公开(公告)号：US20080306442A1

公开(公告)日：2008-12-11

申请号：US12119026

申请日：2008-05-12

申请人： Earl Bardsley ,  Jianlu Ma ,  Thomas J. McEvoy

发明人： Earl Bardsley ,  Jianlu Ma ,  Thomas J. McEvoy

IPC分类号： A61M5/32 ,  A61M29/00

CPC分类号： A61M25/0662 ,  A61B17/0218 ,  A61B17/3417 ,  A61B17/3421 ,  A61B17/3431 ,  A61B17/3439 ,  A61B2017/347 ,  A61B2017/3492 ,  A61M25/0054 ,  A61M25/1002

摘要： An introducer sheath includes an elongated longitudinal body having opposite ends longitudinally disposed. An opening is present at each end of the elongated body and a channel extends longitudinally through the openings of the elongated body. The elongated body of the introducer sheath includes a varying stiffness from one end to the other end. As one example, an introducer sheath can introduce devices and/or medical treatment products used in minimally invasive medical procedures.

摘要翻译： 引导器鞘包括细长纵向体，其纵向设置有相对端。 在细长体的每个端部处存在开口，并且通道纵向延伸穿过细长体的开口。 引导器护套的细长主体包括从一端到另一端的变化的刚度。 作为一个示例，导引器鞘可以引入用于微创医疗程序的装置和/或医疗处理产品。

公开(公告)号：US11006963B2

公开(公告)日：2021-05-18

申请号：US14475047

申请日：2014-09-02

申请人： Jianlu Ma

发明人： Jianlu Ma

IPC分类号： A61B17/12

摘要： The present invention relates to detachment mechanisms for delivering and releasing implantable devices into a body lumen. According to certain aspects, systems of the invention include a junction that couples an implantable device to a delivery member. The junction includes an anodic portion and a cathodic portion galvanically coupled to the anodic portion such that the anodic portion corrodes when exposed to an electrolytic fluid, thereby detaching the implantable device from the delivery member without application of energy from an external power source.

公开(公告)号：US09585741B2

公开(公告)日：2017-03-07

申请号：US14598705

申请日：2015-01-16

申请人： Jianlu Ma

发明人： Jianlu Ma

IPC分类号： A61M29/00 ,  A61F2/01 ,  A61B17/221 ,  A61B17/12 ,  A61B17/29

CPC分类号： A61B17/221 ,  A61B17/12031 ,  A61B17/12036 ,  A61B17/1204 ,  A61B17/12172 ,  A61B17/12177 ,  A61B2017/1205 ,  A61B2017/2212 ,  A61B2017/2215 ,  A61B2017/2905 ,  A61F2/01 ,  A61F2/013 ,  A61F2002/015 ,  A61F2002/016 ,  A61F2002/018 ,  A61F2230/0067 ,  A61F2230/0069 ,  A61F2230/0071

摘要： The present invention provides devices for removing an embolus or thrombus. The device includes an elongate member configured for insertion into the vasculature, an expandable member that extends from the distal end of the elongate member, and a flow restrictor associated with a proximal portion of the expandable member. The expandable member is configured to transition from a compacted state to an expanded state, in which the expandable portion engages with the embolus. The flow restrictor is configured to restrict blood flow and generate a low pressure zone at a location in the vasculature that is distal to the flow restrictor.

摘要翻译： 本发明提供了用于去除栓塞或血栓的装置。 该装置包括构造成用于插入脉管系统的细长构件，从细长构件的远端延伸的可扩张构件以及与可扩张构件的近侧部分相关联的限流器。 可膨胀构件构造成从压实状态转变到膨胀状态，其中可膨胀部分与栓塞接合。 限流器被配置为限制血液流动并且在远离限流器的脉管系统中的位置处产生低压区域。

公开(公告)号：US20150066073A1

公开(公告)日：2015-03-05

申请号：US14475047

申请日：2014-09-02

申请人： Jianlu Ma

发明人： Jianlu Ma

IPC分类号： A61B17/12

CPC分类号： A61B17/12113 ,  A61B17/1214 ,  A61B2017/12063

摘要： The present invention relates to detachment mechanisms for delivering and releasing implantable devices into a body lumen. According to certain aspects, systems of the invention include a junction that couples an implantable device to a delivery member. The junction includes an anodic portion and a cathodic portion galvanically coupled to the anodic portion such that the anodic portion corrodes when exposed to an electrolytic fluid, thereby detaching the implantable device from the delivery member without application of energy from an external power source.

摘要翻译： 本发明涉及用于将可植入装置输送和释放到体腔中的分离机构。 根据某些方面，本发明的系统包括将可植入装置耦合到递送构件的连接点。 接合部包括阳极部分和与阳极部分电流耦合的阴极部分，使得阳极部分暴露于电解液体时会腐蚀，从而将可植入装置从输送部件分离而不需要外部电源的能量。

公开(公告)号：US08961585B2

公开(公告)日：2015-02-24

申请号：US11912616

申请日：2006-04-25

申请人： Jianlu Ma ,  Ott Khouengboua ,  Alex Grafov

发明人： Jianlu Ma ,  Ott Khouengboua ,  Alex Grafov

IPC分类号： A61F2/06 ,  A61F2/915 ,  A61F2/91

CPC分类号： A61F2/89 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/9155 ,  A61F2002/91558 ,  A61F2002/91591 ,  A61F2210/0004 ,  A61F2250/0071

摘要： The invention provides for intra-luminal stents, especially stent having controlled fracture connection, as well as, methods of making and using the same. In one embodiment, a stent for implantation into a vessel has a plurality of annular segments collectively forming tubular shape, characterized by at least first and second adjacent annular segments each defined by a plurality of struts and at least one joint interconnecting respective struts of the first and second segments on a non-permanent basis.

摘要翻译： 本发明提供了腔内支架，特别是具有受控断裂连接的支架，以及制造和使用它们的方法。 在一个实施例中，用于注入血管的支架具有共同形成管状形状的多个环形段，其特征在于至少第一和第二相邻环形区段，每个环形区段由多个支柱限定，以及至少一个联接件，其将第一 和非永久性的第二部分。

公开(公告)号：US20140243882A1

公开(公告)日：2014-08-28

申请号：US14082019

申请日：2013-11-15

申请人： Jianlu Ma

发明人： Jianlu Ma

IPC分类号： A61F2/01

CPC分类号： A61F2/01 ,  A61B17/12031 ,  A61B17/12036 ,  A61B17/1204 ,  A61B17/12177 ,  A61B17/221 ,  A61B2017/1205 ,  A61B2017/2212 ,  A61B2017/2215 ,  A61F2/013 ,  A61F2002/015 ,  A61F2002/018 ,  A61F2230/0067 ,  A61F2230/0071

摘要： A mechanical thrombectomy device system is disclosed that is made from a single piece of biocompatible material, including a proximal flow block portion/feature, and/or, a flow block feature in the device body portion, a guidewire like delivery portion and an expandable, treatment portion. The construction of the device from a single piece allows for a seamless transition from the delivery portion to the treatment portion, thus removing any joints or bonding of the two portions together as separate pieces. This improves the strength of the system as a whole and greatly reduces the possibility of the two parts unintentionally detaching from each other. Likewise, the distal treatment portion is cut from a piece of material the same size as the proximal delivery portion, allowing the device to be compacted to a similar size profile giving it delivery advantages including a lower delivery force required and requiring small access systems, and the treatment portion's surface can be altered to enhance embolus affinity by either coating with a substance or changing the texture by mechanical or chemical means.

摘要翻译： 公开了一种机械性血栓切除装置系统，其由单片生物相容性材料制成，包括近端流动块部分/特征，和/或装置主体部分中的流动块特征，导丝状输送部分和可扩张的， 治疗部分。 从单件构造装置允许从输送部分到处理部分的无缝过渡，从而将两个部分的任何接合部或接合部分一起分离成一体。 这提高了整个系统的强度，并且大大降低了两个部件无意中彼此分离的可能性。 同样地，远端处理部分是从与近端传送部分相同尺寸的一块材料上切割出来的，允许该装置被压实成类似的尺寸轮廓，从而赋予其传送优点，包括所需的较低传送力并且需要小的接入系统，以及 治疗部分的表面可以改变以通过用物质涂覆或通过机械或化学方式改变质地来增强栓塞亲和力。

公开(公告)号：US20080312664A1

公开(公告)日：2008-12-18

申请号：US12119008

申请日：2008-05-12

申请人： Earl Bardsley ,  Jianlu Ma ,  Jean Paul Rasschaert ,  Thomas J. McEvoy ,  Dave Johnson ,  Alex Grafov ,  Anthony Huynh ,  Rob Swain

发明人： Earl Bardsley ,  Jianlu Ma ,  Jean Paul Rasschaert ,  Thomas J. McEvoy ,  Dave Johnson ,  Alex Grafov ,  Anthony Huynh ,  Rob Swain

IPC分类号： A61B17/10

CPC分类号： A61B17/12009 ,  A61B17/0467 ,  A61B17/122 ,  A61B17/1285 ,  A61B17/29 ,  A61B2017/00243 ,  A61B2017/00371 ,  A61B2017/00867 ,  A61B2017/0475 ,  A61B2017/0496 ,  A61B2090/3614

摘要： A medical device is disclosed for tissue, body lumen and/or cavity closure inside a body of a patient. In one particular application, the medical device can be used for minimally invasive access and closure of a left atrial appendage of the heart. The medical device generally includes a tool used for grasping the appendage, a closure member, and at least one tool to deploy, control, and position the closure member for closing the appendage. The device can also include an expander tool for expanding the working area around the left atrial appendage to improve visibility during the procedure. In other embodiments, the medical device may include other tools, for example an imaging tool for viewing the target area and/or other tools that are considered useful in a left atrial appendage closure procedure.

摘要翻译： 公开了用于患者体内的组织，体腔和/或空腔闭合的医疗装置。 在一个特定应用中，医疗装置可以用于微创门禁和闭合心脏的左心耳。 医疗装置通常包括用于抓握附件的工具，闭合构件和用于展开，控制和定位关闭构件以关闭附件的至少一个工具。 该装置还可以包括扩展器工具，用于扩展左心耳周围的工作区域，以提高手术过程中的可视性。 在其他实施例中，医疗装置可以包括其他工具，例如用于观察目标区域的成像工具和/或被认为在左心耳闭合程序中有用的其它工具。

公开(公告)号：US20050070993A1

公开(公告)日：2005-03-31

申请号：US10671581

申请日：2003-09-29

申请人： Peter Boekstegers ,  Peter Wilk ,  Laurence Roth ,  Jianlu Ma ,  Earl Bardsley

发明人： Peter Boekstegers ,  Peter Wilk ,  Laurence Roth ,  Jianlu Ma ,  Earl Bardsley

IPC分类号： A61F2/00 ,  A61F2/01 ,  A61F2/02 ,  A61F2/06

CPC分类号： A61F2/01 ,  A61F2/2493 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/018 ,  A61F2002/068 ,  A61F2002/91533 ,  A61F2002/9155 ,  A61F2002/91575 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2230/0006 ,  A61F2230/0067 ,  A61F2230/0069 ,  A61F2230/0078 ,  A61F2230/008 ,  A61F2250/0039

摘要： Methods, and related devices, for treating a heart by allowing retrograde blood flow in a coronary vein may include flowing blood through a passageway between a blood-containing anatomical structure and a coronary vein so as to cause retrograde blood flow in the coronary vein. The methods, and related devices, may further include measuring an internal pressure of the coronary vein to determine a measured internal pressure and at least partially obstructing the coronary vein at a location upstream of the passageway relative to a direction of the retrograde blood flow based on the measured internal pressure.

摘要翻译： 用于通过允许在冠状静脉中逆行血液流动来治疗心脏的方法和相关装置可以包括使血液通过含血液解剖结构和冠状静脉之间的通道流动，从而在冠状静脉中引起逆行血液流动。 所述方法和相关装置还可以包括测量冠状静脉的内部压力以确定所测量的内部压力，并且至少部分地阻塞冠状静脉在通道上游相对于逆行血流方向的位置，基于 测量的内部压力。

公开(公告)号：US20210275186A1

公开(公告)日：2021-09-09

申请号：US17321431

申请日：2021-05-15

申请人： Jianlu Ma

发明人： Jianlu Ma

IPC分类号： A61B17/12

摘要： The present invention relates to detachment mechanisms for delivering and releasing implantable devices into a body lumen. According to certain aspects, systems of the invention include a junction that couples an implantable device to a delivery member. The junction includes an anodic portion and a cathodic portion galvanically coupled to the anodic portion such that the anodic portion corrodes when exposed to an electrolytic fluid, thereby detaching the implantable device from the delivery member without application of energy from an external power source.

公开(公告)号：US20180325666A1

公开(公告)日：2018-11-15

申请号：US16033831

申请日：2018-07-12

申请人： Jianlu Ma

发明人： Jianlu Ma

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2427 ,  A61F2/2436 ,  A61F2/2442 ,  A61F2/2463 ,  A61F2230/001 ,  A61F2250/0037 ,  A61F2250/0039

摘要： A method and device for treating mitral regurgitation includes providing a treatment device comprising an expandable frame, and a leaflet assembly housed inside the frame. The frame has a tenting element. The treatment device is delivered to the aortic position in a patient's aortic valve, and the frame is expanded at the location of the native aortic valve, with the tenting element pushing the aortic curtain and/or anterior leaflet and/or mitral annulus of the mitral valve towards the mitral valve direction. The leaflet assembly replaces the valve function of the patient's native aortic valve.