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    SUBSTERNAL LEADLESS ELECTRICAL STIMULATION SYSTEM
    21.
    发明申请
    SUBSTERNAL LEADLESS ELECTRICAL STIMULATION SYSTEM 有权

    公开(公告)号：US20230001187A1

    公开(公告)日：2023-01-05

    申请号：US17930994

    申请日：2022-09-09

    Applicant: Medtronic, Inc.

    Inventor： Amy E. Thompson-Nauman ,  Melissa G.T. Christie ,  Paul J. DeGroot ,  Rick D. McVenes

    IPC: A61N1/05 ,  A61N1/365 ,  A61N1/372 ,  A61N1/375

    Abstract: Implantable leadless cardiac pacing systems and methods for providing substernal pacing using the leadless cardiac pacing systems are described. In one embodiment, an implantable leadless cardiac pacing system includes a housing, a first electrode on the housing, a second electrode on the housing, and a pulse generator within the housing and electrically coupled to the first electrode and the second electrode. The housing is implanted substantially within an anterior mediastinum of a patient and the pulse generator is configured to deliver pacing pulses to a heart of the patient via a therapy vector formed between the first and second electrodes.

    Helical fixation member assembly having bi-directional controlled drug release
    22.
    发明授权
    Helical fixation member assembly having bi-directional controlled drug release 有权

    公开(公告)号：US11083889B2

    公开(公告)日：2021-08-10

    申请号：US15884636

    申请日：2018-01-31

    Applicant: Medtronic, Inc.

    Inventor： Zhongping Yang ,  Andrea Asleson ,  Gonzalo Martinez ,  Rick D. McVenes ,  Christopher W. Storment

    IPC: A61N1/05 ,  A61N1/365 ,  A61N1/375

    Abstract: An implantable medical lead having an elongated lead body extending from a proximal end to a distal end, at least one conductor extending within the lead body from the proximal end to the distal end, and a fixation member having a proximal end and a distal end, the proximal end of the electrode configured to be electrically coupled to the distal end of the lead body. The fixation member includes a first delivery port and a second delivery port for releasing a therapeutic agent from the fixation member to tissue of a patient, wherein the first delivery port is positioned along the proximal end of the fixation member to deliver the therapeutic agent to endothelial cells along an endothelial layer of tissue, and the second delivery port is positioned along the distal end of the fixation member and spaced a distance from the first delivery port to deliver the therapeutic agent to myocardial tissue within a myocardial layer of the tissue, and wherein no delivery ports are positioned within the distance that the second delivery port is spaced from the first delivery port.

    SUBSTERNAL LEADLESS ELECTRICAL STIMULATION SYSTEM
    23.
    发明申请
    SUBSTERNAL LEADLESS ELECTRICAL STIMULATION SYSTEM 审中-公开

    公开(公告)号：US20200289816A1

    公开(公告)日：2020-09-17

    申请号：US16885837

    申请日：2020-05-28

    Applicant: Medtronic, Inc.

    Inventor： Amy E. Thompson-Nauman ,  Melissa G.T. Christie ,  Paul J. DeGroot ,  Rick D. McVenes

    IPC: A61N1/05 ,  A61N1/365 ,  A61N1/372 ,  A61N1/375

    Abstract: Implantable leadless cardiac pacing systems and methods for providing substernal pacing using the leadless cardiac pacing systems are described. In one embodiment, an implantable leadless cardiac pacing system includes a housing, a first electrode on the housing, a second electrode on the housing, and a pulse generator within the housing and electrically coupled to the first electrode and the second electrode. The housing is implanted substantially within an anterior mediastinum of a patient and the pulse generator is configured to deliver pacing pulses to a heart of the patient via a therapy vector formed between the first and second electrodes.

    HELICAL FIXATION MEMBER ASSEMBLY HAVING BI-DIRECTIONAL CONTROLLED DRUG RELEASE
    24.
    发明申请
    HELICAL FIXATION MEMBER ASSEMBLY HAVING BI-DIRECTIONAL CONTROLLED DRUG RELEASE 审中-公开

    公开(公告)号：US20190232053A1

    公开(公告)日：2019-08-01

    申请号：US15884636

    申请日：2018-01-31

    Applicant: Medtronic, Inc.

    Inventor： Zhongping Yang ,  Andrea Asleson ,  Gonzalo Martinez ,  Rick D. McVenes ,  Christopher W. Storment

    IPC: A61N1/05 ,  A61N1/375 ,  A61N1/365

    CPC classification number: A61N1/0575 ,  A61N1/365 ,  A61N1/37512 ,  A61N1/3756

    Abstract: An implantable medical lead having an elongated lead body extending from a proximal end to a distal end, at least one conductor extending within the lead body from the proximal end to the distal end, and a fixation member having a proximal end and a distal end, the proximal end of the electrode configured to be electrically coupled to the distal end of the lead body. The fixation member includes a first delivery port and a second delivery port for releasing a therapeutic agent from the fixation member to tissue of a patient, wherein the first delivery port is positioned along the proximal end of the fixation member to deliver the therapeutic agent to endothelial cells along an endothelial layer of tissue, and the second delivery port is positioned along the distal end of the fixation member and spaced a distance from the first delivery port to deliver the therapeutic agent to myocardial tissue within a myocardial layer of the tissue, and wherein no delivery ports are positioned within the distance that the second delivery port is spaced from the first delivery port.

    METHOD AND APPARATUS FOR MONITORING OF PATIENT MEDICATION COMPLIANCE
    25.
    发明申请
    METHOD AND APPARATUS FOR MONITORING OF PATIENT MEDICATION COMPLIANCE 审中-公开
    用于监测患者药物依从性的方法和装置

    公开(公告)号：US20150165214A1

    公开(公告)日：2015-06-18

    申请号：US14105314

    申请日：2013-12-13

    Applicant: Medtronic, Inc.

    Inventor： Michael J. Ebert ,  Amy Thompson-Nauman ,  Nathan A. Grenz ,  Rick D. McVenes

    IPC: A61N1/37

    CPC classification number: A61N1/3702 ,  A61N1/36535 ,  A61N1/36542 ,  A61N1/371 ,  A61N1/37258 ,  A61N1/37264 ,  G16H20/10 ,  G16H40/63

    Abstract: A method and medical device for monitoring patient medication compliance having a plurality of electrodes to deliver a pacing therapy, and a processor configured to determine a pacing threshold in response to the delivered pacing therapy, determine whether there is a change in the pacing threshold, determine, in response to a change in the pacing threshold determined to be occurring, whether the determined change is sustained, and determine patient medication compliance in response determining whether the determined change is sustained.

    Abstract translation: 一种用于监测具有多个电极以递送起搏治疗的患者药物依从性的方法和医疗装置，以及被配置为响应于所输送的起搏治疗来确定起搏阈值的处理器，确定起搏阈值是否存在变化，确定 响应于确定发生的起搏阈值的变化，所确定的变化是否持续，并且响应于确定确定的变化是否持续而确定患者药物依从性。

    ELECTRODE ASSEMBLIES AND ASSOCIATED FIXATION MEMBERS FOR IMPLANTABLE MEDICAL DEVICES
    26.
    发明申请
    ELECTRODE ASSEMBLIES AND ASSOCIATED FIXATION MEMBERS FOR IMPLANTABLE MEDICAL DEVICES 有权
    用于可植入医疗器械的电极组件和相关固定部件

    公开(公告)号：US20150151117A1

    公开(公告)日：2015-06-04

    申请号：US14611838

    申请日：2015-02-02

    Applicant: Medtronic, Inc.

    Inventor： Michael D. Eggen ,  Zhongping Yang ,  Rick D. McVenes ,  Noelle C. Neafus ,  Raymond W. Usher

    IPC: A61N1/05

    CPC classification number: A61N1/0573 ,  A61N1/059 ,  A61N1/37205

    Abstract: A fixation member of an electrode assembly for an implantable medical device includes a tissue engaging portion extending along a circular path, between a piercing distal tip thereof and a fixed end of the member. The circular path extends around a longitudinal axis of the assembly. A helical structure of the assembly, which includes an electrode surface formed thereon and a piercing distal tip, also extends around the longitudinal axis and is located within a perimeter of the circular path. The tissue engaging portion of the fixation member extends from the distal tip thereof in a direction along the circular path that is the same as that in which the helical structure extends from the distal tip thereof. The electrode assembly may include a pair of the fixation members, wherein each tissue engaging portion may extend approximately one half turn along the circular path.

    Abstract translation: 用于可植入医疗装置的电极组件的固定构件包括沿圆形路径延伸的组织接合部分，其穿孔远端和构件的固定端之间。 圆形路径围绕组件的纵向轴线延伸。 包括其上形成的电极表面和穿刺的远端的组件的螺旋结构也围绕纵向轴线延伸并且位于圆形路径的周边内。 固定构件的组织接合部分沿着与其螺旋结构从其远端延伸的方向相同的圆形路径的方向从其远端延伸。 电极组件可以包括一对固定构件，其中每个组织接合部分可以沿着圆形路径延伸约一半匝。

    METHOD AND APPARATUS FOR CARDIAC FUNCTION MONITORING
    27.
    发明申请
    METHOD AND APPARATUS FOR CARDIAC FUNCTION MONITORING 有权
    心脏功能监测的方法和装置

    公开(公告)号：US20150112216A1

    公开(公告)日：2015-04-23

    申请号：US14056003

    申请日：2013-10-17

    Applicant: Medtronic, Inc.

    Inventor： Amy E. Thompson-Nauman ,  Michael J. Ebert ,  Rick D. McVenes ,  Nathan A. Grenz

    IPC: A61B5/0402

    CPC classification number: A61B5/0402 ,  A61B5/14546 ,  A61B5/686 ,  A61N1/0587 ,  A61N1/37247 ,  A61N1/37258 ,  A61N1/37264 ,  G16H40/63

    Abstract: A method and medical device for monitoring cardiac function in a patient that includes a plurality of electrodes to deliver cardiac pacing therapy, and a processor configured to determine a pacing threshold in response to initial delivery of the pacing therapy, determine whether there is a change in the pacing threshold during initial delivery of the pacing therapy, adjust a delivery parameter of the pacing therapy in response to determining the change in the pacing threshold during initial delivery of the pacing therapy, determine whether there is an increase in the pacing threshold during delivery of the adjusted pacing therapy, and determine hypokalemia in response to the increase in the pacing threshold during delivery of the adjusted pacing therapy being present.

    Abstract translation: 一种用于监测患者心脏功能的方法和医疗装置，所述方法和医疗装置包括多个用于递送心脏起搏疗法的电极，以及配置成响应于起搏治疗的初始递送确定起搏阈值的处理器，确定是否存在改变 在起搏治疗的初始递送期间的起搏阈值，响应于确定起搏治疗的初始递送过程中起搏阈值的变化，调整起搏治疗的递送参数，确定在分娩期间起搏阈值是否增加 调整的起搏治疗，并且响应于调节起搏治疗的递送期间起搏阈值的增加来确定低钾血症。

    IMPLANTABLE MEDICAL DEVICE SYSTEM HAVING IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR (ICD) SYSTEM AND SUBSTERNAL LEADLESS PACING DEVICE
    28.
    发明申请
    IMPLANTABLE MEDICAL DEVICE SYSTEM HAVING IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR (ICD) SYSTEM AND SUBSTERNAL LEADLESS PACING DEVICE 有权
    具有可植入式减速器（ICD）系统和后置式无铅装置的可植入医疗装置系统

    公开(公告)号：US20140330326A1

    公开(公告)日：2014-11-06

    申请号：US14261460

    申请日：2014-04-25

    Applicant: Medtronic, Inc.

    Inventor： Amy E. Thompson-Nauman ,  Melissa G.T. Christie ,  Paul J. DeGroot ,  Rick D. McVenes

    IPC: A61N1/39

    CPC classification number: A61N1/3918 ,  A61N1/362 ,  A61N1/37288 ,  A61N1/375 ,  A61N1/39 ,  A61N1/3962

    Abstract: Implantable cardiac systems and methods for providing substernal pacing in an ICD system are described. In one example, an implantable cardiac system comprises an ICD system and an implantable leadless pacing device (LPD) communicatively coupled to the ICD system. The ICD system includes an ICD and an implantable defibrillation lead having a proximal portion coupled to the ICD and a distal portion having a defibrillation electrode configured to deliver a defibrillation shock to a heart of the patient. The LPD includes a housing, a first electrode on the housing, a second electrode on the housing, and a pulse generator within the housing and electrically coupled to the first electrode and the second electrode. The housing of the LPD is implanted substantially within an anterior mediastinum of the patient and the pulse generator is configured to deliver pacing pulses to a heart via the first and second electrodes.

    Abstract translation: 描述了可植入心脏系统和在ICD系统中提供次要起搏的方法。 在一个示例中，可植入心脏系统包括通信地耦合到ICD系统的ICD系统和可植入无引线起搏装置（LPD）。 ICD系统包括ICD和可植入除颤引线，其具有耦合到ICD的近端部分和具有除颤电极的远端部分，该除颤电极构造成将除颤电击递送到患者的心脏。 LPD包括壳体，壳体上的第一电极，壳体上的第二电极，以及壳体内的脉冲发生器，并电耦合到第一电极和第二电极。 LPD的壳体基本上植入患者的前纵隔中，并且脉冲发生器构造成经由第一和第二电极将起搏脉冲输送到心脏。

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