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    Matriptase protein and uses thereof
    21.
    发明授权
    Matriptase protein and uses thereof 有权
    Matriptase蛋白及其用途

    公开(公告)号：US08420091B2

    公开(公告)日：2013-04-16

    申请号：US12701566

    申请日：2010-02-07

    Applicant: Christian Rohlff ,  Jonathan Alexander Terrett

    Inventor： Christian Rohlff ,  Jonathan Alexander Terrett

    IPC: A61K39/395

    CPC classification number: G01N33/573 ,  C12Q1/37 ,  G01N33/574 ,  G01N2333/96433

    Abstract: The present invention provides methods and compositions for treatment, screening, diagnosis, prognosis and therapy of breast cancer, colorectal cancer, esophageal cancer, gastric cancer, prostate cancer and uterine cancer, for monitoring the effectiveness of breast cancer, colorectal cancer, esophageal cancer, gastric cancer, prostate cancer and uterine cancer treatment, and for drug development.

    Abstract translation: 本发明提供乳腺癌，结肠直肠癌，食管癌，胃癌，前列腺癌和子宫癌的治疗，筛选，诊断，预后和治疗的方法和组合物，用于监测乳腺癌，结肠直肠癌，食管癌， 胃癌，前列腺癌和子宫癌治疗，以及药物开发。

    HUMAN MONOCLONAL ANTIBODIES TO PROTEIN TYROSINE KINASE 7 (PTK7) AND METHODS FOR USING ANTI-PTK7 ANTIBODIES
    24.
    发明申请
    HUMAN MONOCLONAL ANTIBODIES TO PROTEIN TYROSINE KINASE 7 (PTK7) AND METHODS FOR USING ANTI-PTK7 ANTIBODIES 有权
    人类单克隆抗体蛋白酪氨酸激酶7（PTK7）和使用抗PTK7抗体的方法

    公开(公告)号：US20100034826A1

    公开(公告)日：2010-02-11

    申请号：US12095986

    申请日：2006-12-08

    Applicant: Jonathan Alexander Terrett ,  Li-Sheng Lu ,  Chin Pan

    Inventor： Jonathan Alexander Terrett ,  Li-Sheng Lu ,  Chin Pan

    IPC: A61K39/395 ,  C07K16/30 ,  A61K51/00 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  C12P21/08

    CPC classification number: C07K16/30 ,  A61K2039/505 ,  C07K16/40 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/77

    Abstract: The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PTK7 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PTK7, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PTK7 antibodies.

    Abstract translation: 本发明提供了以高亲和力特异性结合PTK7的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供用于检测PTK7的方法，以及使用抗PTK7抗体治疗各种疾病（包括癌症和感染性疾病）的方法。

    ANTIBODIES
    27.
    发明申请
    ANTIBODIES 审中-公开
    抗体

    公开(公告)号：US20130259878A1

    公开(公告)日：2013-10-03

    申请号：US13880320

    申请日：2011-10-19

    Applicant: Jonathan Alexander Terrett

    Inventor： Jonathan Alexander Terrett

    IPC: C07K16/28

    CPC classification number: C07K16/30 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/2896 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/77 ,  G01N33/57419 ,  G01N33/57438 ,  G01N33/57446 ,  G01N33/57492

    Abstract: The present disclosure provides antibodies, including isolated monoclonal antibodies, which specifically bind to CDH17 with high affinity. Nucleic acid molecules encoding CDH17 antibodies, expression vectors, host cells and methods for expressing CDH17 antibodies are also provided. Bispecific molecules and pharmaceutical compositions comprising the CDH17 antibodies are also provided. Methods for detecting CD-H17, as well as methods for treating carious cancers, including gastric cancer, pancreatic cancer, colon cancer and colorectal cancer, are disclosed.

    Abstract translation: 本公开提供了以高亲和力特异性结合CDH17的抗体，包括分离的单克隆抗体。 还提供编码CDH17抗体的核酸分子，表达载体，宿主细胞和表达CDH17抗体的方法。 还提供了包含CDH17抗体的双特异性分子和药物组合物。 公开了用于检测CD-H17的方法，以及用于治疗龋癌的方法，包括胃癌，胰腺癌，结肠癌和结肠直肠癌。

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