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38 条记录 (耗时 0.038 秒)

    5′-primary aminoalkyl psoralen compositions with platelets
    21.
    发明授权
    5′-primary aminoalkyl psoralen compositions with platelets 失效
    具有血小板的5'-氨基烷基补骨脂素组合物

    公开(公告)号：US06218100B1

    公开(公告)日：2001-04-17

    申请号：US08900032

    申请日：1997-07-24

    申请人： Susan Wollowitz ,  Stephen T. Isaacs ,  Henry Rapoport ,  Hans Peter Spielmann

    发明人： Susan Wollowitz ,  Stephen T. Isaacs ,  Henry Rapoport ,  Hans Peter Spielmann

    IPC分类号： A01N102

    CPC分类号： C07D493/04 ,  A01N1/0215 ,  A61K31/365 ,  A61K31/37 ,  A61K41/0019 ,  A61K41/0066 ,  A61L2/0011

    摘要： Psoralen compounds are synthesized which have substitutions on the 4, 4′, 5′, and 8 positions of the psoralen, which permit enhanced binding to nucleic acid of pathogens. Higher psoralen binding levels and lower mutagenicity are described, resulting in safer, more efficient, and reliable inactivation of pathogens in blood products. The invention contemplates inactivation methods using the new psoralens which do not compromise the function of blood products for transfusion. In particular, use of 5′-primary aminoalkyl psoralens to inactivate pathogens in platelets is disclosed.

    摘要翻译： 合成补骨脂素化合物，其在补骨脂素的4,4'，5'和8位上具有取代，其允许增强与病原体核酸的结合。 描述了更高的补骨脂素结合水平和较低的致突变性，导致血液制品中病原体的更安全，更有效和可靠的失活。 本发明考虑使用新的补骨脂素的灭活方法，其不损害用于输血的血液制品的功能。 特别地，公开了使用5'-氨基烷基补骨脂素灭活血小板中的病原体。

    Compounds for the photodecontamination of pathogens in blood
    24.
    发明授权
    Compounds for the photodecontamination of pathogens in blood 有权
    用于血液中病原体光致净化的化合物

    公开(公告)号：US06686480B2

    公开(公告)日：2004-02-03

    申请号：US10161589

    申请日：2002-06-03

    申请人： Susan Wollowitz ,  Stephen T. Isaacs ,  Henry Rapoport ,  Hans Peter Spielmann

    发明人： Susan Wollowitz ,  Stephen T. Isaacs ,  Henry Rapoport ,  Hans Peter Spielmann

    IPC分类号： C07D49300

    CPC分类号： C07D493/04 ,  A01N1/0215 ,  A01N43/90 ,  A61K31/365 ,  A61K31/37 ,  A61K41/0019 ,  A61K41/0066 ,  A61L2/0011

    摘要： Psoralen compound compositions are synthesized which have substitutions on the 4, 4′, 5′, and 8 positions of the psoralen, which yet permit their binding to nucleic acid of pathogens. Reaction conditions that photoactivate these bound psoralens result in covalent crosslinking to nucleic acid, thereby inactivating the pathogen. Higher psoralen binding levels and lower mutagenicity results in safer, more efficient, and reliable inactivation of pathogens. In addition to the psoralen compositions, the invention contemplates inactivating methods using the new psoralens.

    摘要翻译： 合成补骨脂素化合物组合物，其在补骨脂素的4,4'，5'和8位上具有取代，其仍然允许它们与病原体的核酸结合。 激活这些结合的补骨脂素的反应条件导致与核酸的共价交联，从而使病原体灭活。 更高的补骨脂素结合水平和较低的致突变性导致更安全，更有效和可靠的病原体失活。 除了补骨脂素组合物之外，本发明考虑使用新的补骨脂素的灭活方法。

    Method for photodecontamination of pathogens in blood using 5'-primary aminopsoralens
    25.
    发明授权
    Method for photodecontamination of pathogens in blood using 5'-primary aminopsoralens 失效
    使用5'-主要氨基补骨脂素对血液中病原体进行光致净化的方法

    公开(公告)号：US06503699B1

    公开(公告)日：2003-01-07

    申请号：US09375340

    申请日：1999-08-16

    申请人： Susan Wollowitz ,  Stephen T. Isaacs ,  Henry Rapoport ,  Hans Peter Spielmann

    发明人： Susan Wollowitz ,  Stephen T. Isaacs ,  Henry Rapoport ,  Hans Peter Spielmann

    IPC分类号： A01N102

    CPC分类号： C07D493/04 ,  A01N1/0215 ,  A61K31/365 ,  A61K31/37 ,  A61K41/0019 ,  A61K41/0066 ,  A61L2/0011

    摘要： Psoralen compound compositions are synthesized which have substitutions on the 4, 4′, 5′, and 8 positions of the psoralen, which yet permit their binding to nucleic acid of pathogens. Reaction conditions that photoactivate these bound psoralens result in covalent crosslinking to nucleic acid, thereby inactivating the pathogen. Higher psoralen binding levels and lower mutagenicity results in safer, more efficient, and reliable inactivation of pathogens. In addition to the psoralen compositions, the invention contemplates inactivating methods using the new psoralens.

    摘要翻译： 合成补骨脂素化合物组合物，其在补骨脂素的4,4'，5'和8位上具有取代，其仍然允许它们与病原体的核酸结合。 激活这些结合的补骨脂素的反应条件导致与核酸的共价交联，从而使病原体灭活。 更高的补骨脂素结合水平和较低的致突变性导致更安全，更有效和可靠的病原体失活。 除了补骨脂素组合物之外，本发明考虑使用新的补骨脂素的灭活方法。

    Nucleic acid hybridization assay employing probes crosslinkable to target sequences
    27.
    发明授权
    Nucleic acid hybridization assay employing probes crosslinkable to target sequences 失效
    使用可靶向序列交联的探针进行核酸杂交测定

    公开(公告)号：US4599303A

    公开(公告)日：1986-07-08

    申请号：US560430

    申请日：1983-12-12

    申请人： Kenichi K. Yabusaki ,  Stephen T. Isaacs ,  Howard B. Gamper, Jr.

    发明人： Kenichi K. Yabusaki ,  Stephen T. Isaacs ,  Howard B. Gamper, Jr.

    IPC分类号： G01N33/50 ,  C07H21/00 ,  C12N15/00 ,  C12N15/09 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/58 ,  G01N33/566

    CPC分类号： C12Q1/6816

    摘要： Novel methods and reagents for determining the presence of specific nucleic acid base sequences by employing crosslinking reactions of unique molecules capable of forming covalent bonds which are bonded with various labels or ligands for amplication.Single stranded nucleic acid probes are employed which contain complementary base sequences to nucleic acid target molecules. By first hybridizing and then forming covalent bonds between the probe and target the amount of label in the crosslinked hybrid can be measured as an extremely sensitive method for assaying for specific nucleic acid sequences.

    摘要翻译： 用于通过使用能够形成共价键的独特分子的交联反应来确定特定核酸碱基序列的存在的新方法和试剂，其与各种标记或配体结合用于扩增。 使用含有核酸靶分子的互补碱基序列的单链核酸探针。 通过首先杂交并在探针和靶之间形成共价键，可以测量交联杂交体中标记的量作为用于测定特异性核酸序列的非常灵敏的方法。

    Method for inactivation of pathogens in platelets using 4' and 5' primary amino-substituted psoralens
    29.
    发明授权
    Method for inactivation of pathogens in platelets using 4' and 5' primary amino-substituted psoralens 失效
    使用4'和5'伯氨基取代的补骨脂素使血小板中的病原体失活的方法

    公开(公告)号：US6004742A

    公开(公告)日：1999-12-21

    申请号：US962903

    申请日：1997-11-03

    申请人： Susan Wollowitz ,  Stephen T. Isaacs ,  Henry Rapoport ,  Hans Peter Spielmann

    发明人： Susan Wollowitz ,  Stephen T. Isaacs ,  Henry Rapoport ,  Hans Peter Spielmann

    IPC分类号： A61K31/37 ,  A61K41/00 ,  A61L2/00 ,  A01N1/02 ,  C12N7/06

    CPC分类号： A61K41/0066 ,  A01N1/0215 ,  A01N1/0294 ,  A61K31/37 ,  A61L2/0011 ,  A61L2/0088

    摘要： Psoralen compounds are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which permit enhanced binding to nucleic add of pathogens. Higher psoralen binding levels and lower mutagenicity are described, resulting in safer, more efficient, and reliable inactivation of pathogens in blood products. The invention contemplates inactivation methods using the new psoralens which do not compromise the function of blood products for transfusion. In particular compounds with primary aminoalkyl substitutions on the 4' or 5' positions of psoralen are used to inactivate pathogens in blood products such as platelets.

    摘要翻译： 合成补骨脂素化合物，其在补骨脂素的4,4'，5'和8位上具有取代，其允许增强与病原体的核酸添加结合。 描述了更高的补骨脂素结合水平和较低的致突变性，导致血液制品中病原体的更安全，更有效和可靠的失活。 本发明考虑使用新的补骨脂素的灭活方法，其不损害用于输血的血液制品的功能。 特别是在补骨脂素的4'或5'位上具有伯氨基烷基取代的化合物用于灭活血液制品如血小板中的病原体。