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58 条记录 (耗时 0.045 秒)

    Alpha B-crystallin as a therapy for rheumatoid arthritis
    23.
    发明授权
    Alpha B-crystallin as a therapy for rheumatoid arthritis 有权
    αB结晶蛋白作为类风湿关节炎的治疗方法

    公开(公告)号：US07875589B2

    公开(公告)日：2011-01-25

    申请号：US12001553

    申请日：2007-12-11

    申请人： Lawrence Steinman ,  Shalina Sheryl Ousman ,  William H. Robinson

    发明人： Lawrence Steinman ,  Shalina Sheryl Ousman ,  William H. Robinson

    IPC分类号： A61K38/16

    CPC分类号： A61K31/711 ,  A61K38/1709

    摘要： The invention provides methods for treating inflammatory diseases by administering to the subject an effective amount of an agent that provides alpha B-crystallin activity, where the dose is effective to suppress or prevent initiation, progression, or relapses of disease, including the progression of established disease. In some embodiments, the methods of the invention comprise administering to a subject having a pre-existing inflammatory disease condition, an effective amount of alpha B-crystallin protein, to suppress or prevent relapses of the disease.

    摘要翻译： 本发明提供了通过向受试者施用有效量的提供αB-晶状蛋白活性的药剂来治疗炎性疾病的方法，其中剂量有效地抑制或预防疾病的起始，进展或复发，包括已建立的 疾病。 在一些实施方案中，本发明的方法包括向具有预先存在的炎症疾病状况的受试者施用有效量的α-B-晶状蛋白，以抑制或预防疾病的复发。

    TRP/HIS Exchange and Kynurenine Induced TRP Transport
    26.
    发明申请
    TRP/HIS Exchange and Kynurenine Induced TRP Transport 失效
    TRP / HIS交换和Kynurenine诱导的TRP运输

    公开(公告)号：US20080227140A1

    公开(公告)日：2008-09-18

    申请号：US12040524

    申请日：2008-02-29

    申请人： Thijs Kaper ,  Michael Platten ,  Lawrence Steinman ,  Wolf Frommer

    发明人： Thijs Kaper ,  Michael Platten ,  Lawrence Steinman ,  Wolf Frommer

    IPC分类号： C12Q1/02 ,  C12N5/06

    CPC分类号： G01N33/6872 ,  G01N33/5008 ,  G01N2333/70596 ,  G01N2800/24

    摘要： The present invention provides methods for detecting changes in tryptophan concentrations in a cell and methods for identifying agents that modulate cellular tryptophan concentrations. In particular, the present invention provides methods for detecting cellular exchange between tryptophan and kynurenine, and methods for identifying agents that modulate this exchange. The present invention also provides methods for treating a disease associated with immunosuppression in a subject in need thereof. In particular, the present invention is directed toward a method of treating a disease associated with immunosuppression comprising contacting the disease with an agent that modulates cellular Trp/kynurenine exchange. Furthermore, the present invention provides methods for identifying an agent that modulates an immunosuppression.

    摘要翻译： 本发明提供了用于检测细胞中色氨酸浓度变化的方法以及鉴定调节细胞色氨酸浓度的试剂的方法。 特别地，本发明提供了检测色氨酸和犬尿氨酸之间的细胞交换的方法，以及用于鉴定调节该交换的试剂的方法。 本发明还提供了在有需要的受试者中治疗与免疫抑制相关的疾病的方法。 特别地，本发明涉及一种治疗与免疫抑制相关的疾病的方法，其包括将疾病与调节细胞Trp /犬尿苷交换的药物接触。 此外，本发明提供了鉴定调节免疫抑制的药剂的方法。

    Antibody profiling for determination of patient responsiveness
    27.
    发明申请
    Antibody profiling for determination of patient responsiveness 审中-公开
    用于确定患者反应性的抗体谱

    公开(公告)号：US20080026485A1

    公开(公告)日：2008-01-31

    申请号：US11788232

    申请日：2007-04-18

    申请人： Wolfgang Hueber ,  William Robinson ,  Lawrence Steinman ,  Paul Utz ,  Mark Genovese

    发明人： Wolfgang Hueber ,  William Robinson ,  Lawrence Steinman ,  Paul Utz ,  Mark Genovese

    IPC分类号： G01N33/564

    CPC分类号： G01N33/6869 ,  G01N33/564 ,  G01N33/6854 ,  G01N33/6863 ,  G01N2333/522 ,  G01N2333/523 ,  G01N2333/525 ,  G01N2333/5412 ,  G01N2333/5421 ,  G01N2333/545 ,  G01N2800/102 ,  G01N2800/52

    摘要： Compositions and methods are provided for prognostic classification of autoimmune disease patients into subtypes, which subtypes are informative of the patient's need for therapy and responsiveness to a therapy of interest. The patterns of circulating blood levels of serum autoantibodies and/or cytokines provides for a signature pattern that can identify patients likely to benefit from therapeutic intervention as well as discriminate patients that have a high probability of responsiveness to a therapy from those that have a low probability of responsiveness. Additionally, serum autoantibody and/or cytokine signature patterns can be utilized to monitor responses to therapy. Assessment of this signature pattern of autoantibodies and/or cytokines in a patient thus allows improved methods of care. In one embodiment of the invention, the autoimmune disease is rheumatoid arthritis.

    摘要翻译： 提供组合物和方法用于将自身免疫性疾病患者预后分类为亚型，其中亚型对患者对治疗的需要和对感兴趣的治疗的反应性提供信息。 血清自身抗体和/或细胞因子的循环血液水平的模式提供了可以识别可能受益于治疗性干预的患者的签名模式，以及将具有低概率的那些对治疗具有高反应性概率的患者区分开来 的反应。 另外，可以利用血清自身抗体和/或细胞因子特征图来监测对治疗的反应。 因此，患者自身抗体和/或细胞因子的这种特征图案的评估因此允许改进的护理方法。 在本发明的一个实施方案中，自身免疫性疾病是类风湿性关节炎。

    Methods and immune modulatory nucleic acid compositions for preventing and treating disease
    29.
    发明申请
    Methods and immune modulatory nucleic acid compositions for preventing and treating disease 有权
    用于预防和治疗疾病的方法和免疫调节核酸组合物

    公开(公告)号：US20050261215A1

    公开(公告)日：2005-11-24

    申请号：US10524643

    申请日：2003-11-21

    申请人： Hideki Garren ,  Peggy Ho ,  Lawrence Steinman

    发明人： Hideki Garren ,  Peggy Ho ,  Lawrence Steinman

    IPC分类号： A61K31/70 ,  A61K31/715 ,  A61K48/00

    CPC分类号： A61K31/715 ,  A61K31/70 ,  A61K48/00

    摘要： This invention relates to methods and compositions for treating or preventing disease comprising the administration of immune modulatory nucleic acids having one or more immune modulatory sequences (IMSs). The invention further relates to the means and methods for the identification of the IMSs for preventing or treating disease, more particularly the treatment and prevention of autoimmune or inflammatory diseases. The invention also relates to the treatment or prevention of disease comprising the administration of the immune modulatory nucleic acids alone or in combination with a polynucleotide encoding self-protein(s), -polypeptide(s) or -peptide(s). The present invention also relates to methods and compositions for treating diseases in a subject associated with one or more self-protein(s), -polypeptide(s) or -peptide(s) that are present in the subject and involved in a non-physiological state.

    摘要翻译： 本发明涉及用于治疗或预防疾病的方法和组合物，其包括施用具有一种或多种免疫调节序列（IMS）的免疫调节核酸。 本发明还涉及用于鉴定用于预防或治疗疾病的IMS的方法和方法，更具体地涉及治疗和预防自身免疫性或炎性疾病。 本发明还涉及治疗或预防疾病，其包括单独施用免疫调节性核酸或与编码自身蛋白，多肽或多肽的多核苷酸组合施用。 本发明还涉及用于治疗与受试者中存在的一种或多种自身蛋白，多肽或肽的受试者相关的疾病的方法和组合物， 生理状态。