摘要:
The invention is to provide a novel anticancer agent or sensitizer for cancer chemotherapy or radiotherapy. A compound of a general formula (I): wherein A means an aryl group or a heteroaryl group, or a group of a formula (a):; R1 means a —(C═O)aOb(C1-C6)alkyl group, a —(C═O)aOb(C2-C6)alkenyl group, a —(C═O)aOb(C3-C6)cycloalkyl group, an aryl group or a heteroaryl group; R2 and R3 each mean a hydrogen atom, a halogen atom, a hydroxyl group, a carboxyl group, a —(C═O)aOb(C1-C6)alkyl group or a group of —(C═O)aN(R1e)R2e; R4 means a hydrogen atom or a (C1-C6)alkyl group, and the like have an excellent Wee 1-kinase-inhibitory effect, and are therefore useful in the field of medicine, especially in the field of various cancer treatments.
摘要:
The invention relates to compounds of a general formula (I): wherein Ar1 is an optionally-substituted aryl or heteroaromatic group; R1 is an optionally-substituted lower alkyl, lower alkenyl, lower alkynyl or cyclo-lower alkyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R2 is a hydrogen atom, a lower alkyl group, a lower alkenyl group or a lower alkynyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R3 is a hydrogen atom or a lower alkyl group; R4 is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a group of —N(R1k)R1m; T and U are a nitrogen atom or a methine group, etc.The compounds of the invention have excellent Weel kinase-inhibitory effect and are therefore useful in the field of medicines, especially treatment of various cancers.
摘要翻译:本发明涉及通式(I)的化合物:其中Ar1是任选取代的芳基或杂芳基; R 1是任选取代的低级烷基,低级烯基,低级炔基或环低级烷基,或者是任选具有取代基的芳基,芳烷基或杂芳基; R2是氢原子,低级烷基,低级烯基或低级炔基,或者是任选具有取代基的芳基,芳烷基或杂芳基; R3是氢原子或低级烷基; R4是氢原子,卤素原子,羟基,低级烷基或-N(R1k)R1m基团; T和U是氮原子或次甲基等。本发明的化合物具有优异的韦尔激酶抑制作用,因此可用于药物领域,特别是治疗各种癌症。
摘要:
The invention relates to compounds of a general formula (I): wherein Ar1 is an optionally-substituted aryl or heteroaromatic group; R1 is an optionally-substituted lower alkyl, lower alkenyl, lower alkynyl or cyclo-lower alkyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R2 is a hydrogen atom, a lower alkyl group, a lower alkenyl group or a lower alkynyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R3 is a hydrogen atom or a lower alkyl group; R4 is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a group of —N(R1k)R1m; T and U are a nitrogen atom or a methine group, etc. The compounds of the invention have excellent Weel kinase-inhibitory effect and are therefore useful in the field of medicines, especially treatment of various cancers.
摘要翻译:本发明涉及通式(I)的化合物:其中Ar1是任选取代的芳基或杂芳基; R 1是任选取代的低级烷基,低级烯基,低级炔基或环低级烷基,或者是任选具有取代基的芳基,芳烷基或杂芳基; R2是氢原子,低级烷基,低级烯基或低级炔基,或者是任选具有取代基的芳基,芳烷基或杂芳基; R3是氢原子或低级烷基; R4是氢原子,卤素原子,羟基,低级烷基或-N(R1k)R1m基团; T和U是氮原子或次甲基等。本发明的化合物具有优异的韦尔激酶抑制作用,因此可用于药物领域,特别是治疗各种癌症。
摘要:
A process control apparatus controls a focus position of a laser beam, while a laser processing mechanism converges the laser beam into a predetermined focus position and performs a laser processing on a workpiece. The process control apparatus includes: a calculator that, based on the magnitude of an output of the laser beam that changes during the laser processing, calculates a change amount of a positional deviation of the focus position in an optical axis direction that changes during the laser processing at a laser beam radiation position; and a control unit that, based on the change amount of the positional deviation that has been calculated by the calculator, controls the focus position of the laser beam during the laser processing so as to resolve the positional deviation of the focus position.
摘要:
A liquid crystal display panel (30a) includes a pair of substrates (10, 20a) arranged facing each other, a liquid crystal layer (25) provided between the pair of substrates (10, 20a), and a sealing member (15) configured to bond the pair of substrates (10, 20a) with each other while maintaining a predetermined gap between the pair of substrates (10, 20a), and enclose the liquid crystal layer (25). One (20a) of the substrates includes a color filter (13) in which a plurality of color layers (13a, 13b, 13c) of at least three colors are arranged, and column-like spacers (14) which are provided, standing on the color layer (13c) of a predetermined one color included in the color filter (13) and supporting the other substrate (10). The sealing member (15) is provided, coinciding with an underlying layer (13ca) formed of the same material as that of the color layer (13c) on which the column-like spacers (14) stand and in the same layer in which the color layer (13c) on which the column-like spacers (14) stand is formed.
摘要:
An engine for a personal watercraft that is equipped with a supercharging machine, including a pressure release device that is configured to, when a pressure in a region of an air-intake passage of the engine that is located upstream of a throttle valve in an intake-air flow direction exceeds a predetermined value, release the pressure outside the air-intake passage.
摘要:
An electric power generation control apparatus has a bridge circuit, a voltage detection circuit, an electric generation control circuit, and an operation mode setting circuit. The bridge circuit has power transistors and diodes through which a field current is supplied to a vehicle alternator driven by a vehicle engine. The voltage detection circuit outputs an instruction signal regarding ON and OFF of supply of the field current so that the output voltage of the vehicle alternator becomes an adjusting voltage. The electric generation control circuit controls the ON and OFF of the power transistors according to the instruction signal from the voltage detection circuit. The operation mode setting circuit selects one of a field wheeling mode and a regenerative mode based on the OFF state of one power transistor, and also selects the regenerative mode when receiving a generation halt instruction form an ECU in the vehicle.
摘要:
A four-cycle engine typically including a crankshaft provided with a first gear, a camshaft provided with a second gear, an endless rotation transmission that is installed around the first and second gears and is configured to transmit rotation of the crankshaft to the camshaft, a crank phase detecting device configured to detect a rotational phase of the crankshaft that is obtained by dividing a phase corresponding to one rotation of the crankshaft by a number that is equal to or more than a half of teeth of the second gear of the camshaft, and a cam phase detecting device configured to detect at least one rotational phase of the camshaft.
摘要:
A voltage controller has a control circuit and a heat radiating member attached to the circuit. The circuit controls a voltage of electric power generated in an alternator of a vehicle while generating heat. The member has a first surface and a second surface. The second surface of the member is formed in a smooth shape having no protrusions or hollows. A cooling wind flows on the second surface. The member receives the heat from the control circuit through the first surface and radiates the heat from the second surface to the wind.
摘要:
An open-looped cooling system is disclosed. The cooling system typically includes a cylinder head including a first water jacket through which cooling water flows, a cooling water inlet through which the first water jacket communicates with outside, and a first cooling water outlet through which the first water jacket communicates with outside, a cylinder block including a second water jacket through which the cooling water within the first water jacket flows, the second water jacket being configured to communicate with the first water jacket, and a second cooling water outlet through which the second water jacket communicates with outside, and a thermostat configured to control a flow rate of the cooling water flowing out from the second cooling water outlet of the cylinder block based on a temperature of the cooling water.