公开(公告)号：US07410776B2

公开(公告)日：2008-08-12

申请号：US10184722

申请日：2002-06-27

申请人： Shuji Hinuma ,  Kazuhiko Tatemoto ,  Masaki Hosoya ,  Yugo Habata ,  Ryo Fujii ,  Chieko Kitada

发明人： Shuji Hinuma ,  Kazuhiko Tatemoto ,  Masaki Hosoya ,  Yugo Habata ,  Ryo Fujii ,  Chieko Kitada

IPC分类号： C12P21/06 ,  C12N5/06 ,  C12N1/20 ,  C12N15/00

CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00 ,  C07K14/4702

摘要： This invention relates to a novel polypeptide involving in the modulation of central nervous system function, circulatory function, immune function, gastrointestinal function, metabolic function, reproductive function, etc., it can be used as a drug for treating or preventing a variety of diseases, e.g. HIV infection or AIDS (acquired immune deficiency syndrome) or the like.

摘要翻译： 本发明涉及一种涉及调节中枢神经系统功能，循环功能，免疫功能，胃肠功能，代谢功能，生殖功能等的新型多肽，可用作治疗或预防各种疾病的药物 ，例如 艾滋病毒感染或艾滋病（获得性免疫缺陷综合征）等。

公开(公告)号：US07323541B2

公开(公告)日：2008-01-29

申请号：US10489537

申请日：2002-09-13

申请人： Masaaki Mori ,  Kozo Hayashi ,  Hiroyuki Miya ,  Shuji Sato ,  Chieko Kitada ,  Hirokazu Matsumoto ,  Toshimi Nagi ,  Yukio Shimomura

发明人： Masaaki Mori ,  Kozo Hayashi ,  Hiroyuki Miya ,  Shuji Sato ,  Chieko Kitada ,  Hirokazu Matsumoto ,  Toshimi Nagi ,  Yukio Shimomura

IPC分类号： A61K38/04

CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00

摘要： The present invention aims at providing a novel polypeptide, a receptor, a DNA thereof, and the like. Specifically, the present invention provides a polypeptide having a binding ability to the protein represented by SEQ ID NO: 1 or SEQ ID NO: 3, or its amide, its ester or its salt, a polynucleotide encoding the polypeptide, an antisense polynucleotide or an antibody to the polypeptide, a screening of agent for prevention and/or treatment of cancer, obesity, etc., which comprises using the above, and the like.The polypeptide, receptor, polynucleotide, antisense polynucleotide, antibody and the like are useful for an agent of prevention and/or treatment of cancer, obesity and the like. Further, they are useful for a screening of an agent for prevention and/or treatment of cancer, obesity and the like.

摘要翻译： 本发明的目的在于提供新的多肽，受体及其DNA等。 具体地说，本发明提供了具有与SEQ ID NO：1或SEQ ID NO：3所代表的蛋白结合能力的多肽或其酰胺，其酯或其盐，编码多肽的多核苷酸，反义多核苷酸或 对多肽的抗体，筛选用于预防和/或治疗癌症，肥胖症等的药剂，其包括使用上述方法等。 多肽，受体，多核苷酸，反义多核苷酸，抗体等可用于预防和/或治疗癌症，肥胖症等。 此外，它们可用于筛选用于预防和/或治疗癌症，肥胖症等的药剂。

公开(公告)号：US20060155109A1

公开(公告)日：2006-07-13

申请号：US11376694

申请日：2006-03-15

申请人： Tetsuya Ohtaki ,  Hideki Matsui ,  Yoshihiro Ishibashi ,  Kazuhiro Ogi ,  Chieko Kitada

发明人： Tetsuya Ohtaki ,  Hideki Matsui ,  Yoshihiro Ishibashi ,  Kazuhiro Ogi ,  Chieko Kitada

IPC分类号： A61K38/22 ,  C07K14/575

CPC分类号： C07K16/18 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/72

摘要： The present invention relates to a peptide comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 35 and having an ability of binding to a receptor protein comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3, or a precursor thereof, its amide or ester, or a salt thereof. An inventive peptide-encoding DNA or equivalent can be employed in (1) a development of a receptor binding assay system using an expression system of a recombinant receptor protein and a screening for a pharmaceutical candidate compound, and (2) a development of a pharmaceutical having a reduced side effect such as a memory function improving agent, an appetite improving agent, an uterine, renal, prostatic, testicular or skeletal muscle function regulating agent.

摘要翻译： 本发明涉及一种肽，其包含与SEQ ID NO：35所示的氨基酸序列相同或基本相同的氨基酸序列，并且具有与受体蛋白结合的能力，所述受体蛋白包含与 由SEQ ID NO：1，SEQ ID NO：2或SEQ ID NO：3表示的氨基酸序列，或其前体，其酰胺或酯或其盐。 本发明的编码编码DNA的DNA或等同物可以用于（1）使用重组受体蛋白质的表达系统和药物候选化合物的筛选的受体结合测定系统的开发，和（2）药物 具有减少的副作用，例如记忆功能改善剂，食欲改善剂，子宫，肾，前列腺，睾丸或骨骼肌功能调节剂。

公开(公告)号：US07074761B1

公开(公告)日：2006-07-11

申请号：US09207168

申请日：1998-12-07

申请人： Shuji Hinuma ,  Shoji Fukusumi ,  Chieko Kitada

发明人： Shuji Hinuma ,  Shoji Fukusumi ,  Chieko Kitada

IPC分类号： A61K38/10 ,  A61K38/31 ,  C07K14/655 ,  C07K4/12 ,  C07K14/46

CPC分类号： C07K14/575 ,  A61K38/00 ,  C07K14/655 ,  Y10S514/806 ,  Y10S930/16

摘要： The peptides and precursors thereof, inclusive salts thereof, of the present invention are useful as a pharmaceutical composition, for example as therapeutic or prophylactic agents for hormone-producing tumors, acromegaly, gigantism, dementia, gastric ulcer and the like, hormone secretion inhibitors, tumor growth inhibitors, neural activity or sleep modulators, etc. The DNAs coding for the peptides or precursors of the invention are useful as a pharmaceutical composition, for example as agents for the gene therapy or prevention of hormone-producing tumors, acromegaly, gigantism, dementia, gastric ulcer and the like, hormone secretion inhibitors, tumor growth inhibitors, neural activity or sleep modulators, etc. Furthermore, the DNAs coding for the peptides or precursors of the invention are useful as agents for the gene diagnosis of various diseases, for example, hormone-producing tumors, acromegaly, gigantism, dementia, gastric ulcer, etc. The antibodies against the peptides, precursors or salts of the invention can be used for assaying the peptides, precursors or salts of the invention in test solutions. The peptides, precursors or salts of the invention are useful as reagents for screening for compounds, or salts thereof, capable of modifying the binding of the peptides, precursors or salts of the invention to certain receptors.

摘要翻译： 本发明的肽及其前体，包括其的盐可用作药物组合物，例如用于激素产生的肿瘤，肢端肥大症，巨人血症，痴呆，胃溃疡等的治疗或预防剂，激素分泌抑制剂， 肿瘤生长抑制剂，神经活性或睡眠调节剂等。编码本发明的肽或前体的DNA可用作药物组合物，例如作为用于基因治疗或预防激素产生性肿瘤，肢端肥大症，巨人症， 痴呆，胃溃疡等，激素分泌抑制剂，肿瘤生长抑制剂，神经活性或睡眠调节剂等。此外，编码本发明的肽或前体的DNA可用作各种疾病的基因诊断的试剂，用于 例如，产生激素的肿瘤，肢端肥大症，巨人症，痴呆，胃溃疡等。针对肽的抗体 本发明的rs或盐可用于在测试溶液中测定本发明的肽，前体或盐。 本发明的肽，前体或盐可用作筛选能够改变本发明的肽，前体或盐与某些受体的结合的化合物或其盐的试剂。

公开(公告)号：US20050209151A1

公开(公告)日：2005-09-22

申请号：US11116727

申请日：2005-04-28

申请人： Chieko Kitada ,  Hirokazu Matsumoto ,  Shuji Hinuma

发明人： Chieko Kitada ,  Hirokazu Matsumoto ,  Shuji Hinuma

IPC分类号： A61K38/17 ,  A61P3/04 ,  A61P5/40 ,  A61K38/22

CPC分类号： A61K38/1709

摘要： The ligand polypeptides of the present invention have activity to regulate CRH secretion, and thus are useful as CRH secretion regulators for the relief, prevention or treatment of various diseases related to CRH secretion, such as hypoaldosteronism, hypocortisolemia, secondary and chronic adrenocorticism, Addison's disease (weakness, nausea, pigmentation, hypogonadism, alopecia, hypotension), adrenal dysfunction, and obesity, and also as analgesics.

摘要翻译： 本发明的配体多肽具有调节CRH分泌的活性，因此可用作CRH分泌调节剂用于缓解，预防或治疗与CRH分泌有关的各种疾病，例如醛糖醛酸降低症，低皮质醇血症，继发性和慢性肾上腺皮质激素，艾迪生病 （虚弱，恶心，色素沉着，性腺机能减退，脱发，低血压），肾上腺功能障碍和肥胖，以及止痛药。

公开(公告)号：US06794491B1

公开(公告)日：2004-09-21

申请号：US09576290

申请日：2000-05-23

申请人： Shuji Hinuma ,  Yugo Habata ,  Yuji Kawamata ,  Masaki Hosoya ,  Ryo Fujii ,  Shoji Fukusumi ,  Chieko Kitada

发明人： Shuji Hinuma ,  Yugo Habata ,  Yuji Kawamata ,  Masaki Hosoya ,  Ryo Fujii ,  Shoji Fukusumi ,  Chieko Kitada

IPC分类号： C07K14475

CPC分类号： C07H21/04 ,  A61K38/00 ,  C07K14/575 ,  C07K14/705 ,  C07K14/72 ,  C07K16/28

摘要： The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins. The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervious system function modulators, and pancreatic function modulators, and (2) development of receptor binding assay systems using the expression of recombinant receptor proteins and screening of pharmaceutical candidate compounds. In particular, by the receptor binding assay systems utilizing the expression of recombinant G protein-coupled receptor proteins in accordance with the invention, agonists and antagonists of G protein-coupled receptors which are specific to human and other warm-blooded animals can be screened and the agonists or antagonists obtained can be used as therapeutic and prophylactic agents for various diseases.

摘要翻译： 本发明涉及用于人垂体和小鼠胰腺衍生的G蛋白偶联受体蛋白质的配体多肽。配体多肽或编码配体多肽的DNA可用于（1）开发诸如垂体的药物 功能调节剂，中枢神经系统功能调节剂和胰腺功能调节剂，以及（2）使用重组受体蛋白质的表达和药物候选化合物的筛选开发受体结合测定系统。特别地，通过受体结合测定系统利用表达 根据本发明的重组G蛋白偶联受体蛋白质，可以筛选对人类和其他温血动物特异性的G蛋白偶联受体的激动剂和拮抗剂，并且所获得的激动剂或拮抗剂可用作治疗和预防 各种疾病的代理

公开(公告)号：US5925731A

公开(公告)日：1999-07-20

申请号：US732289

申请日：1996-10-28

申请人： Chieko Kitada ,  Taiji Asami ,  Tetsuya Ohtaki ,  Toshifumi Watanabe

发明人： Chieko Kitada ,  Taiji Asami ,  Tetsuya Ohtaki ,  Toshifumi Watanabe

IPC分类号： A61K38/00 ,  C07K5/02 ,  C07K5/103 ,  C07K14/575 ,  A61K38/07

CPC分类号： C07K14/57536 ,  C07K5/0202 ,  C07K5/101 ,  A61K38/00

摘要： The peptide derivatives having endothelin receptor-antagonistic action or a salt thereof and medicinal compositions containing them are provided.Since peptide derivatives or a salt thereof of this invention exhibit remarkable endothelin receptor-antagonistic action with low toxicity, they are effective as medicines for prophylaxis and therapy of, for example, cardio- or cerebro-circulatory diseases hepatic diseases and/or renal diseases.

摘要翻译： PCT No.PCT / JP96 / 02778 371日期1996年10月28日第 102（e）1996年10月28日PCT PCT 1996年9月26日PCT公布。 公开号WO97 / 11961 日期1997年3月3日提供具有内皮素受体拮抗作用的肽衍生物或其盐和含有它们的药物组合物。 由于本发明的肽衍生物或其盐表现出显着的低毒性的内皮素受体拮抗作用，因此它们作为预防和治疗例如心脏或脑循环疾病肝脏疾病和/或肾脏疾病的药物是有效的。

公开(公告)号：US5326860A

公开(公告)日：1994-07-05

申请号：US940443

申请日：1992-09-04

申请人： Haruo Onda ,  Akira Arimura ,  Chiharu Kimura ,  Chieko Kitada

发明人： Haruo Onda ,  Akira Arimura ,  Chiharu Kimura ,  Chieko Kitada

IPC分类号： A61K38/00 ,  C07K14/575 ,  C12N15/12 ,  C12N15/60 ,  C07K13/00

CPC分类号： C07K14/57563 ,  A61K38/00 ,  Y02P20/55

摘要： Disclosed are (1) a DNA containing a DNA segment coding for PACAP38; (2) a precursor protein of PACAP38; (3) a transformant containing a DNA having a DNA segment coding for PACAP38; (4) a method for preparing mature PACAP38 comprising cultivating the transformant described in the above (3), producing and accumulating a protein in a culture, and collecting the resulting protein; and (5) a method for preparing the above polypeptide comprising condensing a partial amino acid or a peptide which can constitute the mature PACAP38, with a residual portion, and removing a protective group if a product has the protective group. The DNA is applied to experimental animals to understand their brain functions, which serves to elucidate human brain functions. PACAP38 provides information about growth and maintenance of rat and human brain nerves, and can also be utilized as therapeutic agents for various neuropathy.

摘要翻译： 公开了（1）含有编码PACAP38的DNA片段的DNA; （2）PACAP38的前体蛋白; （3）含有编码PACAP38的DNA区段的DNA的转化体; （4）一种制备成熟PACAP38的方法，包括培养上述（3）中所述的转化体，在培养物中产生和积累蛋白质，并收集所得蛋白质; （5）制备上述多肽的方法，包括将构成成熟PACAP38的部分氨基酸或肽缩合成残留部分，如果产物具有保护基，则除去保护基。 将DNA应用于实验动物以了解其大脑功能，其用于阐明人类大脑功能。 PACAP38提供关于大鼠和人脑神经的生长和维持的信息，并且还可以用作各种神经病变的治疗剂。

公开(公告)号：US5198542A

公开(公告)日：1993-03-30

申请号：US540105

申请日：1990-06-10

申请人： Haruo Onda ,  Akira Arimura ,  Chiharu Kimura ,  Chieko Kitada

发明人： Haruo Onda ,  Akira Arimura ,  Chiharu Kimura ,  Chieko Kitada

IPC分类号： A61K38/00 ,  C07K14/575 ,  C12N15/12 ,  C12N15/60

CPC分类号： C07K14/57563 ,  A61K38/00 ,  Y02P20/55

摘要： Disclosed are (1) a DNA containing a DNA segment coding for PACAP38; (2) a precursor protein of PACAP38; (3) a transformant containing a DNA having a DNA segment coding for PACAP38; (4) a method of preparing mature PACAP38 comprising cultivating the transformant described in the above (3), producing and accumulating a protein in a culture, and collecting the resulting protein; and (5) a method for preparing the above polypeptide comprising condensing a partial amino acid or a peptide which can constitute the mature PACAP38, with a residual portion, and removing a protective group if a product has the protective group. The DNA is applied to experimental animals to understand their brain functions, which serves to elucidate human brain functions. PACAP38 provides information about growth and maintenance of rat and human brain nerves, and can also be utilized as therapeutic agents for various neuropathy.

公开(公告)号：US08778871B2

公开(公告)日：2014-07-15

申请号：US12286671

申请日：2008-10-01

申请人： Chieko Kitada ,  Taiji Asami ,  Naoki Nishizawa

发明人： Chieko Kitada ,  Taiji Asami ,  Naoki Nishizawa

IPC分类号： A61K38/17 ,  C07K14/47

CPC分类号： C07K14/4703 ,  A61K38/00

摘要： The invention provides stable metastin derivatives having excellent biological activities (a cancer metastasis suppressing activity, a cancer growth suppressing activity, etc.). By modifying the constituent amino acids of metastin with specific modifying groups, metastin derivatives having more improved blood stability, etc. than native metastin and showing excellent cancer metastasis suppressing activity or cancer growth suppressing activity have been found. Furthermore, it has been found that these metastin derivatives exhibit effects of suppressing gonadotropic hormone secretion, suppressing sex hormone secretion, etc., which are wholly different from the effects heretofore known.

摘要翻译： 本发明提供具有优异生物活性（癌转移抑制活性，癌生长抑制活性等）的稳定的转铁蛋白衍生物。 已经发现通过用特异性修饰基修饰转氨酶的构成氨基酸，具有比天然转移蛋白更多的改善的血液稳定性的转氨酶衍生物，并且显示出优异的癌症转移抑制活性或癌症生长抑制活性。 此外，已经发现这些转氨酶衍生物表现出抑制促性腺激素分泌，抑制性激素分泌等的作用，其完全不同于迄今已知的效果。