摘要:
The invention relates to compounds of a general formula (I): wherein Ar1 is an optionally-substituted aryl or heteroaromatic group; R1 is an optionally-substituted lower alkyl, lower alkenyl, lower alkynyl or cyclo-lower alkyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R2 is a hydrogen atom, a lower alkyl group, a lower alkenyl group or a lower alkynyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R3 is a hydrogen atom or a lower alkyl group; R4 is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a group of —N(R1k)R1m; T and U are a nitrogen atom or a methine group, etc.The compounds of the invention have excellent Weel kinase-inhibitory effect and are therefore useful in the field of medicines, especially treatment of various cancers.
摘要翻译:本发明涉及通式(I)的化合物:其中Ar1是任选取代的芳基或杂芳基; R 1是任选取代的低级烷基,低级烯基,低级炔基或环低级烷基,或者是任选具有取代基的芳基,芳烷基或杂芳基; R2是氢原子,低级烷基,低级烯基或低级炔基,或者是任选具有取代基的芳基,芳烷基或杂芳基; R3是氢原子或低级烷基; R4是氢原子,卤素原子,羟基,低级烷基或-N(R1k)R1m基团; T和U是氮原子或次甲基等。本发明的化合物具有优异的韦尔激酶抑制作用,因此可用于药物领域,特别是治疗各种癌症。
摘要:
An electrode for a fuel cell, including a porous catalytic carrier including conductive fibers having two particle diameter distribution peaks of a first particle diameter distribution peak existing at a small particle diameter side and a second particle diameter distribution peak existing at a large particle diameter side, wherein said conducting fibers are carbon nano-fibers formed from a catalyst for formation prepared by preparing a mixed powder including one or more of a reducible metallic oxide powder and a non-reducible metallic oxide powder, mixing and pulverizing the mixed powder, and heating the mixed powder under reducing atmosphere; catalyst to be carried on said conductive fibers belonging to the first particle diameter distribution peak; and a proton conductive material adhered on surface of at least the conducive fibers belonging to the first particle diameter distribution peak, so as to come into contact with the catalyst.
摘要:
Long-chain, branched, propylene-based polymers, of which the melt index and the molecular weight distribution and the melt tension and the limiting viscosity both satisfy specific requirements, have good physical properties that are comparable to or better than those of conventional propylene-based polymers. They have good melt workability and are favorable to large-size blow molding and extrusion foaming. They are favorably used as miscibility improvers for propylene homopolymers and propylene-based copolymers.
摘要:
A semiconductor chip pickup apparatus of the present invention includes an aspiration section and an aspiration unit connected to the aspiration section, in which the aspiration unit includes a stage for mounting the semiconductor chip thereon and an adhesive sheet is attached to the semiconductor chip between the stage and the semiconductor chip, the stage includes undulations in at least a part of an area in which the semiconductor chip is mounted, and by operating the aspiration section, a suction force is applied to at least a part of an area in which the undulations are formed.
摘要:
A safety device having a thin plate of a brittle material adapted to be ruptured by a difference between pressures exerted on opposite sides thereof; and a conductive path provided on the thin plate and adapted to be cut off by the rupture of the thin plate. One surface of the thin plate is present in a reference pressure chamber. The safety device with its reference pressure chamber being sealed is incorporated in a secondary battery. When the secondary battery is overcharged, the pressure difference between the opposite sides of the thin plate is increased, so that the thin plate is ruptured to cut off the conductive path.
摘要:
A high frequency heating power device for an implanted device comprises a switch circuit, an input/output circuit, a high-frequency signal generating circuit, and a check circuit. When a high frequency output circuit applies a high frequency measuring voltage between a guide wire and the body ground board, a voltage is detected which corresponds to the impedance of a circuit which is made up of lead wires, the guide wire, the patient's body, and the body grounding board. It is determined by a discriminating circuit whether or not the voltage thus detected is in a predetermined allowable voltage range. The operator is informed of the discrimination by means of a display circuit and a buzzer circuit, so that he can determine the position of the end of the guide wire with respect to the end of the catheter with ease.
摘要:
A disposable pressure transducer for measuring fluid pressure, which includes a sensor assembly in a housing. The housing includes a fluid chamber and a sensor-accommodating chamber which are formed integrally with each other. The sensor assembly comprises: a sensor chip for converting pressure into an electrical signal; an insulating board on which the sensor chip is mounted and which is provided with an integrated-circuit for processing an output signal of the sensor chip so that an external measuring device can read the signal; a cylindrical coupling lid which is bonded to the board in such a manner as to surround the sensor chip and which is fitted into a communication through-hole which provides communication between the fluid chamber and the sensor-accommodating chamber of the housing; a pressure-transmitting medium charged into the interior of the coupling lid so as to provide electrical insulation between the fluid chamber and the sensor chip; and an electrical cable connected to the board and electrically connected to the external measuring device.
摘要:
A manual combinatorial weighing apparatus having one or more weighing devices housed in a casing with each weighing device having a scale plate for placing articles thereon, and indicators associated with the weighing devices for indicating selected weighing devices. As many weighing devices in casings as desired by the user are provided in a desired layout. Weight data items of the articles put on the scale plates are combined to find a weight combination giving a desired total weight. The selected weighing devices are indicated by the indicators, which are held energized until the articles are removed from the selected weighing devices.
摘要:
To provide a double-deck elevator characterized by the fact that by increasing the story height adjustment range in the direction in which the two cars approach each other, it is possible to increase the degree of building design freedom. Two up/down cars (6), (7) arranged in outer frame (5) are connected with each other by means of pantographic mechanisms (11) that can effect an expansion and contraction operation, and the two cars (6), (7) are driven to move towards each other or away from each other by means of pantographic mechanisms (11). The pantographic mechanisms (11) are arranged in the spaces between vertical beams (5a) and the two cars (6), (7) and each has a pivot point at the longitudinal central portion of vertical beams (5a) extending vertically in outer frame (5). Due to the pantographic mechanisms (11), the story height adjustment range in the direction in which the two cars (6), (7) approach each other is not restricted.