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    System governing the sending and delivery of electronic mail using an eMstamp
    5.
    发明申请
    System governing the sending and delivery of electronic mail using an eMstamp 审中-公开
    使用eMstamp管理电子邮件的发送和发送的系统

    公开(公告)号：US20050102526A1

    公开(公告)日：2005-05-12

    申请号：US10704304

    申请日：2003-11-10

    申请人： Melville Davey ,  Melville Davey

    发明人： Melville Davey ,  Melville Davey

    IPC分类号： H04L9/32 ,  H04L29/06

    CPC分类号： H04L63/0428 ,  H04L63/145

    摘要： A system and method for governing the sending and receiving of electronic mail, especially unsolicited bulk mail, spam, and mail viruses is described. A data token called an eMstamp, having a monetary value related to a number of imbedded eMstamp credits, is made a part of an outgoing electronic mail message transaction by the outgoing mail server. A mail server receiving mail examines the data of a message related eMstamp and makes rule based decisions to deliver or reject a mail message to the intended recipient mailbox based on the eMstamp data. Mail servers retain counts of incoming and outgoing eMstamp credits and use incoming eMstamp credits to offset credits needed to send mail. Administrators of mail servers having a greater number of outgoing eMstamp credits over incoming credits, will need to purchase eMstamp credits from an issuing agent to facilitate message delivery to other eMstamp enabled mail servers. Administrators of mail servers having a greater number of incoming eMstamp credits over outgoing credits can periodically redeem the excess of eMstamp credits for a monetary amount related to the purchase cost of credits. An intended consequence of the invention is to transfer revenue derived from the sale of eMstamp credits to eMstamp mail servers receiving more mail than is sent and to discourage the indiscriminate sending of electronic mail and self replicating e-mail viruses.

    摘要翻译： 描述了用于管理电子邮件的发送和接收的系统和方法，特别是未经请求的大量邮件，垃圾邮件和邮件病毒。 称为eMstamp的数据令牌具有与嵌入的eMstamp信用数量相关的货币值，作为外发邮件服务器的外发电子邮件消息交易的一部分。 接收邮件的邮件服务器检查与相关eMstamp相关的消息的数据，并根据eMstamp数据进行基于规则的决定，以将邮件消息传递或拒绝到预期的收件人邮箱。 邮件服务器保留传入和传出eMstamp信用的计数，并使用传入的eMstamp信用抵消发送邮件所需的信用额度。 邮件服务器的管理员具有比传入信用额更大数量的外向eMstamp信用额，将需要从发行代理购买eMstamp信用额，以便于向其他支持eMstamp的邮件服务器发送邮件。 邮件服务器的管理员具有更大数量的传出eMstamp信用额度，可以将额外的eMstamp信用额度兑换为与购买信用额相关的金额。 本发明的预期结果是将从销售eMstamp信用获得的收入转移给接收比发送的邮件更多的邮件的eMstamp邮件服务器，并且阻止不加选择地发送电子邮件和自复制电子邮件病毒。

    Methods and apparatus for measuring analytes
    6.
    发明授权
    Methods and apparatus for measuring analytes 有权
    用于测量分析物的方法和设备

    公开(公告)号：US08776573B2

    公开(公告)日：2014-07-15

    申请号：US13333602

    申请日：2011-12-21

    申请人： Todd Rearick ,  Melville Davey ,  Mark Beauchemin

    发明人： Todd Rearick ,  Melville Davey ,  Mark Beauchemin

    IPC分类号： G01N21/00

    CPC分类号： G01N27/4165 ,  G01N27/4145 ,  G06F19/22

    摘要： A method, computer program product, and system are provided to calibrate a sensor array with a plurality of sensors. The method can include sweeping a voltage of a reference electrode from a first voltage to a second voltage, where the reference electrode is in fluid communication with the sensor array. The output voltage of each of the plurality of sensors can be monitored at one or more voltages within the first and second voltages. An overall average gain of the plurality of sensors can be calculated at each of the one or more voltages. Further, an acquisition window for the sensor may can be determined. The acquisition window can include a maximum distribution of sensors that provides a maximal overall average gain at a particular reference electrode voltage.

    摘要翻译： 提供了一种方法，计算机程序产品和系统来校准具有多个传感器的传感器阵列。 该方法可以包括将参考电极的电压从第一电压扫描到第二电压，其中参考电极与传感器阵列流体连通。 可以在第一和第二电压内的一个或多个电压监视多个传感器中的每一个的输出电压。 可以在一个或多个电压中的每一个处计算多个传感器的总体平均增益。 此外，可以确定传感器阵列的采集窗口。 采集窗口可以包括在特定参考电极电压下提供最大总平均增益的传感器的最大分布。

    Methods, systems, and computer readable media for nucleic acid sequencing
    7.
    发明授权
    Methods, systems, and computer readable media for nucleic acid sequencing 有权

    公开(公告)号：US10241075B2

    公开(公告)日：2019-03-26

    申请号：US13340490

    申请日：2011-12-29

    申请人： Melville Davey ,  Simon Cawley ,  Alan Williams

    发明人： Melville Davey ,  Simon Cawley ,  Alan Williams

    IPC分类号： G01N27/414 ,  G06F19/22 ,  G01N27/27

    摘要： A method for nucleic acid sequencing includes receiving a plurality of signals indicative of a parameter measured for a plurality of defined spaces, at least some of the defined spaces including one or more sample nucleic acids, the signals being responsive to a plurality of nucleotide flows introducing nucleotides to the defined spaces; determining, for at least some of the defined spaces, whether the defined space includes a sample nucleic acid; processing, for at least some of the defined spaces determined to include a sample nucleic acid, the received signals to improve a quality of the received signals; and predicting a plurality of nucleotide sequences corresponding to respective sample nucleic acids for the defined spaces based on the processed signals and the nucleotide flows.

    Predictive model for use in sequencing-by-synthesis
    8.
    发明授权
    Predictive model for use in sequencing-by-synthesis 有权
    用于逐段合成的预测模型

    公开(公告)号：US08666678B2

    公开(公告)日：2014-03-04

    申请号：US13283320

    申请日：2011-10-27

    申请人： Melville Davey ,  Michael Meyer

    发明人： Melville Davey ,  Michael Meyer

    IPC分类号： G06F19/00 ,  G06F15/00 ,  G11C17/00

    CPC分类号： G06F19/12 ,  C12Q1/6874 ,  C12Q2537/165

    摘要： A method of obtaining a more accurate estimate of a signal correction parameter(s) in sequencing-by-synthesis operations, such as incomplete extension rates, carry forward rates, and/or signal droop rates. The sequencing operation produces signal data. A model is constructed to simulate a population of template strands as it undergoes the sequencing process and becomes divided into different phase-states as the sequencing-by-synthesis progresses. For example, the model may be a phase-state model. The output from the model is used to adjust the signal correction parameter(s). For example, the model may be fitted to the signal data. This fitting results in a more accurate estimate of the signal correction parameter(s). In another embodiment, the signal droop rate is modeled as a decaying function and this decaying function is fitted to the signal data to obtain an improved estimate of the signal droop rate.

    摘要翻译： 一种在逐个合成操作中获得信号校正参数的更精确估计的方法，例如不完全扩展速率，结转率和/或信号下降率。 排序操作产生信号数据。 构建模型以模拟模板链的群体，因为其经历了测序过程，并且随着逐个序列合成的进行而分为不同的相态。 例如，模型可以是阶段状态模型。 模型的输出用于调整信号校正参数。 例如，该模型可以适合于信号数据。 该拟合导致信号校正参数的更精确的估计。 在另一个实施例中，信号下降率被建模为衰减函数，并且该衰减函数适合于信号数据以获得信号下降率的改进估计。

    FLUIDICS INTERFACE SYSTEMS AND METHODS
    9.
    发明申请
    FLUIDICS INTERFACE SYSTEMS AND METHODS 有权
    流体界面系统和方法

    公开(公告)号：US20120143531A1

    公开(公告)日：2012-06-07

    申请号：US13340484

    申请日：2011-12-29

    申请人： Melville Davey ,  George Roth ,  David Marran ,  William Mileski ,  John Nobile

    发明人： Melville Davey ,  George Roth ,  David Marran ,  William Mileski ,  John Nobile

    IPC分类号： G06F19/00 ,  G01M3/28

    CPC分类号： G01N33/48785

    摘要： A system including a communication interface to communicatively couple to a sensor cartridge, a fluidic subsystem to exchange a reagent solution with the sensor cartridge, and a computational circuitry communicatively coupled to the communication interface and the fluidic subsystem. The computation circuitry is to monitor a sensor signal of a sensor of the sensor cartridge, detect a leak based on the sensor signal, and control fluid flow of the fluidic subsystem in response to detecting.

    摘要翻译： 一种系统，包括通信接口以通信地耦合到传感器盒，流体子系统以与所述传感器盒交换试剂溶液，以及可通信地耦合到所述通信接口和所述流体子系统的计算电路。 计算电路是监测传感器盒的传感器的传感器信号，基于传感器信号检测泄漏，并响应于检测来控制流体子系统的流体流动。

    METHODS AND APPARATUS FOR MEASURING ANALYTES
    10.
    发明申请
    METHODS AND APPARATUS FOR MEASURING ANALYTES 有权
    测量分析仪的方法和装置

    公开(公告)号：US20120265474A1

    公开(公告)日：2012-10-18

    申请号：US13333602

    申请日：2011-12-21

    申请人： Todd Rearick ,  Melville Davey ,  Mark Beauchemin

    发明人： Todd Rearick ,  Melville Davey ,  Mark Beauchemin

    IPC分类号： G06F19/00

    CPC分类号： G01N27/4165 ,  G01N27/4145 ,  G06F19/22

    摘要： A method, computer program product, and system are provided to calibrate a sensor array with a plurality of sensors. The method can include sweeping a voltage of a reference electrode from a first voltage to a second voltage, where the reference electrode is in fluid communication with the sensor array. The output voltage of each of the plurality of sensors can be monitored at one or more voltages within the first and second voltages. An overall average gain of the plurality of sensors can be calculated at each of the one or more voltages. Further, an acquisition window for the sensor may can be determined. The acquisition window can include a maximum distribution of sensors that provides a maximal overall average gain at a particular reference electrode voltage.

    摘要翻译： 提供了一种方法，计算机程序产品和系统来校准具有多个传感器的传感器阵列。 该方法可以包括将参考电极的电压从第一电压扫描到第二电压，其中参考电极与传感器阵列流体连通。 可以在第一和第二电压内的一个或多个电压监视多个传感器中的每一个的输出电压。 可以在一个或多个电压中的每一个处计算多个传感器的总体平均增益。 此外，可以确定传感器阵列的采集窗口。 采集窗口可以包括在特定参考电极电压下提供最大总平均增益的传感器的最大分布。