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21.发明授权公开(公告)号：US07048775B2
公开(公告)日：2006-05-23
申请号：US10491554
申请日：2002-10-14
IPC分类号： B01D35/143 , B01D37/04
CPC分类号： B01D46/009 , B01D35/143 , B01D46/0086 , B01D46/429 , B01D46/442 , B01D2201/30 , B01D2201/301 , B01D2201/4046 , B01D2201/52 , B01D2201/54 , B01D2201/56 , B01D2273/18
摘要： The invention concerns a device and method for monitoring the integrity of filtering installations consisting of a filter housing (1) designed to perform integrity tests and for filtration, equipped with a plurality of filter elements (2, 3) and an electronic testing and monitoring unit (4) designed for monitoring and performing integrity tests, said filter elements (2, 3) having each a storage element and a communicating part (7) being connected to the monitoring and testing unit arranged in the filtering housing, whereon data of said electronic storage elements can be read. The invention also concerns a method for monitoring the integrity of filter installations by means of a plurality of filter elements (2, 3) in a filter housing (1) and of an electronic testing and monitoting unit designed to monitor and perform integrity tests, data stored by electronic storage elements (6) arranged on the filter elements (6) capable of being exchanged with the monitoring and testing unit, identification data and other data concerning the filter elements derived from the electronic storage elements (6) capable of being selected and of constituting the basis for integrity monitoring and testing.
摘要翻译： 本发明涉及一种用于监测过滤装置的完整性的装置和方法，该过滤装置由设计成执行完整性测试和过滤的过滤器壳体（1）组成，所述过滤器壳体（1）装备有多个过滤元件（2,3）和电子测试和监测单元 （4），用于监测和执行完整性测试，所述过滤元件（2,3）具有每个存储元件和连通部分（7），连接到布置在过滤壳体中的监测和测试单元，其中所述电子 存储元素可以读取。 本发明还涉及一种用于通过过滤器壳体（1）中的多个过滤器元件（2,3）和用于监视和执行完整性测试的电子测试和监视单元来监测过滤器安装的完整性的方法，数据 由布置在能够与监测和测试单元交换的滤波器元件（6）上的电子存储元件（6）存储的识别数据和关于从能够被选择的电子存储元件（6）导出的滤波器元件的其它数据;以及 构成完整性监测和测试的基础。
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公开(公告)号：US08252582B2
公开(公告)日：2012-08-28
申请号：US12226463
申请日：2007-04-24
申请人： Reinhard Baumfalk , Oscar-Werner Reif , Thomas Scheper , Daniel Riechers , Russell Hayden , Philip Nuzzo
发明人： Reinhard Baumfalk , Oscar-Werner Reif , Thomas Scheper , Daniel Riechers , Russell Hayden , Philip Nuzzo
CPC分类号： C12M23/28 , B01L3/505 , B01L2200/026 , B01L2200/04 , B01L2300/0627 , B01L2300/0645 , B01L2300/0654 , C12M23/00 , C12M23/14 , C12M41/00
摘要： The invention relates to a disposable bioreactor comprising a reversible, externally attachable sensor arrangement for measuring a physical variable of a contained medium. A sensor adapter (28) for receiving an electronic sensor arrangement (34, 38; 42; 44a, 44b, 46, 48) interacting with the medium cross-flowing the peripheral lines (14, 16, 18), by means of an inner delimiting surface (32a, 32b; 42; 44a, 44b, 46, 48) of the sensor adapter, is integrated into at least one of the peripheral lines (14, 16, 18) of the bioreactor which is used to supply or discharge the medium. Said sensor adapter (28) is mounted on the peripheral line (14, 16, 18) as an insert extending the peripheral line (14, 16, 18) and which can be cross-flown by the contained medium.
摘要翻译： 本发明涉及一种一次性生物反应器，其包括用于测量所容纳介质的物理变量的可逆的外部可附接的传感器装置。 一种传感器适配器（28），用于接收与所述介质相互作用的电子传感器装置（34,38; 42; 44a，44b，46,48），所述电子传感器装置通过内部 所述传感器适配器的限定表面（32a，32b; 42; 44a，44b，46,48）被整合到所述生物反应器的至少一个外围线路（14,16,18）中，所述外围线路用于供应或排出 中。 所述传感器适配器（28）作为插入件延伸外围线路（14,16,18）而安装在外围线路（14,16,18）上，并可由所容纳的介质交叉流动。
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23.发明授权Disposable container having sensor mounts sealed to the container and sensors in the sensor mounts for measuring at least one parameter of media in the container 有权具有密封到容器的传感器安装件和传感器安装件中的传感器的一次性容器，用于测量容器中的介质的至少一个参数公开(公告)号：US08123397B2
公开(公告)日：2012-02-28
申请号：US11643548
申请日：2006-12-21
IPC分类号： B01F15/04
CPC分类号： B01F7/162 , B01F15/00207 , B01F15/0022 , B01F15/00831 , B01F15/0085 , B01L3/505
摘要： A disposable container is provided for mixing media. The container has at least one closable opening for introducing and/or removing media and has sensor mounts at spaced apart locations on the wall of the container. Each sensor mount has a front surface facing into the container and a rear surface sealed against the wall of the container. Sensors are embedded in the respective sensor mounts at positions adjacent the front surfaces. The sensors measure at least one specified parameter of the media at spaced apart locations in the container. The seals between the rear surfaces of the sensor mounts and the wall of the container ensure sterility for the media in the container.
摘要翻译： 提供一次性容器用于混合介质。 容器具有用于引入和/或移除介质的至少一个可关闭的开口，并且在容器的壁上的间隔开的位置处具有传感器安装件。 每个传感器支架具有面向容器的前表面和密封在容器的壁上的后表面。 传感器嵌入相邻的传感器安装座位于与前表面相邻的位置。 传感器在容器中的间隔开的位置测量介质的至少一个指定参数。 传感器支架后表面和容器壁之间的密封确保了容器中介质的无菌性。
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公开(公告)号：US08123395B2
公开(公告)日：2012-02-28
申请号：US12319727
申请日：2009-01-12
IPC分类号： B01F15/04
CPC分类号： B01F7/162 , B01F15/00207 , B01F15/0022 , B01F15/00831 , B01F15/0085 , B01L3/505
摘要： A method is provided for mixing media in a container. The method includes introducing a first media into the container and then introducing a second media into the container while mixing the media to form a mixture. The method continues by measuring the values of two parameters of the mixture at spaced apart locations in the container. The introduction of the second media into the container may be interrupted based on a comparison of the measured values to a preselected intended value.
摘要翻译： 提供了用于将容器中的介质混合的方法。 该方法包括将第一介质引入容器中，然后将第二介质引入容器中同时混合介质以形成混合物。 该方法通过在容器中的间隔开的位置处测量混合物的两个参数的值来继续。 可以基于将测量值与预选的预期值的比较来中断将第二介质引入容器中。
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公开(公告)号：US08093015B2
公开(公告)日：2012-01-10
申请号：US12227186
申请日：2007-04-24
申请人： Stefan Obermann , Reinhard Baumfalk , Oscar-Werner Reif , Florian Wurm , Maria de Jesus , Matthieu Stettler , Martin Jordan
发明人： Stefan Obermann , Reinhard Baumfalk , Oscar-Werner Reif , Florian Wurm , Maria de Jesus , Matthieu Stettler , Martin Jordan
CPC分类号： G01N33/58 , G01N1/30 , G01N15/042 , G01N33/5005 , Y10T436/25375
摘要： The invention relates to a method for determining the viability of cells in cell cultures, said method comprising the steps of: coloring the sample with a dye which can penetrate into individual cells depending on the viability of the latter, determining the proportions of cells which are colored to differing extents. The invention is distinguished by virtue of the fact that a cell suspension of the colored cells is centrifuged as a sample in a sample vessel (10) until the solid content present in the sample has settled as a compressed cell cake (13), and, in order to determine the proportions, the volumes of differently colored sections (131, 132, 133) of the compressed cell cake (13) are determined as a measure of the proportions of cells of different viability.
摘要翻译： 本发明涉及一种用于确定细胞培养物中细胞存活率的方法，所述方法包括以下步骤：根据染色体的活力来染色样品，所述染料可以渗透到各个细胞中，确定细胞的比例 彩色到不同的程度。 本发明的区别在于，将着色细胞的细胞悬浮液作为样品在样品容器（10）中离心直到样品中存在的固体含量作为压缩细胞饼（13）沉降， 为了确定比例，压缩细胞饼（13）的不同颜色的部分（131,132,133）的体积被确定为不同存活力的细胞比例的量度。
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公开(公告)号：US20100000348A1
公开(公告)日：2010-01-07
申请号：US12584639
申请日：2009-09-09
IPC分类号： G01D21/00
CPC分类号： G01D11/30 , B01F15/00831 , B01F15/0085
摘要： Device for fastening a sensor on containers with a flexible container wall, in particular mixing bags, comprising a sensor support which is fitted with a sensor, bears against an inner wall of the container wall at least with a rear subsurface averted from the sensor, and is guided with a central piece through an opening in the container wall in which the sensor support is fixed on the container wall by a clamping part which can be connected to the central piece, in which the container wall is clamped between the rear subsurface of the sensor support and on a bearing surface, facing an outer wall of the container, of the clamping part, and in which the rear subsurface bears sealingly against the inner wall of the container wall. The sensor support can also have an electronic or optical transmit unit which is connected to the sensor, in which case the transmit unit communicates in a wireless fashion with a receive unit arranged outside the container.
摘要翻译： 用于将具有柔性容器壁的特定混合袋固定在容器上的装置，特别是混合袋，其包括安装有传感器的传感器支撑件，至少与从传感器避开的后表面相对地抵靠容器壁的内壁;以及 由中心件引导通过容器壁中的开口，其中传感器支撑件通过夹持部分固定在容器壁上，该夹紧部分可连接到中心件，容器壁夹在中间件的后表面之间 传感器支撑件以及位于容器的外壁上的支承表面上的夹紧部分，并且后部表面在其中密封地抵靠容器壁的内壁。 传感器支撑件还可以具有连接到传感器的电子或光学发射单元，在这种情况下，发射单元以布置在容器外部的接收单元以无线方式通信。
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公开(公告)号：US20090147617A1
公开(公告)日：2009-06-11
申请号：US12319727
申请日：2009-01-12
IPC分类号： G05D11/02
CPC分类号： B01F7/162 , B01F15/00207 , B01F15/0022 , B01F15/00831 , B01F15/0085 , B01L3/505
摘要： Container and method for the mixing of media, in particular as a disposable container, which has at least one closable opening for the introduction and/or removal of the media and has a first sensor for measurement of at least one parameter of the mixture, in which at least one second sensor for measurement of the same parameter is arranged at a distance from the first sensor.
摘要翻译： 用于混合介质，特别是作为一次性容器的容器和方法，其具有用于引入和/或移除介质的至少一个可闭合的开口，并且具有用于测量混合物的至少一个参数的第一传感器， 其中用于测量相同参数的至少一个第二传感器布置在离第一传感器一定距离处。
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28.发明授权Device, method and computer program product for carrying out integrity tests on filter elements 有权用于对过滤元件执行完整性测试的设备，方法和计算机程序产品公开(公告)号：US07281409B2
公开(公告)日：2007-10-16
申请号：US10492263
申请日：2002-10-14
IPC分类号： G01N15/08
CPC分类号： G01N15/0826 , B01D46/0086 , B01D2201/56 , B01D2273/18
摘要： The invention relates to a device for carrying out integrity tests on filter elements by means of test gases, comprising a device housing (3), with an electronic controller (4), arranged therein for regulation and control of the progress of a test programme for filter elements, a filter housing (6), for housing a filter element (2) under test, a pneumatic unit (5), connected to the controller (4) and the filter housing (6), in particular for the generation and measurement of gas pressures, an electronic memory unit (10), which may be connected to the filter element (2) under test and a communication unit (13′), connected to the controller (4), for the exchange of data between the controller (4) and the electronic memory element (10). The communication unit (13′) is preferably embodied as an antenna (14′) and the electronic memory element (10) as a transponder (11). In addition to the device a method for carrying out integrity tests and a computer programme product are also disclosed.
摘要翻译： 本发明涉及一种用于通过测试气体对过滤元件执行完整性测试的装置，包括设置有用于调节和控制测试程序进度的装置壳体（3），其中安装有电子控制器（4） 过滤器元件，用于容纳被测试的过滤元件（2）的过滤器壳体（6），连接到控制器（4）和过滤器壳体（6）的气动单元（5），特别是用于产生和测量 的气体压力的电子存储器单元（10），可连接到被测试的过滤元件（2）的电子存储器单元（10）和连接到控制器（4）的通信单元（13'），用于在控制器 （4）和电子存储元件（10）。 通信单元（13'）优选地被实施为天线（14'）和作为应答器（11）的电子存储元件（10）。 此外，还公开了用于执行完整性测试的方法和计算机程序产品。
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公开(公告)号：US20070160500A1
公开(公告)日：2007-07-12
申请号：US11651823
申请日：2007-01-10
IPC分类号： G01N21/64
CPC分类号： G01N21/274 , G01N21/0332 , G01N21/7703 , G01N2021/7786
摘要： The invention relates to a sensor for measuring an oxygen content in a liquid or gaseous sample, comprising a first sensor section (14a) that can be brought into contact with the sample and has a luminescent indicator dye embedded in an oxygen-permeable, first polymer matrix, light guiding means (10) for guiding luminescence excitation light from a light source (31, 32) to the first sensor section (14a), and light guiding means (10) for guiding luminescence emission light from the first sensor section (14a) to a detector (39). The invention is distinguished in that arranged adjacent to the first sensor section (14a) is a second sensor section (14b) that includes the same dye, embedded in an oxygen-impermeable, second polymer matrix.
摘要翻译： 本发明涉及一种用于测量液体或气体样品中氧含量的传感器，包括可与样品接触的第一传感器部分（14a），并且具有嵌入氧气可渗透的第一传感器部分 聚合物基体，用于将来自光源（31,32）的发光激发光引导到第一传感器部分（14a）的导光装置（10），以及用于引导来自第一传感器部分的发光发射光的导光装置 （14a）到检测器（39）。 本发明的区别在于邻近第一传感器部分（14a）布置的是包含相同染料的第二传感器部分（14b），其嵌入在不透氧的第二聚合物基质中。
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公开(公告)号：US06907770B2
公开(公告)日：2005-06-21
申请号：US10198074
申请日：2002-07-19
CPC分类号： G01N15/0826 , G01N2015/084
摘要： A test device (10) for filter systems, including a pneumatic unit (12), a control unit (14) for controlling the pneumatic unit (12), and a data processing unit (16), in which the pneumatic unit (12) is separated from the data processing unit (16) and the control unit (14) by a separating device (18) which substantially shields the pneumatic unit (12) against heat generated in the data processing unit (16) and the control unit (14).
摘要翻译： 一种用于过滤器系统的测试装置（10），包括气动单元（12），用于控制气动单元（12）的控制单元（14）和数据处理单元（16），气动单元（12） 通过分离装置（18）与数据处理单元（16）和控制单元（14）分离，该分离装置基本上屏蔽气动单元（12）以抵抗在数据处理单元（16）和控制单元（14）中产生的热量 ）。
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