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21.发明授权公开(公告)号：US08182823B2
公开(公告)日：2012-05-22
申请号：US12895274
申请日：2010-09-30
CPC分类号： C07K16/3015 , A61K35/12 , A61K38/00 , A61K39/00 , A61K2039/5154 , A61K2039/57 , C07K14/47 , C07K14/4748 , C07K2317/34 , C07K2319/00 , C12N9/00 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158 , G01N33/57415 , G01N2500/00
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
摘要翻译： 公开了用于治疗和诊断癌症，特别是乳腺癌的组合物和方法。 示例性组合物包含一种或多种乳腺肿瘤多肽，其免疫原性部分，编码该多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是乳腺癌的诊断，预防和/或治疗。
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22.发明授权公开(公告)号：US06756477B1
公开(公告)日：2004-06-29
申请号：US09590751
申请日：2000-06-08
IPC分类号： C07K1400
CPC分类号： C07K14/47 , A61K35/12 , A61K38/00 , A61K39/00 , A61K2039/5154 , A61K2039/57 , C07K14/4748 , C07K2319/00 , C12N9/00 , C12Q1/6886 , C12Q2600/158 , Y10S530/806 , Y10S530/828
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.
摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如乳腺癌。 组合物可以包含一种或多种乳腺肿瘤蛋白质，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达乳腺肿瘤蛋白的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可以用于例如预防和治疗诸如乳腺癌的疾病。 还提供了基于检测样品中的乳腺肿瘤蛋白或编码这种蛋白质的mRNA的诊断方法。
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23.发明授权公开(公告)号：US07855271B2
公开(公告)日：2010-12-21
申请号：US11930080
申请日：2007-10-30
IPC分类号： C07K14/00
CPC分类号： C07K16/3015 , A61K35/12 , A61K38/00 , A61K39/00 , A61K2039/5154 , A61K2039/57 , C07K14/47 , C07K14/4748 , C07K2317/34 , C07K2319/00 , C12N9/00 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158 , G01N33/57415 , G01N2500/00
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
摘要翻译： 公开了用于治疗和诊断癌症，特别是乳腺癌的组合物和方法。 示例性组合物包含一种或多种乳腺肿瘤多肽，其免疫原性部分，编码该多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是乳腺癌的诊断，预防和/或治疗。
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公开(公告)号：US07598226B2
公开(公告)日：2009-10-06
申请号：US10007805
申请日：2001-12-07
CPC分类号： C07K14/47 , A61K35/12 , A61K38/00 , A61K39/00 , A61K2039/5154 , A61K2039/57 , C07K14/4748 , C07K2319/00 , C12N9/00 , C12Q1/6886 , C12Q2600/158
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
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公开(公告)号：US06586572B2
公开(公告)日：2003-07-01
申请号：US09604287
申请日：2000-06-22
申请人： Yuqiu Jiang , Davin C. Dillon , Jennifer L. Mitcham , Jiangchun Xu , Susan L. Harlocker , William T. Hepler
发明人： Yuqiu Jiang , Davin C. Dillon , Jennifer L. Mitcham , Jiangchun Xu , Susan L. Harlocker , William T. Hepler
IPC分类号： C07K1100
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K2039/5154 , A61K2039/57 , C07K2319/00 , Y10S977/907 , Y10S977/911 , Y10S977/912
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.
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公开(公告)号：US06528054B1
公开(公告)日：2003-03-04
申请号：US09620405
申请日：2000-07-20
申请人： Yuqiu Jiang , Davin C. Dillon , Jennifer L. Mitcham , Jiangchun Xu , Susan L. Harlocker , William T. Hepler
发明人： Yuqiu Jiang , Davin C. Dillon , Jennifer L. Mitcham , Jiangchun Xu , Susan L. Harlocker , William T. Hepler
IPC分类号： A61K39395
CPC分类号： C07K14/47 , A61K35/12 , A61K38/00 , A61K39/00 , A61K2039/5154 , A61K2039/57 , C07K14/4748 , C07K2319/00 , C12N9/00 , C12Q1/6886 , C12Q2600/158 , Y10S977/924
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.
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公开(公告)号：US20140011685A1
公开(公告)日：2014-01-09
申请号：US13540756
申请日：2012-07-03
申请人： Yixin WANG , Baoying Huang , Jack Hu , Yuqiu Jiang , Tim Jatkoe , Yashoda Rajpurohit
发明人： Yixin WANG , Baoying Huang , Jack Hu , Yuqiu Jiang , Tim Jatkoe , Yashoda Rajpurohit
CPC分类号： C12Q1/6883 , C12Q2600/158 , G01N33/56966
摘要： Circulating Endothelial Cells are isolated from patient blood and gene expression of the cells is analyzed to assess a medical condition or the tissue of origin of the cell. Kits for conducting the method are also provided.
摘要翻译： 从患者血液中分离循环内皮细胞，分析细胞的基因表达以评估细胞的医学状况或原始组织。 还提供了用于进行该方法的套件。
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28.发明申请Prediction of response to docetaxel therapy based on the presence of TMPRSSG2:ERG fusion in circulating tumor cells 审中-公开基于TMPRSSG2：ERG融合在循环肿瘤细胞中的存在对多西紫杉醇治疗的预测公开(公告)号：US20110166030A1
公开(公告)日：2011-07-07
申请号：US12924506
申请日：2010-09-28
申请人： Yixin Wang , Yuqiu Jiang , John F. Palma
发明人： Yixin Wang , Yuqiu Jiang , John F. Palma
IPC分类号： C40B30/00
CPC分类号： G01N33/57434 , G01N2800/52
摘要： A method for predicting with high specificity from RTPCR detected markers if a patent is likely to respond to docetaxel treatment is disclosed. RTPCR detects the presence of absence of certain mutations due to fusion events. Together, with other protein markers, additional stratification is possible to identify patents suited for docetaxel therapy as opposed to for alternative treatments.
摘要翻译： 公开了一种如果专利可能对多西紫杉醇治疗作出反应，则从RTPCR检测的标记物以高特异性预测的方法。 RTPCR检测由于融合事件而不存在某些突变。 与其他蛋白质标记一起，额外的分层可以鉴定适合多西他赛治疗的专利，而不是替代治疗。
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公开(公告)号：US07563880B2
公开(公告)日：2009-07-21
申请号：US10714389
申请日：2003-11-13
申请人： Davin C Dillon , Yuqiu Jiang
发明人： Davin C Dillon , Yuqiu Jiang
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , C07K14/47 , C07K2319/00 , G01N33/57415
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
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公开(公告)号：US20070037186A1
公开(公告)日：2007-02-15
申请号：US11435266
申请日：2006-05-16
申请人： Yuqiu Jiang , John Backus , Abhijit Mazumder , Dondapati Chowdary , Fei Yang , Yixin Wang , Timothy Jatkoe
发明人： Yuqiu Jiang , John Backus , Abhijit Mazumder , Dondapati Chowdary , Fei Yang , Yixin Wang , Timothy Jatkoe
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/57407 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/154
摘要： The present invention relates to methods, compositions and articles directed to diagnosing thyroid carcinoma, differentiating between thyroid carcinoma and benign thyroid diseases, testing indeterminate thyroid fine needle aspirate samples of thyroid nodules, and determining patient protocols and outcomes.
摘要翻译： 本发明涉及用于诊断甲状腺癌，区分甲状腺癌和良性甲状腺疾病的方法，组合物和制品，测定甲状腺结节的不确定甲状腺细针抽吸样品，并确定患者的方案和结果。
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