公开(公告)号：US20210178365A1

公开(公告)日：2021-06-17

申请号：US17185604

申请日：2021-02-25

Applicant: Medtronic, Inc.

Inventor： Bryant J. Pudil ,  Christopher M. Hobot

IPC: B01J20/34 ,  B01J20/02 ,  A61M1/16 ,  A61L2/18

Abstract: The invention relates to systems and methods for disinfecting, recharging, and conditioning zirconium phosphate in a reusable sorbent module. The systems and methods provide for reuse of a zirconium phosphate sorbent module after dialysis.

公开(公告)号：US20210178043A1

公开(公告)日：2021-06-17

申请号：US17187256

申请日：2021-02-26

Applicant: Medtronic, Inc.

Inventor： Martin T. Gerber ,  Christopher M. Hobot

IPC: A61M1/28 ,  A61M1/16

Abstract: The invention relates to systems and methods for sensing fluid characteristics of peritoneal dialysate infused into and removed from a patient during treatment. The systems and methods include sensors, processors, and flow paths for determining patient health based on the fluid characteristics of the peritoneal dialysate. The system can be a peritoneal dialysis cycler which can include an infusion line; an effluent line; at least one pump positioned in the infusion and/or effluent line; and at least one sensor fluidly connected to the effluent line. The sensor can be at least one of a flow sensor, an ion selective electrode, a pH sensor, a pressure sensor, a refractive index sensor, and a temperature sensor. The method can include infusing peritoneal dialysate through an infusion line; removing peritoneal dialysate through an effluent line; and determining at least one fluid characteristic of the peritoneal dialysate in the effluent line.

公开(公告)号：US10981148B2

公开(公告)日：2021-04-20

申请号：US15798233

申请日：2017-10-30

Applicant: Medtronic, Inc.

Inventor： Christopher M. Hobot ,  Bryantl J. Pudil

IPC: B01J20/34 ,  A61M1/16 ,  B01J20/28 ,  B01J49/57 ,  B01J49/08 ,  B01J49/07 ,  A61L2/00 ,  B01D15/00 ,  B01J20/02 ,  B01J20/06 ,  C01B25/37 ,  C01G25/02

Abstract: The invention relates to devices, systems, and methods for conditioning a zirconium oxide sorbent module for use in dialysis after recharging. The devices, systems, and methods can provide for conditioning and recharging of zirconium oxide in a single system, or in separate systems.

公开(公告)号：US10821214B2

公开(公告)日：2020-11-03

申请号：US16353202

申请日：2019-03-14

Applicant: Medtronic, Inc.

Inventor： Martin T. Gerber ,  Christopher M. Hobot

IPC: A61M1/16 ,  B01D15/08 ,  B01D61/24

Abstract: An apparatus and method for replenishing urease in a sorbent cartridge for use in sorbent dialysis. The system is configured to allow insertion of a urease pouch, injection of a urease solution, or addition of a urease cartridge, into a dialysis cabinet containing a dialysis flow loop. The urease can be dissolved and the resulting urease solution added to the sorbent cartridge in the flow loop to replenish the urease within the sorbent cartridge. The sorbent cartridge can also comprise other, rechargeable, sorbent materials for removing toxins other than urea from spent dialysate.

公开(公告)号：US10807068B2

公开(公告)日：2020-10-20

申请号：US15938009

申请日：2018-03-28

Applicant: Medtronic, Inc.

Inventor： Martin T. Gerber ,  Christopher M. Hobot

IPC: B01J20/28 ,  B01D15/08 ,  A61M1/16

Abstract: A sorbent pouch for use in sorbent dialysis. The sorbent pouch allows for fluid to freely pass into and through the sorbent materials, while keeping the sorbent materials inside the sorbent pouch.

公开(公告)号：US20190201810A1

公开(公告)日：2019-07-04

申请号：US16353202

申请日：2019-03-14

Applicant: Medtronic, Inc.

Inventor： Martin T. Gerber ,  Christopher M. Hobot

IPC: B01D15/08 ,  A61M1/16

Abstract: An apparatus and method for replenishing urease in a sorbent cartridge for use in sorbent dialysis. The system is configured to allow insertion of a urease pouch, injection of a urease solution, or addition of a urease cartridge, into a dialysis cabinet containing a dialysis flow loop. The urease can be dissolved and the resulting urease solution added to the sorbent cartridge in the flow loop to replenish the urease within the sorbent cartridge. The sorbent cartridge can also comprise other, rechargeable, sorbent materials for removing toxins other than urea from spent dialysate.

公开(公告)号：US20190001303A1

公开(公告)日：2019-01-03

申请号：US16047245

申请日：2018-07-27

Applicant: Medtronic, Inc.

Inventor： Bryant J. Pudil ,  Martin T. Gerber ,  Christopher M. Hobot

IPC: B01J20/34 ,  B01J39/09 ,  B01J20/02 ,  A61M1/16

CPC classification number: B01J20/3475 ,  A61M1/1696 ,  B01J20/0211 ,  B01J20/3483 ,  B01J39/09

Abstract: Methods and related apparatuses for sorbent recharging are provided. The methods and related apparatuses for recharging can recharge a specific rechargeable layer or module of a sorbent material such as zirconium phosphate in a sorbent cartridge. The methods and apparatuses include a fluid source containing at least one recharging fluid, wherein the fluid source is fluidly connectable to at least one rechargeable sorbent module for use in sorbent dialysis in a fluid flow path. The methods and apparatuses include passing a single solution through the zirconium phosphate for ion exchanges, resulting in zirconium phosphate to maintain a substantially consistent pH in a dialysate used during dialysis.

公开(公告)号：US10159957B2

公开(公告)日：2018-12-25

申请号：US15364251

申请日：2016-11-29

Applicant: Medtronic, Inc.

Inventor： Bryant J. Pudil ,  Christopher M. Hobot

IPC: B01J20/34 ,  B01J20/02 ,  A61M1/16 ,  B01J39/09

Abstract: The invention relates to devices, systems, and methods for recharging zirconium phosphate in a reusable zirconium phosphate sorbent module. The devices, systems, and methods provide for customization of the zirconium phosphate effluent pH based on the needs of the user and system. The devices systems and methods also provide for calculation of the volumes of recharge solution needed for fully recharging the zirconium phosphate modules.

公开(公告)号：US10052624B2

公开(公告)日：2018-08-21

申请号：US15143487

申请日：2016-04-29

Applicant: Medtronic, Inc.

Inventor： Kanjimpuredathil Muralikrishna Menon ,  Ramkumar Jeyachandran ,  Kaustubh R. Patil ,  Sukalyan Dutta ,  Gokul Prabhu Loganathan ,  David B. Lura ,  Bryant J. Pudil ,  Christopher M. Hobot

IPC: C22C38/00 ,  B01J49/00 ,  A61L12/00 ,  B01J41/10 ,  B01J39/12 ,  A61M1/16 ,  B01J20/34 ,  B01J20/02 ,  B01J39/09 ,  B01J49/60

CPC classification number: B01J49/60 ,  A61L12/00 ,  A61M1/169 ,  A61M1/1696 ,  A61M2205/0205 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3368 ,  A61M2205/3372 ,  B01J20/0211 ,  B01J20/3475 ,  B01J20/3483 ,  B01J39/09 ,  B01J39/12 ,  B01J41/10

Abstract: Systems and methods for recharging zirconium phosphate and zirconium oxide are provided. The systems and methods provide for recharging of the zirconium phosphate and zirconium oxide in reusable sorbent modules. The systems and methods include recharging flow paths for recharging zirconium phosphate independently or concurrently.

公开(公告)号：US20170319766A1

公开(公告)日：2017-11-09

申请号：US15582830

申请日：2017-05-01

Applicant: Medtronic, Inc.

Inventor： Christopher M. Hobot ,  Martin T. Gerber

IPC: A61M1/16 ,  A61K31/7004 ,  A61K33/00 ,  A61K33/06

Abstract: Systems and methods of generating a customized dialysate solution are provided. The system and methods use stock concentrates, with the addition of spikes to generate a customized dialysate solution based on the needs of the patient.