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公开(公告)号：US20150120204A1
公开(公告)日：2015-04-30
申请号：US14394135
申请日：2012-04-13
申请人： Gengxiong Wu , Weihua Huang , Yinlong Xie , Jingbo Tang , Jun Wang , Jian Wang , Huanming Yang
发明人： Gengxiong Wu , Weihua Huang , Yinlong Xie , Jingbo Tang , Jun Wang , Jian Wang , Huanming Yang
摘要： Provided is a transcriptome assembly method, comprising the following steps of: constructing a sequencing sample transcriptome read into a de Brujin graph; performing filtering and linearization processing on the de Brujin graph, so as to form continuous contigs; obtaining association among the contigs, and filtering association data; performing linearization processing on a continuous sequence without bifurcation; outputting a contig sequence; comparing the read and an end pairing read with the output contig sequence, so as to obtain information between the read and the contig; establishing connections among the contigs, so as to construct a graph with the contigs as points and the connections as edges; pre-processing and dividing the obtained graph, so as to obtain independent sub-graphs; and outputting a transcript according to the sub-graphs. Further provided is a transcriptome assembly system based on the method.
摘要翻译： 提供了一种转录组装方法，包括以下步骤：构建读取到de Brujin图中的测序样本转录组; 对de Brujin图进行滤波和线性化处理，形成连续重叠群; 获得重叠群之间的关联，并过滤关联数据; 对没有分岔的连续序列进行线性化处理; 输出重叠序列; 将读取和结束配对读取与输出contig序列进行比较，以便获得读取和重叠数据之间的信息; 在重叠群之间建立连接，以便以重叠群构建点作为边缘的连接; 预处理和划分获得的图，以获得独立的子图; 并根据子图输出抄本。 还提供了一种基于该方法的转录组装系统。
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公开(公告)号：US20140350866A1
公开(公告)日：2014-11-27
申请号：US14361158
申请日：2011-11-29
申请人： Binghang Liu , Zhenyu Li , Yanxiang Chen , Yingrui Li , Jian Wang , Jun Wang , Huanming Yang
发明人： Binghang Liu , Zhenyu Li , Yanxiang Chen , Yingrui Li , Jian Wang , Jun Wang , Huanming Yang
IPC分类号： G06F19/16
CPC分类号： G16B15/00 , C12Q1/6869 , G16B30/00 , C12Q2537/165
摘要： Provided is a method of gap closing in nucleotide sequence. The nucleic acid sequence comprises a first contig at one end of a gap in an unassembled region, and a second contig at the other end of the gap in the unassembled region. The method comprises: selecting reads having an overlap with one end of the first contig close to the gap as a set of reads for gap closing; selecting reads having a shortest overlap with the first contig in the set of reads for gap closing as a candidate read; determining whether reads having an overlapping length with the first contig shorter than an overlapping length between the candidate read and the first contig present in the set of reads for gap closing, and determining whether reads having no overlapping relationship with the candidate read present in the set of reads for gap closing; obtaining a result of presenting an extension conflict, and determining an unconfident candidate read, if reads having an overlapping length with the first contig shorter than an overlapping length between the candidate read and the first contig present in the set of reads for gap closing, reads having no overlapping relationship with the candidate read present in the set of reads for gap closing, or both reads having an overlapping length with the first contig shorter than an overlapping length between the candidate read and the first contig, and reads having no overlapping relationship with the candidate read present in the set of reads for gap closing; reselecting the candidate read until obtaining a confident candidate read, if the candidate read is unconfident; connecting the confident candidate read to the first contig, to form a new first contig; determining whether one end of the new first contig close to the gap has an overlap with one end of the second contig close to the gap; performing the step of selecting the set of reads for gap closing on the basis of the new first contig, if the one end of the new first contig close to the gap has no overlap with the one end of the second contig close to the gap, wherein the first contig in the step of selecting the set of reads for gap closing is replaced with the new first contig; connecting the new first contig to the second contig to complete gap closing, if one end of the new first contig close to the gap has an overlap with one end of the second contig close to the gap.
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公开(公告)号：US20150155183A1
公开(公告)日：2015-06-04
申请号：US14402853
申请日：2012-05-24
IPC分类号： H01L21/321 , C25F3/30 , H01L21/66
摘要： A method and apparatus for pulse electrochemical polishing a wafer are disclosed. The method comprises steps of: establishing a duty cycle table showing all points on the wafer, a removal thickness corresponding to every point and a duty cycle corresponding to the removal thickness; driving a wafer chuck holding and positioning the wafer to move at a preset speed so that a special point on the wafer is right above a nozzle ejecting charged electrolyte onto the wafer; looking up the duty cycle table and obtaining the removal thickness and the duty cycle corresponding to the special point; and applying a preset pulse power source to the wafer and the nozzle and the actual polishing power source for polishing the special point being equal to the duty cycle multiplying by the preset power source.
摘要翻译： 公开了用于脉冲电化学抛光晶片的方法和装置。 该方法包括以下步骤：建立表示晶片上所有点的占空比表，对应于每个点的去除厚度和对应于去除厚度的占空比; 驱动晶片卡盘保持并定位晶片以预设速度移动，使得晶片上的特殊点恰好在喷射带电电解质的喷嘴上方到晶片上; 查找占空比表，获得与特殊点对应的去除厚度和占空比; 并且将预设的脉冲电源施加到晶片和喷嘴以及用于抛光特殊点的实际抛光电源等于乘以预设电源的占空比。
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公开(公告)号：US09865476B2
公开(公告)日：2018-01-09
申请号：US14402853
申请日：2012-05-24
IPC分类号： H01L21/321 , C25F3/16 , C25F7/00 , H01L21/66 , C25F3/30
摘要： A method and apparatus for pulse electrochemical polishing a wafer are disclosed. The method comprises steps of: establishing a duty cycle table showing all points on the wafer, a removal thickness corresponding to every point and a duty cycle corresponding to the removal thickness; driving a wafer chuck holding and positioning the wafer to move at a preset speed so that a special point on the wafer is right above a nozzle ejecting charged electrolyte onto the wafer; looking up the duty cycle table and obtaining the removal thickness and the duty cycle corresponding to the special point; and applying a preset pulse power source to the wafer and the nozzle and the actual polishing power source for polishing the special point being equal to the duty cycle multiplying by the preset power source.
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25.发明申请公开(公告)号：US20140228226A1
公开(公告)日：2014-08-14
申请号：US14346067
申请日：2011-09-21
申请人： Xuyang Yin , Chunlei Zhang , Yong Qiu , Shengpei Chen , Hui Jiang , Jun Wang , Jian Wang
发明人： Xuyang Yin , Chunlei Zhang , Yong Qiu , Shengpei Chen , Hui Jiang , Jun Wang , Jian Wang
CPC分类号： G16B30/00 , C12Q1/6869 , C12Q1/6881 , C12Q1/6883 , C12Q2600/156
摘要： Disclosed is a method for determining the chromosome aneuploidy of a single cell and a system for determining the chromosome aneuploidy of a single cell. Among them, the method for determining the chromosome aneuploidy of a single cell according to the embodiments of the present invention comprises: the whole genome of the single cell is sequenced to obtain a first sequencing result; the total number of sequencing data from the first sequencing result is counted, obtaining a value L; the number of sequencing data of a first chromosome from the first sequencing result is counted, obtaining a value M; a first parameter is determined based on the value L and the value M; and it is determined whether or not the single cell has aneuploidy in respect of the first chromosome based on the difference between the first parameter and a predetermined control parameter.
摘要翻译： 公开了一种用于确定单个细胞的染色体非整倍性的方法和用于确定单细胞的染色体非整倍性的系统。 其中，根据本发明实施方案的单细胞染色体非整倍性测定方法包括：对单细胞的全基因组进行测序以获得第一测序结果; 计算来自第一测序结果的测序数据的总数，获得值L; 对来自第一测序结果的第一染色体的测序数据的数量进行计数，获得值M; 基于值L和值M确定第一参数; 并且基于第一参数和预定控制参数之间的差来确定单细胞是否相对于第一染色体具有非整倍体。
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公开(公告)号：US11585892B1
公开(公告)日：2023-02-21
申请号：US16862102
申请日：2020-04-29
摘要： A method includes generating emitted signals using transmitter elements and measuring received signals using receiver elements. The received signals are reflected portions of the emitted signals and the received signals correspond to one or more targets. The method also includes applying a first matched filter to the received signals to determine range information for the received signals, filtering the received signals based on the range information to define filtered signals, and determining calibration parameters using the filtered signals. The method also includes correcting the received signals using the calibration parameters to define calibrated signals and determining angle of arrival information for the received signals using the calibrated signals.
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公开(公告)号：US10062174B2
公开(公告)日：2018-08-28
申请号：US15436808
申请日：2017-02-18
申请人： Roman Schaffert , Jian Wang , Anja Borsdorf
发明人： Roman Schaffert , Jian Wang , Anja Borsdorf
IPC分类号： G06K9/00 , G06T7/37 , G06T7/32 , G06T7/246 , G06T7/269 , G06T7/207 , G06T7/564 , G06T7/38 , G06T7/00 , G06T19/00 , G06T11/00 , A61B6/00
CPC分类号： G06T7/37 , A61B6/032 , A61B6/487 , A61B6/5211 , A61B6/5229 , A61B6/5235 , A61B6/5264 , G06T7/0016 , G06T7/207 , G06T7/248 , G06T7/269 , G06T7/32 , G06T7/33 , G06T7/38 , G06T7/564 , G06T11/005 , G06T11/006 , G06T19/003 , G06T2200/04 , G06T2200/28 , G06T2207/10028 , G06T2207/10081 , G06T2207/10088 , G06T2207/10116 , G06T2207/10121 , G06T2207/20016 , G06T2207/20221 , G06T2207/30008
摘要： A method includes, following specification of an initial transformation as a test transformation that is to be optimized, determining a 2D gradient x-ray image and a 3D gradient dataset of the image dataset, carrying out, for each image element of the gradient comparison image, a check for selection as a contour point, and determining an environment best corresponding to a local environment of the contour point and extending around a comparison point in the gradient x-ray image for all contour points in the at least one gradient comparison image. Local 2D displacement information is determined by comparing the contour points with the associated comparison points, and motion parameters of a 3D motion model describing a movement of the target region between the acquisition of the image dataset and the x-ray image are determined from the displacement information and a registration transformation describing the registration.
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30.发明授权公开(公告)号：US09549710B2
公开(公告)日：2017-01-24
申请号：US14339945
申请日：2014-07-24
申请人： Anja Borsdorf , Benno Heigl , Jian Wang
发明人： Anja Borsdorf , Benno Heigl , Jian Wang
CPC分类号： A61B6/5241 , A61B6/032 , A61B6/12 , A61B6/487 , A61B6/501 , A61B6/505 , A61B2090/364 , A61B2090/367 , A61F2/82 , G06T7/246 , G06T7/33 , G06T2207/10072 , G06T2207/10121 , G06T2207/10124 , G06T2207/30004 , G06T2207/30008
摘要： Methods for updating a 2D/3D registration between a three-dimensional image data set corresponding to a target area subjected to a movement and a plurality of two-dimensional projection images of the target area include: selecting a plurality of contour points along a contour, the contour being visible in a first projection image and a three-dimensional image data set registered therewith, the plurality of contour points being associated with a rigid object in the target area; determining a displacement of each contour point of the plurality of contour points between the first projection image and a successively captured second projection image; obtaining movement information for each contour point of the plurality of contour points based on the determined displacement, the movement information describing a movement of the rigid object; and updating the registration based on the obtained movement information.
摘要翻译： 用于更新对应于经受运动的目标区域的三维图像数据集与目标区域的多个二维投影图像之间的2D / 3D配准的方法包括：沿着轮廓选择多个轮廓点， 所述轮廓在第一投影图像和与其对应的三维图像数据集中可见，所述多个轮廓点与所述目标区域中的刚性物体相关联; 确定所述第一投影图像和连续捕获的第二投影图像之间的所述多个轮廓点的每个轮廓点的位移; 基于所确定的位移获得所述多个轮廓点中的每个轮廓点的运动信息，所述运动信息描述所述刚性物体的运动; 以及基于所获得的移动信息更新所述注册。
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