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公开(公告)号：US20110312942A1
公开(公告)日：2011-12-22
申请号：US13217659
申请日：2011-08-25
IPC分类号： A61K31/55 , A61P35/00 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides potent inhibitors of Aurora A kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of cancer.
摘要翻译： 本发明涉及治疗癌症的化合物和方法。 特别地，本发明提供了极光A激酶的有效抑制剂，包含该化合物的药物组合物，以及使用该化合物治疗癌症的方法。
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公开(公告)号：US20110039820A1
公开(公告)日：2011-02-17
申请号：US12903370
申请日：2010-10-13
申请人： Christopher Blackburn , Christopher F. Claiborne , Courtney A. Cullis , Natalie A. Dales , Michael Patane , Matthew Stirling , Omar Stradella , Gabriel S. Weatherhead
发明人： Christopher Blackburn , Christopher F. Claiborne , Courtney A. Cullis , Natalie A. Dales , Michael Patane , Matthew Stirling , Omar Stradella , Gabriel S. Weatherhead
CPC分类号： C07D491/14 , C07D471/14 , C07D487/04 , C07D495/14
摘要： The present invention provides novel compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.
摘要翻译： 本发明提供了可用作蛋白激酶抑制剂的新化合物。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US07459448B2
公开(公告)日：2008-12-02
申请号：US11242413
申请日：2005-10-03
申请人： Christopher Blackburn , Christopher F. Claiborne , Courtney A. Cullis , Natalie A. Dales , Michael Patane , Matthew Stirling , Omar Stradella , Gabriel S. Weatherhead
发明人： Christopher Blackburn , Christopher F. Claiborne , Courtney A. Cullis , Natalie A. Dales , Michael Patane , Matthew Stirling , Omar Stradella , Gabriel S. Weatherhead
IPC分类号： C07D487/04 , A61K31/55
CPC分类号： C07D491/14 , C07D471/14 , C07D487/04 , C07D495/14
摘要： The present invention provides novel compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.
摘要翻译： 本发明提供了可用作蛋白激酶抑制剂的新化合物。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US5481007A
公开(公告)日：1996-01-02
申请号：US201926
申请日：1994-02-23
申请人： K. C. Nicolaou , Christopher F. Claiborne , Philippe G. Nantermet , Elias A. Couladouros , Erik J. Sorensen
发明人： K. C. Nicolaou , Christopher F. Claiborne , Philippe G. Nantermet , Elias A. Couladouros , Erik J. Sorensen
IPC分类号： C07C43/178 , C07C69/00 , C07C69/013 , C07C69/757 , C07D305/14 , C07D317/72 , C07D319/08 , C07D493/08 , C07F7/18 , C07D317/70
CPC分类号： C07D317/72 , C07C43/1788 , C07C69/00 , C07C69/013 , C07C69/757 , C07D305/14 , C07D319/08 , C07D493/08 , C07F7/1852 , C07C2101/16 , C07C2103/00
摘要： Bioactive ABC taxoids accessible by convergent synthesis have an intact AB ring framework of taxol, including the C.sup.13 side chain, and an aromatic C ring which substitutes for the CD ring system found on native taxol. The aromatic C ring may be substituted or unsubstituted. MPT derivatives of ABC taxoids are also disclosed.
摘要翻译： 通过收敛合成可获得的生物活性ABC紫杉醇具有完整的AB环框架的紫杉醇，包括C13侧链和芳香C环，其代替在天然紫杉醇上发现的CD环系统。 芳族C环可以是取代或未取代的。 还披露了ABC紫杉烷的MPT衍生物。
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公开(公告)号：US09988384B2
公开(公告)日：2018-06-05
申请号：US13217729
申请日：2011-08-25
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides potent inhibitors of Aurora A kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of cancer.
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公开(公告)号：US20110312943A1
公开(公告)日：2011-12-22
申请号：US13217729
申请日：2011-08-25
CPC分类号： C07D487/04
摘要： The present invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides potent inhibitors of Aurora A kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of cancer.
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公开(公告)号：US07572784B2
公开(公告)日：2009-08-11
申请号：US11127855
申请日：2005-05-12
申请人： Christopher F. Claiborne , Lloyd J. Payne , Richard J. Boyce , Todd B. Sells , Stephen G. Stroud , Stuart Travers , Tricia J. Vos , Gabriel S. Weatherhead
发明人： Christopher F. Claiborne , Lloyd J. Payne , Richard J. Boyce , Todd B. Sells , Stephen G. Stroud , Stuart Travers , Tricia J. Vos , Gabriel S. Weatherhead
IPC分类号： A61P35/00 , A61K31/55 , C07D487/00
CPC分类号： C07D487/04 , C07D487/14 , C07D491/14 , C07D495/14 , C07D513/14
摘要： This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of cancer.
摘要翻译： 本发明涉及治疗癌症的化合物和方法。 特别地，本发明提供抑制极光激酶的化合物，包含该化合物的药物组合物，以及使用该化合物治疗癌症的方法。
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公开(公告)号：US5760240A
公开(公告)日：1998-06-02
申请号：US527377
申请日：1995-09-13
申请人： K. C. Nicolaou , Christopher F. Claiborne , Philippe G. Nantermet , Elias A. Couladouros , Erik J. Sorenson
发明人： K. C. Nicolaou , Christopher F. Claiborne , Philippe G. Nantermet , Elias A. Couladouros , Erik J. Sorenson
IPC分类号： C07C43/178 , C07C69/00 , C07C69/013 , C07C69/757 , C07D305/14 , C07D317/72 , C07D319/08 , C07D493/08 , C07F7/18 , C07D213/89
CPC分类号： C07D317/72 , C07C43/1788 , C07C69/00 , C07C69/013 , C07C69/757 , C07D305/14 , C07D319/08 , C07D493/08 , C07F7/1852 , C07C2101/16 , C07C2103/00
摘要： Bioactive ABC taxoids accessible by convergent synthesis have an intact AB ring framework of taxol, including the C.sup.13 side chain, and an aromatic C ring which substitutes for the CD ring system found on native taxol. The aromatic C ring may be substituted or unsubstituted. MPT derivatives of ABC taxoids are also disclosed.
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公开(公告)号：US08481550B2
公开(公告)日：2013-07-09
申请号：US13216352
申请日：2011-08-24
申请人： Christopher F. Claiborne , Stephen Critchley , Courtney A. Cullis , Steven P. Langston , Hirotake Mizutani , Edward J. Olhava , Stephane Peluso , Irache Visiers , Stepan Vyskocil , Gabriel S. Weatherhead
发明人： Christopher F. Claiborne , Stephen Critchley , Courtney A. Cullis , Steven P. Langston , Hirotake Mizutani , Edward J. Olhava , Stephane Peluso , Irache Visiers , Stepan Vyskocil , Gabriel S. Weatherhead
IPC分类号： A61K31/505 , C07D239/48
CPC分类号： C07D239/42 , A61K31/53 , C07D213/56 , C07D213/69 , C07D213/74 , C07D213/81 , C07D213/82 , C07D239/36 , C07D239/48 , C07D251/18 , C07D251/48 , C07D401/04 , C07D401/06 , C07D403/04 , C07D471/04 , C07D471/08 , C07D473/30 , C07D473/34 , C07D487/04
摘要： This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
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公开(公告)号：US08026246B2
公开(公告)日：2011-09-27
申请号：US11985277
申请日：2007-11-14
IPC分类号： A61K31/505 , C07D491/00
CPC分类号： C07D487/04
摘要： The present invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides potent inhibitors of Aurora A kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of cancer.
摘要翻译： 本发明涉及治疗癌症的化合物和方法。 特别地，本发明提供了极光A激酶的有效抑制剂，包含该化合物的药物组合物，以及使用该化合物治疗癌症的方法。
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