摘要:
Substituted pyrazole compounds represented by formula (I), or salts thereof are disclosed, wherein R1 is —CH(OH)—CH(R4)-(A)n-Y, —CH2—CH(R4)-(A)n-Y, —CO-B1-A-Y or the like (wherein A is a lower alkylene; Y is an aryl group which may be substituted, for example, by halogen, or the like; R4 is a hydrogen atom or a lower alkyl group; B1 is —CH(R4)— or —N(R4)—; and n is 0 or 1); R2 is a hydrogen atom, a lower alkyl group which may be substituted by hydroxyl or the like, or an aralkyl group; R3 is a phenyl group which may be substituted by halogen or the like, or a pyridyl group; and Q is a pyridyl or quinolyl group. These substituted pyrazole compounds or their salts have an excellent p38MAP kinase inhibiting effect and are hence useful in the prevention or treatment of tumor necrosis factor α-related diseases, interleukin 1-related diseases, interleukin 6-related diseases or cyclooxygenase II-related diseases
摘要翻译:公开了由式(I)表示的取代的吡唑化合物或其盐,其中R 1是-CH(OH)-CH(R 4) - (A) -CH(R 4) - (A)n -Y, - CO(CH 2) -B 1 -I 1等(其中A是低级亚烷基; Y是可以被卤素取代的芳基等); R 4, SUP>是氢原子或低级烷基; B 1是-CH(R 4) - 或-N(R 4) - ;和n为0或1); R 2是氢原子,可以被羟基等取代的低级烷基或芳烷基; R 3是可以被卤素等取代的苯基或吡啶基; Q为吡啶基或喹啉基。 这些取代的吡唑化合物或其盐具有优异的p38MAP激酶抑制作用,因此可用于预防或治疗肿瘤坏死因子α相关疾病,白细胞介素1相关疾病,白细胞介素6相关疾病或环氧合酶II相关疾病
摘要:
A compound of the formula ##STR1## wherein R.sub.1 is a hydrogen atom or a methoxy group, and A is a C.sub.1 -C.sub.4 alkylene group, or a pharmaceutically acceptable salt thereof. This compound is useful as a medicine, particularly as a lipoxygenase inhibitor for polyunsaturated fatty acids.
摘要:
A modifier for paving asphalt, which comprises Trinidad Epure having a maximum size of less than 25 mm and a pulverulent solid having a maximum size of less than 2.5 mm, the powder comprising essentially a substance having a higher softening point than Trinidad Epure and compatibility with paving petroleum asphalt, wherein the volume of the powdery solid is 0.8 to 2.8 times the void volume of the granulated Trinidad Epure when in the stored state.
摘要:
Novel isoquinoline derivatives of the general formula ##STR1## wherein R represents a lower alkyl group, a lower cycloalkyl group, or a group of the formula ##STR2## in which R.sup.2 represents a hydrogen atom, a halogen atom, a methyl group, a trifluoromethyl group, a methoxy group, a methylamino group or a dimethylami no group;R.sup.1 represents a hydrogen atom or a lower alkyl group; andY represents a carboxyl group, a cyano group, a carbamoyl group, a lower alkoxycarbonyl group or a lower alkylaminocarbonyl group;or a salt thereof; a process for the production thereof.The above compound is useful as an anti-inflammatory and analgesic agent.
摘要:
An obtaining unit obtains information about a condition where a vehicle is placed. A detection unit detects at least one of a voice and an action of an occupant of the vehicle. An estimation unit estimates an in-vehicle apparatus to be a controlled target according to the condition where the vehicle is placed. A determination unit determines an in-vehicle apparatus to be a controlled in-vehicle apparatus and determines a control content thereof in consideration of the at least one of a voice and an action. A notification unit notifies the occupant of the in-vehicle apparatus to be controlled and the control content thereof determined by the determination unit. A control unit controls the in-vehicle apparatus according to the determination of the determination unit when receiving a response to the notification of the notification unit from the occupant to permit the control of the in-vehicle apparatus.
摘要:
The present invention provides a moisturizer comprising heat-killed cells of Lactobacillus plantarum as an active ingredient. The moisturizer of the present invention improves the water retention capacity of the stratum corneum, and is useful for prevention and improvement of rough skin.
摘要:
An on-vehicle manipulating system includes a manipulating device having a housing, a first side pushbutton switch disposed at one side of the housing, a second side pushbutton switch disposed at the other side of the housing and an additional switch disposed at a prescribed portion of the housing and a control unit for setting a first function to one of the first and second pushbutton switches and a second function to the other pushbutton switch. In this manipulating system, the control unit changes the function of the first or second side pushbutton switch from the first function such as an ENTER key to the second function, such as a RETURN key, and the function of the other pushbutton switch, such as a MENU key, from the second function to the first function when one of the pushbutton switches being set to change the function is operated subsequent to the other pushbutton switch that has been set the second function is operated in a prescribed period after the additional switch is operated.
摘要:
Disclosed is a novel hydroxy radical generation method which relies on a novel scientific fact relating to the generation of a hydroxy radical and the inactivation of a virus. Also disclosed is an anti-viral material produced by utilizing the method. The anti-viral material comprises a metal oxide powder and a hydroxide which enable the generation of a hydroxy radical that can inactivate a virus. An virus can be inactivated by the action of the hydroxy radical generated from the anti-viral material.
摘要:
The present invention provides a moisturizer comprising heat-killed cells of Lactobacillus plantarum as an active ingredient. The moisturizer of the present invention improves the water retention capacity of the stratum corneum, and is useful for prevention and improvement of rough skin.
摘要:
In a liquid crystal display module, fitting parts 19a for fastening the liquid crystal display module are provided in the corners of a rear case 19 provided with pressings close to the corners thereof, the corners being located toward the inner sections of the rear case, and not at its periphery, whereby plastic support elements 25 are installed to the fitting parts 19a, and mounting brackets 20 for fastening are installed to the rear case via screws that are screwed into screw holes 19b formed in the fitting parts 19a. In this manner, a liquid crystal module for use in a car navigation system, etc., is provided whose fitting portions occupy a small space and can be compactly housed in its onboard location.