公开(公告)号：US4337256A

公开(公告)日：1982-06-29

申请号：US107613

申请日：1979-12-27

申请人： Yasushi Suzuki ,  Kunio Tsukamoto ,  Nobuyoshi Minami ,  Yukio Hasegawa ,  Michitaka Satoh ,  Norio Yamamoto ,  Katsuhiko Miyasaka ,  Takashi Mikami ,  Satoshi Funakoshi

发明人： Yasushi Suzuki ,  Kunio Tsukamoto ,  Nobuyoshi Minami ,  Yukio Hasegawa ,  Michitaka Satoh ,  Norio Yamamoto ,  Katsuhiko Miyasaka ,  Takashi Mikami ,  Satoshi Funakoshi

IPC分类号： C07D217/02 ,  A61K31/47 ,  A61K31/472 ,  A61P7/02 ,  A61P25/04 ,  A61P29/00 ,  A61P43/00 ,  C07C233/12 ,  C07D217/04 ,  C07D217/12 ,  C07D217/14 ,  C07D217/16 ,  C07D217/26

CPC分类号： C07C255/00 ,  C07D217/14 ,  C07D217/16 ,  C07D217/26

摘要： Novel isoquinoline derivatives of the general formula ##STR1## wherein R represents a lower alkyl group, a lower cycloalkyl group, or a group of the formula ##STR2## in which R.sup.2 represents a hydrogen atom, a halogen atom, a methyl group, a trifluoromethyl group, a methoxy group, a methylamino group or a dimethylami no group;R.sup.1 represents a hydrogen atom or a lower alkyl group; andY represents a carboxyl group, a cyano group, a carbamoyl group, a lower alkoxycarbonyl group or a lower alkylaminocarbonyl group;or a salt thereof; a process for the production thereof.The above compound is useful as an anti-inflammatory and analgesic agent.

摘要翻译： 新的通式为（I）的异喹啉衍生物其中R表示低级烷基，低级环烷基或下式的基团：

公开(公告)号：US4673692A

公开(公告)日：1987-06-16

申请号：US789275

申请日：1985-10-18

申请人： Yasushi Suzuki ,  Yukio Hasegawa ,  Michitaka Sato ,  Morinobu Saito ,  Norio Yamamoto ,  Katsuhiko Miyasaka ,  Takashi Mikami ,  Katsuhiko Miyazawa

发明人： Yasushi Suzuki ,  Yukio Hasegawa ,  Michitaka Sato ,  Morinobu Saito ,  Norio Yamamoto ,  Katsuhiko Miyasaka ,  Takashi Mikami ,  Katsuhiko Miyazawa

IPC分类号： C12N9/99 ,  A61K31/135 ,  A61K31/15 ,  A61K31/175 ,  A61K31/19 ,  A61K31/22 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P11/00 ,  A61P25/04 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61P37/08 ,  A61P43/00 ,  C07C251/32 ,  C07C251/48 ,  C07C251/58 ,  C07C251/60 ,  C07C251/64 ,  C07C131/00

CPC分类号： C07C251/72

摘要： A compound represented by the formula ##STR1## wherein R.sup.1 represents a hydroxyl group, an alkanoyloxy group or a group of the formula ##STR2## in which R.sup.2 represents a hydrogen atom or a lower alkyl group, and R.sup.3 represents a hydrogen atom, a lower alkyl group, an alkanoyl group, a phenyl group, a carbamoyl group or a thiocarbamoyl group, or a salt thereof.The said compound can be prepared by reacting a compound represented by the formula ##STR3## with a compound of the formulaNH.sub.2 --R.sup.1 (III)wherein R.sup.1 is as defined hereinabove, or a salt thereof, and as required, alkanoylating the resulting compound of formula (I) in which R.sup.1 represents a hydroxyl group or an amino group, and as required, converting the resulting compound of formula (I) in which R.sup.1 is the group ##STR4## into its salt, and is useful for the treatment of inflammation, pain or rheumatism.

摘要翻译： 由式（I）表示的化合物，其中R 1表示羟基，烷酰氧基或式“IMAGE”的基团，其中R 2表示氢原子或低级烷基，R 3表示氢原子 ，低级烷基，烷酰基，苯基，氨基甲酰基或硫代氨基甲酰基，或其盐。 所述化合物可以通过使由式（II）表示的化合物与其中R1如上所定义的式NH 2 -R 1（III）的化合物或其盐反应制备，并根据需要将烷酰化 得到的式（I）化合物，其中R 1表示羟基或氨基，根据需要，将所得的式（I）化合物（其中R 1为）转化为其盐，并且可用于 治疗炎症，疼痛或风湿病。

公开(公告)号：US4910216A

公开(公告)日：1990-03-20

申请号：US160281

申请日：1988-02-25

申请人： Yasushi Suzuki ,  Yukio Hasegawa ,  Michitaka Sato ,  Morinobu Saito ,  Norio Yamamoto ,  Katsuhiko Miyasaka ,  Takashi Mikami ,  Katsuhiko Miyazawa

发明人： Yasushi Suzuki ,  Yukio Hasegawa ,  Michitaka Sato ,  Morinobu Saito ,  Norio Yamamoto ,  Katsuhiko Miyasaka ,  Takashi Mikami ,  Katsuhiko Miyazawa

IPC分类号： C07D209/12

CPC分类号： C07D209/12

摘要： A compound of the formula ##STR1## wherein R.sub.1 is a hydrogen atom or a methoxy group, and A is a C.sub.1 -C.sub.4 alkylene group, or a pharmaceutically acceptable salt thereof. This compound is useful as a medicine, particularly as a lipoxygenase inhibitor for polyunsaturated fatty acids.

摘要翻译： 其中R 1为氢原子或甲氧基，A为C1-C4亚烷基的式（Ⅰa）化合物或其药学上可接受的盐。 该化合物可用作药物，特别是作为多不饱和脂肪酸的脂氧合酶抑制剂。

公开(公告)号：US4695581A

公开(公告)日：1987-09-22

申请号：US770773

申请日：1985-08-29

申请人： Yasushi Suzuki ,  Yukio Hasegawa ,  Michitaka Sato ,  Morinobu Saito ,  Norio Yamamoto ,  Katsuhiko Miyasaka ,  Takashi Mikami ,  Katsuhiko Miyazawa

发明人： Yasushi Suzuki ,  Yukio Hasegawa ,  Michitaka Sato ,  Morinobu Saito ,  Norio Yamamoto ,  Katsuhiko Miyasaka ,  Takashi Mikami ,  Katsuhiko Miyazawa

IPC分类号： A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61P37/08 ,  A61P43/00 ,  C07D209/12 ,  C07D491/04 ,  C07D491/056

CPC分类号： C07D491/04 ,  C07D209/12

摘要： A compound represented by the formula ##STR1## wherein R.sub.1 represents a lower alkyl group; each of R.sub.2 and R.sub.3 represents an alkyl group having 1 to 3 carbon atoms; and each of R.sub.4, R.sub.5 and R.sub.6 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a lower alkanoyloxy group, an aralkyloxy group, a lower alkylthio group, a lower haloalkyl group, a hydroxyl group, a cyano group, a nitro group, an amino group, a mono- or di-(lower alkyl or aralkyl)amino group or a group of the formula ##STR2## in which R.sub.7 represents a lower alkylene group having at least 2 carbon atoms, one of R.sub.8 and R.sub.9 represents a hydrogen atom or a lower alkyl group and the other represents a lower alkyl group, and R.sub.10 represents a hydrogen atom or a lower alkyl group; or any two of R.sub.4, R.sub.5 and R.sub.6 which are adjacent to each other, together, represent a lower alkylenedioxy group, and a salt thereof; and a process for production thereof. This compound has 5-lipoxygenase inhibiting activity and is useful as a medicament.

摘要翻译： 由式（I）表示的化合物，其中R 1表示低级烷基; R 2和R 3各自表示具有1至3个碳原子的烷基; R4，R5和R6各自表示氢原子，卤素原子，低级烷基，低级烷氧基，低级烷酰氧基，芳烷氧基，低级烷硫基，低级卤代烷基，羟基， 氰基，硝基，氨基，单 - 或二 - （低级烷基或芳烷基）氨基或式“IMAGE”的基团，其中R 7表示具有至少2个碳原子的低级亚烷基， R8和R9中的一个表示氢原子或低级烷基，另一个表示低级烷基，R 10表示氢原子或低级烷基; 或彼此相邻的R 4，R 5和R 6中的任何两个一起代表低级亚烷基二氧基及其盐; 及其制造方法。 该化合物具有5-脂氧合酶抑制活性，可用作药物。

公开(公告)号：US07087624B2

公开(公告)日：2006-08-08

申请号：US10693461

申请日：2003-10-27

申请人： Nobuyoshi Minami ,  Michitaka Sato ,  Koichi Hasumi ,  Norio Yamamoto ,  Katsuyuki Keino ,  Teruaki Matsui ,  Arihiro Kanada ,  Shuji Ohta ,  Takahisa Saito ,  Shuichiro Sato ,  Akira Asagarasu ,  Satoshi Doi ,  Motohiro Kobayashi ,  Jun Sato ,  Hajime Asano

发明人： Nobuyoshi Minami ,  Michitaka Sato ,  Koichi Hasumi ,  Norio Yamamoto ,  Katsuyuki Keino ,  Teruaki Matsui ,  Arihiro Kanada ,  Shuji Ohta ,  Takahisa Saito ,  Shuichiro Sato ,  Akira Asagarasu ,  Satoshi Doi ,  Motohiro Kobayashi ,  Jun Sato ,  Hajime Asano

IPC分类号： A61K31/44 ,  C07D40/00

CPC分类号： C07D231/12 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/4725 ,  C07D233/56 ,  C07D249/08 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  Y02A50/411

摘要： Substituted pyrazole compounds represented by formula (I), or salts thereof are disclosed, wherein R1 is —CH(OH)—CH(R4)-(A)n-Y, —CH2—CH(R4)-(A)n-Y, —CO-B1-A-Y or the like (wherein A is a lower alkylene; Y is an aryl group which may be substituted, for example, by halogen, or the like; R4 is a hydrogen atom or a lower alkyl group; B1 is —CH(R4)— or —N(R4)—; and n is 0 or 1); R2 is a hydrogen atom, a lower alkyl group which may be substituted by hydroxyl or the like, or an aralkyl group; R3 is a phenyl group which may be substituted by halogen or the like, or a pyridyl group; and Q is a pyridyl or quinolyl group. These substituted pyrazole compounds or their salts have an excellent p38MAP kinase inhibiting effect and are hence useful in the prevention or treatment of tumor necrosis factor α-related diseases, interleukin 1-related diseases, interleukin 6-related diseases or cyclooxygenase II-related diseases

摘要翻译： 公开了由式（I）表示的取代的吡唑化合物或其盐，其中R 1是-CH（OH）-CH（R 4） - （A） -CH（R 4） - （A）n -Y， - CO（CH 2） -B 1 -I 1等（其中A是低级亚烷基; Y是可以被卤素取代的芳基等）; R 4， SUP>是氢原子或低级烷基; B 1是-CH（R 4） - 或-N（R 4） - ;和n为0或1）; R 2是氢原子，可以被羟基等取代的低级烷基或芳烷基; R 3是可以被卤素等取代的苯基或吡啶基; Q为吡啶基或喹啉基。 这些取代的吡唑化合物或其盐具有优异的p38MAP激酶抑制作用，因此可用于预防或治疗肿瘤坏死因子α相关疾病，白细胞介素1相关疾病，白细胞介素6相关疾病或环氧合酶II相关疾病

公开(公告)号：US06667325B1

公开(公告)日：2003-12-23

申请号：US09980579

申请日：2001-12-03

申请人： Nobuyoshi Minami ,  Michitaka Sato ,  Koichi Hasumi ,  Norio Yamamoto ,  Katsuyuki Keino ,  Teruaki Matsui ,  Arihiro Kanada ,  Shuji Ohta ,  Takahisa Saito ,  Shuichiro Sato ,  Akira Asagarasu ,  Satoshi Doi ,  Motohiro Kobayashi ,  Jun Sato ,  Hajime Asano

发明人： Nobuyoshi Minami ,  Michitaka Sato ,  Koichi Hasumi ,  Norio Yamamoto ,  Katsuyuki Keino ,  Teruaki Matsui ,  Arihiro Kanada ,  Shuji Ohta ,  Takahisa Saito ,  Shuichiro Sato ,  Akira Asagarasu ,  Satoshi Doi ,  Motohiro Kobayashi ,  Jun Sato ,  Hajime Asano

IPC分类号： C07D40104

CPC分类号： C07D231/12 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/4725 ,  C07D233/56 ,  C07D249/08 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  Y02A50/411

摘要： Substituted pyrazole compounds represented by formula (I), or salts thereof are disclosed, wherein R1 is —CH(OH)—CH(R4)—(A)n—Y, —CH2—CH(R4)—(A)n—Y, —CO—B1—A—Y or the like (wherein A is a lower alkylene; Y is an aryl group which may be substituted, for example, by halogen, or the like; R4 is a hydrogen atom or a lower alkyl group; B1 is —CH(R4)— or —N(R4)—; and n is 0 or 1); R2 is a hydrogen atom, a lower alkyl group which may be substituted by hydroxyl or the like, or an aralkyl group; R3 is a phenyl group which may be substituted by halogen or the like, or a pyridyl group; and Q is a pyridyl or quinolyl group. These substituted pyrazole compounds or their salts have an excellent p38MAP kinase inhibiting effect and are hence useful in the prevention or treatment of tumor necrosis factor &agr;-related diseases, interleukin 1-related diseases, interleukin 6-related diseases or cyclooxygenase II-related diseases.

摘要翻译： 公开了由式（I）表示的取代的吡唑化合物或其盐，其中R 1是-CH（OH）-CH（R 4） - （A）n Y，-CH 2 -CH（R 4） ） - （A）nY，-CO-B 1 -AY等（其中A是低级亚烷基; Y是可以被卤素取代的芳基等; R 4 >是氢原子或低级烷基; B 1是-CH（R 4） - 或-N（R 4） - ，n是0或1）; R 2是氢原子，可以被羟基等取代的低级烷基或芳烷基; R 3是可被卤素等取代的苯基或吡啶基; Q为吡啶基或喹啉基。 这些取代的吡唑化合物或其盐具有优异的p38MAP激酶抑制作用，因此可用于预防或治疗肿瘤坏死因子α相关疾病，白细胞介素1相关疾病，白介素6相关疾病或环加氧酶II相关疾病。

公开(公告)号：US06511997B1

公开(公告)日：2003-01-28

申请号：US09869051

申请日：2001-06-22

申请人： Nobuyoshi Minami ,  Michitaka Sato ,  Koichi Hasumi ,  Norio Yamamoto ,  Katsuyuki Keino ,  Teruaki Matsui ,  Arihiro Kanada ,  Shuji Ohta ,  Takahisa Saito ,  Shuichiro Sato ,  Akira Asagarasu ,  Satoshi Doi ,  Motohiro Kobayashi ,  Jun Sato ,  Hajime Asano

发明人： Nobuyoshi Minami ,  Michitaka Sato ,  Koichi Hasumi ,  Norio Yamamoto ,  Katsuyuki Keino ,  Teruaki Matsui ,  Arihiro Kanada ,  Shuji Ohta ,  Takahisa Saito ,  Shuichiro Sato ,  Akira Asagarasu ,  Satoshi Doi ,  Motohiro Kobayashi ,  Jun Sato ,  Hajime Asano

IPC分类号： A61K314409

CPC分类号： C07D401/04 ,  C07D405/14

摘要： Aminopyrazole derivatives represented by formula (I), or salts thereof, wherein X1 and X2 are each a hydrogen atom or a halogen atom, or X1 and X2 may be united together to form a lower alkylenedioxy group, Q is a pyridyl group or a quinolyl group, R1 is a hydrogen atom, a substituted or unsubstituted lower alkyl or aryl group, R2 is a hydrogen atom, a lower alkyl group, or an aralkyl group, and R3 represents a hydrogen atom, an organic sulfonyl group, or —C(═Y)—R4 in which R4 is a hydrogen atom or an organic residue and Y is an oxygen or sulfur atom, provided that, when R3 is a hydrogen atom, R1 is a group other than a hydrogen atom and R2 is a hydrogen atom. These amimopyrazole derivatives or their salts have excellent p38MAP kinase inhibiting activities and are hence useful in the prevention or treatment of diseases associated with tumor necrosis sis factor &agr;, interleukin 1, interleukin 6 or cyclooxygenase II.

摘要翻译： 式（I）表示的氨基吡唑衍生物或其盐，其中X 1和X 2各自为氢原子或卤素原子，或者X 1和X 2可以一起结合形成低级亚烷基二氧基，Q是吡啶基或喹啉基 基团，R 1是氢原子，取代或未取代的低级烷基或芳基，R 2是氢原子，低级烷基或芳烷基，R 3表示氢原子，有机磺酰基或-C（ = Y）-R4，其中R4为氢原子或有机残基，Y为氧或硫原子，条件是当R3为氢原子时，R1为氢原子以外的基团，R2为氢原子 。 这些酰胺吡唑衍生物或其盐具有优异的p38MAP激酶抑制活性，因此可用于预防或治疗与肿瘤坏死因子α，白细胞介素1，白介素6或环加氧酶II相关的疾病。

公开(公告)号：US09744588B2

公开(公告)日：2017-08-29

申请号：US14000223

申请日：2012-02-27

申请人： Takashi Oda ,  Hisamune Tanaka ,  Takeshi Shiraki ,  Norio Yamamoto

发明人： Takashi Oda ,  Hisamune Tanaka ,  Takeshi Shiraki ,  Norio Yamamoto

IPC分类号： B22D7/06 ,  B22D11/124 ,  F27B7/00 ,  F27D3/14 ,  B22D47/00 ,  F27B19/04 ,  B22D11/00 ,  B22D11/04 ,  B22D11/055 ,  B22D11/14 ,  B22D41/015

CPC分类号： B22D7/005 ,  B22D7/06 ,  B22D7/064 ,  B22D9/006 ,  B22D11/001 ,  B22D11/0403 ,  B22D11/0406 ,  B22D11/041 ,  B22D11/055 ,  B22D11/124 ,  B22D11/1243 ,  B22D11/1245 ,  B22D11/141 ,  B22D11/147 ,  B22D21/005 ,  B22D41/015 ,  B22D47/00 ,  F27B7/00 ,  F27B14/06 ,  F27B14/0806 ,  F27B14/14 ,  F27B19/04 ,  F27B2014/008 ,  F27B2014/0812 ,  F27B2014/0818 ,  F27D3/14 ,  F27D11/12

摘要： In production of a reactive metal using a melting furnace for producing metal having a hearth, ingots can be efficiently produced by efficiently cooling the ingots extracted from the mold provided in the melting furnace. In addition, an apparatus structure in which multiple ingots can be produced with high efficiency and high quality from one hearth, is provided. A melting furnace for producing metal is provided, the furnace has a hearth for having molten metal formed by melting raw material, a mold in which the molten metal is poured, an extracting jig which is provided below the mold for extracting ingot cooled and solidified downwardly, a cooling member for cooling the ingot extracted downwardly of the mold, and an outer case for keeping the hearth, the mold, the extracting jig, and the cooling member separated from the air, wherein at least one mold and extracting jig are provided in the outer case, and the cooling member is provided between the outer case and the ingot, or between the multiple ingots.

公开(公告)号：US20130327493A1

公开(公告)日：2013-12-12

申请号：US14000223

申请日：2012-02-27

申请人： Takashi Oda ,  Hisamune Tanaka ,  Takeshi Shiraki ,  Norio Yamamoto

发明人： Takashi Oda ,  Hisamune Tanaka ,  Takeshi Shiraki ,  Norio Yamamoto

IPC分类号： B22D7/06 ,  B22D47/00

CPC分类号： B22D7/005 ,  B22D7/06 ,  B22D7/064 ,  B22D9/006 ,  B22D11/001 ,  B22D11/0403 ,  B22D11/0406 ,  B22D11/041 ,  B22D11/055 ,  B22D11/124 ,  B22D11/1243 ,  B22D11/1245 ,  B22D11/141 ,  B22D11/147 ,  B22D21/005 ,  B22D41/015 ,  B22D47/00 ,  F27B7/00 ,  F27B14/06 ,  F27B14/0806 ,  F27B14/14 ,  F27B19/04 ,  F27B2014/008 ,  F27B2014/0812 ,  F27B2014/0818 ,  F27D3/14 ,  F27D11/12

摘要： In production of a reactive metal using a melting furnace for producing metal having a hearth, ingots can be efficiently produced by efficiently cooling the ingots extracted from the mold provided in the melting furnace. In addition, an apparatus structure in which multiple ingots can be produced with high efficiency and high quality from one hearth, is provided. A melting furnace for producing metal is provided, the furnace has a hearth for having molten metal formed by melting raw material, a mold in which the molten metal is poured, an extracting jig which is provided below the mold for extracting ingot cooled and solidified downwardly, a cooling member for cooling the ingot extracted downwardly of the mold, and an outer case for keeping the hearth, the mold, the extracting jig, and the cooling member separated from the air, wherein at least one mold and extracting jig are provided in the outer case, and the cooling member is provided between the outer case and the ingot, or between the multiple ingots.

摘要翻译： 在使用用于制造具有炉床的金属的熔炉的反应性金属的制造中，可以通过有效地冷却从设置在熔化炉中的模具中提取的锭而有效地制造锭。 此外，提供了一种可以从一个炉膛以高效率和高质量生产多个锭的装置结构。 提供了一种用于生产金属的熔化炉，炉具有一个炉底，用于熔化原材料形成的熔融金属，一个熔融金属浇注的模具，一个提取夹具，该模具设置在模具下方，用于将铸锭向下冷却和固化 ，用于冷却从模具向下抽出的铸锭的冷却部件，以及用于保持与空气分离的炉床，模具，提取夹具和冷却部件的外壳，其中至少一个模具和提取夹具设置在 外壳和冷却构件设置在外壳和锭之间，或者在多个锭之间。

公开(公告)号：US08231882B2

公开(公告)日：2012-07-31

申请号：US12310073

申请日：2006-08-10

申请人： Koutarou Muroyama ,  Tatsuya Ohara ,  Yoshitaka Hirose ,  Norio Yamamoto ,  Shinji Murosaki ,  Yoshihiro Yamamoto

发明人： Koutarou Muroyama ,  Tatsuya Ohara ,  Yoshitaka Hirose ,  Norio Yamamoto ,  Shinji Murosaki ,  Yoshihiro Yamamoto

IPC分类号： A61K9/00

CPC分类号： A61K31/7016 ,  A61K8/602 ,  A61K31/702 ,  A61Q19/00 ,  Y10S514/847

摘要： The present invention provides a moisturizer comprising, as an active ingredient, a saccharide having 3-O-α-D-glucopyranosyl-D-glucose as a structural unit. The moisturizer of the present invention improves the water retention capacity of the stratum corneum, and is useful for prevention and improvement of rough skin.

摘要翻译： 本发明提供一种保湿剂，其包含作为活性成分的具有3-O-α-D-吡喃葡萄糖基-D-葡萄糖作为结构单元的糖类。 本发明的保湿剂改善了角质层的保水能力，并且可用于预防和改善粗糙皮肤。