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21.发明授权Inhibitors of catechol O-methyl transferase and their use in the treatment of psychotic disorders 有权儿茶酚O-甲基转移酶的抑制剂及其在治疗精神病中的应用公开(公告)号：US09024032B2
公开(公告)日：2015-05-05
申请号：US13582601
申请日：2011-02-28
申请人： Scott Wolkenberg , James C. Barrow , Michael S. Poslusney , Scott T. Harrison , B. Wesley Trotter , James Mulhearn , Kausik K. Nanda , Peter J. Manley , Zhijian Zhao , Jeffrey W. Schubert , Nathan Kett , Amy Zartman
发明人： Scott Wolkenberg , James C. Barrow , Michael S. Poslusney , Scott T. Harrison , B. Wesley Trotter , James Mulhearn , Kausik K. Nanda , Peter J. Manley , Zhijian Zhao , Jeffrey W. Schubert , Nathan Kett , Amy Zartman
IPC分类号： A61K31/44 , C07D211/90 , C07D213/69 , A61K31/4412 , A61K31/4418 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/5377 , A61K31/541 , A61K31/69 , A61K45/06 , C07D213/73 , C07D213/74 , C07D401/10 , C07D401/14 , C07D413/10 , C07D413/12 , C07D417/10 , C07D471/04 , C07F5/02 , C07D401/04 , C07D401/06
CPC分类号： C07F5/025 , A61K31/4412 , A61K31/4418 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/5377 , A61K31/541 , A61K31/69 , A61K45/06 , C07D213/69 , C07D213/73 , C07D213/74 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D413/10 , C07D413/12 , C07D417/10 , C07D471/04
摘要： The present invention relates to 4-pyridinone compounds which are inhibitors of catechol O-methyltransferase (COMT), and are useful in the treatment and prevention of neurological and psychiatric disorders and diseases in which COMT enzyme is involved. The present invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which COMT is involved.
摘要翻译： 本发明涉及作为儿茶酚O-甲基转移酶（COMT）的抑制剂的4-吡啶酮化合物，可用于治疗和预防涉及COMT酶的神经和精神疾病和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及COMT的疾病中的用途。
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22.发明授权Inhibitors of catechol O-methyl transferase and their use in the treatment of psychotic disorders 有权儿茶酚O-甲基转移酶的抑制剂及其在治疗精神病中的应用公开(公告)号：US08969364B2
公开(公告)日：2015-03-03
申请号：US13582637
申请日：2011-02-28
申请人： Scott Wolkenberg , Scott T. Harrison , James C. Barrow , Zhijian Zhao , Jeffrey Melamed , Nathan R. Kett , Amy Zartman
发明人： Scott Wolkenberg , Scott T. Harrison , James C. Barrow , Zhijian Zhao , Jeffrey Melamed , Nathan R. Kett , Amy Zartman
IPC分类号： A01N43/54 , A61K31/505 , C07D401/14 , A61K31/519 , C07D239/54 , C07D239/553 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , C07D413/10 , C07D417/10 , C07D471/04 , C07D498/04 , A61K31/513 , A61K45/06
CPC分类号： C07D401/14 , A61K31/505 , A61K31/513 , A61K31/519 , A61K45/06 , C07D239/54 , C07D239/553 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , C07D413/10 , C07D417/10 , C07D471/04 , C07D498/04
摘要： The present invention relates to 4-pyridinone compounds which are inhibitors of catechol O-methyltransferase (COMT), and are useful in the treatment and prevention of neurological and psychiatric disorders and diseases in which COMT enzyme is involved. The present invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which COMT is involved.
摘要翻译： 本发明涉及作为儿茶酚O-甲基转移酶（COMT）的抑制剂的4-嘧啶酮化合物，可用于治疗和预防涉及COMT酶的神经和精神疾病和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及COMT的疾病中的用途。
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23.发明申请INHIBITORS OF CATECHOL O-METHYL TRANSFERASE AND THEIR USE IN THE TREATMENT OF PSYCHOTIC DISORDERS 有权CATECHOL O-METHYL TRANSFERASE的抑制剂及其在治疗心理疾病中的应用公开(公告)号：US20130196002A1
公开(公告)日：2013-08-01
申请号：US13582637
申请日：2011-02-28
申请人： Scott Wolkenberg , Scott T. Harrison , James C. Barrow , Zhijian Zhao , Jeffrey Melamed , Nathan R. Kett , Amy Zartman
发明人： Scott Wolkenberg , Scott T. Harrison , James C. Barrow , Zhijian Zhao , Jeffrey Melamed , Nathan R. Kett , Amy Zartman
IPC分类号： C07D401/14 , A61K45/06 , C07D401/10 , C07D239/54 , A61K31/513
CPC分类号： C07D401/14 , A61K31/505 , A61K31/513 , A61K31/519 , A61K45/06 , C07D239/54 , C07D239/553 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , C07D413/10 , C07D417/10 , C07D471/04 , C07D498/04
摘要： The present invention relates to 4-pyridinone compounds which are inhibitors of catechol O-methyltransferase (COMT), and are useful in the treatment and prevention of neurological and psychiatric disorders and diseases in which COMT enzyme is involved. The present invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which COMT is involved.
摘要翻译： 本发明涉及作为儿茶酚O-甲基转移酶（COMT）的抑制剂的4-嘧啶酮化合物，可用于治疗和预防涉及COMT酶的神经和精神疾病和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及COMT的疾病中的用途。
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24.发明申请公开(公告)号：US20130084346A1
公开(公告)日：2013-04-04
申请号：US13582601
申请日：2011-02-28
申请人： Scott Wolkenberg , James C. Barrow , Michael S. Poslusney , Scott T. Harrison , B. Wesley Trotter , James Mulhearn , Kausik K. Nanda , Peter J. Manley , Zhijian Zhao , Jeffrey W. Schubert , Nathan Kett , Amy Zartman
发明人： Scott Wolkenberg , James C. Barrow , Michael S. Poslusney , Scott T. Harrison , B. Wesley Trotter , James Mulhearn , Kausik K. Nanda , Peter J. Manley , Zhijian Zhao , Jeffrey W. Schubert , Nathan Kett , Amy Zartman
IPC分类号： C07D213/69 , C07D401/10 , A61K31/4439 , C07D213/73 , C07D213/74 , C07F5/02 , A61K31/69 , A61K31/444 , C07D401/14 , C07D471/04 , A61K31/4725 , A61K31/4709 , A61K45/06 , C07D413/10 , A61K31/5377 , A61K31/4545 , C07D417/10 , A61K31/541 , C07D413/12 , A61K31/4418
CPC分类号： C07F5/025 , A61K31/4412 , A61K31/4418 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/5377 , A61K31/541 , A61K31/69 , A61K45/06 , C07D213/69 , C07D213/73 , C07D213/74 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D413/10 , C07D413/12 , C07D417/10 , C07D471/04
摘要： The present invention relates to 4-pyridinone compounds which are inhibitors of catechol O-methyltransferase (COMT), and are useful in the treatment and prevention of neurological and psychiatric disorders and diseases in which COMT enzyme is involved. The present invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which COMT is involved.
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公开(公告)号：US08263627B2
公开(公告)日：2012-09-11
申请号：US13008161
申请日：2011-01-18
申请人： James C. Barrow , Thomas S. Reger , Zhi-Qiang Yang
发明人： James C. Barrow , Thomas S. Reger , Zhi-Qiang Yang
IPC分类号： A61K31/445 , A61K31/415 , C07D213/00 , C07D213/72
CPC分类号： C07D413/12 , C07D213/40 , C07D213/61 , C07D213/65 , C07D213/73 , C07D213/74 , C07D213/75 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D411/12
摘要： The present invention is directed to pyridyl amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.
摘要翻译： 本发明涉及作为T型钙通道拮抗剂的吡啶酰胺化合物，其可用于治疗或预防其中涉及T型钙通道的疾病和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及T型钙通道的疾病中的用途。
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公开(公告)号：US20100261724A1
公开(公告)日：2010-10-14
申请号：US12739294
申请日：2008-10-23
申请人： James C. Barrow , Paul J. Coleman , Thomas S. Reger , Kelly-Ann S. Schlegel , Youheng Shu , Zhi-Qiang Yang
发明人： James C. Barrow , Paul J. Coleman , Thomas S. Reger , Kelly-Ann S. Schlegel , Youheng Shu , Zhi-Qiang Yang
IPC分类号： A61K31/5025 , C07D401/12 , A61K31/517 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/30 , A61K31/497 , A61K31/4439 , C07D487/04 , C07D413/12 , A61K31/443 , C07D405/12 , C07D417/12 , A61K31/437 , C07D471/04
CPC分类号： C07D401/12 , C07D213/65 , C07D405/12 , C07D413/12 , C07D417/12 , C07D487/04
摘要： The present invention is directed to heterocycle phenyl amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.
摘要翻译： 本发明涉及作为T型钙通道拮抗剂的杂环苯酰胺化合物，其可用于治疗或预防涉及T型钙通道的疾病和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及T型钙通道的疾病中的用途。
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公开(公告)号：US20100222387A1
公开(公告)日：2010-09-02
申请号：US11922390
申请日：2006-06-21
IPC分类号： A61K31/4545 , C07D211/14 , A61K31/445 , C07D401/06 , A61P25/02 , A61P25/16 , A61P25/28 , A61P25/20 , A61P25/22 , A61P25/00 , A61K31/4523 , C07D413/06
CPC分类号： C07D211/38 , C07D405/06 , C07D413/06
摘要： The present invention is directed to 3-fluoro-piperidine compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.
摘要翻译： 本发明涉及作为T型钙通道拮抗剂的3-氟哌啶化合物，其可用于治疗或预防其中涉及T型钙通道的神经和精神疾病和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及T型钙通道的疾病中的用途。
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公开(公告)号：US06403612B2
公开(公告)日：2002-06-11
申请号：US09772352
申请日：2001-01-30
IPC分类号： A61K3154
CPC分类号： C07D207/08 , A61K45/06 , C07D207/12 , C07D211/22 , C07D211/42 , C07D277/04
摘要： A thrombin receptor antagonist having the formula or a pharmaceutically acceptable salt thereof, useful for inhibiting the aggregation of blood platelets. The compounds can be used in a method of acting upon a thrombin receptor which comprises administering a therapeutically effective but non-toxic amount of such compound to a mammal, preferably a human.
摘要翻译： 具有下式的凝血酶受体拮抗剂或其药学上可接受的盐，其可用于抑制血小板聚集。 该化合物可用于作用于凝血酶受体的方法，该方法包括向哺乳动物，优选人类施用治疗有效但无毒量的此类化合物。
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29.发明授权公开(公告)号：US09309199B2
公开(公告)日：2016-04-12
申请号：US13582555
申请日：2011-02-28
申请人： Scott Wolkenberg , James C. Barrow , Scott T. Harrison , B. Wesley Trotter , Kausik K. Nanda , Peter J. Manley , Zhijian Zhao
发明人： Scott Wolkenberg , James C. Barrow , Scott T. Harrison , B. Wesley Trotter , Kausik K. Nanda , Peter J. Manley , Zhijian Zhao
IPC分类号： C07D211/86 , C07D213/69 , C07D213/84 , C07D213/85 , C07D401/04 , C07D413/10 , C07D417/04
CPC分类号： C07D213/69 , C07D211/86 , C07D213/84 , C07D213/85 , C07D401/04 , C07D413/10 , C07D417/04
摘要： The present invention relates to 4-pyridinone compounds which are inhibitors of catechol O-methyltransferase (COMT), and are useful in the treatment and prevention of neurological and psychiatric disorders and diseases in which COMT enzyme is involved. The present invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which COMT is involved.
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公开(公告)号：US08637513B2
公开(公告)日：2014-01-28
申请号：US12739294
申请日：2008-10-23
申请人： James C. Barrow , Paul J. Coleman , Thomas S. Reger , Kelly-Ann S. Schlegel , Youheng Shu , Zhi-Qiang Yang
发明人： James C. Barrow , Paul J. Coleman , Thomas S. Reger , Kelly-Ann S. Schlegel , Youheng Shu , Zhi-Qiang Yang
IPC分类号： C07D401/12 , A61K31/517 , A61K31/497 , A61K31/4439 , C07D487/04 , A61K31/5025 , C07D413/12 , A61K31/443 , C07D417/12 , A61K31/4436 , C07D213/63 , C07D239/74 , C07D241/36 , C07D471/02 , A61P25/08 , A61P29/00 , A61P25/18 , A61P25/16 , A61P25/24 , A61P25/22 , A61P9/08 , A61P9/12 , A61P35/00 , A61P31/10
CPC分类号： C07D401/12 , C07D213/65 , C07D405/12 , C07D413/12 , C07D417/12 , C07D487/04
摘要： The present invention is directed to heterocycle phenyl amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.
摘要翻译： 本发明涉及作为T型钙通道拮抗剂的杂环苯酰胺化合物，其可用于治疗或预防涉及T型钙通道的疾病和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及T型钙通道的疾病中的用途。
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