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公开(公告)号:US20100216779A1
公开(公告)日:2010-08-26
申请号:US12602289
申请日:2008-05-28
申请人: Eric W. Baum , Kyle Allen Emmitte , Kevin Wayne Kuntz , Robert Anthony Mook, JR. , Kristen Elizabeth Nailor , James Michael Salovich , John Brad Shotwell , Stephon Cornell Smith , Kirk Lawrence Stevens , David Edward Uehling , Alex Gregory Waterson , Mui Cheung , Ganesh S. Moorthy , Brian John Wilson
发明人: Eric W. Baum , Kyle Allen Emmitte , Kevin Wayne Kuntz , Robert Anthony Mook, JR. , Kristen Elizabeth Nailor , James Michael Salovich , John Brad Shotwell , Stephon Cornell Smith , Kirk Lawrence Stevens , David Edward Uehling , Alex Gregory Waterson , Mui Cheung , Ganesh S. Moorthy , Brian John Wilson
IPC分类号: A61K31/506 , C07D471/04 , A61K31/5377 , A61K31/551 , A61P35/00
CPC分类号: C07D471/04
摘要: The present invention provides imidazopyridine compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
摘要翻译: 本发明提供咪唑并吡啶化合物,含有它们的组合物,以及其制备方法和用作药剂的方法。
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公开(公告)号:US20080300247A1
公开(公告)日:2008-12-04
申请号:US11754653
申请日:2007-05-29
申请人: Kevin Kuntz , Kyle Allen Emmitte , Tara Renae Rheault , Stephon Smith , Keith Hornberger , Hamilton Dickson , Mui Cheung
发明人: Kevin Kuntz , Kyle Allen Emmitte , Tara Renae Rheault , Stephon Smith , Keith Hornberger , Hamilton Dickson , Mui Cheung
IPC分类号: A61K31/5377 , A61K31/454 , A61K31/4545 , A61P35/00 , C07D401/14 , C07D409/14 , C07D413/14 , C07D403/14 , A61P7/00 , A61K31/496 , A61K31/513
CPC分类号: C07D409/04 , C07D409/14 , C07D413/14
摘要: The present invention provides benzimidazole thiophene compounds pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
摘要翻译: 本发明提供了苯并咪唑噻吩化合物含有它们的药物组合物,其制备方法及其作为药剂的用途。
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公开(公告)号:US20070270437A1
公开(公告)日:2007-11-22
申请号:US11467577
申请日:2006-08-28
申请人: Mui Cheung , Kyle Emmitte , James Salovich
发明人: Mui Cheung , Kyle Emmitte , James Salovich
IPC分类号: A61K31/4184 , A61K31/435 , A61K31/496 , A61P35/00 , C07D221/00 , C07D235/04 , C07D295/00
CPC分类号: C07D409/04 , C07D409/14
摘要: The present invention provides benzimidazole thiophene compounds pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
摘要翻译: 本发明提供苯并咪唑噻吩化合物,其含有它们的药物组合物,其制备方法及其作为药剂的用途。
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公开(公告)号:US20070142437A1
公开(公告)日:2007-06-21
申请号:US11670498
申请日:2007-02-02
申请人: Matthew Brown , Mui Cheung , Scott Dickerson , Cassandra Gauthier , Philip Harris , Robert Hunter , Gregory Pacofsky , Michael Peel , Jeffrey Stafford
发明人: Matthew Brown , Mui Cheung , Scott Dickerson , Cassandra Gauthier , Philip Harris , Robert Hunter , Gregory Pacofsky , Michael Peel , Jeffrey Stafford
IPC分类号: A61K31/4439 , A61K31/427 , A61K31/423 , C07D413/02 , C07D417/02
CPC分类号: C07D263/48 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14
摘要: Oxazole derivatives, which are useful as VEGFR2, CDK2, and CDK4 inhibitors are described herein. The described invention also includes methods of making such oxazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要翻译: 本文描述了可用作VEGFR2,CDK2和CDK4抑制剂的恶唑衍生物。 所述的发明还包括制备这种恶唑衍生物的方法以及使用它们在治疗过度增殖性疾病中的方法。
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公开(公告)号:US20070015756A1
公开(公告)日:2007-01-18
申请号:US11383229
申请日:2006-05-15
申请人: Amogh Boloor , Mui Cheung , Ronda Davis , Philip Harris , Kevin Hinkle , Robert Mook , Jeffery Stafford , James Veal
发明人: Amogh Boloor , Mui Cheung , Ronda Davis , Philip Harris , Kevin Hinkle , Robert Mook , Jeffery Stafford , James Veal
IPC分类号: A61K31/53 , A61K31/506 , C07D403/02
CPC分类号: C07D239/30 , C07D231/56 , C07D235/08 , C07D403/12 , C07D413/14
摘要: Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要翻译: 本文描述了可用作VEGFR2抑制剂的嘧啶衍生物。 所述的发明还包括制备此类嘧啶衍生物的方法以及使用该嘧啶衍生物的方法来治疗过度增殖性疾病。
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公开(公告)号:US09187464B2
公开(公告)日:2015-11-17
申请号:US14125378
申请日:2012-06-15
申请人: Carl Brooks , Mui Cheung , Hilary Schenck Eidam , Krista B. Goodman , Marlys Hammond , Mark A. Hilfiker , Tram H. Hoang , Jaclyn R. Patterson , Patrick Stoy , Guosen Ye
发明人: Carl Brooks , Mui Cheung , Hilary Schenck Eidam , Krista B. Goodman , Marlys Hammond , Mark A. Hilfiker , Tram H. Hoang , Jaclyn R. Patterson , Patrick Stoy , Guosen Ye
IPC分类号: C07D263/02 , A61K31/423 , C07D413/14 , C07D417/14 , C07D495/04 , C07F9/6558 , C07D419/14
CPC分类号: C07D413/14 , C07D417/14 , C07D419/14 , C07D495/04 , C07F9/65583
摘要: The present invention relates to spirocarbamate compounds of Formula (I) in which R1, (R2)Y, R3, R4, X and A have the meanings given in the specification. The invention further provides pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts thereof and relates to their use of these compounds as TRPV4 antagonists in treating or preventing conditions associated with TRPV4 imbalance.
摘要翻译: 本发明涉及其中R1,(R2)Y,R3,R4,X和A具有本说明书中给出的含义的式(I)的螺氨酸甲酯化合物。 本发明还提供含有化合物或其药学上可接受的盐的药物组合物,并且涉及它们在治疗或预防与TRPV4不平衡相关的病症中作为TRPV4拮抗剂的用途。
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公开(公告)号:US20140080809A1
公开(公告)日:2014-03-20
申请号:US14118976
申请日:2012-05-18
IPC分类号: C07D498/04
CPC分类号: C07D519/00 , C07D498/04
摘要: This invention relates to novel compounds which are inhibitors of acyl coenzymeA: diacylglycerol acyltransferase 1 (DGAT-1), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the prevention or treatment of diseases related to DGAT-1 dysfunction or where modulation of DGAT-1 activity may have therapeutic benefit including but not limited to obesity, obesity related disorders, hypertriglyceridemia, hyperlipoproteinemia, chylomicronemia, dyslipidemia, non-alcoholic steatohepatitis, diabetes, insulin resistance, metabolic syndrome, hepatitis C virus infection and acne or other skin disorders.
摘要翻译: 本发明涉及作为酰基辅酶A:二酰基甘油酰基转移酶1(DGAT-1)的抑制剂的新化合物,含有它们的药物组合物,其制备方法及其在治疗中用于预防或治疗与DGAT有关的疾病 -1功能障碍或DGAT-1活性的调节可能具有治疗益处,包括但不限于肥胖症,肥胖症相关疾病,高甘油三酯血症,高脂蛋白血症,乳糜微粒血症,血脂异常,非酒精性脂肪性肝炎,糖尿病,胰岛素抵抗,代谢综合征,丙型肝炎病毒 感染和痤疮或其他皮肤疾病。
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公开(公告)号:US08093239B2
公开(公告)日:2012-01-10
申请号:US12128099
申请日:2008-05-28
申请人: Kevin Kuntz , David Edward Uehling , Alex Gregory Waterson , Kyle Allen Emmitte , Kirk Stevens , John Brad Shotwell , Stephon Cornell Smith , Kristen E. Nailor , James M. Salovich , Brian John Wilson , Mui Cheung , Robert Anthony Mook , Erich W. Baum , Ganesh Moorthy
发明人: Kevin Kuntz , David Edward Uehling , Alex Gregory Waterson , Kyle Allen Emmitte , Kirk Stevens , John Brad Shotwell , Stephon Cornell Smith , Kristen E. Nailor , James M. Salovich , Brian John Wilson , Mui Cheung , Robert Anthony Mook , Erich W. Baum , Ganesh Moorthy
IPC分类号: A61K31/55 , A61K31/505 , A61K31/497 , A61K31/535 , C07D243/08 , C07D413/14 , C07D403/14 , C07D239/02
CPC分类号: C07D471/04
摘要: The present invention provides imidazopyridine compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
摘要翻译: 本发明提供咪唑并吡啶化合物,含有它们的组合物,以及其制备方法和用作药剂的方法。
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公开(公告)号:US20080214567A1
公开(公告)日:2008-09-04
申请号:US12065668
申请日:2006-08-28
IPC分类号: A61K31/496 , C07D409/14 , A61P35/04
CPC分类号: C07D409/04 , C07D409/14
摘要: The present invention provides benzimidazole thiophene compounds, pharmaceutical compositions containing the same, and their use as pharmaceutical agents.
摘要翻译: 本发明提供苯并咪唑噻吩化合物,含有它们的药物组合物及其作为药剂的用途。
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公开(公告)号:US20070292513A1
公开(公告)日:2007-12-20
申请号:US11830608
申请日:2007-07-30
申请人: Amogh Boloor , Mui Cheung , Ronda Davis , Philip Harris , Kevin Hinkle , Robert Mook , Jeffery Stafford , James Veal
发明人: Amogh Boloor , Mui Cheung , Ronda Davis , Philip Harris , Kevin Hinkle , Robert Mook , Jeffery Stafford , James Veal
IPC分类号: C07D403/12 , A61K31/506 , A61K9/28 , A61P35/00 , C07D231/56
CPC分类号: C07D239/30 , C07D231/56 , C07D235/08 , C07D403/12 , C07D413/14
摘要: Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
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