摘要:
The present invention relates to novel compounds that are inhibitors of wild type and mutant dihydrofolate reductase (DHFR) of Plasmodium falciparum, which are useful for the treatment of malaria. It also relates to processes of making and using such compounds. The antimalarial compounds of the present invention have low toxicity to a host infected with the malarial parasite, and are potent when administered in pharmaceutical compositions.
摘要:
The working area of an immersive environment is presented on a display without relying on any system chrome. Two regions are defined within the immersive environment, one of which is a larger primary region and the second of which is a smaller non-primary region. The two regions are presented so that they not overlap with one another. The content of one executing user-interactive application is presented in the primary region and, simultaneously, content of one or more other executing user-interactive applications are presented in the non-primary region. In some implementations the non-primary is docked to one side of the display.
摘要:
An apparatus and method are disclosed to provide transformerless safety isolation in a power supply. One example regulated power converter includes input terminals included in a primary circuit of the power converter. Output terminals are included in a secondary circuit of the power converter. A plurality of safety capacitors including first and second safety capacitors are also included. Each of the plurality of safety capacitors includes a respective first terminal coupled to the primary circuit and a respective second terminal coupled to the secondary circuit. The plurality of safety capacitors galvanically isolates the primary circuit from the secondary circuit. A power switch is included in the primary circuit. The power switch is coupled such that switching of the power switch causes energy to transfer between the primary and secondary circuits through the plurality of safety capacitors. Substantially all of the energy that is transferred between the primary and secondary circuits is through the plurality of safety capacitors.
摘要:
An operating system program launch menu, such as a Start menu, provides various mechanisms for a user to quickly and efficiently locate and launch desired data items such as programs, data files, storage locations, and the like. A search box within the program launch menu may be used to quickly locate programs, documents, communications, and other data items. An auto-complete feature may be used, e.g., when the user restricts the locations searched for the user-entered search text. A most commonly used program list may include programs based on various criteria including both frequency of use and recent use, thereby always including a most recently used item. An all programs view may display programs and documents in a hosted-tree view within the original confines of the program launch menu, thereby negating the need to open sub-menus on top of a large portion of the desktop displayed on the display device.
摘要:
A method and apparatus for transforming a work area and displaying an information component in a graphical user interface is provided. The graphical user interface utilizes a three-dimensional transformation to move a presently displayed work area, for example a desktop with open windows, revealing a background presentation area behind it. In the portion of the presentation area revealed, an information component, such as a Start Menu, is displayed. Use of the three-dimensional transformation effectively decouples an operating system from the applications it hosts. The transformation further prevents visual clutter by separating the information component from the previously underlying desktop.
摘要:
Methods of making slide-zippered reclosable packages are provided. In one embodiment, a pair of opposing film extensions are provided on each package between which a zipper and slider are attached. In another embodiment, sliders are inserted on to zippered packages output from a form-fill-seal machine or the like. In yet another embodiment, during package formation a reclosable zipper is sealed to each package and then a slider is inserted on to the zipper. In yet another embodiment, during package formation a reclosable zipper is sealed to each package and a slider is inserted on to each zipper, either before or after zipper sealing.
摘要:
In an implementation of initiate multiple applications, a user interface includes a user-selectable control to initiate that multiple applications start together at approximately a same time. The user interface includes user-selectable configurations to designate a multiple application start-up configuration.
摘要:
A combustor and injector system to inject a selected fuel into a combustor of a gas powered turbine. Generally, the injector is able to inject a selected fuel into a stream of an oxidizer to substantially mix the fuel with the oxidizer stream before any of the fuel in the fuel fan reaches an auto ignition temperature. Therefore the fuel may be substantially combusted at once and without any substantial hot spots.
摘要:
The embodiments include a wide mouth gusseted package wherein four machine direction edge seals are formed on the film, and the zipper is applied in the transverse direction on the opposite side of the film from where the machine direction edge seals are formed. In the resulting package, the edge seals are at the exterior of the four corners of the package, and the resulting gussets can be folded inwardly or outwardly. The package may further include a sealing strip with a peel seal layer and a sealant layer whereby a hermetic package may be produced at higher production rates and lower productions costs.
摘要:
Described herein are compounds, pharmaceutical compositions and methods for the inhibition of Hedgehog signaling. Said compounds, pharmaceutical compositions and methods have utility in the treatment of human and veterinary diseases and disorders.