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    2-(3,5-dialkyl-4-hydroxyphenyl)indole derivatives
    6.
    发明授权
    2-(3,5-dialkyl-4-hydroxyphenyl)indole derivatives 失效
    2-（3,5-二烷基-4-羟基苯基）吲哚衍生物

    公开(公告)号：US4695581A

    公开(公告)日：1987-09-22

    申请号：US770773

    申请日：1985-08-29

    申请人： Yasushi Suzuki ,  Yukio Hasegawa ,  Michitaka Sato ,  Morinobu Saito ,  Norio Yamamoto ,  Katsuhiko Miyasaka ,  Takashi Mikami ,  Katsuhiko Miyazawa

    发明人： Yasushi Suzuki ,  Yukio Hasegawa ,  Michitaka Sato ,  Morinobu Saito ,  Norio Yamamoto ,  Katsuhiko Miyasaka ,  Takashi Mikami ,  Katsuhiko Miyazawa

    IPC分类号： A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61P37/08 ,  A61P43/00 ,  C07D209/12 ,  C07D491/04 ,  C07D491/056

    CPC分类号： C07D491/04 ,  C07D209/12

    摘要： A compound represented by the formula ##STR1## wherein R.sub.1 represents a lower alkyl group; each of R.sub.2 and R.sub.3 represents an alkyl group having 1 to 3 carbon atoms; and each of R.sub.4, R.sub.5 and R.sub.6 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a lower alkanoyloxy group, an aralkyloxy group, a lower alkylthio group, a lower haloalkyl group, a hydroxyl group, a cyano group, a nitro group, an amino group, a mono- or di-(lower alkyl or aralkyl)amino group or a group of the formula ##STR2## in which R.sub.7 represents a lower alkylene group having at least 2 carbon atoms, one of R.sub.8 and R.sub.9 represents a hydrogen atom or a lower alkyl group and the other represents a lower alkyl group, and R.sub.10 represents a hydrogen atom or a lower alkyl group; or any two of R.sub.4, R.sub.5 and R.sub.6 which are adjacent to each other, together, represent a lower alkylenedioxy group, and a salt thereof; and a process for production thereof. This compound has 5-lipoxygenase inhibiting activity and is useful as a medicament.

    摘要翻译： 由式（I）表示的化合物，其中R 1表示低级烷基; R 2和R 3各自表示具有1至3个碳原子的烷基; R4，R5和R6各自表示氢原子，卤素原子，低级烷基，低级烷氧基，低级烷酰氧基，芳烷氧基，低级烷硫基，低级卤代烷基，羟基， 氰基，硝基，氨基，单 - 或二 - （低级烷基或芳烷基）氨基或式“IMAGE”的基团，其中R 7表示具有至少2个碳原子的低级亚烷基， R8和R9中的一个表示氢原子或低级烷基，另一个表示低级烷基，R 10表示氢原子或低级烷基; 或彼此相邻的R 4，R 5和R 6中的任何两个一起代表低级亚烷基二氧基及其盐; 及其制造方法。 该化合物具有5-脂氧合酶抑制活性，可用作药物。