公开(公告)号：US20180008648A1

公开(公告)日：2018-01-11

申请号：US15548120

申请日：2016-01-31

Applicant: Ramot at Tel-Aviv University Ltd. ,  Technion Research & Development Foundation Limited

Inventor： Shulamit LEVENBERG ,  Sandu PITARU ,  Daniel OFFEN ,  Javier Ganz ,  Sivan Ida COHEN-MATSLIAH ,  Erez SHOR

IPC: A61K35/38 ,  A61L27/26 ,  A61L27/54 ,  A61L27/58 ,  A61K9/00 ,  A61L27/56 ,  A61L27/36

CPC classification number: A61K35/38 ,  A61K9/0085 ,  A61L27/26 ,  A61L27/3604 ,  A61L27/3675 ,  A61L27/3834 ,  A61L27/3878 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/64 ,  A61L2430/32 ,  A61L2430/38 ,  C12N5/0632 ,  C12N2533/40 ,  C12N2533/56

Abstract: A method of treating a spinal cord injury in a subject in need thereof is disclosed. The method comprises implanting a scaffold into the spinal cord of a subject, wherein the scaffold is seeded with oral mucosa stem cells (OMSC) and/or cells that have been ex vivo differentiated from said OMSCs, thereby treating the spinal cord injury.

公开(公告)号：US20160375098A1

公开(公告)日：2016-12-29

申请号：US15261959

申请日：2016-09-11

Applicant: Ramot at Tel-Aviv University Ltd. ,  BrainStorm Cell Therapeutics Ltd.

Inventor： Avinoam KADOURI ,  Avihay BAR-ILAN ,  Eldad MELAMED ,  Daniel OFFEN ,  Ofer SADAN ,  Merav BAHAT-STROMZA

IPC: A61K38/18

CPC classification number: A61K38/185 ,  A61K35/12 ,  A61K35/28 ,  C12N5/0618 ,  C12N5/0662 ,  C12N5/0663 ,  C12N5/0664 ,  C12N5/0665 ,  C12N5/0666 ,  C12N5/0667 ,  C12N5/0668 ,  C12N5/0669 ,  C12N2500/84 ,  C12N2501/01 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/135 ,  C12N2506/1353

Abstract: An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.

公开(公告)号：US20160279169A1

公开(公告)日：2016-09-29

申请号：US15180152

申请日：2016-06-13

Applicant: Ramot at Tel-Aviv University Ltd. ,  Yeda Research and Development Co. Ltd.

Inventor： Daniel OFFEN ,  Michal DADON-NACHUM ,  Tali BEN-ZUR ,  Eldad MELAMED ,  David YAFFE

IPC: A61K35/34 ,  A61K38/30 ,  C12N5/077 ,  A61K38/18

CPC classification number: A61K35/34 ,  A61K35/12 ,  A61K38/00 ,  A61K38/185 ,  A61K38/1866 ,  A61K38/30 ,  C12N5/0658 ,  C12N5/0659 ,  C12N2501/105 ,  C12N2501/13 ,  C12N2501/165 ,  C12N2510/00

Abstract: An isolated muscle progenitor cell being MyoD positive, CD34 negative and CD45 negative is disclosed. The muscle progenitor cell is genetically modified to express at least one neurotrophic factor. In addition, cell populations are disclosed, comprising at least four subpopulations of muscle cells each being genetically modified to express a different neurotrophic factor, wherein said neurotrophic factor is selected from the group consisting of glial derived neurotrophic factor (GDNF), insulin growth factor (IGF-1), vascular endothelial growth factor (VEGF) and brain-derived neurotrophic factor (BDNF). Uses of the cell populations are also disclosed.