公开(公告)号：US09079026B2

公开(公告)日：2015-07-14

申请号：US14386626

申请日：2012-03-21

申请人： Yuehu Pu ,  Masahiro Ikeda ,  Taizo Honda

发明人： Yuehu Pu ,  Masahiro Ikeda ,  Taizo Honda

IPC分类号： A61N5/10

CPC分类号： A61N5/1071 ,  A61N5/103 ,  A61N5/1031 ,  A61N5/1043 ,  A61N2005/1087

摘要： A particle beam scanning irradiation method includes the steps of calculating a planned irradiating particle count of a particle beam for each of irradiation spots, on the basis of a relative amount of particle beam irradiation and a prescription particle-beam dose determined from a particle-beam therapy plan; simulating an irradiation process of the particle beam at each irradiation spot, on the basis of the planned irradiating particle count and a beam current waveform of the particle beam, and calculating a particle count of the particle beam irradiating the diseased portion during a scan shift of the particle beam; correcting the planned irradiating particle count for each irradiation spot by using the irradiating particle count during the scan shift; converting the corrected planned-irradiation particle count into a count value used in a dose monitor; and irradiating the irradiation spot with the particle beam, on the basis of the converted count value.

摘要翻译： 粒子束扫描照射方法包括以下步骤：基于粒子束照射的相对量和从粒子束确定的处方粒子束剂量来计算每个照射点的粒子束的计划照射粒子数 治疗方案; 基于所计划的照射粒子数和粒子束的束电流波形，模拟在各照射点处的粒子束的照射过程，计算在扫描位移期间照射患病部位的粒子束的粒子数 粒子束; 通过使用扫描偏移期间的照射粒子数来校正每个照射点的计划照射粒子数; 将校正的计划照射粒子数转换为剂量监视器中使用的计数值; 并且基于转换后的计数值，用粒子束照射照射点。

公开(公告)号：US20150080631A1

公开(公告)日：2015-03-19

申请号：US14390087

申请日：2012-05-14

申请人： Yuehu Pu ,  Masahiro Ikeda

发明人： Yuehu Pu ,  Masahiro Ikeda

IPC分类号： A61N5/10

CPC分类号： A61N5/1043 ,  A61N5/103 ,  A61N5/1044 ,  A61N2005/1087 ,  F04C2270/0421

摘要： A particle beam scanning irradiation system includes a computer establishing a scanning sequence for irradiation of a tumor portion in a patient; and a particle beam irradiation device irradiating the tumor portion in accordance with the established scanning sequence of the particle beam. The computer selects all conceivable combinations of pairs of irradiation spots among the plurality of irradiation spots arranged in the tumor portion, and determines whether each path for the particle beam to shift between two spots constituting the selected pair passes through the tumor portion; determines a penalty matrix expressing whether each path passes through the tumor portion on the basis of the determination result; evaluates a function for the shift paths on the basis of an optimizing algorithm, and establishes the scanning sequence of the particle beam by an optimized solution of the function.

摘要翻译： 粒子束扫描照射系统包括建立用于照射患者肿瘤部分的扫描序列的计算机; 以及根据建立的粒子束扫描顺序照射肿瘤部分的粒子束照射装置。 计算机选择布置在肿瘤部分中的多个照射点之间的所有可能的照射点对的组合，并且确定用于粒子束在构成所选择的对的两个点之间移动的每个路径是否通过肿瘤部分; 根据确定结果确定表示每个路径是否通过肿瘤部分的惩罚矩阵; 基于优化算法对移位路径的功能进行评估，并通过优化的功能解决方案建立粒子束的扫描序列。

公开(公告)号：US20120228521A1

公开(公告)日：2012-09-13

申请号：US13258772

申请日：2011-03-10

申请人： Taizo Honda ,  Masahiro Ikeda ,  Yuehu Pu ,  Kazushi Hanakawa

发明人： Taizo Honda ,  Masahiro Ikeda ,  Yuehu Pu ,  Kazushi Hanakawa

IPC分类号： A61N5/00

CPC分类号： A61N5/1043 ,  A61N5/1048 ,  A61N5/1077 ,  A61N2005/1074 ,  A61N2005/1087

摘要： The objective is to obtain a particle beam therapy system that can suppress the effect of a leakage dose. There are provided a scanning nozzle that irradiates in a predetermined direction a particle beam emitted from an accelerator; an irradiation control unit that controls operation of the irradiation nozzle in such a way that the particle beam of a predetermined dose is sequentially irradiated onto each of a plurality of spots set in a planar direction in an irradiation subject; and a control unit that on/off-controls emission of the particle beam from the accelerator. The irradiation control unit makes the irradiation nozzle scan in a diluting manner the particle beam onto a predetermined area in the irradiation subject, in a predetermined period after a time point when emission is switched from ON to OFF, or in a period from the time point when emission is switched from ON to OFF to a time point when the particle beam is cut off.

摘要翻译： 目的是获得能够抑制泄漏剂量影响的粒子束治疗系统。 提供了沿预定方向照射从加速器发射的粒子束的扫描喷嘴; 照射控制单元，其以照射对象的平面方向上设置的多个点顺序地照射预定剂量的粒子束的方式控制照射喷嘴的动作; 以及控制单元，其控制来自加速器的粒子束的发射。 照射控制单元使得照射喷嘴在发射从ON切换到OFF之后的预定时间内或在从时间点开始的时间段内，将粒子束以稀释的方式扫描到照射对象的预定区域上 当发射从ON切换到截止到粒子束的时间点时。

公开(公告)号：US09327140B2

公开(公告)日：2016-05-03

申请号：US14115028

申请日：2011-08-23

申请人： Taizo Honda ,  Yuichi Yamamoto ,  Yuehu Pu

发明人： Taizo Honda ,  Yuichi Yamamoto ,  Yuehu Pu

IPC分类号： G01K1/08 ,  A61N5/10 ,  G21K5/04

CPC分类号： A61N5/1048 ,  A61N5/1043 ,  A61N5/1075 ,  A61N5/1077 ,  A61N2005/1074 ,  A61N2005/1087 ,  G21K5/04

摘要： A beam data processing apparatus has a plurality of channel data conversion units that convert a plurality of analogue signals outputted from a position monitor into digital signals, a position size processing unit that calculates a beam position, based on voltage information items obtained through processing by the plurality of channel data conversion units, an abnormality determination processing unit that determines the beam position and generates a position abnormality signal, and an integrated control unit that controls the plurality of channel data conversion units in such a way that while a beam is stopped at an irradiation spot, digital signal conversion processing is implemented two or more times; the channel data conversion unit has a plurality of A/D converters, a demultiplexer that distributes analogue signals, and a multiplexer that switches respective digital signals processed by the A/D converters so as to output them to the position size processing unit.

摘要翻译： 波束数据处理装置具有多个通道数据转换单元，其将从位置监视器输出的多个模拟信号转换为数字信号，位置大小处理单元，基于通过处理所获得的电压信息项，计算波束位置 多个通道数据转换单元，确定光束位置并产生位置异常信号的异常判定处理单元，以及控制多个通道数据转换单元的集成控制单元，使得当光束停止在 照射点，数字信号转换处理两次以上; 信道数据转换单元具有多个A / D转换器，分配模拟信号的多路分解器和切换由A / D转换器处理的各个数字信号的多路复用器，以便将它们输出到位置大小处理单元。

公开(公告)号：US20140061498A1

公开(公告)日：2014-03-06

申请号：US14115028

申请日：2011-08-23

申请人： Taizo Honda ,  Yuichi Yamamoto ,  Yuehu Pu

发明人： Taizo Honda ,  Yuichi Yamamoto ,  Yuehu Pu

IPC分类号： A61N5/10

CPC分类号： A61N5/1048 ,  A61N5/1043 ,  A61N5/1075 ,  A61N5/1077 ,  A61N2005/1074 ,  A61N2005/1087 ,  G21K5/04

摘要： A beam data processing apparatus has a plurality of channel data conversion units that convert a plurality of analogue signals outputted from a position monitor into digital signals, a position size processing unit that calculates a beam position, based on voltage information items obtained through processing by the plurality of channel data conversion units, an abnormality determination processing unit that determines the beam position and generates a position abnormality signal, and an integrated control unit that controls the plurality of channel data conversion units in such a way that while a beam is stopped at an irradiation spot, digital signal conversion processing is implemented two or more times; the channel data conversion unit has a plurality of A/D converters, a demultiplexer that distributes analogue signals, and a multiplexer that switches respective digital signals processed by the ND converters so as to output them to the position size processing unit.

摘要翻译： 波束数据处理装置具有多个通道数据转换单元，其将从位置监视器输出的多个模拟信号转换为数字信号，位置大小处理单元，基于通过处理所获得的电压信息项，计算波束位置 多个通道数据转换单元，确定光束位置并产生位置异常信号的异常判定处理单元，以及控制多个通道数据转换单元的集成控制单元，使得当光束停止在 照射点，数字信号转换处理两次以上; 信道数据转换单元具有多个A / D转换器，分配模拟信号的多路分解器，以及多路复用器，其切换由ND转换器处理的各个数字信号，以将其输出到位置大小处理单元。

公开(公告)号：US20130320245A1

公开(公告)日：2013-12-05

申请号：US13985759

申请日：2011-04-25

申请人： Yuehu Pu ,  Taizo Honda ,  Takaaki Iwata

发明人： Yuehu Pu ,  Taizo Honda ,  Takaaki Iwata

IPC分类号： A61N5/10

CPC分类号： A61N5/1048 ,  A61N5/1042 ,  A61N2005/1087 ,  A61N2005/1095 ,  G21K1/10

摘要： There is provided a particle-beam energy changing apparatus that is capable of changing energy of a particle beam quickly and silently, in which a first energy changing unit and a second energy changing unit for changing energy of a particle beam passing therethrough by varying thicknesses of their attenuators attenuating the particle beam energy are arranged so that the particle beam passes through the first energy changing unit and the second energy changing unit; and the maximum attenuation amount by the first energy changing unit is set smaller than the maximum attenuation amount by the second energy changing unit.

摘要翻译： 提供了一种能够快速且静默地改变粒子束能量的粒子束能量改变装置，其中第一能量改变单元和第二能量改变单元用于通过改变粒子束的厚度来改变通过其的粒子束的能量 其衰减粒子束能量的衰减器被布置成使得粒子束通过第一能量改变单元和第二能量改变单元; 并且第一能量改变单元的最大衰减量被设定为小于第二能量变化单元的最大衰减量。

公开(公告)号：US06034377A

公开(公告)日：2000-03-07

申请号：US69944

申请日：1998-04-30

申请人： Yuehu Pu

发明人： Yuehu Pu

IPC分类号： G21K1/093 ,  A61N5/10 ,  G21K5/02 ,  G21K5/04 ,  G21K5/10 ,  A61N5/00

CPC分类号： A61N5/1043 ,  G21K5/02 ,  G21K5/10 ,  A61N2005/1087 ,  A61N2005/1095

摘要： A charged particle beam irradiation apparatus includes two electromagnets arranged in series along a direction of an incident axis of a charged particle beam, for deflecting the charged particle beam in opposite directions, an energy modulator including a cylindrical member having a length and a distribution of wall thickness in a circumferential direction, a first rotational drive for rotating the cylindrical member around a rotation axis, and a detector for detecting the angular position of the cylindrical member. The energy modulator is disposed at a downstream side of the scanning electromagnets so that the deflected charged particle beam passes through the rotation axis. The apparatus includes an energy degrader for limiting energy of the charged particle beam, and a second rotational drive for rotating the scanning electromagnets and the energy modulator together around the incident axis of the charged particle beam.

摘要翻译： 带电粒子束照射装置包括沿着带电粒子束的入射轴的方向串联布置的两个电磁体，用于使带电粒子束沿相反方向偏转，能量调制器包括具有长度和壁分布的圆柱形构件 在圆周方向上的厚度，用于使圆筒形构件围绕旋转轴线旋转的第一旋转驱动器和用于检测圆柱形构件的角位置的检测器。 能量调制器设置在扫描电磁体的下游侧，使得偏转的带电粒子束通过旋转轴。 该装置包括用于限制带电粒子束的能量的能量降解器，以及用于围绕带电粒子束的入射轴旋转扫描电磁体和能量调制器的第二旋转驱动器。

公开(公告)号：US08525448B2

公开(公告)日：2013-09-03

申请号：US13368435

申请日：2012-02-08

申请人： Hirofumi Tanaka ,  Kazuo Yamamoto ,  Nobuyuki Haruna ,  Yuehu Pu ,  Kanji Shinkawa ,  Takayuki Kashima

发明人： Hirofumi Tanaka ,  Kazuo Yamamoto ,  Nobuyuki Haruna ,  Yuehu Pu ,  Kanji Shinkawa ,  Takayuki Kashima

IPC分类号： H05H13/00

CPC分类号： H05H13/005 ,  H05H7/12 ,  H05H13/02

摘要： The circular accelerator comprises: a bending electromagnet that generates a bending magnetic field; a radio-frequency power source that generates a radio-frequency electric field in accordance with an orbital frequency of charged particles; a radio-frequency electromagnetic field coupling part connected to the radio-frequency power source; an acceleration electrode connected to the radio-frequency electromagnetic field coupling part; and an acceleration-electrode-opposing ground plate provided to form an acceleration gap between the plate itself and the acceleration electrode, for generating the radio-frequency electromagnetic field in an orbiting direction of the charged particles; wherein the bending electromagnet generates the bending magnetic field varying in such a way that the orbital frequency of the charged particles varies in a variation range of 0.7% to 24.7% with respect to an orbital frequency at the charged-particles' extraction portion, during a time of injection to extraction of the particles.

摘要翻译： 圆形加速器包括：产生弯曲磁场的弯曲电磁体; 射频电源，其根据带电粒子的轨道频率产生射频电场; 连接到所述射频电源的射频电磁场耦合部; 连接到射频电磁场耦合部分的加速电极; 以及加速电极对置的接地板，其设置成在板本身和加速电极之间形成加速间隙，用于在带电粒子的运动方向上产生射频电磁场; 其中所述弯曲电磁体产生所述弯曲磁场，所述弯曲磁场以使得所述带电粒子的轨道频率相对于所述带电粒子提取部分的轨道频率在0.7％至24.7％的变化范围内变化的方式变化， 注射时间来提取颗粒。

公开(公告)号：US07947969B2

公开(公告)日：2011-05-24

申请号：US12023134

申请日：2008-01-31

申请人： Yuehu Pu

发明人： Yuehu Pu

IPC分类号： A61N5/10

CPC分类号： A61N5/10 ,  A61N2005/1087 ,  A61N2005/1095

摘要： A stacked conformation radiotherapy system capable of homogenizing a radiation dose distribution, including an irradiation head and irradiation control means. The irradiation head projects a particle beam accelerated by an accelerator, toward an object to-be-irradiated, and it includes wobbler electromagnets for deflecting and scanning the particle beam. In carrying out stacked conformation radiotherapy by deflecting and scanning the particle beam, the irradiation control means subjects the wobbler electromagnets to magnetization controls so that the particle beam may depict a one-stroke revolving orbit which begins with a start point and returns to the start point, and it performs a control so that the irradiation period of the particle beam to be outputted from the irradiation head may become integral times a wobbler cycle which is required for the particle beam to make one revolution of the revolving orbit.

摘要翻译： 一种能够使放射剂量分布均匀化的堆叠构象放射治疗系统，包括照射头和照射控制装置。 照射头投影由加速器加速的粒子束朝向被照射物体，并且其包括用于偏转和扫描粒子束的摆动电磁体。 在通过偏转和扫描粒子束进行堆叠构象放射治疗时，照射控制装置使摇摆电磁体进行磁化控制，使得粒子束可以描绘以起始点开始的一冲程旋转轨道，并返回起始点 ，并且进行控制，使得从照射头输出的粒子束的照射周期可以与粒子束进行旋转轨道一圈所需的摆动周期成为一个整数倍。

公开(公告)号：US06268610B1

公开(公告)日：2001-07-31

申请号：US09146036

申请日：1998-09-02

申请人： Yuehu Pu

发明人： Yuehu Pu

IPC分类号： A61N500

CPC分类号： G21K5/04 ,  A61N5/10 ,  A61N5/1043 ,  A61N2005/1087

摘要： A charged-particle beam irradiation apparatus capable of realizing spot-scanning in which the spot of a beam parallel to the axis of incidence thereof is shifted in two axial directions within a radiation area, and having a compact and lightweight design. A pair of scanning electromagnets, that are linked by linkage frames, generate a scanning field composed of a pair of magnetic fields effective in bending a charged-particle beam by the same angle in mutually opposite directions. Rotation of the apparatus is accomplished by rotary driving gear having the scanning electromagnets mounted thereon and motors. Thus, spot scanning in which the spot of a beam parallel to the axis of incidence thereof is shifted in two axial directions can be realized.

摘要翻译： 一种带电粒子束照射装置，其能够实现点阵扫描，其中平行于其入射轴的光束点在辐射区域内沿两个轴向移动，并且具有紧凑且轻便的设计。 通过连杆机构链接的一对扫描电磁体产生由有效地使带电粒子束以相反方向弯曲相同角度的一对磁场组成的扫描场。 设备的旋转通过其上安装有扫描电磁体的旋转驱动齿轮和电动机来实现。 因此，可以实现其中平行于其入射轴的光束的光斑在两个轴向上偏移的点扫描。