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21.发明授权Method and apparatus for post-shock evaluation using tissue oxygenation measurements 有权使用组织氧合测量进行休克后评估的方法和装置公开(公告)号：US08639332B2
公开(公告)日：2014-01-28
申请号：US12845830
申请日：2010-07-29
IPC分类号： A61N1/365
CPC分类号： A61B5/14551 , A61B5/1459 , A61B5/6846 , A61B5/7285 , A61N1/36557 , A61N1/3925 , A61N1/3956
摘要： A method and device for delivering therapy that includes an electrode to sense cardiac signals and to deliver a therapy, a therapy delivery module coupled to the electrode to deliver a therapy via the electrode in response to the sensed cardiac signals, a sensor emitting light and detecting emitted light scattered by a tissue volume adjacent the optical sensor to generate a corresponding detected light intensity output signal, a control module coupled to the sensor to control light emission of the sensor in response to delivering the therapy, and a controller coupled to the therapy delivery module and the sensor, the controller configured to determine tissue oxygenation measurements in response to the output signal, determine a tissue oxygenation trend in response to the tissue oxygenation measurements, and determine whether the delivered therapy restored cardiac hemodynamic function in response to the determined tissue oxygenation trend.
摘要翻译： 一种用于递送治疗的方法和装置，其包括用于感测心脏信号并递送治疗的电极，治疗递送模块，其耦合到所述电极，以响应于感测到的心脏信号经由所述电极递送治疗;发射光和检测的传感器 发射由邻近光学传感器的组织体积散射的光，以产生对应的检测到的光强度输出信号;耦合到传感器的控制模块，以响应于递送治疗来控制传感器的光发射;以及耦合到治疗传递的控制器 模块和传感器，所述控制器被配置为响应于所述输出信号确定组织氧合测量，响应于所述组织氧合测量确定组织氧合趋势，并且确定所递送的治疗是否响应于所确定的组织氧合来恢复心脏血液动力学功能 趋势。
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22.发明授权公开(公告)号：US08489168B2
公开(公告)日：2013-07-16
申请号：US12948884
申请日：2010-11-18
IPC分类号： A61B5/1455
CPC分类号： A61B5/1459 , A61B5/0075 , A61B5/14535 , A61B5/14542 , A61B5/14551 , A61B5/1495 , A61B5/4836
摘要： A first concentration of a chromophore corresponding to a measurement volume of an optical sensor is determined. A second concentration of the chromophore is obtained in the vicinity of the measurement volume corresponding to a change in at least one of a total concentration of the chromophore and a relative concentration of a first form of the chromophore to the total concentration of the chromophore in the measurement volume. Light remittance measurements including a first light wavelength and a second light wavelength are obtained corresponding to the first chromophore concentration and the second chromophore concentration. A coefficient for computing an index of a change in the chromophore concentration is computed using the difference between the first and second chromophore concentrations and the first and second light remittance measurements.
摘要翻译： 确定对应于光学传感器的测量体积的发色团的第一浓度。 在测量体积附近获得发色团的第二浓度，其对应于发色团的总浓度和发色团的第一形式的相对浓度与发色团的总浓度中的至少一个的变化相关 测量体积。 对应于第一发色团浓度和第二发色团浓度获得包括第一光波长和第二光波长的光汇率测量。 使用第一和第二生色团浓度与第一和第二光汇率测量之间的差来计算计算发色团浓度变化指数的系数。
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23.发明授权Device and method for monitoring of absolute oxygen saturation and total hemoglobin concentration 有权用于监测绝对氧饱和度和总血红蛋白浓度的装置和方法公开(公告)号：US08463345B2
公开(公告)日：2013-06-11
申请号：US12797736
申请日：2010-06-10
IPC分类号： A61B5/0215
CPC分类号： A61B5/14552 , A61B5/0084 , A61B5/14546 , A61B5/1459 , A61B5/7239 , A61N1/36557
摘要： A medical device for monitoring of oxygen saturation includes an optical sensor adapted for positioning adjacent to a tissue volume. The optical sensor has a light emitting portion capable of emitting light at a plurality of wavelengths and a light detecting portion capable of generating an electrical output signal corresponding to light incident on the detecting portion. A control module coupled to the optical sensor controls the light emitted by the light emitting portion. A monitoring module receives the output signal from the light detecting portion and computes a volume-independent measure of oxygen saturation in the volume of tissue using the output signal.
摘要翻译： 用于监测氧饱和度的医疗装置包括适于邻近组织体积定位的光学传感器。 光学传感器具有能够发射多个波长的光的发光部和能够产生与入射到检测部上的光对应的电输出信号的光检测部。 耦合到光学传感器的控制模块控制由发光部分发射的光。 监测模块接收来自光检测部分的输出信号，并使用输出信号计算组织体积中的氧饱和度的体积无关测量。
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公开(公告)号：US08352008B2
公开(公告)日：2013-01-08
申请号：US12797831
申请日：2010-06-10
申请人： Jonathan L. Kuhn , David A. Anderson , Can Cinbis
发明人： Jonathan L. Kuhn , David A. Anderson , Can Cinbis
IPC分类号： A61B5/00
CPC分类号： A61B5/1459 , A61B5/1495
摘要： A medical device system and associated method are used for monitoring tissue oxygenation. An optical sensor produces a signal corresponding to tissue light attenuation. A processor receives the optical sensor signal and computes a first measure of light attenuation at a first light wavelength and a second measure of light attenuation at a second light wavelength. In one embodiment, noise cancellation circuitry receives the first measure and the second measure and generates a guessed ratio of the first and second measures. Using the first measure, the second measure and the guessed ratio, the noise cancellation circuitry provides a peak output power when the guessed ratio corresponds to an actual ratio of the first and second measures.
摘要翻译： 医疗器械系统和相关方法用于监测组织氧合。 光学传感器产生对应于组织光衰减的信号。 处理器接收光学传感器信号并且计算第一光波长处的光衰减的第一测量值和在第二光波长处的光衰减的第二测量值。 在一个实施例中，噪声消除电路接收第一测量和第二测量并产生第一和第二测量的猜测比率。 使用第一测量，第二测量和猜测比率，当猜测比率对应于第一和第二测量的实际比率时，噪声消除电路提供峰值输出功率。
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25.发明申请METHOD AND APPARATUS FOR POST-SHOCK EVALUATION USING TISSUE OXYGENATION MEASUREMENTS 有权使用组织氧化测量法进行后期评估的方法和装置公开(公告)号：US20110066198A1
公开(公告)日：2011-03-17
申请号：US12845830
申请日：2010-07-29
IPC分类号： A61N1/36
CPC分类号： A61B5/14551 , A61B5/1459 , A61B5/6846 , A61B5/7285 , A61N1/36557 , A61N1/3925 , A61N1/3956
摘要： A method and device for delivering therapy that includes an electrode to sense cardiac signals and to deliver a therapy, a therapy delivery module coupled to the electrode to deliver a therapy via the electrode in response to the sensed cardiac signals, a sensor emitting light and detecting emitted light scattered by a tissue volume adjacent the optical sensor to generate a corresponding detected light intensity output signal, a control module coupled to the sensor to control light emission of the sensor in response to delivering the therapy, and a controller coupled to the therapy delivery module and the sensor, the controller configured to determine tissue oxygenation measurements in response to the output signal, determine a tissue oxygenation trend in response to the tissue oxygenation measurements, and determine whether the delivered therapy restored cardiac hemodynamic function in response to the determined tissue oxygenation trend.
摘要翻译： 一种用于递送治疗的方法和装置，其包括用于感测心脏信号并递送治疗的电极，治疗递送模块，其耦合到所述电极，以响应于感测到的心脏信号经由所述电极递送治疗;发射光和检测的传感器 发射由邻近光学传感器的组织体积散射的光，以产生对应的检测到的光强度输出信号;耦合到传感器的控制模块，以响应于递送治疗来控制传感器的光发射;以及耦合到治疗传递的控制器 模块和传感器，所述控制器被配置为响应于所述输出信号确定组织氧合测量，响应于所述组织氧合测量确定组织氧合趋势，并且确定所递送的治疗是否响应于所确定的组织氧合来恢复心脏血液动力学功能 趋势。
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26.发明申请Absolute calibrated tissue oxygen saturation and total hemoglobin volume fraction 有权绝对校准组织氧饱和度和总血红蛋白体积分数公开(公告)号：US20100317940A1
公开(公告)日：2010-12-16
申请号：US12797800
申请日：2010-06-10
申请人： Jonathan L. Kuhn , David A. Anderson , Can Cinbis , Richard J. O'Brien , Yong K. Cho , Thomas J. Mullen , Avram Scheiner , Rodolphe P. Katra
发明人： Jonathan L. Kuhn , David A. Anderson , Can Cinbis , Richard J. O'Brien , Yong K. Cho , Thomas J. Mullen , Avram Scheiner , Rodolphe P. Katra
IPC分类号： A61B5/1455
CPC分类号： A61N1/36557 , A61B5/1459 , A61N1/37258
摘要： A medical device for monitoring a patient condition includes a sensor capable of being advanced transvascularly to be positioned along a volume of tissue, the sensor including a first combination of a light source and a light detector to emit light into a volume of tissue and to detect light scattered by the volume of tissue and to generate a first output signal corresponding to an intensity of the detected light. A control module is coupled to the light source to control the light source to emit light at least four spaced-apart light wavelengths, and a monitoring module is coupled to the light detector to receive the output signal and compute a measure of tissue oxygenation using the light detector output signal.
摘要翻译： 用于监测患者状况的医疗装置包括能够经血管内先进地沿着组织体积定位的传感器，所述传感器包括光源和光检测器的第一组合，以将光发射到一定体积的组织中并且检测 通过组织体积散射的光并产生对应于检测到的光的强度的第一输出信号。 控制模块耦合到光源以控制光源发射至少四个间隔开的光波长的光，并且监测模块耦合到光检测器以接收输出信号并且使用 光检测器输出信号。
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27.发明申请Device and Method for Monitoring of Absolute Oxygen Saturation and Tissue Hemoglobin Concentration 有权用于监测绝对氧饱和度和组织血红蛋白浓度的装置和方法公开(公告)号：US20100317939A1
公开(公告)日：2010-12-16
申请号：US12797770
申请日：2010-06-10
申请人： Jonathan L. Kuhn , Can Cinbis , James K. Carney
发明人： Jonathan L. Kuhn , Can Cinbis , James K. Carney
IPC分类号： A61B5/1455
CPC分类号： A61B5/14552 , A61B5/0084 , A61B5/14546 , A61B5/1459 , A61B5/7239 , A61N1/36557
摘要： A method and medical device for detecting signals that detects emitted light scattered by a volume of tissue delivered along a first pathway and a second pathway different from the first pathway, detects emitted light scattered by a volume of tissue delivered along a third pathway and a fourth pathway different from the third pathway, determines a first uniformity corresponding to the emitted light detected along the first pathway and the second pathway, determines a second uniformity corresponding to the emitted light detected along third pathway and the fourth pathway, determines a total uniformity in response to the determined first uniformity and the determined second uniformity, and alters sensing by the device in response to the determined total uniformity.
摘要翻译： 一种用于检测信号的方法和医疗装置，其检测由沿着第一路径传送的组织体积散射的发射光和不同于第一路径的第二路径的信号，检测由沿着第三路径传送的组织体积散射的发射光， 确定与沿着第一路径和第二路径检测到的发射光相对应的第一均匀度，确定对应于沿着第三路径和第四路径检测的发射光的第二均匀度，确定响应中的总均匀性 到所确定的第一均匀性和确定的第二均匀性，并且改变由所述装置响应于所确定的总均匀性的感测。
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公开(公告)号：US20100185262A1
公开(公告)日：2010-07-22
申请号：US12690957
申请日：2010-01-21
申请人： Jonathan L. Kuhn , Jonathan P. Roberts , Andrew J. Ries , James D. Reinke , Jeffrey M. Jelen , Robert M. Ecker , Timothy J. Davis , Can Cinbis , Thomas A. Anderson
发明人： Jonathan L. Kuhn , Jonathan P. Roberts , Andrew J. Ries , James D. Reinke , Jeffrey M. Jelen , Robert M. Ecker , Timothy J. Davis , Can Cinbis , Thomas A. Anderson
CPC分类号： A61B5/1459 , A61B5/14542 , A61B5/1495 , A61B2562/0233 , A61B2562/046 , A61N1/36557 , G06F19/00 , G16H40/63
摘要： An implantable medical device having an optical sensor selects the function of modular opto-electronic assemblies included in the optical sensor. Each assembly is provided with at least one light emitting device and at least one light detecting device. A device controller coupled to the optical sensor controls the function of each the assemblies. The controller executes a sensor performance test and selects at least one of the plurality of assemblies to operate as a light emitting assembly in response to a result of the performance test. The controller selects at least one other of the plurality of optical sensor assemblies to operate as a light detecting assembly in response to a result of the performance test
摘要翻译： 具有光学传感器的可植入医疗装置选择包括在光学传感器中的模块化光电组件的功能。 每个组件设置有至少一个发光装置和至少一个光检测装置。 耦合到光学传感器的设备控制器控制每个组件的功能。 控制器执行传感器性能测试，并且响应于性能测试的结果，选择多个组件中的至少一个作为发光组件进行操作。 响应于性能测试的结果，控制器选择多个光学传感器组件中的至少另一个作为光检测组件进行操作
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公开(公告)号：US20090270953A1
公开(公告)日：2009-10-29
申请号：US12107921
申请日：2008-04-23
申请人： Robert M. Ecker , Jonathan L. Kuhn , James D. Reinke , Can Cinbis , Timothy J. Davis , Paul F. Gerrish , Jonathan P. Roberts
发明人： Robert M. Ecker , Jonathan L. Kuhn , James D. Reinke , Can Cinbis , Timothy J. Davis , Paul F. Gerrish , Jonathan P. Roberts
CPC分类号： A61B5/0086 , A61B2562/028 , A61N1/3621 , A61N1/36557 , A61N1/375 , A61N1/3956
摘要： A reflectance-type optical sensor includes one or more photodiodes formed in a semiconductor substrate. A well having sidewalls and a bottom is formed in the top surface of the substrate, and a reflective layer is formed on the sidewalls and bottom. A light-emitting diode (LED) is mounted in the well, so that light emitted laterally and rearwardly from the LED strikes the sidewalls or bottom and is redirected in a direction generally perpendicular to the top surface of the substrate. The optical sensor can be fabricated using microelectromechanical systems (MEMS) fabrication techniques.
摘要翻译： 反射型光学传感器包括在半导体衬底中形成的一个或多个光电二极管。 在衬底的顶表面中形成具有侧壁和底部的阱，并且在侧壁和底部上形成反射层。 发光二极管（LED）安装在井中，使得从LED侧向和向后发射的光撞击侧壁或底部，并且在大体上垂直于衬底的顶表面的方向上重定向。 光学传感器可以使用微机电系统（MEMS）制造技术来制造。
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公开(公告)号：US08275435B2
公开(公告)日：2012-09-25
申请号：US12690957
申请日：2010-01-21
申请人： Jonathan L. Kuhn , Jonathan P. Roberts , Andrew J. Ries , James D. Reinke , Jeffrey M. Jelen , Robert M. Ecker , Timothy J. Davis , Can Cinbis , Thomas A. Anderson
发明人： Jonathan L. Kuhn , Jonathan P. Roberts , Andrew J. Ries , James D. Reinke , Jeffrey M. Jelen , Robert M. Ecker , Timothy J. Davis , Can Cinbis , Thomas A. Anderson
IPC分类号： A61B5/00
CPC分类号： A61B5/1459 , A61B5/14542 , A61B5/1495 , A61B2562/0233 , A61B2562/046 , A61N1/36557 , G06F19/00 , G16H40/63
摘要： An implantable medical device having an optical sensor selects the function of modular opto-electronic assemblies included in the optical sensor. Each assembly is provided with at least one light emitting device and at least one light detecting device. A device controller coupled to the optical sensor controls the function of each the assemblies. The controller executes a sensor performance test and selects at least one of the plurality of assemblies to operate as a light emitting assembly in response to a result of the performance test. The controller selects at least one other of the plurality of optical sensor assemblies to operate as a light detecting assembly in response to a result of the performance test.
摘要翻译： 具有光学传感器的可植入医疗装置选择包括在光学传感器中的模块化光电组件的功能。 每个组件设置有至少一个发光装置和至少一个光检测装置。 耦合到光学传感器的设备控制器控制每个组件的功能。 控制器执行传感器性能测试，并且响应于性能测试的结果，选择多个组件中的至少一个作为发光组件进行操作。 响应于性能测试的结果，控制器选择多个光学传感器组件中的至少一个以作为光检测组件进行操作。
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