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    System using leo satellites for centimeter-level navigation
    21.
    发明授权
    System using leo satellites for centimeter-level navigation 有权
    系统采用利奥卫星厘米级导航

    公开(公告)号：US06373432B1

    公开(公告)日：2002-04-16

    申请号：US09625419

    申请日：2000-07-25

    Applicant: Matthew Rabinowitz ,  Bradford W. Parkinson ,  Clark E. Cohen ,  David G. Lawrence

    Inventor： Matthew Rabinowitz ,  Bradford W. Parkinson ,  Clark E. Cohen ,  David G. Lawrence

    IPC: G01S502

    CPC classification number: G01S19/04 ,  G01S19/05 ,  G01S19/11 ,  G01S19/20 ,  G01S19/44 ,  G01S19/46 ,  H04B7/18552

    Abstract: Disclosed herein is a system for rapidly resolving position with centimeter-level accuracy for a mobile or stationary receiver [4]. This is achieved by estimating a set of parameters that are related to the integer cycle ambiguities which arise in tracking the carrier phase of satellite downlinks [5,6]. In the preferred embodiment, the technique involves a navigation receiver [4] simultaneously tracking transmissions [6] from Low Earth Orbit Satellites (LEOS) [2] together with transmissions [5] from GPS navigation satellites [1]. The rapid change in the line-of-sight vectors from the receiver [4] to the LEO signal sources [2], due to the orbital motion of the LEOS, enables the resolution with integrity of the integer cycle ambiguities of the GPS signals [5] as well as parameters related to the integer cycle ambiguity on the LEOS signals [6]. These parameters, once identified, enable real-time centimeter-level positioning of the receiver [4]. In order to achieve high-precision position estimates without the use of specialized electronics such as atomic clocks, the technique accounts for instabilities in the crystal oscillators driving the satellite transmitters, as well as those in the reference [3] and user [4] receivers. In addition, the algorithm accommodates as well as to LEOS that receive signals from ground-based transmitters, then re-transmit frequency-converted signals to the ground.

    Abstract translation: 本文公开了一种用于快速分辨移动或固定接收机的厘米级精度位置的系统[4]。 这通过估计与在跟踪卫星下行链路的载波相位中出现的整数周期模糊度相关的一组参数来实现[5,6]。 在优选实施例中，该技术涉及同时从低地球轨道卫星（LEOS）[2]跟踪来自GPS导航卫星[5]的传输[5]的导航接收机[4]。 由于LEOS的轨道运动，从接收机[4]到LEO信号源[2]的视距矢量的快速变化使得能够以GPS信号的整数周期模糊度的完整性得到分辨率[ 5]以及与LEOS信号的整数周期模糊度相关的参数[6]。 这些参数一旦被识别，就能实现接收机的实时厘米级定位[4]。 为了在不使用诸如原子钟之类的专门电子装置的情况下实现高精度位置估计，该技术解决了驱动卫星发射机的晶体振荡器以及参考文献[3]和用户[4]接收机中的不稳定性 。 此外，该算法还适用于从地面发射机接收信号的LEOS，然后将频率转换的信号重新发射到地面。

    SYSTEM AND METHOD FOR CLEANING NOISY GENETIC DATA FROM TARGET INDIVIDUALS USING GENETIC DATA FROM GENETICALLY RELATED INDIVIDUALS
    22.
    发明申请
    SYSTEM AND METHOD FOR CLEANING NOISY GENETIC DATA FROM TARGET INDIVIDUALS USING GENETIC DATA FROM GENETICALLY RELATED INDIVIDUALS 审中-公开
    使用遗传资料从遗传相关个体清除目标个体的噪声遗传数据的系统和方法

    公开(公告)号：US20140193816A1

    公开(公告)日：2014-07-10

    申请号：US14156433

    申请日：2014-01-15

    Applicant: Matthew Rabinowitz ,  Milena Banjevic ,  Zachary Demko ,  David Johnson

    Inventor： Matthew Rabinowitz ,  Milena Banjevic ,  Zachary Demko ,  David Johnson

    IPC: G06F19/18

    CPC classification number: C12Q1/6883 ,  C12Q1/6827 ,  C12Q1/6876 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/158 ,  G16B20/00 ,  G16B25/00 ,  G16B30/00 ,  G16B40/00 ,  C12Q2537/16 ,  C12Q2537/165

    Abstract: A system and method for determining the genetic data for one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available, are disclosed. Genetic data for the target individual is acquired and amplified using known methods, and poorly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related subjects. In accordance with one embodiment of the invention incomplete genetic data is acquired from embryonic cells, fetal cells, or cell-free fetal DNA isolated from the mother's blood, and the incomplete genetic data is reconstructed using the more complete genetic data from a larger sample diploid cells from one or both parents, with or without genetic data from haploid cells from one or both parents, and/or genetic data taken from other related individuals.

    Abstract translation: 公开了一种用于确定一个或一小组细胞遗传数据的系统和方法，或从有限数量的遗传数据获得的片段DNA。 使用已知方法获取和扩增目标个体的遗传数据，并且使用目标基因组与基因相关受试者的基因组之间的预期相似性重建差测量的碱基对，缺失的等位基因和缺失区域。 根据本发明的一个实施方案，从母体血液中分离的胚胎细胞，胎儿细胞或无细胞胎儿DNA获得不完全遗传数据，并使用更大的样本二倍体的更完整的遗传数据重建不完全遗传数据 来自一个或两个亲本的细胞，具有或不具有来自一个或两个亲本的单倍体细胞的遗传数据，和/或从其他相关个体获取的遗传数据。

    System and method for cleaning noisy genetic data and determining chromosome copy number
    23.
    发明授权
    System and method for cleaning noisy genetic data and determining chromosome copy number 有权
    清除嘈杂遗传数据和确定染色体拷贝数的系统和方法

    公开(公告)号：US08515679B2

    公开(公告)日：2013-08-20

    申请号：US12076348

    申请日：2008-03-17

    Applicant: Matthew Rabinowitz ,  Milena Banjevic ,  Zachary Demko ,  David Scott Johnson ,  Dusan Kijacic ,  Dimitri Petrov ,  Josh Sweetkind-Singer ,  Jing Xu

    Inventor： Matthew Rabinowitz ,  Milena Banjevic ,  Zachary Demko ,  David Scott Johnson ,  Dusan Kijacic ,  Dimitri Petrov ,  Josh Sweetkind-Singer ,  Jing Xu

    IPC: G01N33/48 ,  G01N31/00 ,  G06G7/48 ,  G06G7/58

    CPC classification number: G06F19/16 ,  C12Q1/6855 ,  C12Q1/6874 ,  G06F19/18 ,  G06F19/24 ,  G06Q50/22

    Abstract: Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Genetic material from the target individual is acquired, amplified and the genetic data is measured using known methods. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment of the invention, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment of the invention, the chromosome copy number can be determined from the measured genetic data of a single or small number of cells, with or without genetic information from one or both parents. In another embodiment of the invention, these determinations are made for the purpose of embryo selection in the context of in-vitro fertilization. In another embodiment of the invention, the genetic data can be reconstructed for the purposes of making phenotypic predictions.

    Abstract translation: 本文公开了一种系统和方法，用于增加测量的遗传数据的保真度，进行等位基因调用，并确定在一组或一组细胞中或从片段DNA中确定非整倍体的状态，其中有限数量的遗传数据 是可用的 获取，扩增来自目标个体的遗传物质，并使用已知方法测量遗传数据。 使用目标基因组与遗传相关个体的基因组之间的预期相似性来重建差或不正确测量的碱基对，缺失的等位基因和缺失区域。 根据本发明的一个实施方案，使用来自一个或两个亲本的二倍体细胞的较大样本的更完整的遗传数据，在多个基因座重建来自胚胎细胞的不完全遗传数据，具有或不具有来自一个的单倍体遗传数据 或双亲。 在本发明的另一个实施方案中，染色体拷贝数可以从单个或少数细胞的测量的遗传数据确定，具有或不具有来自一个或两个亲本的遗传信息。 在本发明的另一个实施方案中，这些确定是为了在体外受精的背景下进行胚胎选择的目的。 在本发明的另一个实施方案中，为了进行表型预测的目的，可以重建遗传数据。

    Position determination using wireless local area network signals and television signals
    24.
    发明授权
    Position determination using wireless local area network signals and television signals 有权
    使用无线局域网信号和电视信号进行位置确定

    公开(公告)号：US08149168B1

    公开(公告)日：2012-04-03

    申请号：US11622838

    申请日：2007-01-12

    Applicant: Matthew Rabinowitz ,  Todd Young ,  James J. Spilker, Jr.

    Inventor： Matthew Rabinowitz ,  Todd Young ,  James J. Spilker, Jr.

    IPC: G01S3/02

    CPC classification number: G01S5/0242 ,  G01S5/0263

    Abstract: Apparatus having corresponding methods and computer-readable media comprise a first receiver to receive a wireless television signal; a first measurement unit to generate a measurement of the wireless television signal; wherein a position of the apparatus is determined based on the measurement of the wireless television signal; a second receiver to receive a wireless local area network (WLAN) signal; and a second measurement unit to generate a measurement of the WLAN signal; wherein a position of a transmitter of the WLAN signal is determined based on the position of the apparatus and the measurement of the WLAN signal.

    Abstract translation: 具有相应方法和计算机可读介质的设备包括：接收无线电视信号的第一接收机; 第一测量单元，用于产生无线电视信号的测量; 其中，所述装置的位置基于所述无线电视信号的测量来确定; 接收无线局域网（WLAN）信号的第二接收机; 以及第二测量单元，用于生成WLAN信号的测量; 其中，基于所述装置的位置和所述WLAN信号的测量来确定所述WLAN信号的发送器的位置。

    Methods for Allele Calling and Ploidy Calling
    25.
    发明申请
    Methods for Allele Calling and Ploidy Calling 审中-公开
    等位基因调用和倍性调用方法

    公开(公告)号：US20110178719A1

    公开(公告)日：2011-07-21

    申请号：US13057350

    申请日：2009-08-04

    Applicant: Matthew Rabinowitz ,  George Gemelos ,  Milena Banjevic ,  Allison Ryan ,  Joshua Sweetkind-Singer

    Inventor： Matthew Rabinowitz ,  George Gemelos ,  Milena Banjevic ,  Allison Ryan ,  Joshua Sweetkind-Singer

    IPC: G06F17/18 ,  G06F19/10

    CPC classification number: G16B20/00 ,  C12Q1/6883 ,  C12Q2600/156 ,  G16B40/00

    Abstract: Disclosed herein is a system and method for making allele calls, and for determining the ploidy state, in one or a small set of cells, or where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed and the haplotypes are determined using expected similarities between the target genome and the knowledge of the genomes of genetically related individuals. In one embodiment, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the genetic data from both parents, and possibly one or more sperm and/or sibling embryos. In another embodiment, the chromosome copy number can be determined using the same input data. In another embodiment, these determinations are made for embryo selection during IVF, for non-invasive prenatal diagnosis, or for making phenotypic predictions.

    Abstract translation: 本文公开了一种用于在一个或一小组细胞中或其中有限数量的遗传数据可用的等位基因调用和用于确定倍性状态的系统和方法。 重建不良或不正确的碱基对，缺失的等位基因和缺失区域，并使用目标基因组与遗传相关个体基因组知识之间的预期相似性来确定单倍型。 在一个实施方案中，使用来自双亲和可能的一个或多个精子和/或同胞胚胎的遗传数据在多个基因座重建来自胚胎细胞的不完全遗传数据。 在另一个实施方案中，可以使用相同的输入数据来确定染色体拷贝数。 在另一个实施方案中，进行这些测定用于IVF期间的胚胎选择，用于非侵入性产前诊断或用于进行表型预测。

    METHODS FOR CELL GENOTYPING
    26.
    发明申请
    METHODS FOR CELL GENOTYPING 审中-公开
    细胞基因分析方法

    公开(公告)号：US20110033862A1

    公开(公告)日：2011-02-10

    申请号：US12918445

    申请日：2009-02-19

    Applicant: Matthew Rabinowitz ,  David S. Johnson ,  Johan Baner ,  Zachary Demko ,  Cengiz Cinnioglu

    Inventor： Matthew Rabinowitz ,  David S. Johnson ,  Johan Baner ,  Zachary Demko ,  Cengiz Cinnioglu

    IPC: C12Q1/68 ,  C12P19/34

    CPC classification number: C12Q1/6876 ,  C12Q2600/156 ,  C12Q2600/16 ,  C12Q2600/172

    Abstract: Methods for cell genotyping are disclosed herein. A method for determining the genomic data of one or a small number of cells, or from fragmentary DNA, where a limited quantity of genetic data is available may include adding one or more targeted primers to a whole genome amplification of a cell, increasing the accuracy with which key alleles are measured in the context of a whole genome amplification. The genetic material from a single cell may be divided into fractions, each of which may be separately genotyped, allowing the reconstruction of the cells haplotype. The genetic material from a single cell may be divided into fractions, each of which may be separately genotyped, and the distribution of the various alleles in the different fractions may be used to determine the ploidy state of one or a plurality of chromosomes in the cell.

    Abstract translation: 本文公开了细胞基因分型的方法。 用于确定有限数量的遗传数据可用的一个或少数细胞或来自片段DNA的基因组数据的方法可包括向细胞的全基因组扩增添加一种或多种靶向引物，增加细胞的准确度 在全基因组扩增的情况下测量关键等位基因。 来自单个细胞的遗传物质可以被分成各自的部分，每一个可以分开进行基因分型，允许重建细胞单元型。 来自单个细胞的遗传物质可以分成各自的部分，每个可以分别进行基因分型，并且可以使用不同级分中各种等位基因的分布来确定细胞中一条或多条染色体的倍性状态 。

    Wide-lane pseudorange measurements using FM signals
    28.
    发明授权
    Wide-lane pseudorange measurements using FM signals 有权
    使用FM信号的宽行距伪距测量

    公开(公告)号：US07498873B2

    公开(公告)日：2009-03-03

    申请号：US11554765

    申请日：2006-10-31

    Applicant: Guttorm Opshaug ,  David Burgess ,  George Flammer ,  Scott Furman ,  Andy Lee ,  Matthew Rabinowitz ,  Harvind Samra

    Inventor： Guttorm Opshaug ,  David Burgess ,  George Flammer ,  Scott Furman ,  Andy Lee ,  Matthew Rabinowitz ,  Harvind Samra

    IPC: G01S1/00 ,  H03D3/00 ,  H04B1/16

    CPC classification number: G01S11/02 ,  G01S5/0263 ,  G01S5/12

    Abstract: Apparatus having corresponding methods and computer-readable media comprises a receiver to receive a wireless stereo frequency-modulation (FM) signal comprising a plurality of spectral signal components including a first tone and one or more frequency bands; one or more tone generators each to generate a respective second tone based on a respective one of the frequency bands; a plurality of phase circuits each to measure a phase of a respective one of the first and second tones; and a difference element to determine a phase difference between two of the phases.

    Abstract translation: 具有相应方法和计算机可读介质的装置包括：接收器，用于接收包括包括第一音调和一个或多个频带的多个频谱信号分量的无线立体声调频（FM）信号; 一个或多个音调发生器，每个音调发生器基于相应的一个频带产生相应的第二音调; 多个相位电路，各自测量第一和第二音调中的相应一个的相位; 以及差分元件，以确定两相之间的相位差。

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