one or more times by an alkyl radical, or a cycloalkyl group having three to six carbon atoms;R.sub.1 and R.sub.2 may furthermore form, with the nitrogen atom to which they are attached, a nitrogen heterocycle containing possibly a second heteroatom selected from among oxygen and nitrogen;under the condition, however, that when R.sub.2 represents a hydroxy-alkyl group R.sub.1 may not be a hydrogen atom.Use as hypnotic agents for the treatment of insomnia.

    Amino-aryl 1,24-triazines useful in the treatment of diverse pain
    27.
    发明授权
    Amino-aryl 1,24-triazines useful in the treatment of diverse pain 失效
    氨基 - 芳基1,24-三嗪可用于治疗多种疼痛

    公开(公告)号：US4188387A

    公开(公告)日：1980-02-12

    申请号：US884732

    申请日：1978-03-09

    申请人： Guy Pitet ,  Henri Cousse ,  Gilbert Mouzin ,  Antoine Stenger

    发明人： Guy Pitet ,  Henri Cousse ,  Gilbert Mouzin ,  Antoine Stenger

    IPC分类号： C07D253/06 ,  A61K31/53 ,  A61K31/535 ,  A61P29/00 ,  C07D253/07 ,  C07D413/10

    CPC分类号： C07D253/065 ,  C07D253/07 ,  Y10S514/825

    摘要： The invention relates to new chemical compounds which can be used as analgesic drugs and their preparation.The new chemical compounds have the general formula: ##STR1## in which: R is a lower alkylR.sub.1, which is always other than H, is a linear or branched lower alkyl, an allyl, amino alkyl of type ##STR2## in which n=2 to 4, R.sub.2 R.sub.3 represent a lower alkyl; they may also form a heterocycle with the nitrogen atom.Y is a hydrogen, halogen, lower alkyl, alkoxy, ##STR3## R being a lower alkyl. The position of Y is variable on the ring.X=oxygen or sulfur atom.The drugs containing these active principles may be used in the treatment of rheumatismal disturbances and various pains.

    摘要翻译： 本发明涉及可用作止痛药及其制剂的新化合物。 新的化合物具有以下通式：其中：R为低级烷基，其总是不是H，是直链或支链的低级烷基，类型为“IMAGE”的烯丙基，氨基烷基，其中n = 2〜4，R2R3表示低级烷基; 它们也可以与氮原子形成杂环。 Y是氢，卤素，低级烷基，烷氧基，R是低级烷基。 Y的位置在环上是可变的。 X =氧或硫原子。 含有这些活性成分的药物可用于治疗风湿性疾病和各种疼痛。

    Use of a Serenoa repens extract for the production of a medicament to treat prostate cancer
    30.
    发明授权
    Use of a Serenoa repens extract for the production of a medicament to treat prostate cancer 有权
    使用Serenoa repens提取物生产用于治疗前列腺癌的药物

    公开(公告)号：US06599540B1

    公开(公告)日：2003-07-29

    申请号：US09937676

    申请日：2001-09-28

    申请人： Pierre Fabre ,  Jean-Pierre Raynaud ,  Henri Cousse

    发明人： Pierre Fabre ,  Jean-Pierre Raynaud ,  Henri Cousse

    IPC分类号： A61K3578

    CPC分类号： A61K36/889 ,  A61K2300/00

    摘要： The invention relates to the use of a lipido-sterolic Serenoa repens extract for the production of a medicament which is administered in an isolated manner or in an associated manner, in a simultaneous, separated or staggered manner, with prostatectomy, radiotherapy and/or hormonotherapy in order to prevent and/or treat prostate cancer.

    摘要翻译： 本发明涉及使用脂质 - 甾体Serenoa repens提取物来生产药物，其以前列腺切除术，放射治疗和/或激素治疗以同时，分离或交错的方式以孤立的方式或以相关联的方式施用 以预防和/或治疗前列腺癌。