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公开(公告)号:US08614218B2
公开(公告)日:2013-12-24
申请号:US12731880
申请日:2010-03-25
申请人: Swen Hölder , Matthias Vennemann , Gerrit Beneke , Armin Zülch , Volker Gekeler , Thomas Beckers , Astrid Zimmermann , Hemant Joshi
发明人: Swen Hölder , Matthias Vennemann , Gerrit Beneke , Armin Zülch , Volker Gekeler , Thomas Beckers , Astrid Zimmermann , Hemant Joshi
IPC分类号: A01N43/90 , A61K31/519 , C07D487/00
CPC分类号: C07D487/04
摘要: Compounds of formula (I) a tautomer or stereoisomer thereof, or a salt thereof, wherein ring B and the pyrimidine to which it is fused, R4, R5, R6 and R7 have the meanings as given in the description and the claims, are effective inhibitors of the Pi3K/Akt pathway.
摘要翻译: 式(I)化合物其互变异构体或立体异构体或其盐,其中环B和其稠合的嘧啶,R4,R5,R6和R7具有在说明书和权利要求书中给出的含义,是有效的 Pi3K / Akt途径的抑制剂。
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公开(公告)号:US07776864B2
公开(公告)日:2010-08-17
申请号:US12191703
申请日:2008-08-14
申请人: Swen Hölder , Matthias Vennemann , Gerrit Beneke , Armin Zülch , Volker Gekeler , Thomas Beckers , Astrid Zimmermann , Hemant Joshi
发明人: Swen Hölder , Matthias Vennemann , Gerrit Beneke , Armin Zülch , Volker Gekeler , Thomas Beckers , Astrid Zimmermann , Hemant Joshi
IPC分类号: A61K31/4965 , A61K31/505 , A61K31/519 , A61K31/445 , C07D471/04 , C07D471/22 , C07D487/00 , C07D491/00 , C07D403/00 , C07D239/02 , A01N43/54 , A01N43/90 , A01N43/40
CPC分类号: C07D487/04
摘要: Compounds of formula (I) a tautomer or stereoisomer thereof, or a salt thereof, wherein ring B and the pyrimidine to which it is fused, R4, R5, R6 and R7 have the meanings as given in the description and the claims, are effective inhibitors of the Pi3K/Akt pathway.
摘要翻译: 式(I)化合物其互变异构体或立体异构体或其盐,其中环B和其稠合的嘧啶,R4,R5,R6和R7具有在说明书和权利要求书中给出的含义,是有效的 Pi3K / Akt途径的抑制剂。
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公开(公告)号:US20100184782A1
公开(公告)日:2010-07-22
申请号:US12731880
申请日:2010-03-25
申请人: Swen Hölder , Matthias Vennemann , Gerrit Beneke , Armin Zülch , Volker Gekeler , Thomas Beckers , Astrid Zimmermann , Hemant Joshi
发明人: Swen Hölder , Matthias Vennemann , Gerrit Beneke , Armin Zülch , Volker Gekeler , Thomas Beckers , Astrid Zimmermann , Hemant Joshi
IPC分类号: A61K31/519 , A61P35/00 , A61P35/02
CPC分类号: C07D487/04
摘要: Compounds of formula (I) a tautomer or stereoisomer thereof, or a salt thereof, wherein ring B and the pyrimidine to which it is fused, R4, R5, R6 and R7 have the meanings as given in the description and the claims, are effective inhibitors of the Pi3K/Akt pathway.
摘要翻译: 式(I)化合物其互变异构体或立体异构体或其盐,其中环B和其稠合的嘧啶,R4,R5,R6和R7具有在说明书和权利要求书中给出的含义,是有效的 Pi3K / Akt途径的抑制剂。
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公开(公告)号:US08592591B2
公开(公告)日:2013-11-26
申请号:US12191706
申请日:2008-08-14
申请人: Swen Hölder , Armin Zülch , Thomas Bär , Thomas Maier , Astrid Zimmermann , Thomas Beckers , Volker Gekeler , Hemant Joshi , Yogesh Munot , Umesh Bhise , Sunil Chavan , Sachin Shivatare , Sarvesh Patel , Vikas Gore
发明人: Swen Hölder , Armin Zülch , Thomas Bär , Thomas Maier , Astrid Zimmermann , Thomas Beckers , Volker Gekeler , Hemant Joshi , Yogesh Munot , Umesh Bhise , Sunil Chavan , Sachin Shivatare , Sarvesh Patel , Vikas Gore
IPC分类号: C07D401/04 , C07D401/14 , A61K31/4188 , A61K31/4465 , A61P35/00
CPC分类号: A61K31/454 , A61K31/4545 , A61K31/5025 , A61K31/519 , A61K45/06 , C07D401/10 , C07D417/04 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04
摘要: Compounds of formula (I) a tautomer or stereoisomer thereof, or a salt thereof, wherein ring B and the imidazole to which it is fused, R4, R6 and R7 have the meanings as given in the description and the claims, are effective inhibitors of the Pi3K/Akt pathway.
摘要翻译: 式(I)化合物其互变异构体或立体异构体或其盐,其中环B和与其稠合的咪唑,R4,R6和R7具有在说明书和权利要求书中给出的含义,是有效的抑制剂 Pi3K / Akt途径。
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公开(公告)号:US20090137607A1
公开(公告)日:2009-05-28
申请号:US12191703
申请日:2008-08-14
申请人: Swen Holder , Matthias Vennemann , Gerrit Beneke , Armin Zulch , Volker Gekeler , Thomas Beckers , Astrid Zimmermann , Hemant Joshi
发明人: Swen Holder , Matthias Vennemann , Gerrit Beneke , Armin Zulch , Volker Gekeler , Thomas Beckers , Astrid Zimmermann , Hemant Joshi
IPC分类号: A61K31/497 , C07D487/02 , A61K31/519 , A61P35/00
CPC分类号: C07D487/04
摘要: Compounds of formula (I) a tautomer or stereoisomer thereof, or a salt thereof, wherein ring B and the pyrimidine to which it is fused, R4, R5, R6 and R7 have the meanings as given in the description and the claims, are effective inhibitors of the Pi3K/Akt pathway.
摘要翻译: 式(I)化合物其互变异构体或立体异构体或其盐,其中环B和其稠合的嘧啶,R4,R5,R6和R7具有在说明书和权利要求书中给出的含义,是有效的 Pi3K / Akt途径的抑制剂。
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公开(公告)号:US08440830B2
公开(公告)日:2013-05-14
申请号:US12678806
申请日:2008-09-19
申请人: Thomas Maier , Thomas Beckers , Thomas Baer , Matthias Vennemann , Volker Gekeler , Astrid Zimmermann , Petra Gimmnich , Kamlesh Padiya , Hemant Joshi , Uday Joshi , Mahindra Makhija , Dipak Harel
发明人: Thomas Maier , Thomas Beckers , Thomas Baer , Matthias Vennemann , Volker Gekeler , Astrid Zimmermann , Petra Gimmnich , Kamlesh Padiya , Hemant Joshi , Uday Joshi , Mahindra Makhija , Dipak Harel
IPC分类号: C07D471/04 , A61K31/4355 , A61K31/4365 , A61K31/4353 , A61K31/437
CPC分类号: C07D513/04 , C07D471/04 , C07D491/04 , C07D495/04
摘要: The compounds of formula (I), wherein ring D and ring E together form a fused ring system selected from formula (II), (III), (IV), (V), (VI), (VII), and the salts of these compounds are novel, effective inhibitors of histone deacetylases.
摘要翻译: 式(I)化合物,其中环D和环E一起形成选自式(II),(III),(IV),(V),(VI),(VII) 的这些化合物是组蛋白脱乙酰酶的新颖有效的抑制剂。
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7.
公开(公告)号:US20110021494A1
公开(公告)日:2011-01-27
申请号:US12678806
申请日:2008-09-19
申请人: Thomas Maier , Thomas Beckers , Thomas Baer , Matthias Vennemann , Volker Gekeler , Astrid Zimmermann , Petra Gimmnich , Kamlesh Padiya , Hemant Joshi , Uday Joshi , Mahindra Makhija , Dipak Harel
发明人: Thomas Maier , Thomas Beckers , Thomas Baer , Matthias Vennemann , Volker Gekeler , Astrid Zimmermann , Petra Gimmnich , Kamlesh Padiya , Hemant Joshi , Uday Joshi , Mahindra Makhija , Dipak Harel
IPC分类号: A61K31/5377 , A61K31/497 , A61K31/437 , A61K31/4355 , C07D471/04 , C07D513/04 , C07D498/04 , A61P29/00 , A61K31/4365 , A61P35/04 , A61P37/00
CPC分类号: C07D513/04 , C07D471/04 , C07D491/04 , C07D495/04
摘要: The compounds of formula (I), wherein ring D and ring E together form a fused ring system selected from formula (II), (III), (IV), (V), (VI), (VII), and the salts of these compounds are novel, effective inhibitors of histone deacetylases.
摘要翻译: 式(I)化合物,其中环D和环E一起形成选自式(II),(III),(IV),(V),(VI),(VII) 的这些化合物是组蛋白脱乙酰酶的新颖有效的抑制剂。
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公开(公告)号:US20090156604A1
公开(公告)日:2009-06-18
申请号:US12191706
申请日:2008-08-14
申请人: Swen HOLDER , Armin Zulch , Thomas Bar , Thomas Maier , Astrid Zimmermann , Thomas Beckers , Volker Gekeler , Hemant Joshi , Yogesh Munot , Umesh Bhise , Sunil Chavan , Sachin Shivatare , Sarvesh Patel , Vikas Gore
发明人: Swen HOLDER , Armin Zulch , Thomas Bar , Thomas Maier , Astrid Zimmermann , Thomas Beckers , Volker Gekeler , Hemant Joshi , Yogesh Munot , Umesh Bhise , Sunil Chavan , Sachin Shivatare , Sarvesh Patel , Vikas Gore
IPC分类号: A61K31/53 , C07D487/02 , A61K31/519 , A61K31/497 , A61K31/4545 , A61K31/5025 , A61P35/00 , A61K31/4985 , C07D401/14 , C07D471/02 , A61K31/437
CPC分类号: A61K31/454 , A61K31/4545 , A61K31/5025 , A61K31/519 , A61K45/06 , C07D401/10 , C07D417/04 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04
摘要: Compounds of formula (I) a tautomer or stereoisomer thereof, or a salt thereof, wherein ring B and the imidazole to which it is fused, R4, R6 and R7 have the meanings as given in the description and the claims, are effective inhibitors of the Pi3K/Akt pathway.
摘要翻译: 式(I)化合物其互变异构体或立体异构体或其盐,其中环B和与其稠合的咪唑,R4,R6和R7具有在说明书和权利要求书中给出的含义,是有效的抑制剂 Pi3K / Akt途径。
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公开(公告)号:US08530493B2
公开(公告)日:2013-09-10
申请号:US12280424
申请日:2007-02-21
IPC分类号: A61K31/435 , A61K31/44 , A61K31/41 , A61K31/40
CPC分类号: C07D471/14
摘要: Compounds of a certain formula I, in which R1, R2, R3, R4, R5 and R6 have the meanings indicated in the description, are effective compounds with anti-proliferative and/or apoptosis inducing activity.
摘要翻译: 其中R1,R2,R3,R4,R5和R6具有说明书中所示含义的某种式I化合物是具有抗增殖和/或凋亡诱导活性的有效化合物。
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公开(公告)号:US20090246169A1
公开(公告)日:2009-10-01
申请号:US12280264
申请日:2007-02-21
IPC分类号: A61K38/20 , C07D471/12 , A61K31/437 , C07D401/14 , A61K31/496 , C07D413/14 , A61K31/5377 , A61K31/55 , A61K31/397 , A61P35/00
CPC分类号: C07D471/14
摘要: Compounds of a certain formula I, in which R1, R2, R3, R4, R5 and R6 have the meanings indicated in the description, are effective compounds with anti-proliferative and/or apoptosis inducing activity.
摘要翻译: 其中R1,R2,R3,R4,R5和R6具有说明书中所示含义的某种式I化合物是具有抗增殖和/或凋亡诱导活性的有效化合物。
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