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21.发明授权Compliant composites for application of drug-eluting coatings to tissue surfaces 有权适用于药物洗脱涂层在组织表面应用的复合材料公开(公告)号：US08795707B2
公开(公告)日：2014-08-05
申请号：US12991944
申请日：2009-05-07
CPC分类号： A61K31/337 , A61K9/0024 , A61K9/7007 , A61K31/4745 , A61K31/475 , A61K31/555 , A61K33/24 , A61K45/06 , A61K47/34 , A61L27/34 , A61L27/48 , A61L27/54 , A61L2300/416 , A61L2300/604 , A61L2300/608 , A61K2300/00
摘要： A compliant composite for delivering a bioactive agent including a scaffolding material and a polymer coating that together can be attached to compliant tissue surfaces is disclosed, along with methods for constructing and applying these composites. In some embodiments, the composite further comprises a barrier layer for localized delivery of the bioactive agent.
摘要翻译： 公开了一种用于递送包括脚手架材料和聚合物涂层的生物活性剂的柔顺复合材料，其可以连接到柔顺的组织表面，以及用于构造和应用这些复合材料的方法。 在一些实施方案中，所述复合物还包含用于所述生物活性剂的局部递送的阻挡层。
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公开(公告)号：US20140058047A1
公开(公告)日：2014-02-27
申请号：US14065817
申请日：2013-10-29
申请人： Mark W. Grinstaff , Michel Wathier
发明人： Mark W. Grinstaff , Michel Wathier
IPC分类号： C07C229/24 , C07C59/305 , C08F120/06 , C08G65/00 , C08F236/12 , C07F9/54 , C07D403/12 , C07C211/14
CPC分类号： C07C229/24 , C07C59/305 , C07C211/09 , C07C211/14 , C07D403/12 , C07F9/28 , C07F9/5407 , C08F120/06 , C08F236/12 , C08G65/00 , C08L33/08 , C08L33/14 , C08L35/06 , C08L43/02 , C10N2220/04 , C08L2666/04 , C08L2666/02
摘要： One embodiment of the present invention relates to ionic liquids and ionic viscoelastics formed between [1] a small molecule or macromolecule containing two or more cations; and [2] a small molecule or macromolecule containing two or more anions. Another embodiment of the invention is the use of the inventive ionic liquids and ionic viscoelastics, formed between a small molecule or macromolecule containing two or more cations and a small molecule or macromolecule containing two or more anions, to form a crosslinked network. In certain embodiments, the ionic liquids formed can be viscous liquids, viscous liquid formed networks, or viscoelastic networks/gels. In certain embodiments, the ionic material of the invention may be used for a variety of applications including, but not limited to, lubricants, additives, gas separation, liquid separation, membranes, fuel cells, sensors, batteries, coatings, heat storage, liquid crystals, biocompatible fluids, solvents, and electronic materials.
摘要翻译： 本发明的一个实施方案涉及在[1]含有两个或多个阳离子的小分子或大分子之间形成的离子液体和离子粘弹性体; 和[2]含有两个或多个阴离子的小分子或大分子。 本发明的另一个实施方案是使用形成于含有两个或多个阳离子的小分子或大分子之间的本发明的离子液体和离子粘弹性体，以及含有两个或多个阴离子的小分子或大分子形成交联网络。 在某些实施方案中，形成的离子液体可以是粘性液体，形成粘性液体的网络或粘弹性网络/凝胶。 在某些实施方案中，本发明的离子材料可用于多种应用，包括但不限于润滑剂，添加剂，气体分离，液体分离，膜，燃料电池，传感器，电池，涂料，储热，液体 晶体，生物相容性流体，溶剂和电子材料。
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公开(公告)号：US08367845B2
公开(公告)日：2013-02-05
申请号：US12297756
申请日：2007-04-20
申请人： Mark W. Grinstaff , Michel Wathier
发明人： Mark W. Grinstaff , Michel Wathier
IPC分类号： C07D403/02
CPC分类号： C07C229/24 , C07C59/305 , C07C211/09 , C07C211/14 , C07D403/12 , C07F9/28 , C07F9/5407 , C08F120/06 , C08F236/12 , C08G65/00 , C08L33/08 , C08L33/14 , C08L35/06 , C08L43/02 , C10N2220/04 , C08L2666/04 , C08L2666/02
摘要： One embodiment of the present invention relates to ionic liquids and ionic viscoelastics formed between [1] a small molecule or macromolecule containing two or more cations; and [2] a small molecule or macromolecule containing two or more anions. Another embodiment of the invention is the use of the inventive ionic liquids and ionic viscoelastics, formed between a small molecule or macromolecule containing two or more cations and a small molecule or macromolecule containing two or more anions, to form a crosslinked network. In certain embodiments, the ionic liquids formed can be viscous liquids, viscous liquid formed networks, or viscoelastic networks/gels. In certain embodiments, the ionic material of the invention may be used for a variety of applications including, but not limited to, lubricants, additives, gas separation, liquid separation, membranes, fuel cells, sensors, batteries, coatings, heat storage, liquid crystals, biocompatible fluids, solvents, and electronic materials.
摘要翻译： 本发明的一个实施方案涉及在[1]含有两个或多个阳离子的小分子或大分子之间形成的离子液体和离子粘弹性体; 和[2]含有两个或多个阴离子的小分子或大分子。 本发明的另一个实施方案是使用形成于含有两个或多个阳离子的小分子或大分子之间的本发明的离子液体和离子粘弹性体，以及含有两个或多个阴离子的小分子或大分子形成交联网络。 在某些实施方案中，形成的离子液体可以是粘性液体，形成粘性液体的网络或粘弹性网络/凝胶。 在某些实施方案中，本发明的离子材料可用于多种应用，包括但不限于润滑剂，添加剂，气体分离，液体分离，膜，燃料电池，传感器，电池，涂料，储热，液体 晶体，生物相容性流体，溶剂和电子材料。
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24.发明申请COMPLIANT COMPOSITES FOR APPLICATION OF DRUG-ELUTING COATINGS TO TISSUE SURFACES 有权将药物涂层涂抹于组织表面的合适的复合材料公开(公告)号：US20110172785A1
公开(公告)日：2011-07-14
申请号：US12991944
申请日：2009-05-07
CPC分类号： A61K31/337 , A61K9/0024 , A61K9/7007 , A61K31/4745 , A61K31/475 , A61K31/555 , A61K33/24 , A61K45/06 , A61K47/34 , A61L27/34 , A61L27/48 , A61L27/54 , A61L2300/416 , A61L2300/604 , A61L2300/608 , A61K2300/00
摘要： A compliant composite for delivering a bioactive agent including a scaffolding material and a polymer coating that together can be attached to compliant tissue surfaces is disclosed, along with methods for constructing and applying these composites. In some embodiments, the composite further comprises a barrier layer for localized delivery of the bioactive agent.
摘要翻译： 公开了一种用于递送包括脚手架材料和聚合物涂层的生物活性剂的柔顺复合材料，其可以连接到柔顺的组织表面，以及用于构造和应用这些复合材料的方法。 在一些实施方案中，所述复合物还包含用于所述生物活性剂的局部递送的阻挡层。
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公开(公告)号：US20090208589A1
公开(公告)日：2009-08-20
申请号：US12301410
申请日：2007-05-18
申请人： Mark W. Grinstaff , Michel Wathier
发明人： Mark W. Grinstaff , Michel Wathier
CPC分类号： C08B37/006 , A61K9/0024 , A61L27/52 , C08G61/08 , C08G61/125 , C08G2261/1426 , C08G2261/3324 , C08G2261/3342 , C08L65/00
摘要： The present invention provides new biopolymers which mimic the properties of natural polysaccharides found in vivo. The inventive polysaccharides can be used as viscosupplements, viscoelastics, tissue space fillers, and/or anti-adhesive agents. Also provided are pharmaceutical compositions comprising the inventive polymers and methods of using them including, for example, in the treatment of arthritic and sport-injured knee joints; in reconstruction or cosmetic procedures, intervertebral disc repair, treatment of vocal cord problems, treatment of urinary incontinence, and prevention of adhesion formation following abdominal or gynecological surgery.
摘要翻译： 本发明提供了新的生物聚合物，其模拟体内发现的天然多糖的性质。 本发明的多糖可以用作粘稠剂，粘弹塑料，组织空间填料和/或抗粘剂。 还提供了包含本发明聚合物的药物组合物和使用它们的方法，包括例如治疗关节炎和运动损伤的膝关节; 在重建或整容手术中，椎间盘修复，声带问题治疗，尿失禁治疗，以及预防腹部或妇科手术后粘连形成。
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公开(公告)号：US20090176956A1
公开(公告)日：2009-07-09
申请号：US12297756
申请日：2007-04-20
申请人： Mark W. Grinstaff , Michel Wathier
发明人： Mark W. Grinstaff , Michel Wathier
CPC分类号： C07C229/24 , C07C59/305 , C07C211/09 , C07C211/14 , C07D403/12 , C07F9/28 , C07F9/5407 , C08F120/06 , C08F236/12 , C08G65/00 , C08L33/08 , C08L33/14 , C08L35/06 , C08L43/02 , C10N2220/04 , C08L2666/04 , C08L2666/02
摘要： One embodiment of the present invention relates to ionic liquids and ionic viscoelastics formed between [1] a small molecule or macromolecule containing two or more cations; and [2] a small molecule or macromolecule containing two or more anions. Another embodiment of the invention is the use of the inventive ionic liquids and ionic viscoelastics, formed between a small molecule or macromolecule containing two or more cations and a small molecule or macromolecule containing two or more anions, to form a crosslinked network. In certain embodiments, the ionic liquids formed can be viscous liquids, viscous liquid formed networks, or viscoelastic networks/gels. In certain embodiments, the ionic material of the invention may be used for a variety of applications including, but not limited to, lubricants, additives, gas separation, liquid separation, membranes, fuel cells, sensors, batteries, coatings, heat storage, liquid crystals, biocompatible fluids, solvents, and electronic materials.
摘要翻译： 本发明的一个实施方案涉及在[1]含有两个或多个阳离子的小分子或大分子之间形成的离子液体和离子粘弹性体; 和[2]含有两个或多个阴离子的小分子或大分子。 本发明的另一个实施方案是使用形成于含有两个或多个阳离子的小分子或大分子之间的本发明的离子液体和离子粘弹性体，以及含有两个或多个阴离子的小分子或大分子形成交联网络。 在某些实施方案中，形成的离子液体可以是粘性液体，形成粘性液体的网络或粘弹性网络/凝胶。 在某些实施方案中，本发明的离子材料可用于多种应用，包括但不限于润滑剂，添加剂，气体分离，液体分离，膜，燃料电池，传感器，电池，涂料，储热，液体 晶体，生物相容性流体，溶剂和电子材料。
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27.发明授权Methods for the preparation of pharmaceutically active agents for in vivo delivery 失效用于制备用于体内递送的药物活性剂的方法
公开(公告)号：US5665382A
公开(公告)日：1997-09-09
申请号：US485448
申请日：1995-06-07
申请人： Mark W. Grinstaff , Patrick Soon-Shiong , Michael Wong , Paul A. Sandford , Kenneth S. Suslick , Neil P. Desai
发明人： Mark W. Grinstaff , Patrick Soon-Shiong , Michael Wong , Paul A. Sandford , Kenneth S. Suslick , Neil P. Desai
CPC分类号： A61K47/48876 , A23L33/40 , A61K47/48869 , A61K49/126 , A61K49/18 , A61K49/1818 , A61K49/1863 , A61K49/222 , A61K49/223 , A61K49/226 , A61K9/0026 , A61K9/5052 , A61K9/5138 , A61K9/5146 , A61K9/5161 , A61K9/5169 , B82Y5/00
摘要： In accordance with the present invention, there are provided compositions useful for the in vivo delivery of a biologic, wherein the biologic is associated with a polymeric shell formulated from a biocompatible material. The biologic can be associated with the polymeric shell itself, and/or the biologic, optionally suspended/dispersed in a biocompatible dispersing agent, can be encased by the polymeric shell. In another aspect, the biologic associated with polymeric shell is administered to a subject, optionally dispersed in a suitable biocompatible liquid.
摘要翻译： 根据本发明，提供了可用于生物体的体内递送的组合物，其中生物体与由生物相容性材料配制的聚合物壳相关联。 生物体可以与聚合物壳本身相关联，和/或任选地悬浮/分散在生物相容性分散剂中的生物物质可以被聚合物壳包裹。 在另一方面，将与聚合物壳相关的生物体施用于受试者，任选地分散在合适的生物相容性液体中。
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28.发明授权Methods for in vivo delivery of nutriceuticals and compositions useful therefor 失效用于体内递送营养物质和用于其的组合物的方法
公开(公告)号：US5650156A
公开(公告)日：1997-07-22
申请号：US482272
申请日：1995-06-07
申请人： Mark W. Grinstaff , Patrick Soon-Shiong , Michael Wong , Paul A. Sandford , Kenneth S. Suslick , Neil P. Desai
发明人： Mark W. Grinstaff , Patrick Soon-Shiong , Michael Wong , Paul A. Sandford , Kenneth S. Suslick , Neil P. Desai
CPC分类号： A61K47/48876 , A23L33/40 , A61K47/48869 , A61K49/126 , A61K49/18 , A61K49/1818 , A61K49/1863 , A61K49/222 , A61K49/223 , A61K49/226 , A61K9/0026 , A61K9/5052 , A61K9/5138 , A61K9/5146 , A61K9/5161 , A61K9/5169 , B82Y5/00
摘要： In accordance with the present invention, there are provided compositions useful for the in vivo delivery of a biologic, wherein the biologic is associated with a polymeric shell formulated from a biocompatible material. The biologic can be associated with the polymeric shell itself, and/or the biologic, optionally suspended/dispersed in a biocompatible dispersing agent, can be encased by the polymeric shell. In another aspect, the biologic associated with polymeric shell is administered to a subject, optionally dispersed in a suitable biocompatible liquid.
摘要翻译： 根据本发明，提供了可用于生物体的体内递送的组合物，其中生物体与由生物相容性材料配制的聚合物壳相关联。 生物体可以与聚合物壳本身相关联，和/或任选地悬浮/分散在生物相容性分散剂中的生物物质可以被聚合物壳包裹。 在另一方面，将与聚合物壳相关的生物体施用于受试者，任选地分散在合适的生物相容性液体中。
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29.发明授权
公开(公告)号：US5635207A
公开(公告)日：1997-06-03
申请号：US480621
申请日：1995-06-07
申请人： Mark W. Grinstaff , Patrick Soon-Shiong , Michael Wong , Paul A. Sandford , Kenneth S. Suslick , Neil P. Desai
发明人： Mark W. Grinstaff , Patrick Soon-Shiong , Michael Wong , Paul A. Sandford , Kenneth S. Suslick , Neil P. Desai
IPC分类号： A23L33/00 , A61K9/00 , A61K9/50 , A61K9/51 , A61K47/30 , A61K47/48 , A61K49/00 , A61K49/04 , A61K49/18 , A61K49/22 , A61K51/00 , A61K9/127
CPC分类号： A61K9/0026 , A23L33/40 , A61K47/48869 , A61K47/48876 , A61K49/126 , A61K49/18 , A61K49/1818 , A61K49/1863 , A61K49/222 , A61K49/223 , A61K49/226 , A61K9/5052 , A61K9/5138 , A61K9/5146 , A61K9/5161 , A61K9/5169 , B82Y5/00
摘要： In accordance with the present invention, there are provided compositions useful for the in vivo delivery of a biologic, wherein the biologic is associated with a polymeric shell formulated from a biocompatible material. The biologic can be associated with the polymeric shell itself, and/or the biologic, optionally suspended/dispersed in a biocompatible dispersing agent, can be encased by the polymeric shell. In another aspect, the biologic associated with polymeric shell is administered to a subject, optionally dispersed in a suitable biocompatible liquid.
摘要翻译： 根据本发明，提供了可用于生物体的体内递送的组合物，其中生物体与由生物相容性材料配制的聚合物壳相关联。 生物体可以与聚合物壳本身相关联，和/或任选地悬浮/分散在生物相容性分散剂中的生物物质可以被聚合物壳包裹。 在另一方面，将与聚合物壳相关的生物体施用于受试者，任选地分散在合适的生物相容性液体中。
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30.发明授权Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell 失效用包含在交联聚合物壳中的碳氟化合物进行磁共振成像
公开(公告)号：US5362478A
公开(公告)日：1994-11-08
申请号：US35150
申请日：1993-03-26
申请人： Neil P. Desai , Patrick Soon-Shiong , Paul A. Sandford , Mark W. Grinstaff , Kenneth S. Suslick
发明人： Neil P. Desai , Patrick Soon-Shiong , Paul A. Sandford , Mark W. Grinstaff , Kenneth S. Suslick
CPC分类号： A61K49/223 , A61K47/48853 , A61K47/48869 , A61K49/126 , A61K49/18 , A61K49/1806 , A61K49/186 , A61K49/1863 , A61K49/1869 , A61K49/222 , Y10S436/806 , Y10T436/24
摘要： In accordance with the present invention, compositions comprising fluorine-containing magnetic resonance imaging agent(s) contained within polymeric shells are provided. Invention compositions are useful, for example, as contrast agents for magnetic resonance imaging (MRI). Fluorinated compounds in general are hydrophobic and as such have limited water solubility; thus the invention method permits preparation of such compounds in a biocompatible form suitable for ready delivery. The shell diameter is typically approximately 2 microns in diameter. Consequently, these materials have organ specificity due to rapid scavenging by the reticuloendothial system (RES) or the mononuclear phagocyte (MNP) system upon intravenous injection. Furthermore, fluorocarbon filled polymeric shells of the invention can be used to measure and monitor local oxygen and temperature.
摘要翻译： 根据本发明，提供了包含在聚合物壳内的含氟磁共振成像剂的组合物。 本发明组合物可用作例如磁共振成像（MRI）的造影剂。 氟化合物通常是疏水性的，因此具有有限的水溶性; 因此本发明的方法允许以适于准备输送的生物相容形式制备这些化合物。 壳直径一般约为2微米。 因此，这些材料由于网状上游系统（RES）或单核吞噬细胞（MNP）系统在静脉注射后迅速清除而具有器官特异性。 此外，本发明的氟碳填充聚合物壳可用于测量和监测局部氧气和温度。
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