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公开(公告)号：US08903492B2
公开(公告)日：2014-12-02
申请号：US11349540
申请日：2006-02-07
IPC分类号： A61N1/36 , A61B5/11 , A61B5/145 , A61B5/1473 , A61B5/00 , A61N1/365 , A61B5/053 , A61M5/142 , A61M5/172
CPC分类号： A61B5/14546 , A61B5/053 , A61B5/1107 , A61B5/1451 , A61B5/14542 , A61B5/1473 , A61B5/4519 , A61B5/686 , A61B5/7278 , A61B2562/0219 , A61M5/14276 , A61M5/1723 , A61N1/36135 , A61N1/36167 , A61N1/36557
摘要： In general, the invention is directed to methods and devices for determining an ion concentration in the extracellular fluid of a patient. As examples, the ion may be one or more of potassium, sodium, chloride, or calcium. A system includes an electrode deployed in or near a tissue, such as a skeletal muscle, of the patient. A pulse generator supplies one or more stimulations to the tissue, and a sensor, such as an accelerometer, detects the response of the tissue to the stimulations. A processor determines a concentration of ions in the extracellular fluid as a function of the response. The system may detect an ion imbalance based upon the determined concentration of ions.
摘要翻译： 通常，本发明涉及用于确定患者的细胞外液中的离子浓度的方法和装置。 作为实例，离子可以是钾，钠，氯或钙中的一种或多种。 系统包括部署在患者的组织（例如骨骼肌）中或附近的电极。 脉冲发生器向组织提供一个或多个刺激，并且诸如加速度计的传感器检测组织对刺激的响应。 处理器确定细胞外液中的离子浓度作为响应的函数。 该系统可以基于确定的离子浓度检测离子不平衡。
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公开(公告)号：US08571620B2
公开(公告)日：2013-10-29
申请号：US12797816
申请日：2010-06-10
IPC分类号： A61B5/00
CPC分类号： A61N1/36557
摘要： A medical device system and associated method are used for monitoring a heart failure patient. A medical device for monitoring delivery of a therapy includes a sensor sensing an optical sensor signal corresponding to light attenuation by a volume of body tissue of a patient, a therapy delivery module to deliver a therapy, and a processor configured to compute a first tissue oxygenation measurement from the optical sensor signal prior to initiating delivery of the therapy, compute a second tissue oxygenation measurement from the optical sensor signal subsequent to initiating delivery of the therapy, compare the first and the second tissue oxygenation measurements, and determine whether the delivered therapy was successful in response to the first tissue oxygenation measurement and the second tissue oxygenation measurement.
摘要翻译： 医疗器械系统和相关方法用于监测心力衰竭患者。 用于监测治疗递送的医疗装置包括传感器，其感测对应于患者的身体组织的体积的光衰减的光学传感器信号，用于递送治疗的治疗递送模块和被配置为计算第一组织氧合的处理器 在开始递送治疗之前从光学传感器信号进行的测量，在开始递送治疗之后从光学传感器信号计算第二组织氧合测量，比较第一和第二组织氧合测量，并确定递送的治疗是否为 成功地响应于第一次组织氧合测量和第二次组织氧合测量。
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公开(公告)号：US08525643B2
公开(公告)日：2013-09-03
申请号：US12771095
申请日：2010-04-30
申请人： Michael T. Green , James K. Carney , G. Sean Haag
发明人： Michael T. Green , James K. Carney , G. Sean Haag
IPC分类号： G05B23/00
CPC分类号： A61B5/0002 , A61B8/4236 , A61B8/4438 , A61B2562/08 , G06F19/00
摘要： A medical system that includes an identification patch having a memory that stores identification information associated with the patch. A monitoring device to be used with the identification patch interrogates the patch to obtain the identification information stored within the memory of the patch. The monitoring device determines whether the identification information is valid and, if so, measures values representing one or more parameters of the patient. If the identification information is not valid, monitoring device does not measure values representing the one or more parameters of the patient.
摘要翻译： 一种医疗系统，其包括具有存储器的识别补丁，所述存储器存储与所述补丁相关联的识别信息。 与识别补丁一起使用的监视装置会询问补丁以获得存储在补丁存储器内的识别信息。 监视装置确定识别信息是否有效，如果是，则测量表示患者的一个或多个参数的值。 如果识别信息无效，则监视装置不测量表示患者的一个或多个参数的值。
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公开(公告)号：US20110218408A1
公开(公告)日：2011-09-08
申请号：US12771095
申请日：2010-04-30
申请人： Michael T. Green , James K. Carney , G. Sean Haag
发明人： Michael T. Green , James K. Carney , G. Sean Haag
CPC分类号： A61B5/0002 , A61B8/4236 , A61B8/4438 , A61B2562/08 , G06F19/00
摘要： A medical system that includes an identification patch having a memory that stores identification information associated with the patch. A monitoring device to be used with the identification patch interrogates the patch to obtain the identification information stored within the memory of the patch. The monitoring device determines whether the identification information is valid and, if so, measures values representing one or more parameters of the patient. If the identification information is not valid, monitoring device does not measure values representing the one or more parameters of the patient.
摘要翻译： 一种医疗系统，其包括具有存储器的识别补丁，所述存储器存储与所述补丁相关联的识别信息。 与识别补丁一起使用的监视装置会询问补丁以获得存储在补丁存储器内的识别信息。 监视装置确定识别信息是否有效，如果是，则测量表示患者的一个或多个参数的值。 如果识别信息无效，则监视装置不测量表示患者的一个或多个参数的值。
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公开(公告)号：US20100318146A1
公开(公告)日：2010-12-16
申请号：US12797815
申请日：2010-06-10
IPC分类号： A61N1/365
CPC分类号： A61N1/36557
摘要： A medical device for monitoring delivery of a therapy that includes a therapy delivery module to deliver a therapy, a controller to set a therapy delivery control parameter, an optical sensor to produce a signal corresponding to tissue light attenuation, and a processor configured to compute a tissue oxygenation measurement from the optical sensor signal, wherein the controller, the optical sensor, and the processor operate cooperatively to determine a setting of the therapy delivery control parameter corresponding to a maximum tissue oxygenation.
摘要翻译： 一种用于监测治疗递送的医疗装置，其包括用于递送疗法的治疗递送模块，用于设置治疗递送控制参数的控制器，用于产生对应于组织光衰减的信号的光学传感器，以及被配置为计算 来自光学传感器信号的组织氧合测量，其中所述控制器，所述光学传感器和所述处理器协同工作以确定对应于最大组织氧合的所述治疗传递控制参数的设置。
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公开(公告)号：US20100317942A1
公开(公告)日：2010-12-16
申请号：US12797816
申请日：2010-06-10
IPC分类号： A61B5/00
CPC分类号： A61N1/36557
摘要： A medical device system and associated method are used for monitoring a heart failure patient. A medical device for monitoring delivery of a therapy includes a sensor sensing an optical sensor signal corresponding to light attenuation by a volume of body tissue of a patient, a therapy delivery module to deliver a therapy, and a processor configured to compute a first tissue oxygenation measurement from the optical sensor signal prior to initiating delivery of the therapy, compute a second tissue oxygenation measurement from the optical sensor signal subsequent to initiating delivery of the therapy, compare the first and the second tissue oxygenation measurements, and determine whether the delivered therapy was successful in response to the first tissue oxygenation measurement and the second tissue oxygenation measurement.
摘要翻译： 医疗器械系统和相关方法用于监测心力衰竭患者。 用于监测治疗递送的医疗装置包括传感器，其感测对应于患者的身体组织的体积的光衰减的光学传感器信号，用于递送治疗的治疗递送模块和被配置为计算第一组织氧合的处理器 在开始递送治疗之前从光学传感器信号进行的测量，在开始递送治疗之后从光学传感器信号计算第二组织氧合测量，比较第一和第二组织氧合测量，并确定递送的治疗是否为 成功地响应于第一次组织氧合测量和第二次组织氧合测量。
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27.发明申请Device and Method for Monitoring of Absolute Oxygen Saturation and Tissue Hemoglobin Concentration 有权用于监测绝对氧饱和度和组织血红蛋白浓度的装置和方法公开(公告)号：US20100317939A1
公开(公告)日：2010-12-16
申请号：US12797770
申请日：2010-06-10
申请人： Jonathan L. Kuhn , Can Cinbis , James K. Carney
发明人： Jonathan L. Kuhn , Can Cinbis , James K. Carney
IPC分类号： A61B5/1455
CPC分类号： A61B5/14552 , A61B5/0084 , A61B5/14546 , A61B5/1459 , A61B5/7239 , A61N1/36557
摘要： A method and medical device for detecting signals that detects emitted light scattered by a volume of tissue delivered along a first pathway and a second pathway different from the first pathway, detects emitted light scattered by a volume of tissue delivered along a third pathway and a fourth pathway different from the third pathway, determines a first uniformity corresponding to the emitted light detected along the first pathway and the second pathway, determines a second uniformity corresponding to the emitted light detected along third pathway and the fourth pathway, determines a total uniformity in response to the determined first uniformity and the determined second uniformity, and alters sensing by the device in response to the determined total uniformity.
摘要翻译： 一种用于检测信号的方法和医疗装置，其检测由沿着第一路径传送的组织体积散射的发射光和不同于第一路径的第二路径的信号，检测由沿着第三路径传送的组织体积散射的发射光， 确定与沿着第一路径和第二路径检测到的发射光相对应的第一均匀度，确定对应于沿着第三路径和第四路径检测的发射光的第二均匀度，确定响应中的总均匀性 到所确定的第一均匀性和确定的第二均匀性，并且改变由所述装置响应于所确定的总均匀性的感测。
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公开(公告)号：US07684872B2
公开(公告)日：2010-03-23
申请号：US11380315
申请日：2006-04-26
申请人： James K. Carney , Michael A. Schugt , Qingshan Ye , Can Cinbis
发明人： James K. Carney , Michael A. Schugt , Qingshan Ye , Can Cinbis
IPC分类号： A61N1/08
CPC分类号： A61B5/0422 , A61B5/0215 , A61B5/02158 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B2562/028 , A61N1/056 , A61N1/36514
摘要： A medical device for implantation within a patient comprising a lead body including a conductor within the lead body and a transducer supported by the lead body. The conductor is electrically coupled to the transducer by a conductive fluid, paste or gel. The conductive fluid, paste or gel may be contained within a well in the lead body. The transducer may be a MEMS chip and/or an integrated circuit and may perform any of a variety of functions such as sensing physiological data.
摘要翻译： 一种用于植入患者体内的医疗装置，包括：引线体，其包括引线体内的导体;以及由引线体支撑的换能器。 导体通过导电流体，糊剂或凝胶电耦合到换能器。 导电流体，糊状物或凝胶可以包含在引线体内的阱中。 换能器可以是MEMS芯片和/或集成电路，并且可以执行诸如感测生理数据的各种功能中的任何一种。
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公开(公告)号：US20090299198A1
公开(公告)日：2009-12-03
申请号：US12129955
申请日：2008-05-30
IPC分类号： A61B5/0215 , A61B5/021
CPC分类号： A61B5/0215 , A61B5/02028
摘要： A method for estimating pulmonary artery diastolic pressure, for a single heart beat, includes establishing a time window for sampling and storing pressure data points from a right ventricular pressure transducer. The time window may be established according to predetermined parameters and/or according to one or more triggering events. An approximate time at which the pulmonary artery valve opens is determined, either via the sampled pressure data points, or via another form of more direct monitoring, during the time window, in order to estimate the pulmonary artery diastolic pressure. A plurality of sets of N pressure data points may be collected, from the sampled data, and, for each collected set, a weighted sum is calculated. Each weighted sum may be employed to evaluate a quality of the sampled data and/or to estimate the pulmonary artery diastolic pressure, if the more direct monitoring of the pulmonary artery valve is not employed.
摘要翻译： 用于估计单次心跳的肺动脉舒张压的方法包括建立用于从右心室压力传感器采样和存储压力数据点的时间窗口。 可以根据预定参数和/或根据一个或多个触发事件建立时间窗口。 通过采样的压力数据点或在时间窗口期间通过另一种形式的更直接的监测来确定肺动脉瓣打开的大致时间，以便估计肺动脉舒张压。 可以从采样数据收集多组N个压力数据点，并且对于每个收集的集合，计算加权和。 如果不采用更直接的肺动脉瓣监测，则每个加权和可用于评估采样数据的质量和/或估计肺动脉舒张压。
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30.发明授权公开(公告)号：US07571008B2
公开(公告)日：2009-08-04
申请号：US10920818
申请日：2004-08-17
申请人： David A. Dinsmoor , James K. Carney
发明人： David A. Dinsmoor , James K. Carney
IPC分类号： A61N1/00
摘要： An integrated activation system for an implantable medical device (IMD) sharing a power source, the activation system having a switching circuit and a sensing element coupled to the switching circuit. The switching circuit is configured to gate power from the power source to the IMD. The sensing element is configured to draw current from the power source of less than or equal to about 1 nA during inactivation, enable an operation interval of the switching circuit, and trigger a first state change in the switching circuit. The switching circuit further is configured to gate power to the IMD upon receipt of a pre-determined number of signals from the sensing element.
摘要翻译： 一种用于共享电源的可植入医疗设备（IMD）的集成激活系统，所述激活系统具有切换电路和耦合到所述切换电路的感测元件。 开关电路被配置为将电力从电源门控到IMD。 感测元件被配置为在停用期间从电源抽取小于或等于约1nA的电流，使能开关电路的操作间隔，并触发开关电路中的第一状态变化。 开关电路还被配置为在从感测元件接收到预定数量的信号时对IMD进行栅极电源。
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