公开(公告)号：US20090285877A1

公开(公告)日：2009-11-19

申请号：US12453566

申请日：2009-05-14

申请人： Takashi Yasukochi ,  Yukihisa Naka ,  Tsuyoshi Endo ,  Hirotoshi Adachi

发明人： Takashi Yasukochi ,  Yukihisa Naka ,  Tsuyoshi Endo ,  Hirotoshi Adachi

IPC分类号： A61K9/70 ,  A61K31/473

CPC分类号： A61K31/473 ,  A61K9/7053 ,  A61K9/7061 ,  A61K9/7076

摘要： There is provided a percutaneous absorption preparation that has a simple laminated structure and a long shelf life, while maintaining excellent percutaneous absorption for palonosetron. The percutaneous absorption preparation comprises a support and a drug-containing pressure-sensitive adhesive layer formed on at least one side of the support, wherein the drug-containing pressure-sensitive adhesive layer comprises, as essential constituent components, an adhesive base, palonosetron or a pharmaceutically acceptable acid addition salt thereof, and at least one type of fatty alcohol selected from the group consisting of C6-12 straight-chain saturated alcohols, C10-22 straight-chain unsaturated alcohols, C10-22 branched alcohols and C10-15 cyclic alcohols, and the constituent components other than palonosetron or its pharmaceutically acceptable acid addition salt are carboxyl group-free components.

摘要翻译： 提供了具有简单的层压结构和长的保存期限的经皮吸收制剂，同时保持帕洛诺司琼的优异的经皮吸收。 经皮吸收制剂包括在载体的至少一侧上形成的载体和含药物的压敏粘合剂层，其中药物压敏粘合剂层包含作为必要组分的组分的粘合剂基质，帕洛诺司琼或 其药学上可接受的酸加成盐和至少一种选自C 6-12直链饱和醇，C10-22直链不饱和醇，C10-22支链醇和C10-15环状脂肪醇的脂肪醇 醇，除了帕洛诺司琼或其药学上可接受的酸加成盐以外的组成成分是无羧基组分。

公开(公告)号：US08858962B2

公开(公告)日：2014-10-14

申请号：US13367679

申请日：2012-02-07

申请人： Seiji Tokumoto ,  Hirotoshi Adachi ,  Tetsuji Kuwahara

发明人： Seiji Tokumoto ,  Hirotoshi Adachi ,  Tetsuji Kuwahara

IPC分类号： A61K9/00 ,  A61K39/39 ,  A61K47/26 ,  A61K39/00 ,  A61K47/34 ,  A61K47/10 ,  A61K47/12

CPC分类号： A61K39/39 ,  A61K9/0009 ,  A61K9/0014 ,  A61K9/0021 ,  A61K9/006 ,  A61K39/145 ,  A61K47/10 ,  A61K47/12 ,  A61K47/26 ,  A61K47/34 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/541 ,  A61K2039/55511 ,  A61M37/0092 ,  A61N1/325 ,  A61N1/327 ,  C12N7/00 ,  C12N2760/16034 ,  Y02A50/401

摘要： An adjuvant for transdermal or transmucosal administration which comprises at least one substance selected from an aliphatic alcohol, a free fatty acid and a fatty acid derivative but does not contain a substance represented by the following formula: wherein R3 and R4 may together form a cyclic ring, and R1 and R2 independently represent an alkyl side chain having 1 to 16 carbon atoms.

摘要翻译： 一种用于经皮或经粘膜给药的佐剂，其包含至少一种选自脂族醇，游离脂肪酸和脂肪酸衍生物的物质，但不含下式表示的物质：其中R3和R4可以一起形成环状 R 1和R 2独立地表示碳原子数1〜16的烷基侧链。

公开(公告)号：US07937141B1

公开(公告)日：2011-05-03

申请号：US09958113

申请日：2000-04-06

申请人： Kazutaka Inoue ,  Hirotoshi Adachi

发明人： Kazutaka Inoue ,  Hirotoshi Adachi

IPC分类号： A61N1/30

CPC分类号： A61N1/30

摘要： A device for iontophoresis that reduces irritation at the beginning of energization and efficiently supplies an amount of current required for drug administration in a predetermined length of time, is provided. With the device for iontophoresis, the oscillation frequency and duty cycle of a transistor 15 are adjusted at the beginning of energization, thereby controlling a back electromotive force developed across a coil 13 to gradually increase the output voltage. The microcomputer 12 controls the transistor 15 so as to receive signals from an output voltage detecting circuit that is formed of resistors 23 and 24 and an output current detecting circuit that is formed of resistors 25 and 26 and a capacitor 27, preventing an increasing of the output voltage when the detected output current reaches a limiting value, and preventing an increasing of the output current when the detected output voltage reaches a limiting value.

摘要翻译： 提供一种用于离子电渗疗法的装置，其在通电开始时减少刺激，并且在预定时间长度内有效地提供药物施用所需的电流量。 利用离子电渗法的装置，在通电开始时调整晶体管15的振荡频率和占空比，由此控制在线圈13上产生的反电动势，逐渐增加输出电压。 微型计算机12控制晶体管15以接收来自由电阻器23和24形成的输出电压检测电路的信号和由电阻器25和26以及电容器27形成的输出电流检测电路，从而防止 当检测到的输出电流达到极限值时，输出电压，并且当检测到的输出电压达到极限值时防止输出电流的增加。

公开(公告)号：US07883504B2

公开(公告)日：2011-02-08

申请号：US12441842

申请日：2007-08-31

申请人： Seiji Tokumoto ,  Hirotoshi Adachi ,  Yasushi Fuchita ,  Tatsuya Ogawa ,  Hitoshi Otomo

发明人： Seiji Tokumoto ,  Hirotoshi Adachi ,  Yasushi Fuchita ,  Tatsuya Ogawa ,  Hitoshi Otomo

IPC分类号： A61K9/22

CPC分类号： A61N1/0448 ,  A61N1/0436 ,  A61N1/044

摘要： The invention provides a device for a percutaneous absorption preparation, provided with a solution storage container which can exhibit good solution migration independently of the level of force. The device for a percutaneous absorption preparation comprises an electrode film comprising a base member (1) and an electrode layer (2) and having a dissolution liquid passage hole (9), a drug impregnation member (3) mounted on the electrode layer (2) side of the electrode film, and a dissolution liquid storage container (5) bonded to the base member (1) side of the electrode film via a lid member (7) covering the solution passage hole (9). The dissolution liquid storage container (5) comprises a bottom and a sidewall. A protrusion (5b) which faces the dissolution liquid passage hole (9) is provided at the center of the bottom, and the sidewall is provided with a vertically folded part (5c).

摘要翻译： 本发明提供了一种用于经皮吸收制剂的装置，其具有能够独立于力水平显示良好的溶液迁移的溶液储存容器。 用于经皮吸收制剂的装置包括：电极膜，包括基底部件（1）和电极层（2），并具有溶解液体通过孔（9）;药物浸渍部件（3），安装在电极层 ）侧，以及通过覆盖所述溶液通孔（9）的盖部件（7）与所述电极膜的​​基材（1）侧接合的溶解液收容容器（5）。 溶解液储存容器（5）包括底部和侧壁。 在底部的中心设有面向溶解液通路孔（9）的突起（5b），侧壁设有垂直折叠部（5c）。

公开(公告)号：US20090240190A1

公开(公告)日：2009-09-24

申请号：US12087056

申请日：2006-12-25

申请人： Seiji Tokumoto ,  Hirotoshi Adachi ,  Yasushi Fuchita ,  Saori Takahashi ,  Tatsuya Ogawa

发明人： Seiji Tokumoto ,  Hirotoshi Adachi ,  Yasushi Fuchita ,  Saori Takahashi ,  Tatsuya Ogawa

IPC分类号： A61N1/30 ,  B32B37/12

CPC分类号： A61N1/0448 ,  A61N1/044 ,  Y10T156/1056

摘要： To provide an easily producible mass-production type iontophoresis device having a structure that a dissolution liquid-storing container is integrated with an iontophoresis electrode, a dissolution liquid and a drug can be mixed by simple operations, and it is free from a risk of leakage of electricity. The device comprises an electrode film having an electrode layer (2) formed on a base (1), a drug-loaded member (3) arranged on the electrode-layer-forming side of the electrode film, and a dissolution liquid-storing container (5) arranged on the non-electrode-layer-forming side of the electrode film, wherein the electrode film is provided with a dissolution liquid passing hole (9), a resin lid member (7) is bonded to the electrode film via a thermoplastic resin layer (10) or an adhesive layer to cover the dissolution liquid passing hole, and a flange (5a) of the dissolution liquid-storing container (5) is bonded to the electrode film via the resin lid member (7).

摘要翻译： 为了提供容易生产的批量生产型离子电渗疗法装置，其具有溶解液储存容器与离子电渗电极结合的结构，溶解液和药物可以通过简单的操作混合，并且没有泄漏的风险 的电力。 该装置包括具有形成在基底（1）上的电极层（2）和布置在电极膜的电极层形成侧的药物负载构件（3）的电极膜和溶解液储存容器 （5），设置在所述电极膜的​​非电极层形成侧，其中，所述电极膜设置有溶解液通过孔（9），树脂盖构件（7）经由 热塑性树脂层（10）或覆盖溶解液通过孔的粘合剂层，并且溶解储液容器（5）的凸缘（5a）经由树脂盖构件（7）接合到电极膜。