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公开(公告)号：US11276479B2
公开(公告)日：2022-03-15
申请号：US16465997
申请日：2017-11-30
发明人： Andrew Nguyen , John Zachary Sanborn , Charles Joseph Vaske , Shahrooz Rabizadeh , Kayvan Niazi , Patrick Soon-Shiong , Stephen Charles Benz
摘要： Methods for targeting a tumor antigen for immunotherapy based on HLA allele type and the mutations present in the tumor antigen are presented. A patient's HLA allele type and a tumor antigen derived from a mutation in cancer driver gene can be matched with a majority allele type having a minimum affinity to the same tumor antigen or with those of a plurality of patients with a history of cancer treatment. Upon matching, a cancer treatment against the tumor antigen can be selected and administered to the patient to achieve a desired effect.
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公开(公告)号：US11154597B2
公开(公告)日：2021-10-26
申请号：US15468046
申请日：2017-03-23
IPC分类号： A61K39/00 , A61K39/39 , C07K7/06 , C07K14/74 , C07K14/705 , C12N7/00 , C12N15/86 , G16B20/00 , G16B20/20
摘要： Systems and methods are presented that allow for selection of tumor neoepitopes that are then used to generate a recombinant polytope that is optimized for proper trafficking and processing. In preferred methods, the polytope is encoded in a viral expression system that is used as a therapeutic agent.
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公开(公告)号：US10467523B2
公开(公告)日：2019-11-05
申请号：US15818462
申请日：2017-11-20
发明人： Kamil Wnuk , Jeremi Sudol , Shahrooz Rabizadeh , Patrick Soon-Shiong , Christopher Szeto , Charles Vaske
摘要： Techniques are provided for predicting DNA accessibility. DNase-seq data files and RNA-seq data files for a plurality of cell types are paired by assigning DNase-seq data files to RNA-seq data files that are at least within a same biotype. A neural network is configured to be trained using batches of the paired data files, where configuring the neural network comprises configuring convolutional layers to process a first input comprising DNA sequence data from a paired data file to generate a convolved output, and fully connected layers following the convolutional layers to concatenate the convolved output with a second input comprising gene expression levels derived from RNA-seq data from the paired data file and process the concatenation to generate a DNA accessibility prediction output. The trained neural network is used to predict DNA accessibility in a genomic sample input comprising RNA-seq data and whole genome sequencing for a new cell type.
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24.发明申请公开(公告)号：US20190034582A1
公开(公告)日：2019-01-31
申请号：US16073105
申请日：2017-02-10
发明人： Andrew Nguyen , John Zachary Sanborn , Steven Charles Benz , Kayvan Niazi , Shahrooz Rabizadeh , Patrick Soon-Shiong , Charles Joseph Vaske
摘要： Systems and methods are presented that allow for selection of tumor neoepitopes that are filtered for various criteria. In particularly contemplated aspects, filtering includes a step in which the mutation leading to the neoepitope is ascertained as being located in a cancer driver gene.
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25.发明申请SYNTHETIC GENOMIC VARIANT-BASED SECURE TRANSACTION DEVICES, SYSTEMS AND METHODS 审中-公开合成基于变量的安全交易设备，系统和方法公开(公告)号：US20160072800A1
公开(公告)日：2016-03-10
申请号：US14844974
申请日：2015-09-03
IPC分类号： H04L29/06
CPC分类号： H04L63/0861 , G06F19/28 , G06F21/32 , G06F21/35 , H04L9/0872 , H04L9/3231 , H04L63/0853 , H04L2463/102
摘要： Various devices, systems, structures and methods are disclosed related to securely authorizing a transaction by synchronizing digital genomic data with associated synthetic genomic variants. An embodiment of the present invention utilizes digital genomic data associated with an entity, such as a person, who may utilize a genome-based security device to complete a transaction. In one embodiment, a person may use a genome-based security device to communicate with an external device over a wireless or other communication interface, synchronize digital genomic data and an associated synthetic variant received from the external device with digital genomic data and associated synthetic variant stored on the genome-based security device.
摘要翻译： 公开了通过使数字基因组数据与相关联的合成基因组变体同步来安全地授权交易的各种装置，系统，结构和方法。 本发明的一个实施例利用与可以利用基于基因组的安全设备完成交易的实体（例如人）相关联的数字基因组数据。 在一个实施例中，人可以使用基于基因组的安全设备通过无线或其他通信接口与外部设备通信，使用数字基因组数据和相关联的合成变体同步数字基因组数据和从外部设备接收的相关联的合成变体 存储在基于基因组的安全设备上。
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公开(公告)号：US10392397B2
公开(公告)日：2019-08-27
申请号：US15745588
申请日：2016-08-08
发明人： Chunlin Tao , Qinwei Wang , Patrick Soon-Shiong
IPC分类号： C07D491/048 , C07D491/044 , C07D491/052 , C07D471/04 , C07D495/04 , A61P35/00
摘要： Pharmaceutical compounds, compositions, and methods are presented in which various heterocyclic thiosemicarbazone derivatives are prepared. Contemplated compounds will be suitable to inhibit or reduce cellular growth or proliferation and are thus beneficial in the manufacture of drugs to treat neoplastic diseases.
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公开(公告)号：US20230134725A1
公开(公告)日：2023-05-04
申请号：US16961026
申请日：2019-01-16
IPC分类号： C07K14/705 , C07K14/525 , C07K14/54 , A61K47/64
摘要： Chimeric molecules and molecule complexes that include an Fc portion of an antibody and an immunomodulatory portion and uses thereof are contemplated. Typically, the chimeric molecule comprises at least two immune effectors, for example, IL-15 antagonist and PD-L1 binding domain. It is contemplated that a tumor cell or an immune competent cell can be exposed to the chimeric molecule to increase the effectiveness tumor cell lysis via an antibody-dependent cell-mediated cytotoxicity.
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公开(公告)号：US20190233900A1
公开(公告)日：2019-08-01
申请号：US16264379
申请日：2019-01-31
申请人： Nantomics, LLC , NantBio, Inc.
IPC分类号： C12Q1/6886 , A61K33/243
CPC分类号： C12Q1/6886 , A61K33/243 , C12Q2600/106 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158
摘要： Compositions, methods, and uses of de novo pyrimidine synthesis pathway element, CAD, and optionally a second gene in a nucleotide excision repair pathway, POLD2 in determining a predicted survival rate, predicted responsiveness to a cisplatin-based chemotherapy of a patient diagnosed with bladder urothelial carcinoma are provided.
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29.发明授权公开(公告)号：US12089621B2
公开(公告)日：2024-09-17
申请号：US18224686
申请日：2023-07-21
发明人： Patrick Soon-Shiong
CPC分类号： A23L33/16 , A23C9/1522 , A23C9/1524 , A23C9/156 , A23C11/10 , A23C11/103 , A23L2/02 , A23L2/54 , A23L2/60 , A23L27/30 , A23V2002/00
摘要： Beverage compositions and methods of preparing the same are provided herein. The beverage compositions can include calcium supplied from a calcium carbonate source including aragonite and a liquid component, such as water, a juice, a milk, and a combination thereof. Calcium components including aragonite particles and at least one additive agent as well as sweetener components including aragonite particles and at least one sweetener are also provided herein.
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公开(公告)号：US20240296570A1
公开(公告)日：2024-09-05
申请号：US18647472
申请日：2024-04-26
发明人： Patrick Soon-Shiong
CPC分类号： G06T7/246 , G06F16/70 , G09B19/0038 , H04N7/181 , G06T2207/30221
摘要： A computer-based filming production system is described. An illustrative system includes a real-world, physical environment having a set of sensors disposed about a filming volume and a production center computing system including at least one computer readable memory that enables a processor to store a prioritization policy including priorities for digital data streams and for each filming production workflow stage of a set of multiple filming production workflow stages, receive a set of sensor data representing a filming production in the filming production from the set of sensors, generate a set of digital data streams of renderable content from the set of sensor data via the filming production workflow stages and according to the priorities for each filming production workflow stage, where each digital data streams comprises prioritized rendering instructions for their respective renderable content derived from the prioritization policy, and then transmit the set of digital data streams.
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