公开(公告)号：US20100035252A1

公开(公告)日：2010-02-11

申请号：US12319140

申请日：2008-12-31

Applicant: Jonathan M. Rothberg ,  John H. Leamon ,  John F. Davidson ,  Antoine M. Van Oijen ,  Wolfgang Hinz ,  Melville Davey ,  Bradley Hann ,  Jonathan Schultz

Inventor： Jonathan M. Rothberg ,  John H. Leamon ,  John F. Davidson ,  Antoine M. Van Oijen ,  Wolfgang Hinz ,  Melville Davey ,  Bradley Hann ,  Jonathan Schultz

IPC: C12Q1/68 ,  C12M1/00

CPC classification number: C12Q1/6874 ,  C12Q2523/303 ,  C12Q2565/131 ,  C12Q2525/204 ,  C12Q2521/101 ,  C12Q2535/122

Abstract: The invention provides apparatuses and methods of use thereof for sequencing nucleic acids subjected to a force, and thus considered under tension. The methods may employ but are not dependent upon incorporation of extrinsically detectably labeled nucleotides.

Abstract translation: 本发明提供了用于测序经受力的核酸的装置及其使用方法，并因此在张力下考虑。 所述方法可以采用但不依赖于外源可检测标记的核苷酸的引入。

公开(公告)号：US20220000198A1

公开(公告)日：2022-01-06

申请号：US17477264

申请日：2021-09-16

Applicant: Robert Schultz ,  Jonathan Schultz

Inventor： Robert Schultz ,  Jonathan Schultz

IPC: A41D13/12

Abstract: An adjustable hospital gown is designed to cover the bodies of users of varying shape and size. The gown has a torso-covering garment, a pair of backflaps, and an adjustable fastener. The torso-covering garment is used to cover the front side of the user's body. The pair of backflaps are connected along backflap seams that are positioned on opposite sides of the torso-covering garment. As a result, the pair of backflaps can be transitioned between an opened and a closed configuration. The adjustable fastener is connected in between one of the backflaps and the torso-covering garment such that the backflap can be repositioned to cinch the gown around the body of the user. By connecting the adjustable fastener to various anchor points, the size of the gown can be modified to accommodate user's of varying shape.

公开(公告)号：US08906617B2

公开(公告)日：2014-12-09

申请号：US13044361

申请日：2011-03-09

Applicant: Jonathan M. Rothberg ,  John H. Leamon ,  John F. Davidson ,  Antoine M. Van Oijen ,  Wolfgang Hinz ,  Melville Davey ,  Bradley Hann ,  Jonathan Schultz

Inventor： Jonathan M. Rothberg ,  John H. Leamon ,  John F. Davidson ,  Antoine M. Van Oijen ,  Wolfgang Hinz ,  Melville Davey ,  Bradley Hann ,  Jonathan Schultz

IPC: C12Q1/00 ,  C12Q1/68

CPC classification number: C12Q1/6874 ,  C12Q2523/303 ,  C12Q2565/131 ,  C12Q2525/204 ,  C12Q2521/101 ,  C12Q2535/122

Abstract: The invention provides apparatuses and methods of use thereof for sequencing nucleic acids subjected to a force, and thus considered under tension. The methods may employ but are not dependent upon incorporation of extrinsically detectably labeled nucleotides.

Abstract translation: 本发明提供了用于测序经受力的核酸的装置及其使用方法，并因此在张力下考虑。 所述方法可以采用但不依赖于外源可检测标记的核苷酸的引入。

公开(公告)号：US20110251110A1

公开(公告)日：2011-10-13

申请号：US13044352

申请日：2011-03-09

Applicant: Jonathan M. Rothberg ,  John H. Leamon ,  John F. Davidson ,  Antoine M. Van Oijen ,  Wolfgang Hinz ,  Melville Davey ,  Bradley Hann ,  Jonathan Schultz

Inventor： Jonathan M. Rothberg ,  John H. Leamon ,  John F. Davidson ,  Antoine M. Van Oijen ,  Wolfgang Hinz ,  Melville Davey ,  Bradley Hann ,  Jonathan Schultz

IPC: C40B60/12 ,  C12M1/40

CPC classification number: C12Q1/6874 ,  C12Q2523/303 ,  C12Q2565/131 ,  C12Q2525/204 ,  C12Q2521/101 ,  C12Q2535/122

Abstract: The invention provides apparatuses and methods of use thereof for sequencing nucleic acids subjected to a force, and thus considered under tension. The methods may employ but are not dependent upon incorporation of extrinsically detectably labeled nucleotides.

公开(公告)号：US20110217697A1

公开(公告)日：2011-09-08

申请号：US13001182

申请日：2009-06-25

Applicant: Jonathan M. Rothberg ,  Wolfgang Hinz ,  Kim Johnson ,  James Bustillo ,  John Leamon ,  Jonathan Schultz

Inventor： Jonathan M. Rothberg ,  Wolfgang Hinz ,  Kim Johnson ,  James Bustillo ,  John Leamon ,  Jonathan Schultz

IPC: C12Q1/68

CPC classification number: C12Q1/6874 ,  B01L3/502761 ,  B01L2300/046 ,  B01L2300/0663 ,  B01L2300/0851 ,  B01L2400/086 ,  C12Q1/6869 ,  G01N27/4145 ,  G01N27/4148 ,  C12Q2565/607 ,  C12Q2565/301 ,  C12Q2565/629

Abstract: Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in the concentration of inorganic pyrophosphate (PPi), hydrogen ions, and nucleotide triphosphates.

Abstract translation: 与用于分析物测量的非常大规模的FET阵列相关的方法和装置。 可以使用基于提高测量灵敏度和精度的改进的FET像素和阵列设计的传统CMOS处理技术来制造ChemFET（例如，ISFET）阵列，并且同时促进显着小的像素尺寸和致密阵列。 改进的阵列控制技术提供了从大型和密集阵列的快速数据采集。 可以使用这样的阵列来检测各种化学和/或生物过程中各种分析物类型的存在和/或浓度变化。 在一个示例中，chemFET阵列基于监测无机焦磷酸盐（PPi），氢离子和核苷酸三磷酸盐的浓度变化来促进DNA测序技术。