公开(公告)号：US20110014707A1

公开(公告)日：2011-01-20

申请号：US12892614

申请日：2010-09-28

申请人： Paul Harris ,  Alfredo Lopez de Leon ,  Micheal Rey ,  Hanshu Ding ,  Elena Vlasenko

发明人： Paul Harris ,  Alfredo Lopez de Leon ,  Micheal Rey ,  Hanshu Ding ,  Elena Vlasenko

IPC分类号： C12N15/01 ,  C07H21/04 ,  C12N15/63 ,  C12N9/42 ,  C12N5/10

CPC分类号： C12N9/2437 ,  C11D3/38636 ,  C12N15/8246 ,  C12Y302/01004

摘要： The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.

公开(公告)号：US07868227B2

公开(公告)日：2011-01-11

申请号：US12823036

申请日：2010-06-24

申请人： Nikolaj Spodsberg ,  Paul Harris ,  Randall Kramer

发明人： Nikolaj Spodsberg ,  Paul Harris ,  Randall Kramer

IPC分类号： A01H9/00 ,  C12N1/00 ,  C12N5/02 ,  C12P21/06 ,  C07H21/04

CPC分类号： C12N9/2434

摘要： The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

摘要翻译： 本发明涉及具有纤维素分解增强活性的分离的多肽和编码多肽的分离的多核苷酸。 本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。

公开(公告)号：US20100306879A1

公开(公告)日：2010-12-02

申请号：US12789259

申请日：2010-05-27

申请人： Ye Liu ,  Lan Tang ,  Paul Harris ,  Wenping Wu

发明人： Ye Liu ,  Lan Tang ,  Paul Harris ,  Wenping Wu

IPC分类号： A01H5/00 ,  C07H21/00 ,  C12N1/14 ,  C07H21/02 ,  C12P21/00 ,  C12P19/00 ,  C12N5/10

CPC分类号： C12N9/2437 ,  C12N1/22 ,  C12N15/1137 ,  C12N2310/14 ,  C12P7/10 ,  C12P19/02 ,  C12P19/14 ,  C12Y302/01091 ,  C12Y302/01099 ,  Y02E50/16

摘要： The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

摘要翻译： 本发明涉及具有纤维二糖水解酶活性的分离的多肽和编码多肽的分离的多核苷酸。 本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。

公开(公告)号：US07771983B2

公开(公告)日：2010-08-10

申请号：US12631101

申请日：2009-12-04

申请人： Nikolaj Spodsberg ,  Paul Harris ,  Randall Kramer

发明人： Nikolaj Spodsberg ,  Paul Harris ,  Randall Kramer

IPC分类号： C07K14/00 ,  D21C1/00 ,  C11D3/386

CPC分类号： C12N9/2434

摘要： The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

摘要翻译： 本发明涉及具有纤维素分解增强活性的分离的多肽和编码多肽的分离的多核苷酸。 本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。

公开(公告)号：US20100196968A1

公开(公告)日：2010-08-05

申请号：US12707154

申请日：2010-02-17

申请人： Paul Harris ,  Elizabeth Golightly

发明人： Paul Harris ,  Elizabeth Golightly

IPC分类号： C12P19/02

CPC分类号： C12N9/2445 ,  C12Y302/01021

摘要： The present invention relates to isolated polypeptides having beta-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.

摘要翻译： 本发明涉及具有β-葡糖苷酶活性的分离多肽和编码多肽的分离的多核苷酸。 本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及生产和使用多肽的方法。

公开(公告)号：US07608689B2

公开(公告)日：2009-10-27

申请号：US11541099

申请日：2006-09-29

申请人： Paul Harris ,  Michael Rey ,  Hanshu Ding

发明人： Paul Harris ,  Michael Rey ,  Hanshu Ding

IPC分类号： C07K1/00 ,  C12N9/24 ,  C07H21/04

CPC分类号： C12P7/10 ,  C12N9/2402 ,  C12N9/2437 ,  C12P7/26 ,  C12P7/40 ,  C12P13/04 ,  C12P19/14 ,  C12Y302/01004 ,  C12Y302/01021 ,  C13K1/02 ,  Y02E50/16 ,  Y02E50/17

摘要： The present invention relates to methods for degrading or converting a cellulosic material and for producing a substance from a cellulosic material.

公开(公告)号：US20080201805A1

公开(公告)日：2008-08-21

申请号：US11997625

申请日：2006-08-04

申请人： Kristian Krogh ,  Paul Harris

发明人： Kristian Krogh ,  Paul Harris

IPC分类号： A01H5/00 ,  C12N9/00 ,  C07H21/04 ,  C12N15/00 ,  C12P1/00 ,  D06M16/00 ,  C12N1/20 ,  C12P21/04

CPC分类号： C12N9/2477 ,  C12N9/2437

摘要： The present invention relates to isolated polypeptides having beta-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.

摘要翻译： 本发明涉及具有β-葡糖苷酶活性的分离多肽和编码多肽的分离的多核苷酸。 本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及生产和使用多肽的方法。

公开(公告)号：US07228180B1

公开(公告)日：2007-06-05

申请号：US10682292

申请日：2003-10-09

申请人： Scott Wofford ,  Dale L. Phillips, Jr. ,  Paul Harris

发明人： Scott Wofford ,  Dale L. Phillips, Jr. ,  Paul Harris

IPC分类号： A61N1/18

CPC分类号： A61N1/36014 ,  A61N1/326 ,  A61N1/36003

摘要： The current invention provides novel methods for treating victims of cerebrovascular diseases such as stroke. The methods of the current invention rehabilitate weakened and atrophied muscles by applying electrical stimulation to the muscles. Preferably, the electric current cycles between on and off thereby at 10 second intervals thereby stimulating the muscle for 10 seconds and allowing the muscle to relax for 10 seconds. Treatment periods are preferably 15 minutes per day, five days per week. In general, treatments are performed over a 3 to 12 month period. Patients treated according to the disclosed methodology experience significant improvements in their overall quality of life.

摘要翻译： 本发明提供了治疗脑血管疾病如中风的受害者的新方法。 本发明的方法通过对肌肉进行电刺激来恢复弱化和萎缩的肌肉。 优选地，电流在10秒间隔开启和关闭之间循环，由此刺激肌肉10秒，并允许肌肉放松10秒。 治疗期优选为每天15分钟，每周5天。 一般来说，治疗在3至12个月的时间内进行。 根据公开的方法治疗的患者在整体生活质量方面经历显着改善。

公开(公告)号：US20060217295A1

公开(公告)日：2006-09-28

申请号：US10549951

申请日：2004-03-16

申请人： Paul Harris ,  Margaret Brimble

发明人： Paul Harris ,  Margaret Brimble

IPC分类号： C07K5/12 ,  C07D487/04 ,  A61K38/12

CPC分类号： C07D487/04 ,  C07D471/04 ,  C07K5/06139 ,  C07K5/0821

摘要： Embodiments of this invention provide novel peptidomimetics that contain a macrocycle. Such compounds are neuroprotective and have utility as therapeutic agents for treatment of diseases, injuries and other conditions characterised by neuronal degeneration and/or death. Compounds are also useful for manufacture of medicaments useful for treatment of such conditions.

公开(公告)号：US20050210548A1

公开(公告)日：2005-09-22

申请号：US11054191

申请日：2005-02-09

申请人： Debbie Yaver ,  Paul Harris ,  Suzanne Otani ,  Janine Lin ,  Haiyan Ge

发明人： Debbie Yaver ,  Paul Harris ,  Suzanne Otani ,  Janine Lin ,  Haiyan Ge

IPC分类号： A01H1/00 ,  C07H21/04 ,  C12N5/04 ,  C12N9/24 ,  C12N15/87 ,  C12Q1/68

CPC分类号： C12N9/2482 ,  C12N9/248 ,  C12Y302/01008

摘要： The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.

摘要翻译： 本发明涉及具有木聚糖酶活性的分离的多肽和编码多肽的分离的多核苷酸。 本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及生产和使用多肽的方法。