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60 条记录 (耗时 0.031 秒)

    Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same
    22.
    发明授权
    Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same 失效
    吡唑衍生物，其制备方法和包含其的药物组合物

    公开(公告)号：US5550147A

    公开(公告)日：1996-08-27

    申请号：US413939

    申请日：1995-03-30

    申请人： Masaaki Matsuo ,  Kiyoshi Tsuji ,  Takashi Ogino ,  Nobukiyo Konishi

    发明人： Masaaki Matsuo ,  Kiyoshi Tsuji ,  Takashi Ogino ,  Nobukiyo Konishi

    IPC分类号： C07D231/12 ,  C07D231/14 ,  C07D231/16 ,  C07D405/04 ,  A61K31/495 ,  C07D231/10

    CPC分类号： C07D231/12 ,  C07D231/14 ,  C07D231/16 ,  C07D405/04

    摘要： The present invention relates to new pyrazole derivatives represented by the following general formula (I) ##STR1## wherein R.sup.1 is aryl which is substituted with substituent(s) selected from the group consisting of lower alkylthio, cyclo(lower)alkyl, hydroxy, hydroxy(lower)alkyl, cyano, lower alkylenedioxy, acyl, acyloxy, aryloxy and lower alkoxy optionally substituted with acyl or lower alkoxy, R.sup.2 is halogen, halo(lower)alkyl, cyano or acyl, and R.sup.3 is aryl substituted with nitro, hydroxy, lower alkoxy, lower alkylthio, lower alkylsulfinyl or lower alkylsulfonyl, provided that when R.sup.3 is aryl substituted with nitro, hydroxy or lower alkoxy, then R.sup.1 is aryl substituted with lower alkylthio, lower alkylsulfinyl or lower alkylsulfonyl, and pharmaceutically acceptable salts thereof.

    摘要翻译： 本发明涉及由以下通式（I）表示的新的吡唑衍生物：其中R 1是被选自下列基团的取代基取代的芳基：低级烷硫基，环（低级）烷基， 羟基，羟基（低级）烷基，氰基，低级亚烷基二氧基，酰基，酰氧基，芳氧基和任选被酰基或低级烷氧基取代的低级烷氧基，R2是卤素，卤素（低级）烷基，氰基或酰基，R3是被硝基取代的芳基 羟基，低级烷氧基，低级烷硫基，低级烷基亚磺酰基或低级烷基磺酰基，条件是当R 3为被硝基，羟基或低级烷氧基取代的芳基时，则R 1为被低级烷硫基，低级烷基亚磺酰基或低级烷基磺酰基取代的芳基及其药学上可接受的盐 。

    Alkanesulfonanilide derivatives, processes for preparation thereof and pharmaceutical composition comprising the same
    25.
    发明授权
    Alkanesulfonanilide derivatives, processes for preparation thereof and pharmaceutical composition comprising the same 失效
    烷基磺酰苯胺衍生物，其制备方法和包含其的药物组合物

    公开(公告)号：US4866091A

    公开(公告)日：1989-09-12

    申请号：US202017

    申请日：1988-06-02

    申请人： Masaaki Matsuo ,  Kiyoshi Tsuji ,  Nobukiyo Konishi

    发明人： Masaaki Matsuo ,  Kiyoshi Tsuji ,  Nobukiyo Konishi

    IPC分类号： C07D213/20 ,  C07D257/04 ,  C07D271/06 ,  C07D271/07 ,  C07D277/40 ,  C07D277/42 ,  C07D277/46 ,  C07D295/192

    CPC分类号： C07D213/20 ,  C07D257/04 ,  C07D271/07 ,  C07D277/40 ,  C07D277/46 ,  C07D295/192

    摘要： This invention relates to new alkane-sulfonanilide derivatives of the formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.8 are each hydrogen, cyano, halogen, lower alkyl, halo (lower) alkyl, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl or lower alkoxy,R.sup.3 is lower alkyl,R.sup.4 is acyl, cyano, carboxy, hydroxy(lower)-alkyl, mercapto, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, 5-membered unsaturated heterocyclic group which may have amino, lower alkanoylamino, lower alkylthio or lower alkylsulfonyl, phenylthio which may have nitro or amino, lower alkanoyl(lower)alkenyl or a group of the formula: ##STR2## wherein R.sup.6 is hydrogen, amino or lower alkyl andR.sup.7 is hydroxy, lower alkoxy, carboxy(lower)alkoxy, lower alkoxycarbonyl(lower)alkoxy, ureido or thioureido, andR.sup.5 is hydrogen, halogen, lower alkyl or lower alkanoyl, and pharmaceutically acceptable salts thereof.More particularly, it relates to alkanesulfonanilide derivatives and pharmaceutically acceptable salts thereof which have antiinflammatory activities and analgesic activities, to processes for the preparation thereof, to a pharmaceutical composition comprising the same and to a method for the treatment of inflammatory disease or pains in human being and animals".

    Quinolylbenzofuran derivatives as leukotriene antagonists
    26.
    发明授权
    Quinolylbenzofuran derivatives as leukotriene antagonists 失效
    喹啉基苯并呋喃衍生物作为白三烯拮抗剂

    公开(公告)号：US5661159A

    公开(公告)日：1997-08-26

    申请号：US256735

    申请日：1994-08-02

    申请人： Masaaki Matsuo ,  Kazuo Okumura ,  Shinji Shigenaga

    发明人： Masaaki Matsuo ,  Kazuo Okumura ,  Shinji Shigenaga

    IPC分类号： A61K31/47 ,  A61K31/473 ,  A61P11/00 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D401/04

    CPC分类号： C07D405/04 ,  C07D405/14

    摘要： This invention relates to new quinolylbenzofuran derivatives having activities as leukotrien and Slow Reacting Substance of Anaphylaxis antagonists and inhibitors and represented by the general formula (I): ##STR1## wherein R.sup.1 is halogen, etc.,R.sup.2 is hydrogen or halogen,R.sup.3 is hydrogen, halogen, hydroxy, lower alkyl or lower alkoxy,R.sup.4 is hydrogen, acyl, cyano, nitro, substituted or unsubstituted aryl, or substituted or unsubstituted lower alkyl,R.sup.5 is hydrogen, hydroxy, lower alkyl or lower alkoxy,A is lower alkylene, lower alkenylene or a single bond,X is a single bond, O, NH, S, SO or SO.sub.2, andY is O or S,provided that when R.sup.3 is hydrogen, R.sup.4 is hydrogen,R.sup.5 is hydrogen, A is a single bond and X is a single bond, then R.sup.1 is halogen, etc.,and pharmaceutically acceptable salts thereof to processes for the preparation thereof and to a pharmaceutical composition comprising the same.

    摘要翻译： PCT No.PCT / JP93 / 00198 Sec。 371日期1994年8月2日 102（e）日期1994年8月2日PCT提交1993年2月18日PCT公布。 出版物WO93 / 17013 日本1993年9月2日本发明涉及具有作为白三烯和慢反应物质的过敏反应物和抑制剂的新的喹啉基苯并呋喃衍生物，由通式（I）表示：其中R 1为卤素等，R 2 R 3是氢或卤素，R 3是氢，卤素，羟基，低级烷基或低级烷氧基，R 4是氢，酰基，氰基，硝基，取代或未被取代的芳基或取代或未取代的低级烷基，R 5是氢，羟基，低级烷基或 低级烷氧基，A为低级亚烷基，低级亚烯基或单键，X为单键，O，NH，S，SO或SO 2，Y为O或S，前提条件是当R3为氢时，R4为氢，R5为 是氢，A是单键，X是单键，然后R 1是卤素等，及其药学上可接受的盐，用于制备它们以及包含它们的药物组合物。

    Field effect transistor array including doped two-cell isolation region for preventing latchup
    27.
    发明授权
    Field effect transistor array including doped two-cell isolation region for preventing latchup 失效
    场效应晶体管阵列包括用于防止闭锁的掺杂的二单元隔离区

    公开(公告)号：US6043522A

    公开(公告)日：2000-03-28

    申请号：US61090

    申请日：1998-04-16

    申请人： Michio Nakajima ,  Makoto Hatakenaka ,  Akira Kitaguchi ,  Kiyoyuki Shiroshima ,  Takekazu Yamashita ,  Masaaki Matsuo

    发明人： Michio Nakajima ,  Makoto Hatakenaka ,  Akira Kitaguchi ,  Kiyoyuki Shiroshima ,  Takekazu Yamashita ,  Masaaki Matsuo

    IPC分类号： H01L21/761 ,  H01L21/8238 ,  H01L27/092 ,  H01L27/10 ,  H01L27/105

    CPC分类号： H01L27/105 ,  H01L21/761 ,  Y10S257/901 ,  Y10S257/909

    摘要： A semiconductor device capable of solving a problem of a conventional semiconductor device in that a high density integration cannot be expected because each cell, which includes a pair of N and P wells disposed adjacently, requires a countermeasure against latchup individually. The high density integration prevents an effective countermeasure against latchup. The present semiconductor device arranges two cells, which are adjacent in the direction of an alignment of the N wells and P wells, in opposite directions so that two P wells (or two N wells) of the two adjacent cells are disposed successively, and includes an isolation layer extending across the two adjacent cells to enclose the two successively disposed P wells, thereby isolating the two P wells collectively from the substrate.

    摘要翻译： 能够解决现有的半导体器件的问题的半导体器件的原因在于，由于包括一对相邻地设置的一对N阱和P阱的每个单元需要单独地闭锁的对策，所以不能期望高密度积分。 高密度集成防止锁定的有效对策。 本半导体装置将N个阱和P个阱的排列方向相邻的两个电池相反地配置，使得两个相邻电池的两个P阱（或两个N阱）相继配置，并且包括 隔离层延伸穿过两个相邻的电池以封闭两个连续设置的P阱，从而将两个P阱与衬底共同隔离。

    Cephem compounds
    30.
    发明授权
    Cephem compounds 失效
    头孢烯化合物

    公开(公告)号：US4443443A

    公开(公告)日：1984-04-17

    申请号：US213232

    申请日：1980-12-05

    申请人： Ikuo Ueda ,  Masaaki Matsuo ,  Kiyoshi Tsuji ,  Masayuki Kato

    发明人： Ikuo Ueda ,  Masaaki Matsuo ,  Kiyoshi Tsuji ,  Masayuki Kato

    IPC分类号： C07D209/48 ,  C07D257/04 ,  C07D277/20 ,  C07D295/13 ,  C07D295/205 ,  C07D501/36 ,  A61K31/545

    CPC分类号： C07D209/48 ,  C07D257/04 ,  C07D277/587 ,  C07D295/13 ,  C07D295/205 ,  Y02P20/55

    摘要： This invention relates to novel cephem compounds of high antimicrobial activity, of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group;R.sup.2 is carboxy or a protected carboxy group;A is lower alkylene which may have an oxo group;R.sup.3 is carboxy, a protected carboxy group, lower alkyl, lower alkenyl, hydroxy (lower) alkyl, phenyl (lower) alkyl, phenyl, tolyl, xylyl, cumenyl, or naphthyl; andR.sup.4 is hydrogen or lower alkoxy, and pharmaceutically acceptable salts thereof.

    摘要翻译： 本发明涉及高抗微生物活性的新型头孢烯化合物，其具有下式：其中R 1是氨基或被保护的氨基; R2是羧基或被保护的羧基; A是可以具有氧代基的低级亚烷基; R3是羧基，被保护的羧基，低级烷基，低级烯基，羟基（低级）烷基，苯基（低级）烷基，苯基，甲苯基，二甲苯基，枯烯基或萘基; 和R4是氢或低级烷氧基，及其药学上可接受的盐。