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公开(公告)号：US20090048148A1
公开(公告)日：2009-02-19
申请号：US12058447
申请日：2008-03-28
IPC分类号： A61K48/00 , A61K38/02 , A61K31/7088 , A61P35/00
CPC分类号： A61K47/186 , A61K9/0019 , A61K38/1709 , A61K47/10 , A61K48/00 , C07K14/4736 , C07K14/4746 , C12N15/87 , C12N2799/022
摘要： A method and pharmaceutical composition for the treatment of cancer using a gene delivery system, such as a viral vector delivery system, comprising a therapeutic gene such as p53 or a retinoblastoma tumor suppressor gene wherein the gene delivery system is formulated in a buffer comprising a delivery-enhancing agent such as ethanol or a detergent.
摘要翻译： 一种用于使用基因递送系统（例如病毒载体递送系统）治疗癌症的方法和药物组合物，其包含治疗性基因如p53或成视网膜细胞瘤肿瘤抑制基因，其中所述基因递送系统配制在包含递送 - 增强剂如乙醇或洗涤剂。
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公开(公告)号：US07462351B2
公开(公告)日：2008-12-09
申请号：US11442653
申请日：2006-05-25
IPC分类号： A61K48/00 , C12N15/861
CPC分类号： C12N15/87 , A61K31/715 , A61K31/724 , A61K35/761 , A61K38/1758 , A61K48/00 , A61K48/0008 , C12N15/86 , C12N2710/10332 , C12N2710/10343 , Y10S435/932 , A61K2300/00
摘要： The present invention provides formulations and methods to enhance the delivery of nucleic acids to cells. Formulations comprising dextrin polymers in combination with sugars provide enhanced delivery of nucleic acids, particularly eucaryotic expression vectors, demonstrate enhanced delivery of nucleic acids to cells in vivo. The present invention also provides methods of treatment in combination with such formulations.
摘要翻译： 本发明提供了增强核酸向细胞递送的制剂和方法。 包含与糖组合的糊精聚合物的制剂提供增强的核酸递送，特别是真核表达载体，证明核酸在体内增强的细胞递送至细胞。 本发明还提供了与这些制剂组合的治疗方法。
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公开(公告)号：US20060199782A1
公开(公告)日：2006-09-07
申请号：US11359997
申请日：2006-02-21
IPC分类号： A61K48/00 , A61K31/704 , A61K31/56
CPC分类号： A61K48/00
摘要： A method and pharmaceutical composition for the enhancement of transfer of a therapeutic agent to a cell wherein the therapeutic agent is formulated in a buffer comprising a compound of Formula I: wherein: n is an integer from 2-8; X1 is a cholic acid group or deoxycholic acid group; and X2 and X3 are each independently selected from the group consisting of a cholic acid group, a deoxycholic acid group, and a saccharide group, wherein the saccharide group is selected from the group consisting of pentose monosaccharide groups, hexose monosaccharide groups, pentose-pentose disaccharide groups, hexose-hexose disaccharide groups, pentose-hexose disaccharide groups, and hexose-pentose disaccharide groups; and wherein at least one of X2 and X3 is a saccharide group.
摘要翻译： 一种用于增强治疗剂转移至细胞的方法和药物组合物，其中所述治疗剂配制在包含式I化合物的缓冲液中：其中：n为2-8的整数; X 1是胆酸基或脱氧胆酸基; X 2和X 3各自独立地选自胆酸基，脱氧胆酸基和糖基，其中选择糖基团 从戊糖单糖组，己糖单糖组，戊糖 - 戊糖二糖基团，己糖 - 六糖基团，戊糖 - 六糖二糖基团和己糖 - 戊糖二糖基团组成的组; 并且其中X 2和X 3中的至少一个是糖基团。
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公开(公告)号：US06392069B1
公开(公告)日：2002-05-21
申请号：US09112074
申请日：1998-07-08
IPC分类号： C07J5300
摘要： This invention provides methods and compositions for enhancing transfer of an agent into a cell. The agents can include polypeptides, polynucleotides such as genes and antisense nucleic acids, and other molecules. In some embodiments, the agents are modulating agents that can modulate a cellular activity or function when introduced into the cell. The methods and compositions are useful for introducing agents into individual cells, as well as cells that are present as a tissue or organ.
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公开(公告)号：US08022044B2
公开(公告)日：2011-09-20
申请号：US12422807
申请日：2009-04-13
IPC分类号： A61K31/70
CPC分类号： A61K48/00
摘要： A method and pharmaceutical composition for the enhancement of transfer of a therapeutic agent to a cell wherein the therapeutic agent is formulated in a buffer comprising a compound of Formula I: wherein: n is an integer from 2-8; X1 is a cholic acid group or deoxycholic acid group; and X2 and X3 are each independently selected from the group consisting of a cholic acid group, a deoxycholic acid group, and a saccharide group, wherein the saccharide group is selected from the group consisting of pentose monosaccharide groups, hexose monosaccharide groups, pentose-pentose disaccharide groups, hexose-hexose disaccharide groups, pentose-hexose disaccharide groups, and hexose-pentose disaccharide groups; and wherein at least one of X2 and X3 is a saccharide group.
摘要翻译： 一种用于增强治疗剂转移至细胞的方法和药物组合物，其中所述治疗剂配制在包含式I化合物的缓冲液中：其中：n为2-8的整数; X1是胆酸基或脱氧胆酸基; X2和X3各自独立地选自胆酸基，脱氧胆酸基和糖基，其中所述糖基选自戊糖单糖基，己糖单糖基，戊糖 - 戊糖基 二糖基团，己糖 - 己糖二糖基团，戊糖 - 己糖二糖基团和己糖 - 六糖二糖基团; 并且其中X 2和X 3中的至少一个是糖基团。
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26.发明授权Compositions and methods for the treatment of cancer using recombinant viral vector delivery systems 失效使用重组病毒载体递送系统治疗癌症的组合物和方法公开(公告)号：US06312681B1
公开(公告)日：2001-11-06
申请号：US08938089
申请日：1997-09-26
申请人： Heidrun Engler , Dan Maneval
发明人： Heidrun Engler , Dan Maneval
IPC分类号： A61K4800
CPC分类号： A61K47/186 , A61K9/0019 , A61K38/1709 , A61K47/10 , A61K48/00 , C07K14/4736 , C07K14/4746 , C12N15/87 , C12N2799/022
摘要： A method and pharmaceutical composition for the treatment of cancer using a gene delivery system, such as a viral vector delivery system, comprising a therapeutic gene wherein the gene delivery system is formulated in a buffer comprising a delivery-enhancing agent such as ethanol.
摘要翻译： 用于使用基因递送系统（例如病毒载体递送系统）治疗癌症的方法和药物组合物，其包含治疗基因，其中所述基因递送系统配制在包含递送增强剂如乙醇的缓冲液中。
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公开(公告)号：US6165779A
公开(公告)日：2000-12-26
申请号：US779627
申请日：1997-01-07
IPC分类号： A61K38/17 , A61K47/10 , A61K47/18 , A61K48/00 , C07K14/47 , C12N15/87 , C12N15/63 , A61K38/00 , C12N7/00
CPC分类号： A61K47/186 , A61K9/0019 , A61K38/1709 , A61K47/10 , A61K48/00 , C07K14/4736 , C07K14/4746 , C12N15/87 , C12N2799/022
摘要： A method and pharmaceutical composition for the treatment of cancer using a gene delivery system, such as a viral vector delivery system, comprising a therapeutic gene such as p53 or a retinoblastoma tumor suppressor gene wherein the gene delivery system is formulated in a buffer comprising a delivery-enhancing agent such as ethanol or a detergent.
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公开(公告)号：US5108998A
公开(公告)日：1992-04-28
申请号：US512812
申请日：1990-04-23
IPC分类号： C07D233/64 , A61K31/53 , A61K31/54 , A61P9/04 , C07D285/16 , C07D403/12 , C07D403/14 , C07D417/12 , C07D417/14
CPC分类号： C07D403/12 , C07D403/14 , C07D417/12 , C07D417/14
摘要： New diazine derivatives corresponding to the general formula I ##STR1## and the physiologically acceptable salts thereof are described. The compounds according to the invention are new positive inotropic compounds having a higher and/or more selective action than compounds hitherto known and are therefore suitable for the treatment and prevention of diseases of the heart and circulation.
摘要翻译： 描述了对应于通式I（I）的新的二嗪衍生物及其生理上可接受的盐。 根据本发明的化合物是具有比迄今已知的化合物更高和/或更多选择性作用的新的正性肌力复合物，因此适用于治疗和预防心脏和血液循环的疾病。
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