公开(公告)号：US07486978B2

公开(公告)日：2009-02-03

申请号：US10554352

申请日：2004-04-23

申请人： Michael Cornelis Van Beek ,  Coen Theodorus Hubertus Fransiscus Liedenbaum ,  Gerhardus Wilhelmus Lucassen ,  Wouter Harry Jacinth Rensen

发明人： Michael Cornelis Van Beek ,  Coen Theodorus Hubertus Fransiscus Liedenbaum ,  Gerhardus Wilhelmus Lucassen ,  Wouter Harry Jacinth Rensen

IPC分类号： A61B5/1455

CPC分类号： A61B5/14532 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/1459 ,  A61B6/481 ,  A61B6/504 ,  A61B2562/0238

摘要： The present invention relates to a catheter head comprising: means (104, 108; 306, 304; 320; 322; 326; 338) for directing of radiation to a blood detection volume (220; 310), means (104, 108; 306, 304; 320; 322; 326; 332, 334, 330; 338) for receiving of return radiation from the blood detection volume, means (104; 306; 330) for transmitting of the return radiation to means (122) for analysis of the return radiation for determination of at least one property of the blood.

摘要翻译： 本发明涉及一种导管头，包括：用于将辐射引导到血液检测体积（220; 310）的装置（104,108; 306,304; 320; 322; 326; 338） 用于从所述血液检测体积接收返回辐射的装置，用于将所述返回辐射传送到装置（122）的装置（104; 306; 330）用于分析 用于确定血液的至少一种性质的返回辐射。

公开(公告)号：US08406835B2

公开(公告)日：2013-03-26

申请号：US11568363

申请日：2005-02-14

申请人： Gerhardus Wilhelmus Lucassen ,  Wouter Harry Jacinth Rensen ,  Michael Cornelis Van Beek ,  Marjolein Van Der Voort ,  Bernardus Leonardus Gerardus Bakker

发明人： Gerhardus Wilhelmus Lucassen ,  Wouter Harry Jacinth Rensen ,  Michael Cornelis Van Beek ,  Marjolein Van Der Voort ,  Bernardus Leonardus Gerardus Bakker

IPC分类号： A61B5/1455 ,  A61B5/00 ,  G02B6/44

CPC分类号： A61B5/0059 ,  A61B5/489 ,  A61B2562/0242

摘要： A spectroscopic system for determining a property of a fluid flowing through a volume of interest underneath the surface of the skin of a patient is described. The spectroscopic system comprises: a probe head having an objective for directing an excitation beam into the volume of interest and for collecting return radiation from the volume of interest; a base station having a spectroscopic analysis unit and a power supply; and a cable connecting the probe head and the base station for transmission of the return radiation from the probe head to the base station and for providing the probe head with power from the power supply of the base station.

摘要翻译： 描述了用于确定流过患者皮肤表面下方的感兴趣体积的流体的性质的光谱系统。 分光系统包括：探头，其具有用于将激发光束引导到感兴趣体积中并用于从感兴趣体积收集返回辐射的目标; 具有光谱分析单元和电源的基站; 以及连接探头和基站的电缆，用于将返回辐射从探头传输到基站，并为探头提供来自基站的电源的电力。

公开(公告)号：US20100087739A1

公开(公告)日：2010-04-08

申请号：US12442603

申请日：2007-09-25

申请人： Gerhardus Wilhelmus Lucassen ,  Wouter Harry Jacinth Rensen

发明人： Gerhardus Wilhelmus Lucassen ,  Wouter Harry Jacinth Rensen

IPC分类号： A61B6/00 ,  G01N21/47 ,  G01J4/00

CPC分类号： A61B5/0059 ,  A61B5/441 ,  A61B5/6843 ,  A61B2562/146

摘要： An apparatus for optical body analysis is built with an illumination and detection head, and an optical coupler. The illumination and detection head comprises a light source for illuminating a body portion to analyze through the optical coupler and a detector for receiving light diffusely reflected by the body portion. The optical coupler is mechanically decoupled from the illumination and detection head and is adapted to be in contact with an outer surface of the body portion while the contact between the optical coupler and the body portion minimally affects physical properties of the body portion. The apparatus may further comprise a position unit adapted to adjust the position of the illumination and detection head relative to the optical coupler so that the detector receives through the optical coupler light generated by the light source and diffusely reflected by the body portion.

摘要翻译： 用于光学体分析的装置由照明和检测头以及光耦合器构成。 照明和检测头包括用于照亮身体部分以通过光耦合器分析的光源和用于接收由身体部分漫反射的光的检测器。 光耦合器与照明和检测头机械地分离，并且适于与主体部分的外表面接触，同时光耦合器和主体部分之间的接触最小程度地影响主体部分的物理特性。 该装置还可以包括位置单元，其适于调整照明和检测头相对于光学耦合器的位置，使得检测器通过光耦合器接收由光源产生的并被身体部分漫反射的光。

公开(公告)号：US20090198113A1

公开(公告)日：2009-08-06

申请号：US12303431

申请日：2007-06-05

申请人： Wouter Harry Jacinth Rensen ,  Golo Von Basum ,  Markus Laubscher ,  Gerhardus Wilhelmus Lucassen ,  Miguel Palacios

发明人： Wouter Harry Jacinth Rensen ,  Golo Von Basum ,  Markus Laubscher ,  Gerhardus Wilhelmus Lucassen ,  Miguel Palacios

IPC分类号： A61B5/1455

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  G01N21/314 ,  G01N21/359

摘要： Apparatus and method for an analyte determination in blood, relying on spectroscopic techniques, in which sample is illuminated with light having dedicated spectral characteristics. The first light source (20) is a broadband light source in the IR-range, the second light source (25) is comprised of one or more monochromatic sources, such as laser diodes. The sources are chosen to correspond to wavelength highly correlated with glucose adsorption.

摘要翻译： 依靠光谱技术在血液中进行分析物测定的装置和方法，其中样品用具有专用光谱特征的光照射。 第一光源（20）是IR范围内的宽带光源，第二光源（25）由一个或多个单色源（例如激光二极管）组成。 选择来源对应于与葡萄糖吸附高度相关的波长。

公开(公告)号：US07453564B2

公开(公告)日：2008-11-18

申请号：US10595358

申请日：2004-10-15

申请人： Wouter Harry Rensen ,  Michael Cornelis Van Beek ,  Marjolein Van Der Voort ,  Bernardus Leonardus Bakker ,  Gerhardus Wilhelmus Lucassen ,  Teunis Willem Tukker

发明人： Wouter Harry Rensen ,  Michael Cornelis Van Beek ,  Marjolein Van Der Voort ,  Bernardus Leonardus Bakker ,  Gerhardus Wilhelmus Lucassen ,  Teunis Willem Tukker

IPC分类号： G01J3/00

CPC分类号： A61B5/0059 ,  A61B5/0068 ,  A61B5/489

摘要： A property of a fluid is determined spectroscopically, such as for the purposes of in vivo blood analysis. First the position of a volume of interest through which the fluid flows is determined by an optical detection step by making use of an objective. Preferably the optical detection step is an imaging step. Next the objective is moved to bring the focal point of the objective into coincidence with the volume of interest. In this position an optical spectroscopic step is performed. This has the advantage that the measurement beam for performing the optical spectroscopy travels along the optical axis for optimum efficiency.

摘要翻译： 光谱性质确定流体的性质，例如用于体内血液分析的目的。 首先，通过利用目标的光学检测步骤来确定流体流过的感兴趣体积的位置。 优选地，光学检测步骤是成像步骤。 接下来的目标是使目标的焦点与感兴趣的数量相吻合。 在该位置，进行光学分光步骤。 这具有以下优点：用于执行光学光谱的测量光束沿着光轴行进以获得最佳效率。

公开(公告)号：US09498136B2

公开(公告)日：2016-11-22

申请号：US14112555

申请日：2012-04-10

申请人： Gerhardus Wilhelmus Lucassen ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Rami Nachabe

发明人： Gerhardus Wilhelmus Lucassen ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Rami Nachabe

IPC分类号： A61B5/00 ,  A61B1/00 ,  G01N21/64

CPC分类号： A61B5/0075 ,  A61B1/00 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0091 ,  A61B5/4887 ,  A61B5/6848 ,  A61B5/6852 ,  G01N21/64 ,  G01N2021/6421

摘要： The present invention deals with discrimination of malignant tissue from normal and benign tissue in a single patient on the basis of optical spectroscopic measurements. Starting from spectroscopic measurements in normal tissue, reference values are obtained for the normal class. With spectroscopic measurements in other tissues data points can be assigned to new class(es) when the spectral characteristics fall outside a threshold defining the reference class. Thresholds between different classes can also be defined. Finding (the transition to) malignant tissue is based on comparing the spectroscopic values to the classification threshold discriminating normal and benign versus malignant tissue. Thus, the basis of normal spectroscopic measurements is tuned to the individual patient characteristic. Discriminating the normal plus benign and malignant from that reference is more efficient compared to the reference of the all patient database.

摘要翻译： 本发明基于光学光谱测量法处理单个患者中恶性组织与正常和良性组织的鉴别。 从正常组织中的光谱测量开始，获得正常类的参考值。 通过在其他组织中的光谱测量，当光谱特性落在定义参考类的阈值之外时，可以将数据点分配给新类。 也可以定义不同类之间的阈值。 寻找（过渡到）恶性组织是基于将光谱值与鉴别正常和良性与恶性组织的分类阈值进行比较。 因此，正常光谱测量的基础被调整到个体患者的特征。 与所有患者数据库的参考相比，从该参考文献中区分正常和良性和恶性的效果更高。

公开(公告)号：US09072475B2

公开(公告)日：2015-07-07

申请号：US13881379

申请日：2011-10-17

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Gerhardus Wilhelmus Lucassen ,  Rami Nachabe ,  Theodoor Jacques Marie Ruers

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Gerhardus Wilhelmus Lucassen ,  Rami Nachabe ,  Theodoor Jacques Marie Ruers

IPC分类号： A61B5/1459 ,  A61B5/00 ,  A61M25/06

CPC分类号： A61B5/1459 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/6848 ,  A61B5/6882 ,  A61M25/065

摘要： A needle comprises an elongated first shaft element with a C-shaped cross section and an elongated second shaft element with a C-shaped cross section. The first shaft element and the second shaft element are adapted to be detachably connected to each other. This is achieved by an overlap of respective end sections of the first and second shaft elements. Within the channel formed by the shaft elements, an optical probe may be accommodated from which the shaft elements may be removed by separating the two shaft elements from each other.

摘要翻译： 针包括具有C形横截面的细长的第一轴元件和具有C形横截面的细长的第二轴元件。 第一轴元件和第二轴元件适于彼此可拆卸地连接。 这通过第一和第二轴元件的相应端部部分的重叠来实现。 在由轴元件形成的通道内，可以容纳光学探针，通过将两个轴元件彼此分离，可以从中移除轴元件。

公开(公告)号：US20140142563A1

公开(公告)日：2014-05-22

申请号：US14131518

申请日：2012-07-05

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Nicolaas Jan Noordhoek ,  Gerhardus Wilhelmus Lucassen ,  Pieter Maria Mielekamp ,  Rami Nachabé ,  Marjolein Van Der Voort ,  Waltherus Cornelis Jozef Bierhoff

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Nicolaas Jan Noordhoek ,  Gerhardus Wilhelmus Lucassen ,  Pieter Maria Mielekamp ,  Rami Nachabé ,  Marjolein Van Der Voort ,  Waltherus Cornelis Jozef Bierhoff

IPC分类号： A61B19/00 ,  A61B18/14

CPC分类号： A61B34/10 ,  A61B18/14 ,  A61B2018/00577 ,  A61B2034/101

摘要： The invention relates to an energy application planning apparatus for planning an application of energy to an object (3) like a tumor. An energy application element representation represents an energy application element (5) like an ablation needle including an energy application part for applying energy and a sensing part (7). An arrangement of the energy application element (5) with respect to the object (3) is determined depending on the positions of the energy application part and the sensing part (7) with respect to the energy application element (5) as defined by the energy application element representation and depending on the object representation. The application of energy can therefore not only be planned such that the application of energy is performed as desired, but also such that the object and/or a surrounding of the object are sensible as desired. In this way, the planning procedure can be improved.

摘要翻译： 本发明涉及一种能量应用计划装置，用于规划能量到诸如肿瘤的物体（3）的应用。 能量应用元件表示代表诸如包括用于施加能量的能量施加部分和感测部分（7）的消融针的能量施加元件（5）。 能量施加元件（5）相对于物体（3）的布置根据能量施加部分和感测部分（7）相对于能量施加元件（5）的位置来确定，如由 能量应用元素表示，并取决于对象表示。 因此，能量的施加不仅可以被规划，使得能量的应用按照需要执行，而且还使得物体和/或物体的周围是期望的。 这样可以提高规划程序。

公开(公告)号：US20140121538A1

公开(公告)日：2014-05-01

申请号：US14127692

申请日：2012-06-13

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Gerhardus Wilhelmus Lucassen ,  Jeroen Jan Lambertus Horiks ,  Susanne Dorien Van Den Bergdams ,  Christian Reich ,  Stephan Voss ,  Axel Winkel ,  Rami Nachabe ,  Manfred Muller ,  Marjolein Van Der Voort

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Gerhardus Wilhelmus Lucassen ,  Jeroen Jan Lambertus Horiks ,  Susanne Dorien Van Den Bergdams ,  Christian Reich ,  Stephan Voss ,  Axel Winkel ,  Rami Nachabe ,  Manfred Muller ,  Marjolein Van Der Voort

IPC分类号： A61B5/00 ,  A61B10/02 ,  A61B1/00 ,  A61B1/06 ,  A61B1/07

CPC分类号： A61B1/00009 ,  A61B1/0646 ,  A61B1/0684 ,  A61B1/07 ,  A61B5/0071 ,  A61B5/0073 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/6848 ,  A61B10/0233 ,  F04C2270/0421 ,  Y10T29/49826

摘要： A needle is proposed including a cannula or hollow shaft with a multilumen insert inside. The insert comprises at least two lumen. Both the insert as well as the cannula have bevelled ends. In the insert substantially straight cleaved fibers are present that may be connected at the proximal end to a console. At least one of the distal fiber ends in the insert may protrude more than half the fiber diameter out of the insert. Furthermore, the bevel angle of the insert is different from the bevel angle of the cannula such that combination cannula and insert is such that the fiber ends do not protrude the bevel surface of the cannula.

摘要翻译： 提出了一种针头，其中包括插入件或空心轴，其中具有多孔插入件。 插入件包括至少两个内腔。 插入件以及套管均具有倾斜端部。 在插入件中，存在基本上直的切割的纤维，其可以在近端连接到控制台。 插入件中的远端纤维端部中的至少一个可以突出超过插入件的纤维直径的一半以上。 此外，插入件的斜角与插管的斜角不同，使得组合插管和插入件使得纤维端部不突出套管的斜面。

公开(公告)号：US08417323B2

公开(公告)日：2013-04-09

申请号：US12302053

申请日：2007-05-30

申请人： Natallia Uzunbajakava ,  Rachel Estelle Thilwind ,  Joachim Kahlert ,  Gerhardus Wilhelmus Lucassen

发明人： Natallia Uzunbajakava ,  Rachel Estelle Thilwind ,  Joachim Kahlert ,  Gerhardus Wilhelmus Lucassen

IPC分类号： A61B6/00

CPC分类号： A61B5/0086 ,  A61B5/0084 ,  A61B5/1459 ,  A61B18/24 ,  A61B2562/0242

摘要： An apparatus for depth-resolved measurements of properties of tissue includes an illuminator that illuminates the tissue with light, a collector for collecting light which has not been absorbed by the tissue, and a determination device configured to determine properties of the tissue in different depths from the collected light. A casing for advancing into a hollow object includes at least a part of the illuminator and collector. The illuminator and collector are configured to collect light depth-resolved, and the determination device is configured to determine depth-resolved properties of the tissue from the light which has been collected depth-resolved.

摘要翻译： 用于对组织性质进行深度分辨测量的装置包括用光照射组织的照明器，用于收集未被组织吸收的光的收集器;以及确定装置，其被配置为确定不同深度的组织的性质 收集的光。 用于前进到中空物体的壳体包括照明器和收集器的至少一部分。 照明器和收集器被配置为收集深度分辨的光，并且确定装置被配置为确定已经被深度分辨的光的组织的深度分辨特性。