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公开(公告)号:US20100184782A1
公开(公告)日:2010-07-22
申请号:US12731880
申请日:2010-03-25
申请人: Swen Hölder , Matthias Vennemann , Gerrit Beneke , Armin Zülch , Volker Gekeler , Thomas Beckers , Astrid Zimmermann , Hemant Joshi
发明人: Swen Hölder , Matthias Vennemann , Gerrit Beneke , Armin Zülch , Volker Gekeler , Thomas Beckers , Astrid Zimmermann , Hemant Joshi
IPC分类号: A61K31/519 , A61P35/00 , A61P35/02
CPC分类号: C07D487/04
摘要: Compounds of formula (I) a tautomer or stereoisomer thereof, or a salt thereof, wherein ring B and the pyrimidine to which it is fused, R4, R5, R6 and R7 have the meanings as given in the description and the claims, are effective inhibitors of the Pi3K/Akt pathway.
摘要翻译: 式(I)化合物其互变异构体或立体异构体或其盐,其中环B和其稠合的嘧啶,R4,R5,R6和R7具有在说明书和权利要求书中给出的含义,是有效的 Pi3K / Akt途径的抑制剂。
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22.
公开(公告)号:US20070105840A1
公开(公告)日:2007-05-10
申请号:US10562142
申请日:2004-06-30
申请人: Thomas Bar , Matthias Vennemann
发明人: Thomas Bar , Matthias Vennemann
IPC分类号: A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/506 , A61K31/496 , A61K31/4745 , C07D471/04
CPC分类号: A61K31/4745
摘要: The invention relates to the use of a pyrrolo ‘2,1-a’ isoquinoline structure-element as an integral part of the overall structure of compounds which inhibit PDE10.
摘要翻译: 本发明涉及吡咯并[2,1-a'异喹啉结构元素作为抑制PDE10的化合物整体结构的组成部分的用途。
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公开(公告)号:US20090246169A1
公开(公告)日:2009-10-01
申请号:US12280264
申请日:2007-02-21
IPC分类号: A61K38/20 , C07D471/12 , A61K31/437 , C07D401/14 , A61K31/496 , C07D413/14 , A61K31/5377 , A61K31/55 , A61K31/397 , A61P35/00
CPC分类号: C07D471/14
摘要: Compounds of a certain formula I, in which R1, R2, R3, R4, R5 and R6 have the meanings indicated in the description, are effective compounds with anti-proliferative and/or apoptosis inducing activity.
摘要翻译: 其中R1,R2,R3,R4,R5和R6具有说明书中所示含义的某种式I化合物是具有抗增殖和/或凋亡诱导活性的有效化合物。
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公开(公告)号:US08530493B2
公开(公告)日:2013-09-10
申请号:US12280424
申请日:2007-02-21
IPC分类号: A61K31/435 , A61K31/44 , A61K31/41 , A61K31/40
CPC分类号: C07D471/14
摘要: Compounds of a certain formula I, in which R1, R2, R3, R4, R5 and R6 have the meanings indicated in the description, are effective compounds with anti-proliferative and/or apoptosis inducing activity.
摘要翻译: 其中R1,R2,R3,R4,R5和R6具有说明书中所示含义的某种式I化合物是具有抗增殖和/或凋亡诱导活性的有效化合物。
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公开(公告)号:US08957064B2
公开(公告)日:2015-02-17
申请号:US13201277
申请日:2010-02-02
申请人: Matthias Vennemann , Thomas Bär , Thomas Maier , Swen Hölder , Gerrit Beneke , Florian Dehmel , Armin Zülch , Andreas Strub , Stuart Ince , Hartmut Rehwinkel , Ningshu Liu , Ulf Bömer , Barbara Beckers
发明人: Matthias Vennemann , Thomas Bär , Thomas Maier , Swen Hölder , Gerrit Beneke , Florian Dehmel , Armin Zülch , Andreas Strub , Thomas Beckers , Stuart Ince , Hartmut Rehwinkel , Ningshu Liu , Ulf Bömer
IPC分类号: A61K31/495 , A61K31/519 , A61K31/505 , C07D401/12 , C07D487/04 , A61K45/06 , C07D471/04
CPC分类号: A61K31/519 , A61K31/495 , A61K31/505 , A61K45/06 , C07D401/12 , C07D471/04 , C07D487/04
摘要: Compounds of formula (I) or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer, wherein ring B and the pyrimidine to which it is fused, R4, R5, R6, R7, m and n have the meanings as given in the description and the claims, which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.
摘要翻译: 式(I)化合物或所述化合物的N-氧化物,盐,互变异构体或立体异构体,或所述N-氧化物,互变异构体或立体异构体的盐,其中环B和与其稠合的嘧啶,R4 R5,R6,R7,m和n具有在描述和权利要求中给出的含义,它们是Pi3K / Akt途径的有效抑制剂,其生产方法及其作为药物的用途。
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公开(公告)号:US20090233902A1
公开(公告)日:2009-09-17
申请号:US12280424
申请日:2007-02-21
IPC分类号: A61K31/437 , C07D471/14 , A61K31/55 , A61P35/00
CPC分类号: C07D471/14
摘要: Compounds of a certain formula I, in which R1, R2, R3, R4, R5 and R6 have the meanings indicated in the description, are effective compounds with anti-proliferative and/or apoptosis inducing activity.
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公开(公告)号:US08044065B2
公开(公告)日:2011-10-25
申请号:US12749623
申请日:2010-03-30
申请人: Matthias Vennemann , Thomas Baer , Gudrun Groegor
发明人: Matthias Vennemann , Thomas Baer , Gudrun Groegor
IPC分类号: A61K31/437
CPC分类号: C07D471/14 , C07D495/14
摘要: Compounds of a certain formula I, in which R1, R2, R3, R4 and X have the meanings indicated in the description, are novel effective compounds with Eg5 inhibitory, anti-proliferative and/or apoptosis inducing activity.
摘要翻译: 其中R1,R2,R3,R4和X具有说明书中所示含义的某种式I化合物是具有Eg5抑制,抗增殖和/或凋亡诱导活性的新型有效化合物。
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公开(公告)号:US20100104659A1
公开(公告)日:2010-04-29
申请号:US12373433
申请日:2007-07-12
申请人: Matthias Vennemann , Thomas Bär , Thomas Maier , Andreas Lindenmaier , Jürgen Braunger , Markus Boehm , Astrid Zimmermann , Volker Gekeler
发明人: Matthias Vennemann , Thomas Bär , Thomas Maier , Andreas Lindenmaier , Jürgen Braunger , Markus Boehm , Astrid Zimmermann , Volker Gekeler
IPC分类号: A61K31/4162 , C07D491/04 , C07D471/02 , C07D401/14 , C07D403/14 , A61K31/4738 , A61K31/454 , A61K31/496 , A61K33/24 , A61P35/00 , A61K31/397
CPC分类号: C07D491/04
摘要: Compounds of a certain formula I, in which Ra, Rb and Rc have the meanings indicated in the description, are effective compounds with anti-proliferative and/or apoptosis inducing activity.
摘要翻译: 其中Ra,Rb和Rc具有说明书中所示含义的某种式I化合物是具有抗增殖和/或凋亡诱导活性的有效化合物。
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公开(公告)号:US20110091889A1
公开(公告)日:2011-04-21
申请号:US12934317
申请日:2009-03-24
CPC分类号: G01N33/5035 , G01N2333/914
摘要: The present invention provides a centrosome assay for the identification of preferably, Eg5 inhibitors.
摘要翻译: 本发明提供了用于鉴定优选Eg5抑制剂的中心体测定法。
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