公开(公告)号：US08679772B2

公开(公告)日：2014-03-25

申请号：US12996609

申请日：2008-06-06

申请人： Zhiqiang Gao ,  Jie Zhang

发明人： Zhiqiang Gao ,  Jie Zhang

IPC分类号： G01N33/53

CPC分类号： G01N33/5438 ,  G01N33/54306

摘要： The invention provides a highly sensitive immunoassay for detection of a biological species. The immunoassay comprises exposing an electrode to an analyte liquid putatively containing the biological species so as to couple the biological species, if present in the analyte liquid, to a binding antibody on the electrode. The electrode comprises a binding antibody and an anchor group, each being coupled to an electrically conductive substrate, said binding antibody being capable of binding to the biological species and said anchor group being capable of binding to a redox polymer. The electrode is then exposed to an antibody-enzyme liquid comprising an antibody-enzyme species, said antibody-enzyme species comprising a detection antibody capable of binding to the biological species, said detection antibody being coupled to a redox enzyme, whereby, if the analyte liquid comprises the biological species, the redox enzyme couples to the electrode by means of the coupling of both the detection antibody and the binding antibody to the biological species. The electrode is then exposed to a polymer solution comprising the redox polymer and to an enzyme substrate, whereby if the redox enzyme is coupled to the anchor group on the electrode the redox polymer is reduced and couples to the anchor group on the electrode. A voltage is then applied between the electrode and a reference electrode and the electrode is exposed to an oxidizable species, whereby a magnitude of an electric current between said electrode and a reference electrode is indicative of the presence or absence of the biological species.

摘要翻译： 本发明提供用于检测生物物种的高度灵敏的免疫测定。 免疫测定包括将电极暴露于假设含有生物物质的分析物液体，以将生物物质（如果存在于分析物液体中）与电极上的结合抗体相连接。 电极包含结合抗体和锚定基团，每个锚定基团与导电底物偶联，所述结合抗体能够结合生物物种，所述锚定基团能够结合至氧化还原聚合物。 然后将电极暴露于包含抗体 - 酶物质的抗体 - 酶液体，所述抗体 - 酶物质包含能够结合生物物种的检测抗体，所述检测抗体与氧化还原酶偶联，由此，如果分析物 液体包括生物物种，氧化还原酶通过检测抗体和结合抗体与生物物种的偶联而与电极偶联。 然后将电极暴露于包含氧化还原聚合物和酶底物的聚合物溶液，由此如果氧化还原酶与电极上的锚定基团偶联，则氧化还原聚合物被还原并连接到电极上的锚定基团上。 然后将电压施加在电极和参考电极之间，并且电极暴露于可氧化物质，由此所述电极和参比电极之间的电流的大小指示生物物种的存在或不存在。

公开(公告)号：US08637506B2

公开(公告)日：2014-01-28

申请号：US10849067

申请日：2004-05-19

申请人： Dianqing Wu ,  Yazhou Zhang ,  Peng Liu ,  Xiaofeng Li ,  Jie Zhang ,  Jufang Shan ,  Dean Engelhardt

发明人： Dianqing Wu ,  Yazhou Zhang ,  Peng Liu ,  Xiaofeng Li ,  Jie Zhang ,  Jufang Shan ,  Dean Engelhardt

IPC分类号： A61K31/535 ,  C07C50/18

CPC分类号： G01N33/6893 ,  A61K38/00 ,  G01N33/6887 ,  G01N2500/00 ,  G01N2800/10 ,  G01N2800/108

摘要： The mechanism by which the high bone mass (HBM) mutation (G171V) of the Wnt coreceptor LRP5 regulates the canonical Wnt signaling was investigated. The mutation was previously shown to reduce Dkk protein-1-mediated antagonism, suggesting that the first YWTD repeat domain where G171 is located may be responsible for Dkk protein-mediated antagonism. However, we found that the third YWTD repeat, but not the first repeat domain, is required for DKK1-mediated antagonism. Instead, we found that the G171V mutation disrupted the interaction of LRP5 with Mesd, a chaperon protein for LRP5/6 that is required for the coreceptors' transport to cell surfaces, resulting in less LRP5 molecules on the cell surface. Although the reduction in the level of cell surface LRP5 molecules led to a reduction in Wnt signaling in a paracrine paradigm, the mutation did not appear to affect the activity of coexpressed Wnt in an autocrine paradigm. Together with the observation that osteoblast cells produce autocrine canonical Wnt, Wnt7b, and that osteocytes produce paracrine Dkk1, we believe that the G171V mutation may cause an increase in Wnt activity in osteoblasts by reducing the number of targets for paracrine Dkk1 to antagonize without affecting the activity of autocrine Wnt.

摘要翻译： 研究了Wnt共同受体LRP5的高骨量（HBM）突变（G171V）调节规范Wnt信号传导的机制。 以前显示突变可以降低Dkk蛋白-1介导的拮抗作用，这表明G171位于第一个YWTD重复结构域可能是Dkk蛋白介导的拮抗作用的原因。 然而，我们发现第三个YWTD重复，但不是第一个重复结构域，是DKK1介导的拮抗作用所必需的。 相反，我们发现G171V突变破坏了LRP5与Mesd的相互作用，Mesd是共受体转运到细胞表面所需的LRP5 / 6的伴侣蛋白，导致细胞表面上较少的LRP5分子。 尽管细胞表面LRP5分子水平的降低导致旁分泌范例中Wnt信号传导的降低，但突变似乎不影响共表达Wnt在自分泌范式中的活性。 连同观察到成骨细胞产生自分泌的正常Wnt，Wnt7b，并且该骨细胞产生旁分泌的Dkk1，我们认为G171V突变可能通过减少旁分泌Dkk1靶向拮抗的目标数量引起成骨细胞中Wnt活性的增加，而不会影响 自分泌Wnt的活性。

公开(公告)号：US08629164B2

公开(公告)日：2014-01-14

申请号：US13258512

申请日：2010-03-25

申请人： Jie Zhang ,  Drago Robert Sliskovic ,  Charles E. Ducker

发明人： Jie Zhang ,  Drago Robert Sliskovic ,  Charles E. Ducker

IPC分类号： A01N43/40 ,  A61K31/44 ,  C07D213/22

CPC分类号： C07D303/36 ,  C07D405/12 ,  C07D407/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

摘要： The invention relates to compounds of formulae (1) and (2): and pharmaceutically acceptable salts thereof for the treatment of cancer, inflammation, auto-immune diseases, diabetes and diabetic complications, infection, cardiovascular disease and ischemia-reperfusion injuries.

摘要翻译： 本发明涉及式（1）和（2）的化合物及其药学上可接受的盐，用于治疗癌症，炎症，自身免疫疾病，糖尿病和糖尿病并发症，感染，心血管疾病和缺血再灌注损伤。

公开(公告)号：US20130338127A1

公开(公告)日：2013-12-19

申请号：US13695669

申请日：2011-05-04

申请人： Hyder Aliyar ,  Jie Zhang

发明人： Hyder Aliyar ,  Jie Zhang

IPC分类号： A61K31/58

CPC分类号： A61K31/58 ,  A61K9/0014 ,  A61K31/57 ,  A61K47/10 ,  A61K47/32

摘要： The present invention is drawn to formulations and related methods for treating dermatitis or psoriasis. The formulation can include triamcinolone acetonide, a polymer selected from the group of a poly(2-hydroxyalkylacrylate), a poly(2-hydroxyalkylmethacrylate), and combinations thereof. The formulation also includes a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least one non-volatile solvent.

摘要翻译： 本发明涉及用于治疗皮炎或牛皮癣的制剂和相关方法。 制剂可以包括曲安奈德，选自聚（2-羟烷基丙烯酸酯），聚（2-羟烷基甲基丙烯酸酯）和其组合的聚合物。 该制剂还包括包含至少一种挥发性溶剂的挥发性溶剂体系和包含至少一种非挥发性溶剂的非挥发性溶剂体系。

公开(公告)号：US08604143B2

公开(公告)日：2013-12-10

申请号：US13284744

申请日：2011-10-28

申请人： Chao Wang ,  Chuanqing Li ,  Guozhu Yu ,  Aimin Liang ,  Jie Zhang ,  Lin Xu ,  Pengfei Lv ,  Huiling Liu

发明人： Chao Wang ,  Chuanqing Li ,  Guozhu Yu ,  Aimin Liang ,  Jie Zhang ,  Lin Xu ,  Pengfei Lv ,  Huiling Liu

IPC分类号： C08F4/44 ,  C08F4/02 ,  C08F4/60 ,  B01J31/00 ,  B01J37/00

CPC分类号： C08F36/08 ,  C08F136/08 ,  C08F4/6494

摘要： Disclosed are catalyst compositions for isoprene polymerization formed from components comprising (A) at least one titanium halide; (B) at least one organic aluminum compound comprising at least one alkyl aluminum of formula AlR3, wherein each of the three Rs is independently chosen from linear and branched C1-6 alkyl groups; and (C) at least one electron donor comprising at least one polyether compound of formula (I) and/or at least one tetrahydro-furfuryl ether compound of formula (II). Also disclosed are processes for preparation of the catalyst compositions and processes using the catalyst compositions for isoprene polymerization.

摘要翻译： 公开了由组分（A）至少一种卤化钛组成的异戊二烯聚合催化剂组合物， （B）至少一种包含至少一种式AlR 3的烷基铝的有机铝化合物，其中三个R 3中的每一个独立地选自直链和支链C 1-6烷基; 和（C）包含至少一种式（I）的聚醚化合物和/或至少一种式（II）的四氢糠基醚化合物的至少一种电子给体。 还公开了制备催化剂组合物的方法和使用该催化剂组合物用于异戊二烯聚合的方法。

公开(公告)号：US20130219204A1

公开(公告)日：2013-08-22

申请号：US13882410

申请日：2011-09-08

申请人： Xiangning Chen ,  Jie Zhang ,  Lifang Hao

发明人： Xiangning Chen ,  Jie Zhang ,  Lifang Hao

IPC分类号： G06F1/32

CPC分类号： G06F1/3234 ,  H04M1/738 ,  H04W52/0229 ,  Y02D70/00

摘要： Disclosed are a method and a system for remote wake-up and status check, with a wake-up signal generating unit generating and transmitting a wake-up signal to wake up an electricity supply unit of a remote device to operate normally and provide electricity for the remote device. The wake-up signal has an assigned electric voltage with specific characteristics for detection by the electricity supply unit while in power-off mode and, upon signal detection, the electricity supply unit wakes up to provide normal electric voltage output. The wake-up signal generating unit determines, according to an electric current on a wake-up signal feed line, whether the remote device is in an active mode. A low wake-up energy consumption enables system wake-up and a true powered-off sleep mode.

摘要翻译： 公开了一种用于远程唤醒和状态检查的方法和系统，其中唤醒信号产生单元产生并发送唤醒信号以唤醒远程设备的电力供应单元以正常运行并为 远程设备。 唤醒信号具有分配电压，具有特定的特性，用于在断电模式下由电力供应单元进行检测，并且在信号检测时，供电单元唤醒以提供正常的电压输出。 唤醒信号发生单元根据唤醒信号馈送线上的电流来确定远程设备是否处于活动模式。 低唤醒能耗使系统唤醒和真正关闭睡眠模式。

公开(公告)号：US20130197455A1

公开(公告)日：2013-08-01

申请号：US13638577

申请日：2011-03-30

申请人： Jie Zhang

发明人： Jie Zhang

IPC分类号： A61L29/16 ,  A61M25/00

CPC分类号： A61L29/16 ,  A61L2300/402 ,  A61L2300/404 ,  A61L2300/602 ,  A61L2420/02 ,  A61M19/00 ,  A61M25/00 ,  A61M25/0009 ,  A61M25/002 ,  A61M25/0045 ,  A61M2025/0057

摘要： The present disclosure relates to medical catheters, tubes, and other medical devices, systems, and methods. The catheter, tube, or other medical device is capable of releasing drugs for extended periods of time. Drugs can be loaded into the wall thereof with a loading solution. The drug in the wall of the device and in the loading solution can be in dynamic equilibrium, yielding stable and easy-to-manufacture products.

摘要翻译： 本公开涉及医疗导管，管和其它医疗装置，系统和方法。 导管，管或其他医疗装置能够长时间释放药物。 药物可以用加载溶液装入其壁。 装置壁和装载液中的药物可以处于动态平衡状态，产生稳定且易于制造的产品。

公开(公告)号：US08439705B2

公开(公告)日：2013-05-14

申请号：US13241292

申请日：2011-09-23

申请人： Jie Zhang

发明人： Jie Zhang

IPC分类号： H01R13/66

CPC分类号： H01R13/6461 ,  H01F27/36 ,  H01R24/64

摘要： An electrical connector (100) includes an insulative housing (2) defining a receiving cavity (20) for insertion of a mating connector, a terminal module (3) including a number of mating terminals (311) projecting into the receiving cavity and a number of magnetic components connected with the mating terminals, and a respective shielding plate (33) located between adjacent magnetic components to reduce crosstalk.

摘要翻译： 电连接器（100）包括限定用于插入配合连接器的接收腔（20）的绝缘壳体（2），包括突出到容纳腔中的多个配合端子（311）的端子模块（3） 与配合端子连接的磁性部件以及位于相邻的磁性部件之间的相应的屏蔽板（33），以减少串扰。

公开(公告)号：US08416865B2

公开(公告)日：2013-04-09

申请号：US12495945

申请日：2009-07-01

申请人： Jie Zhang ,  Hua Zhou ,  Jun Tian

发明人： Jie Zhang ,  Hua Zhou ,  Jun Tian

IPC分类号： H04K1/10

CPC分类号： H04L27/2607 ,  H04L5/0007 ,  H04L5/003 ,  H04L5/0058

摘要： The present invention provides a wireless transmission method and system based on maximum multi-path delay estimation. A wireless transmission method based on an estimation of maximum multi-paths delay, comprising: a communication apparatus involved in wireless communication estimates the maximum multi-paths delay of a currently received frame; the communication apparatus performs a quantization and coding on feedback information related with the estimated maximum multi-paths delay, and then sends the feedback information which has been subjected to the quantization and coding to an opposing communication apparatus which is in wireless communication with the communication apparatus; the opposing communication apparatus recovers the feedback information by demodulating and decoding the feedback information which has been subjected to the quantization and coding; the opposing communication apparatus performs an adaptive adjustment of wireless signals transmitted to the communication apparatus, based on the recovered feedback information. With this method, system parameters can be adaptively adjusted so as to that sufficiently improves the spectrum utilization efficiency of wireless resources (the throughput is increased by about 5%).

摘要翻译： 本发明提供一种基于最大多径延迟估计的无线传输方法和系统。 一种基于最大多路径延迟的估计的无线传输方法，包括：无线通信中涉及的通信装置估计当前接收到的帧的最大多径延迟; 通信装置对与估计的最大多径延迟相关的反馈信息进行量化和编码，然后将经过量化和编码的反馈信息发送到与通信装置无线通信的相对的通信装置 ; 相对的通信装置通过对经过量化和编码的反馈信息进行解调和解码来恢复反馈信息; 相对的通信装置基于恢复的反馈信息对发送到通信装置的无线信号进行自适应调整。 通过这种方法，可以自适应地调整系统参数，以充分提高无线资源的频谱利用效率（吞吐量提高约5％）。

公开(公告)号：US08386220B2

公开(公告)日：2013-02-26

申请号：US12639433

申请日：2009-12-16

申请人： Jie Zhang

发明人： Jie Zhang

IPC分类号： G06G7/48

CPC分类号： G06G7/48 ,  G06T17/20

摘要： Systems and methods for representing a surface with faces. Defining a face with inner and outer concave constraint lines. Representing the face with five initial vertices spread equidistant on each of the inner and outer concave constraint lines. Using a triangulation refinement method to transform the initial set of vertices into a first set of representative vertices.

摘要翻译： 用表示表面的系统和方法。 定义具有内外凹面约束线的面。 表示具有五个初始顶点的面在每个内部和外部凹形约束线上等距延伸。 使用三角剖分细化方法将初始顶点集合变换为第一组代表性顶点。