-
公开(公告)号：US10196637B2
公开(公告)日：2019-02-05
申请号：US15284494
申请日：2016-10-03
发明人： Yoshiro Niitsu , Victor Knopov , Joseph E. Payne , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Violetta Akopian , Yasunobu Tanaka , Elena Feinstein , Sharon Avkin-Nahum , Hagar Kalinski , Igor Mett , Kenjiro Minomi , Wenbin Ying , Yun Liu , Zheng Hou , John A. Gaudette , Priya Karmali , Sridhar C. Nagarajan
IPC分类号： C12N15/113 , A61K31/713 , A61K47/18 , A61K47/24 , A61K9/127 , C07H21/02 , C12N15/11 , A61K45/06
摘要： What is described is a pharmaceutical composition for treating a fibrotic disease comprising a drug carrier, which comprises a lipid and a retinoid, and a double-stranded nucleic acid molecule, which comprises an antisense sequence to mRNA encoding human hsp47.
-
公开(公告)号：US10000447B2
公开(公告)日：2018-06-19
申请号：US15177269
申请日：2016-06-08
发明人： Yoshiro Niitsu , Joseph E. Payne , John A. Gaudette , Zheng Hou , Victor Knopov , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Yasunobu Tanaka , Violetta Akopian
IPC分类号： C07C237/22 , C07F9/10 , A61K9/127 , A61K31/713 , C12N15/113 , C07C233/21 , C07C235/08 , C07C235/48 , A61K47/55 , A61K31/07
CPC分类号： C07C237/22 , A61K9/127 , A61K9/1271 , A61K31/07 , A61K31/713 , A61K47/551 , C07C233/21 , C07C235/08 , C07C235/48 , C07C2601/16 , C07F9/10 , C12N15/113 , C12N2310/14 , C12N2320/32 , Y10S977/773 , Y10S977/906 , Y10S977/907
摘要： Here described are compounds consisting of the structure (targeting molecule)m-linker-(targeting molecule)n, wherein the targeting molecule is a retinoid or a fat soluble vitamin having a specific receptor on the target cell; wherein m and n are independently 0, 1, 2 or 3; and wherein the linker comprises a polyethylene glycol (PEG) or PEG-like molecule, as well as compositions and pharmaceutical formulations including these compounds which are useful for the targeting and delivery of therapeutic agents; and methods of using these compositions and pharmaceutical formulations.
-
23.发明申请公开(公告)号：US20170001950A1
公开(公告)日：2017-01-05
申请号：US15177284
申请日：2016-06-08
发明人： Yoshiro Niitsu , Joseph E. Payne , John A. Gaudette , Zheng Hou , Victor Knopov , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Yasunobu Tanaka , Violetta Akopian
IPC分类号： C07C237/22 , A61K9/127 , C12N15/113 , C07C233/21 , C07C235/48 , C07F9/10 , C07C235/08
CPC分类号： C07C237/22 , A61K9/127 , A61K9/1271 , A61K31/07 , A61K31/713 , A61K47/551 , C07C233/21 , C07C235/08 , C07C235/48 , C07C2601/16 , C07F9/10 , C12N15/113 , C12N2310/14 , C12N2320/32 , Y10S977/773 , Y10S977/906 , Y10S977/907
摘要： Here described are compounds consisting of the structure (targeting molecule)m-linker-(targeting molecule)n, wherein the targeting molecule is a retinoid or a fat soluble vitamin having a specific receptor on the target cell; wherein m and n are independently 0, 1, 2 or 3; and wherein the linker comprises a polyethylene glycol (PEG) or PEG-like molecule, as well as compositions and pharmaceutical formulations including these compounds which are useful for the targeting and delivery of therapeutic agents; and methods of using these compositions and pharmaceutical formulations.
摘要翻译： 这里描述的是由结构（靶向分子）m-连接体（靶向分子）n组成的化合物，其中靶向分子是靶细胞上具有特异性受体的类视黄醇或脂溶性维生素; 其中m和n独立地为0,1,2或3; 并且其中所述接头包含聚乙二醇（PEG）或PEG样分子，以及包含这些化合物的组合物和药物制剂，其可用于治疗剂的靶向和递送; 以及使用这些组合物和药物制剂的方法。
-
公开(公告)号：US20160074514A1
公开(公告)日：2016-03-17
申请号：US14872951
申请日：2015-10-01
发明人： Joseph E. Payne , John A. Gaudette , Zheng Hou , Mohammad Ahmadian , Lei Yu , Victor Knopov , Violetta Akopian , Priya Karmali , Richard P. Witte , Neda Safarzadeh , Wenbin Ying , Jun Zhang
IPC分类号： A61K47/18 , C07C237/16 , C07C323/60 , C07C317/44 , A61K9/127 , C07D333/38 , A61K47/20 , A61K47/22 , C07D207/16 , C07C237/08 , C07C333/04
摘要： The description is directed to ionizable lipids useful for enhancing the delivery of therapeutic agents in liposomes.
摘要翻译： 该描述针对可用于增强脂质体中治疗剂递送的可离子化脂质。
-
公开(公告)号：US20160015656A2
公开(公告)日：2016-01-21
申请号：US13789032
申请日：2013-03-07
发明人： Yoshiro Niitsu , Akihiro Yoneda , Hirotoshi Ishiwatari , Joseph E Payne , John A Gaudette , Zheng Hou , Victor Knopov , Richard P Witte , Mohammad Ahmadian , Loren A Perelman , Yasunobu Tanaka , Violetta Akopian
CPC分类号： A61K31/07 , A61K31/203 , A61K38/05 , A61K38/4886 , A61K45/00 , A61K45/06 , A61K47/551 , A61K47/60 , C07C2601/16 , C07F9/106 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition and a method for regenerating normal tissue from fibrotic tissue, the pharmaceutical composition and the method employing a collagen-reducing substance. In accordance with the present invention, normal tissue can be therapeutically regenerated from fibrotic tissue.
-
公开(公告)号：US20130171127A1
公开(公告)日：2013-07-04
申请号：US13789032
申请日：2013-03-07
发明人： Yoshiro Niitsu , Akihiro Yoneda , Hirotoshi Ishiwatari , Joseph E. Payne , John A. Gaudette , Zheng Hou , Victor Knopov , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Yasunobu Tanaka , Violetta Akopian
CPC分类号： A61K31/07 , A61K31/203 , A61K38/05 , A61K38/4886 , A61K45/00 , A61K45/06 , A61K47/551 , A61K47/60 , C07C2601/16 , C07F9/106 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition and a method for regenerating normal tissue from fibrotic tissue, the pharmaceutical composition and the method employing a collagen-reducing substance. In accordance with the present invention, normal tissue can be therapeutically regenerated from fibrotic tissue.
-
-
-
-
-
搜索结果
26 条记录 (耗时 0.033 秒)
