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公开(公告)号：US20090325924A1
公开(公告)日：2009-12-31
申请号：US11922765
申请日：2006-06-29
Applicant: Stuart Edward , Graham John Dawson , Matthew Colin Thor Fyfe Oxford , Lisa Sarah Bertram , William Gattrell , Revathy Perpetua Jeevaratnam , John Keily , Neela Sumit Mistry , Martin James Procter , Chrystelle Marie Rasamison , Philip John Rushworth , Colin Peter Sambrook-Smith , David French Stonehouse
Inventor： Stuart Edward , Graham John Dawson , Matthew Colin Thor Fyfe Oxford , Lisa Sarah Bertram , William Gattrell , Revathy Perpetua Jeevaratnam , John Keily , Neela Sumit Mistry , Martin James Procter , Chrystelle Marie Rasamison , Philip John Rushworth , Colin Peter Sambrook-Smith , David French Stonehouse
IPC: A61K31/4245 , C07D413/14 , C07D413/12 , C07D271/06 , A61K31/454 , A61K31/5377 , A61K31/496 , A61K31/506 , A61P3/00
CPC classification number: C07D271/06 , C07D401/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/14
Abstract: Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.
Abstract translation: 式（I）化合物或其药学上可接受的盐是GPCR激动剂，可用于治疗肥胖症和糖尿病。
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公开(公告)号：US20080261952A1
公开(公告)日：2008-10-23
申请号：US11660405
申请日：2005-08-16
Applicant: Jason Bloxham , Matthew Colin Thor Fyfe , James Horswill , Revathy Perpetua Jeevaratnam , John Keily , Martin James Procter , Karen Lesley Schofield , Salam Shaaban , Andrew Simon Swain , Phillppe Wong-Kai-In
Inventor： Jason Bloxham , Matthew Colin Thor Fyfe , James Horswill , Revathy Perpetua Jeevaratnam , John Keily , Martin James Procter , Karen Lesley Schofield , Salam Shaaban , Andrew Simon Swain , Phillppe Wong-Kai-In
IPC: A61K31/167 , A61P1/00
CPC classification number: A61K31/381 , A61K31/341 , A61K31/404 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/455
Abstract: A method of treating a condition associated with the CB-1 receptor, in particular obesity, by administering an effective amount of an aryl urea CB-1 receptor modulating compound to a subject in need of such treatment.
Abstract translation: 通过向需要这种治疗的受试者施用有效量的芳基脲CB-1受体调节化合物来治疗与CB-1受体相关的病症，特别是肥胖症的方法。
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公开(公告)号：US07115745B2
公开(公告)日：2006-10-03
申请号：US10775405
申请日：2004-02-10
Applicant: Daniel Y. Du , Martin James Procter , Matthew Colin Thor Fyfe , Vilasben Kanji Shah , Geoffrey Martyn Williams , Karen Lesley Schofield
Inventor： Daniel Y. Du , Martin James Procter , Matthew Colin Thor Fyfe , Vilasben Kanji Shah , Geoffrey Martyn Williams , Karen Lesley Schofield
IPC: C07D435/02 , A01N43/90
CPC classification number: C07D215/227 , C07D311/08 , C07D311/14 , C07D405/12
Abstract: The present invention is directed to a new class of 6-benzyl urea/thiourea-quinolin-2-one derivatives and 2-oxo-6-benzylurea/thiourea-chromene derivatives. These compound are androgen antagonists and are useful in the treatment of alopecia, acne and other conditions associated with inappropriate activation of the androgen receptor.
Abstract translation: 本发明涉及一类新的6-苄基脲/硫脲 - 喹啉-2-酮衍生物和2-氧代-6-苄基脲/硫脲 - 色烯衍生物。 这些化合物是雄激素拮抗剂，可用于治疗脱发，痤疮和与雄激素受体不适当激活相关的其他病症。
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公开(公告)号：US07098340B2
公开(公告)日：2006-08-29
申请号：US10824456
申请日：2004-04-14
Applicant: Daniel Y. Du , Martin James Procter , Matthew Colin Thor Fyfe , Vilasben Kanji Shah , Geoffrey Martyn Williams , Karen Lesley Schofield
Inventor： Daniel Y. Du , Martin James Procter , Matthew Colin Thor Fyfe , Vilasben Kanji Shah , Geoffrey Martyn Williams , Karen Lesley Schofield
IPC: C07D215/16
CPC classification number: C07D405/12 , C07D215/227 , C07D311/18 , C07D401/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: The present invention is directed to a new class of 6-benzylsulfonamido-quinoline/chromene derivatives, to their use as androgen antagonists, and to formulations containing these androgen antagonists.
Abstract translation: 本发明涉及一类新的6-苄基磺酰氨基 - 喹啉/色烯衍生物，其用作雄激素拮抗剂，以及含有这些雄激素拮抗剂的制剂。
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公开(公告)号：US07057048B2
公开(公告)日：2006-06-06
申请号：US10758581
申请日：2004-01-15
Applicant: Daniel Y. Du , Matthew Colin Thor Fyfe , Martin James Procter , Karen Lesley Schofield , Vilasben Kanji Shah , Geoffrey Martyn Williams
Inventor： Daniel Y. Du , Matthew Colin Thor Fyfe , Martin James Procter , Karen Lesley Schofield , Vilasben Kanji Shah , Geoffrey Martyn Williams
IPC: C07D215/16 , C07D311/02
CPC classification number: C07D215/227 , C07D311/54 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/12 , C07D491/08 , C07D491/10
Abstract: The present invention is directed to a new class of 6-sulfonamido-quinolin-2-one and 6-sulfonamido-2-oxo-chromene derivatives to their use as androgen antagonists, and to relieve conditions associated with inappropriate activation of the androgen receptor.
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Patent Agency Ranking
公开(公告)号：US06933319B2
公开(公告)日：2005-08-23
申请号：US10839432
申请日：2004-05-05
Applicant: Andrew Francis Browning , Eric William Collington , Martin James Procter , Joanna Victoria Geden
Inventor： Andrew Francis Browning , Eric William Collington , Martin James Procter , Joanna Victoria Geden
IPC: A61K8/34 , A61K8/35 , A61K8/40 , A61K8/41 , A61K8/46 , A61K8/49 , A61K8/69 , A61Q19/02 , C07C69/013 , C07C69/76 , C07C215/64 , C07C233/23 , C07C235/40 , C07C251/44 , C07C259/08 , C07C271/24 , C07C271/36 , C07C311/07 , C07C317/20 , C07C323/17 , C07D295/096 , A61K31/045
CPC classification number: C07D295/096 , A61K8/347 , A61K8/35 , A61K8/40 , A61K8/41 , A61K8/466 , A61K8/49 , A61K8/494 , A61K8/69 , A61Q19/02 , C07C69/013 , C07C69/76 , C07C215/64 , C07C233/23 , C07C235/40 , C07C251/44 , C07C259/08 , C07C271/24 , C07C271/36 , C07C311/07 , C07C317/20 , C07C323/17 , C07C2601/08 , C07C2601/14
Abstract: The present invention relates to the use of certain resorcinol derivatives as skin lightening agents.
Abstract translation: 本发明涉及某些间苯二酚衍生物作为增白剂的用途。
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27.发明授权Bicyclic aryl and heteroaryl compounds for the treatment of metabolic disorders 失效用于治疗代谢紊乱的双环芳基和杂芳基化合物公开(公告)号：US08278442B2
公开(公告)日：2012-10-02
申请号：US12601100
申请日：2008-05-22
Applicant: Jason Bloxham , Stuart Edward Bradley , Tom Banksia Dupree , Peter Timothy Fry , Patrick Eric Hanrahan , Thomas Martin Krulle , Martin James Procter , Colin Peter Sambrook-Smith , Karen Lesley Schofield , Donald Smyth , Alan John Stewart
Inventor： Jason Bloxham , Stuart Edward Bradley , Tom Banksia Dupree , Peter Timothy Fry , Patrick Eric Hanrahan , Thomas Martin Krulle , Martin James Procter , Colin Peter Sambrook-Smith , Karen Lesley Schofield , Donald Smyth , Alan John Stewart
IPC: C07D213/84 , C07D217/22 , C07D403/12 , C07D413/12
CPC classification number: C07D213/62 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Compounds of formula (I): or pharmaceutically acceptable salts thereof, are opioid receptor modulators, e.g. mu-opioid receptor antagonists, neutral antagonists or inverse agonists, and are useful for the treatment of metabolic disorders including obesity.
Abstract translation: 式（I）化合物或其药学上可接受的盐是阿片样物质受体调节剂，例如 μ-阿片受体拮抗剂，中性拮抗剂或反向激动剂，并且可用于治疗包括肥胖症在内的代谢紊乱。
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公开(公告)号：US20080188472A1
公开(公告)日：2008-08-07
申请号：US10592011
申请日：2005-03-08
Applicant: Stuart Edward Bradley , Revathy Perpetua Jeevaratnam , Thomas Martin Krulle , Martin James Procter , Robert John Rowley , Gerard Hugh Thomas , Ana Valdes
Inventor： Stuart Edward Bradley , Revathy Perpetua Jeevaratnam , Thomas Martin Krulle , Martin James Procter , Robert John Rowley , Gerard Hugh Thomas , Ana Valdes
IPC: A61K31/5377 , C07D209/42 , C07D409/12 , A61K31/404 , A61K31/427 , A61K31/422 , A61K31/4178 , C07D417/12 , C07D413/12 , A61P9/10 , A61P3/10 , C07D403/12 , C07D401/12 , C07D471/04 , C07D413/14 , A61K31/4725 , A61K31/4439 , A61K31/437
CPC classification number: C07D471/04 , C07D209/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D495/04
Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia, e.g. myocardial ischemia, or as cardioprotectants or inhibitors of abnormal cell growth.
Abstract translation: 式（I）化合物或其药学上可接受的盐是糖原磷酸化酶的抑制剂，可用于预防或治疗糖尿病，高血糖症，高胆固醇血症，高胰岛素血症，高脂血症，高血压，动脉粥样硬化或组织缺血。 心肌缺血或作为心脏保护剂或异常细胞生长的抑制剂。
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公开(公告)号：US07884112B2
公开(公告)日：2011-02-08
申请号：US10591895
申请日：2007-11-05
Applicant: Stuart Edward Bradley , Revathy Perpetua Jeevaratnam , Thomas Martin Krulle , Martin James Procter , Robert John Rowley , Gerard Hugh Thomas , Ana Valdesabril
Inventor： Stuart Edward Bradley , Revathy Perpetua Jeevaratnam , Thomas Martin Krulle , Martin James Procter , Robert John Rowley , Gerard Hugh Thomas , Ana Valdesabril
IPC: A61K31/437 , C07D471/04
CPC classification number: C07D471/04
Abstract: Compounds of Formula (I) or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, or as cardioprotectants or inhibitors of abnormal cell growth.
Abstract translation: 式（I）化合物或其药学上可接受的盐是糖原磷酸化酶的抑制剂，可用于预防或治疗糖尿病，高血糖症，高胆固醇血症，高胰岛素血症，高脂血症，高血压，动脉粥样硬化或组织缺血。 心肌缺血或作为心脏保护剂或异常细胞生长的抑制剂。
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30.发明申请BICYCLIC ARYL AND HETEROARYL COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS 失效用于治疗代谢性疾病的双相ARYL和HETEROARYL化合物公开(公告)号：US20100173886A1
公开(公告)日：2010-07-08
申请号：US12601100
申请日：2008-05-22
Applicant: Jason Bloxham , Stuart Edward Bradley , Tom Banksia Dupree , Peter Timothy Fry , Patrick Eric Hanrahan , Thomas Martin Krulle , Martin James Procter , Colin Peter Sambrook-Smith , Karen Lesley Schofield , Donald Smyth , Alan John Stewart
Inventor： Jason Bloxham , Stuart Edward Bradley , Tom Banksia Dupree , Peter Timothy Fry , Patrick Eric Hanrahan , Thomas Martin Krulle , Martin James Procter , Colin Peter Sambrook-Smith , Karen Lesley Schofield , Donald Smyth , Alan John Stewart
IPC: A61K31/397 , C07D213/84 , A61K31/44 , C07D217/22 , A61K31/47 , C07D403/12 , A61K31/496 , C07D413/12 , A61K31/5377 , A61P3/10 , A61P9/12 , A61P25/24 , A61P25/32 , A61P25/36
CPC classification number: C07D213/62 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Compounds of formula (I): or pharmaceutically acceptable salts thereof, are opioid receptor modulators, e.g. mu-opioid receptor antagonists, neutral antagonists or inverse agonists, and are useful for the treatment of metabolic disorders including obesity.
Abstract translation: 式（I）化合物或其药学上可接受的盐是阿片样物质受体调节剂，例如 μ-阿片受体拮抗剂，中性拮抗剂或反向激动剂，并且可用于治疗包括肥胖症在内的代谢紊乱。
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