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公开(公告)号：US20080285823A1
公开(公告)日：2008-11-20
申请号：US12094641
申请日：2006-11-13
IPC分类号： G06K9/00
CPC分类号： G01N21/4795 , A61B5/0091 , G01N21/6456 , G01N2021/1787 , G01N2021/6421
摘要： The invention relates to a device (1) for imaging an interior of a turbid medium (25). The device (1) may be used to accommodate a turbid medium (25) inside a measurement volume (20) and irradiate the turbid medium (25) with light from a light source (5), after which light emanating from the measurement volume (20) is detected and used to determine an image of the interior of the turbid medium (25). The device (1) is adapted such that additional means are introduced for irradiating the turbid medium (25) with light causing fluorescent emission in a contrast agent present in the turbid medium (25), for detecting the fluorescent emission in at least two spectral regions, and for calculating an image reconstruction for the at least two spectral regions detected. By detecting the fluorescent emission spectroscopically, that is as a function of wavelength, information can be obtained from which the concentration of a predetermined component present inside the turbid medium can be determined.
摘要翻译： 本发明涉及一种用于对浑浊介质（25）的内部进行成像的装置（1）。 装置（1）可以用于容纳测量体积（20）内部的混浊介质（25），并用来自光源（5）的光照射混浊介质（25），之后从测量体积 20）被检测并用于确定混浊介质（25）内部的图像。 装置（1）适于使得附加装置被引入以用在浑浊介质（25）中存在的造影剂中引起荧光发射的光照射混浊介质，用于检测至少两个光谱区域中的荧光发射 并且用于计算所检测的所述至少两个光谱区域的图像重建。 通过检测荧光发射光谱，即作为波长的函数，可以获得可以确定存在于混浊介质内的预定成分的浓度的信息。
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公开(公告)号：US20080062401A1
公开(公告)日：2008-03-13
申请号：US11570137
申请日：2005-06-22
CPC分类号： G01N21/65 , G01N2021/653 , G01N2021/655
摘要： The present invention provides a spectroscopic system for non invasive spectral analysis of substances or biological structures (114, 116) that are located in a plurality of various volumes of interest (110, 112). The inventive spectroscopic system makes use of a multiplicity of various probe heads (106, 108) that are connected to a base station (100) providing a spectroscopic light source (104) and spectroscopic analysis means (102) . By additionally implementing a coupling unit (132) the present invention allows to realize a spectroscopic analysis environment that makes spectroscopic analysis available in a variety of different locations, e.g. various rooms of a hospital.
摘要翻译： 本发明提供了一种用于对位于多个不同感兴趣体积（110,112）中的物质或生物结构（114,116）进行无创光谱分析的光谱系统。 本发明的光谱系统利用连接到提供分光光源（104）的基站（100）和光谱分析装置（102）的多个各种探头（106,108）。 通过附加地实现耦合单元（132），本发明允许实现使得光谱分析在各种不同位置（例如， 一间医院的各种房间。
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公开(公告)号：US09398877B2
公开(公告)日：2016-07-26
申请号：US12094670
申请日：2006-11-17
IPC分类号： A61B5/1455 , A61B5/00
CPC分类号： A61B5/4312 , A61B5/0091 , A61B5/1455 , A61B5/14551
摘要： Disclosed is a method and a device for optical imaging of a turbid medium. This method comprises a reference measurement of reference intensities of light emanating from the turbid medium at a reference blood oxygen saturation (SaO2) in the turbid medium and a reference imaging step for reconstructing a reference image of the turbid medium from the measured reference intensities. Furthermore the method comprises a contrast measurement of the contrast intensity of the light emanating from the turbid medium at a contrast blood oxygen saturation (SaO2) level in the turbid medium and a contrast imaging step for reconstructing a contrast image of the turbid medium from the measured contrast intensities. A comparison is made between the contrast image to the reference image of the turbid medium.
摘要翻译： 公开了一种用于浑浊介质的光学成像的方法和装置。 该方法包括在混浊介质中以参考血氧饱和度（SaO2）从混浊介质发出的光的参考光强度的参考测量值，以及用于根据测量的参考光强度重建浊度介质的参考图像的参考成像步骤。 此外，该方法包括在浑浊培养基中以对比血氧饱和度（SaO2）水平从浑浊培养基发出的光的对比度强度的对比度测量，以及用于从所测量的重量中重建浑浊培养基的对比度图像的对比度成像步骤 对比强度。 对比图像与混浊介质的参考图像之间进行比较。
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24.发明申请公开(公告)号：US20100258741A1
公开(公告)日：2010-10-14
申请号：US12741044
申请日：2008-11-03
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , A61B5/0091 , G01N21/6456 , G01N2021/1787 , G01N2021/6484
摘要： The invention relates to a method and a device (30, 125) for imaging an interior of an optically turbid medium (40). Light from a light source (35) is coupled into the turbid medium (40). Detection light emanating from the turbid medium (40) as a result of coupling (5) light from the light source (35) into the turbid medium (40) is collected. A first characteristic and a second characteristic of collected detection light are measured simultaneously. Next, the ratio of a first linear combination of the measured characteristics and a second linear combination of the measured characteristics is taken based on the recognition that the noise in both linear combinations is correlated.
摘要翻译： 本发明涉及一种用于对光学混浊介质（40）的内部进行成像的方法和装置（30,125）。 来自光源（35）的光被耦合到混浊介质（40）中。 收集从光源（35）到混浊介质（40）的耦合（5）从混浊介质（40）发出的检测光。 同时测量收集的检测光的第一特性和第二特性。 接下来，基于两个线性组合中的噪声相关的认识来获得测量特性的第一线性组合与测量特性的第二线性组合的比率。
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25.发明申请SYSTEM, DEVICE, METHOD, COMPUTER-READABLE MEDIUM, AND USE FOR IN VIVO IMAGING OF TISSUE IN AN ANATOMICAL STRUCTURE 审中-公开系统，装置，方法，计算机可读介质，以及用于在解剖结构中进行组织成像的用途公开(公告)号：US20100056916A1
公开(公告)日：2010-03-04
申请号：US12515023
申请日：2007-11-16
申请人： Levinus Peter Bakker , Michael Cornelis Van Beek , Martinus Bernardus Van Der Mark , Rene Van Den Ham , Bernardus Hendrikus Wilhelmus Hendriks , Ralf Hoffmann , Nijs Cornelis Van Der Vaart , Marjolein Van Der Voort
发明人： Levinus Peter Bakker , Michael Cornelis Van Beek , Martinus Bernardus Van Der Mark , Rene Van Den Ham , Bernardus Hendrikus Wilhelmus Hendriks , Ralf Hoffmann , Nijs Cornelis Van Der Vaart , Marjolein Van Der Voort
CPC分类号： A61B5/0095 , A61B5/0035 , A61B5/0084 , A61B5/0086 , A61B8/12 , A61B8/4416
摘要： A system is provided that may be used for locating and diagnosing lesions in the human body in vivo. In some embodiments, once the exact position of a lesion is found, a biopsy may be taken from the lesion using e.g. ultra sound techniques for guidance of the biopsy needle. Use of the system drastically reduces the negative biopsy samples compared to currently used “blind sampling” techniques. This reduces patient discomfort and minimizes infections as the number of biopsy samples is reduced. A method and computer-readable medium is also provided.
摘要翻译： 提供了可用于在体内定位和诊断人体损伤的系统。 在一些实施例中，一旦发现病变的确切位置，可以使用例如病变从病变中取出活组织检查。 超声技术用于指导活检针。 与目前使用的“盲采”技术相比，使用该系统大大减少了活检样本的阴性。 随着活检样本的数量减少，这减少了患者的不适，并使感染最小化。 还提供了一种方法和计算机可读介质。
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公开(公告)号：US20090231587A1
公开(公告)日：2009-09-17
申请号：US12513686
申请日：2007-11-13
IPC分类号： A61B5/00
CPC分类号： A61B5/4312 , A61B5/0091
摘要： The invention relates to a device (1) for imaging an interior of a turbid medium (55) comprising a receptacle (20) with the receptacle (20) comprising a measurement volume (15) for receiving the turbid medium (55). The device (1) is adapted such that the inner surface of the receptacle (20), including at least part of the optical channels (70) is covered with a layer (80).
摘要翻译： 本发明涉及一种用于对包含容器（20）的混浊介质（55）的内部成像的装置（1），所述容器（20）包括用于接收混浊介质（55）的测量体积（15）。 设备（1）适于使得包括至少部分光通道（70）的容器（20）的内表面被层（80）覆盖。
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公开(公告)号：US07557916B2
公开(公告)日：2009-07-07
申请号：US11570137
申请日：2005-06-22
IPC分类号： G01J3/30
CPC分类号： G01N21/65 , G01N2021/653 , G01N2021/655
摘要： The present invention provides a spectroscopic system for non invasive spectral analysis of substances or biological structures (114, 116) that are located in a plurality of various volumes of interest (110, 112). The inventive spectroscopic system makes use of a multiplicity of various probe heads (106, 108) that are connected to a base station (100) providing a spectroscopic light source (104) and spectroscopic analysis means (102) . By additionally implementing a coupling unit (132) the present invention allows to realize a spectroscopic analysis environment that makes spectroscopic analysis available in a variety of different locations, e.g. various rooms of a hospital.
摘要翻译： 本发明提供了一种用于对位于多个不同感兴趣体积（110,112）中的物质或生物结构（114,116）进行无创光谱分析的光谱系统。 本发明的光谱系统利用连接到提供分光光源（104）的基站（100）和光谱分析装置（102）的多个各种探头（106,108）。 通过附加地实现耦合单元（132），本发明允许实现使得光谱分析在各种不同位置（例如， 一间医院的各种房间。
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公开(公告)号：US20090046291A1
公开(公告)日：2009-02-19
申请号：US12093964
申请日：2006-10-27
申请人： Martinus Bernadus Van Der Mark , Michael Cornelis Van Beek , Levinus Pieter Bakker , arnoldus Johannes Martinus Jozeph Ras
发明人： Martinus Bernadus Van Der Mark , Michael Cornelis Van Beek , Levinus Pieter Bakker , arnoldus Johannes Martinus Jozeph Ras
IPC分类号： G01N21/49
CPC分类号： A61B5/4312 , A61B5/0073 , A61B5/0091 , A61B2562/146
摘要： The invention relates to a device (1) for imaging an interior of a turbid medium (55) comprising a receptacle (20) with the receptacle (20) comprising a measurement volume (15) for receiving the turbid medium (55). The device (1) is adapted such that the device (1) further comprises a further receptacle (60), arranged to be inserted into the receptacle (20), with the further receptacle (60) comprising a restricted measurement volume (75) for receiving the turbid medium (55).
摘要翻译： 本发明涉及一种用于对包含容器（20）的混浊介质（55）的内部成像的装置（1），所述容器（20）包括用于接收混浊介质（55）的测量体积（15）。 装置（1）适于使得装置（1）还包括设置成插入到容器（20）中的另一个容器（60），另外的容器（60）包括限制的测量体积（75），用于 接收混浊介质（55）。
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公开(公告)号：US07486978B2
公开(公告)日：2009-02-03
申请号：US10554352
申请日：2004-04-23
申请人： Michael Cornelis Van Beek , Coen Theodorus Hubertus Fransiscus Liedenbaum , Gerhardus Wilhelmus Lucassen , Wouter Harry Jacinth Rensen
发明人： Michael Cornelis Van Beek , Coen Theodorus Hubertus Fransiscus Liedenbaum , Gerhardus Wilhelmus Lucassen , Wouter Harry Jacinth Rensen
IPC分类号： A61B5/1455
CPC分类号： A61B5/14532 , A61B5/14542 , A61B5/14546 , A61B5/1459 , A61B6/481 , A61B6/504 , A61B2562/0238
摘要： The present invention relates to a catheter head comprising: means (104, 108; 306, 304; 320; 322; 326; 338) for directing of radiation to a blood detection volume (220; 310), means (104, 108; 306, 304; 320; 322; 326; 332, 334, 330; 338) for receiving of return radiation from the blood detection volume, means (104; 306; 330) for transmitting of the return radiation to means (122) for analysis of the return radiation for determination of at least one property of the blood.
摘要翻译： 本发明涉及一种导管头，包括：用于将辐射引导到血液检测体积（220; 310）的装置（104,108; 306,304; 320; 322; 326; 338） 用于从所述血液检测体积接收返回辐射的装置，用于将所述返回辐射传送到装置（122）的装置（104; 306; 330）用于分析 用于确定血液的至少一种性质的返回辐射。
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30.发明申请OPTICAL ANALYSIS SYSTEM, BLOOD ANALYSIS SYSTEM AND METHOD OF DETERMINING AN AMPLITUDE OF A PRINCIPAL COMPONENT 审中-公开光学分析系统，血液分析系统和确定主成分的幅度的方法公开(公告)号：US20090015819A1
公开(公告)日：2009-01-15
申请号：US10596563
申请日：2004-12-13
申请人： Michael Cornelis Van Beek , Bernardus Leonardus Bakker , Wouter Harry Jacinth Rensen , Frank Jeroen Pieter Schuurmans
发明人： Michael Cornelis Van Beek , Bernardus Leonardus Bakker , Wouter Harry Jacinth Rensen , Frank Jeroen Pieter Schuurmans
IPC分类号： G01N33/48
CPC分类号： G01N21/31 , G01J3/28 , G01N21/274 , G01N21/64 , G01N21/6445 , G01N21/65 , G01N2021/3196 , G01N2021/6417 , G01N2021/655
摘要： The optical analysis system (20) is arranged to determine an amplitude of a principal component of an optical signal. The optical analysis system (20) comprises a multivariate optical element (5, 6) for weighing the optical signal by a spectral weighing function and a detector (7, 8) for detecting the weighed optical signal. The optical signal comprises the principal component and a further component which was not accounted for when designing the spectral weighing function. Therefore, the detected weighed optical signal comprises a part relating to the amplitude of the principal component and a further part relating to a further amplitude of the further component. The optical analysis system (20) further comprises a modulator element (13) for modulating the detected weighed optical signal. The difference between the modulated detected weighed optical signal and the detected weighed optical signal relates to the amplitude of the principal component and thus allows for determining the amplitude of the principal component in an accurate way. The blood analysis system (40) comprises such an optical analysis system (20). The method of determining an amplitude of an principal component makes use of the optical analysis system (20).
摘要翻译： 光学分析系统（20）被布置成确定光信号的主分量的幅度。 光学分析系统（20）包括用于通过光谱称重功能称量光信号的多元光学元件（5,6）和用于检测加权光信号的检测器（7,8）。 光信号包括主分量和另外的分量，在设计光谱称重功能时不考虑。 因此，检测到的加权光信号包括与主分量的振幅有关的部分，以及与另一分量的另一幅度相关的另一部分。 光学分析系统（20）还包括用于调制检测到的称重光信号的调制器元件（13）。 调制检测到的称重光信号与检测到的称重光信号之间的差异与主分量的振幅有关，因此允许以准确的方式确定主分量的振幅。 血液分析系统（40）包括这样的光学分析系统（20）。 确定主成分的振幅的方法利用光学分析系统（20）。
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