公开(公告)号：US08658991B2

公开(公告)日：2014-02-25

申请号：US13003688

申请日：2009-06-03

申请人： Yuehu Pu ,  Katsuhisa Yoshida ,  Yuichi Yamamoto ,  Hidenobu Sakamoto ,  Taizo Honda ,  Hisashi Harada ,  Takaaki Iwata

发明人： Yuehu Pu ,  Katsuhisa Yoshida ,  Yuichi Yamamoto ,  Hidenobu Sakamoto ,  Taizo Honda ,  Hisashi Harada ,  Takaaki Iwata

IPC分类号： A61N5/00

CPC分类号： A61N5/10 ,  A61N5/1043 ,  A61N2005/1087

摘要： In order to obtain a particle beam irradiation apparatus that enlarges the dose distribution of beam spots while suppressing a decrease of the maximum available range of a charged particle beam, the particle beam irradiation apparatus includes a particle beam acceleration means; particle beam transport means; scanning apparatus that includes first scanning means and second scanning means, and two-dimensionally scans the beam; and irradiation control means that controls the scanning apparatus so as to irradiate the beam onto a target region including a plurality of small regions. The irradiation control means controls the first scanning means so as to scan the beam over a small region serving as an irradiation subject among the plurality of the small regions, and controls the second scanning means so as to change the small region serving as the irradiation subject to be a different small region among the plurality of the small regions.

摘要翻译： 为了获得粒子束照射装置，其粒子束照射装置包括粒子束加速装置，粒子束照射装置在抑制带电粒子束的最大可用范围的减小的同时，扩大束斑的剂量分布， 粒子束传送装置; 扫描装置，其包括第一扫描装置和第二扫描装置，并二维地扫描光束; 以及照射控制装置，其控制扫描装置以将束照射到包括多个小区域的目标区域上。 照射控制装置控制第一扫描装置，以便在多个小区域中的用作照射对象的小区域上扫描光束，并且控制第二扫描装置以改变用作照射对象的小区域 成为多个小区域中的不同小区域。

公开(公告)号：US20110108737A1

公开(公告)日：2011-05-12

申请号：US13003688

申请日：2009-06-03

申请人： Yuehu Pu ,  Katsuhisa Yoshida ,  Yuichi Yamamoto ,  Hidenobu Sakamoto ,  Taizo Honda ,  Hisashi Harada ,  Takaaki Iwata

发明人： Yuehu Pu ,  Katsuhisa Yoshida ,  Yuichi Yamamoto ,  Hidenobu Sakamoto ,  Taizo Honda ,  Hisashi Harada ,  Takaaki Iwata

IPC分类号： H01J37/147

CPC分类号： A61N5/10 ,  A61N5/1043 ,  A61N2005/1087

摘要： In order to obtain a particle beam irradiation apparatus that enlarges the dose distribution of beam spots while suppressing a decrease of the maximum available range of a charged particle beam, the particle beam irradiation apparatus includes a particle beam acceleration means; particle beam transport means; scanning apparatus that includes first scanning means and second scanning means, and two-dimensionally scans the beam; and irradiation control means that controls the scanning apparatus so as to irradiate the beam onto a target region including a plurality of small regions. The irradiation control means controls the first scanning means so as to scan the beam over a small region serving as an irradiation subject among the plurality of the small regions, and controls the second scanning means so as to change the small region serving as the irradiation subject to be a different small region among the plurality of the small regions.

摘要翻译： 为了获得粒子束照射装置，其粒子束照射装置包括粒子束加速装置，粒子束照射装置在抑制带电粒子束的最大可用范围的减小的同时，扩大束斑的剂量分布， 粒子束传送装置; 扫描装置，其包括第一扫描装置和第二扫描装置，并二维地扫描光束; 以及照射控制装置，其控制扫描装置以将束照射到包括多个小区域的目标区域上。 照射控制装置控制第一扫描装置，以便在多个小区域中的用作照射对象的小区域上扫描光束，并且控制第二扫描装置以改变用作照射对象的小区域 成为多个小区域中的不同小区域。

公开(公告)号：US20130320245A1

公开(公告)日：2013-12-05

申请号：US13985759

申请日：2011-04-25

申请人： Yuehu Pu ,  Taizo Honda ,  Takaaki Iwata

发明人： Yuehu Pu ,  Taizo Honda ,  Takaaki Iwata

IPC分类号： A61N5/10

CPC分类号： A61N5/1048 ,  A61N5/1042 ,  A61N2005/1087 ,  A61N2005/1095 ,  G21K1/10

摘要： There is provided a particle-beam energy changing apparatus that is capable of changing energy of a particle beam quickly and silently, in which a first energy changing unit and a second energy changing unit for changing energy of a particle beam passing therethrough by varying thicknesses of their attenuators attenuating the particle beam energy are arranged so that the particle beam passes through the first energy changing unit and the second energy changing unit; and the maximum attenuation amount by the first energy changing unit is set smaller than the maximum attenuation amount by the second energy changing unit.

摘要翻译： 提供了一种能够快速且静默地改变粒子束能量的粒子束能量改变装置，其中第一能量改变单元和第二能量改变单元用于通过改变粒子束的厚度来改变通过其的粒子束的能量 其衰减粒子束能量的衰减器被布置成使得粒子束通过第一能量改变单元和第二能量改变单元; 并且第一能量改变单元的最大衰减量被设定为小于第二能量变化单元的最大衰减量。

公开(公告)号：US08314411B2

公开(公告)日：2012-11-20

申请号：US12738705

申请日：2009-04-24

申请人： Hisashi Harada ,  Takaaki Iwata ,  Taizo Honda ,  Yuehu Pu ,  Yuichi Yamamoto ,  Toshihiro Otani ,  Hidenobu Sakamoto

发明人： Hisashi Harada ,  Takaaki Iwata ,  Taizo Honda ,  Yuehu Pu ,  Yuichi Yamamoto ,  Toshihiro Otani ,  Hidenobu Sakamoto

IPC分类号： A61N5/10 ,  H01J37/256

CPC分类号： A61N5/1077 ,  A61N2005/1087 ,  A61N2005/1095

摘要： There is obtained a particle beam therapy system in which the beam size is reduced. There are provided an accelerator 14 that accelerates a charged particle beam; an irradiation apparatus that has a beam scanning apparatus 5a, 5b for performing scanning with the charged particle beam and irradiates the charged particle beam onto an irradiation subject; and a beam transport apparatus 15 that has a duct for ensuring a vacuum region or gas region that continues from the accelerator 14 to a beam outlet window 7 disposed at a more downstream position than the beam scanning apparatus 5a, 5b, and that transports the charged particle beam exiting from the accelerator 14 to the irradiation apparatus.

摘要翻译： 获得了粒径减小的粒子束治疗系统。 提供加速带电粒子束的加速器14; 具有用于利用带电粒子束进行扫描并将带电粒子束照射到照射对象上的光束扫描装置5a，5b的照射装置; 以及具有用于确保从加速器14延伸到设置在比光束扫描装置5a，5b的更下游位置处的光束出射窗口7的真空区域或气体区域的管道的光束传送装置15，并且传送带电 粒子束从加速器14离开到照射装置。

公开(公告)号：US08405042B2

公开(公告)日：2013-03-26

申请号：US12864002

申请日：2010-01-28

申请人： Taizo Honda ,  Hisashi Harada ,  Yuehu Pu ,  Yuichi Yamamoto ,  Takaaki Iwata

发明人： Taizo Honda ,  Hisashi Harada ,  Yuehu Pu ,  Yuichi Yamamoto ,  Takaaki Iwata

IPC分类号： G21K1/08

CPC分类号： A61N5/1042 ,  A61N5/1043 ,  A61N5/1048 ,  A61N2005/1087

摘要： The objective of the present invention is to reduce the effect of the hysteresis of a scanning electromagnet so as to obtain a particle beam therapy system that realizes high-accuracy beam irradiation. There are included an irradiation management apparatus (32) that controls the scanning electromagnet (3), based on target irradiation position coordinates (Pi) of a charged particle beam (1b), and a position monitor (7) that measures measurement position coordinates (Ps) of the charged particle beam (1b). The irradiation management apparatus (32) has a command value creator (25) that outputs a control input (Io (Ir)) to the scanning electromagnet (3), based on the target irradiation position coordinates (Pi) and correction data (Ia) created on the basis of the measurement position coordinates (Ps), measured by the position monitor (7) in the preliminary irradiation in which the excitation pattern of the scanning electromagnet is the same as that of the main irradiation plan, and the target irradiation position coordinates (Pi).

摘要翻译： 本发明的目的是减少扫描电磁体的滞后效果，以获得实现高精度光束照射的粒子束治疗系统。 包括基于带电粒子束（1b）的目标照射位置坐标（Pi）来控制扫描电磁体（3）的照射管理装置（32）和测量位置坐标（ Ps）的带电粒子束（1b）。 照射管理装置（32）具有基于目标照射位置坐标（Pi）和校正数据（Ia）向扫描电磁体（3）输出控制输入（Io（Ir））的指令值生成器（25） 基于由扫描电磁体的激励图案与主照射平面的激励图案相同的预备照射中的位置监视器（7）测量的测量位置坐标（Ps）和目标照射位置 坐标（Pi）。

公开(公告)号：US08809815B2

公开(公告)日：2014-08-19

申请号：US13985759

申请日：2011-04-25

申请人： Yuehu Pu ,  Taizo Honda ,  Takaaki Iwata

发明人： Yuehu Pu ,  Taizo Honda ,  Takaaki Iwata

IPC分类号： A61N5/10 ,  G21K1/10

CPC分类号： A61N5/1048 ,  A61N5/1042 ,  A61N2005/1087 ,  A61N2005/1095 ,  G21K1/10

摘要： There is provided a particle-beam energy changing apparatus that is capable of changing energy of a particle beam quickly and silently, in which a first energy changing unit and a second energy changing unit for changing energy of a particle beam passing therethrough by varying thicknesses of their attenuators attenuating the particle beam energy are arranged so that the particle beam passes through the first energy changing unit and the second energy changing unit; and the maximum attenuation amount by the first energy changing unit is set smaller than the maximum attenuation amount by the second energy changing unit.

摘要翻译： 提供了一种能够快速且静默地改变粒子束能量的粒子束能量改变装置，其中第一能量改变单元和第二能量改变单元用于通过改变粒子束的厚度来改变通过其的粒子束的能量 其衰减粒子束能量的衰减器被布置成使得粒子束通过第一能量改变单元和第二能量改变单元; 并且第一能量改变单元的最大衰减量被设定为小于第二能量变化单元的最大衰减量。

公开(公告)号：US20110260074A1

公开(公告)日：2011-10-27

申请号：US12864002

申请日：2010-01-28

申请人： Taizo Honda ,  Hisashi Harada ,  Yuehu Pu ,  Yuichi Yamamoto ,  Takaaki Iwata

发明人： Taizo Honda ,  Hisashi Harada ,  Yuehu Pu ,  Yuichi Yamamoto ,  Takaaki Iwata

IPC分类号： G21K1/08

CPC分类号： A61N5/1042 ,  A61N5/1043 ,  A61N5/1048 ,  A61N2005/1087

摘要： The objective of the present invention is to reduce the effect of the hysteresis of a scanning electromagnet so as to obtain a particle beam therapy system that realizes high-accuracy beam irradiation. There are included an irradiation management apparatus (32) that controls the scanning electromagnet (3), based on target irradiation position coordinates (Pi) of a charged particle beam (1b), and a position monitor (7) that measures measurement position coordinates (Ps) of the charged particle beam (1b). The irradiation management apparatus (32) has a command value creator (25) that outputs a control input (Io (Ir)) to the scanning electromagnet (3), based on the target irradiation position coordinates (Pi) and correction data (Ia) created on the basis of the measurement position coordinates (Ps), measured by the position monitor (7) in the preliminary irradiation in which the excitation pattern of the scanning electromagnet is the same as that of the main irradiation plan, and the target irradiation position coordinates (Pi).

摘要翻译： 本发明的目的是减少扫描电磁体的滞后效果，以获得实现高精度光束照射的粒子束治疗系统。 包括基于带电粒子束（1b）的目标照射位置坐标（Pi）来控制扫描电磁体（3）的照射管理装置（32）和测量位置坐标（ Ps）的带电粒子束（1b）。 照射管理装置（32）具有基于目标照射位置坐标（Pi）和校正数据（Ia）向扫描电磁体（3）输出控制输入（Io（Ir））的指令值生成器（25） 基于由扫描电磁体的激励图案与主照射平面的激励图案相同的预备照射中的位置监视器（7）测量的测量位置坐标（Ps）和目标照射位置 坐标（Pi）。

公开(公告)号：US20110218429A1

公开(公告)日：2011-09-08

申请号：US12738705

申请日：2009-04-24

申请人： Hisashi Harada ,  Takaaki Iwata ,  Taizo Honda ,  Yuehu Pu ,  Yuichi Yamamoto ,  Toshihiro Otani ,  Hidenobu Sakamoto

发明人： Hisashi Harada ,  Takaaki Iwata ,  Taizo Honda ,  Yuehu Pu ,  Yuichi Yamamoto ,  Toshihiro Otani ,  Hidenobu Sakamoto

IPC分类号： G03B42/02 ,  H01J3/26

CPC分类号： A61N5/1077 ,  A61N2005/1087 ,  A61N2005/1095

摘要： There is obtained a particle beam therapy system in which the beam size is reduced. There are provided an accelerator 14 that accelerates a charged particle beam; an irradiation apparatus that has a beam scanning apparatus 5a, 5b for performing scanning with the charged particle beam and irradiates the charged particle beam onto an irradiation subject ; and a beam transport apparatus 15 that has a duct for ensuring a vacuum region or gas region that continues from the accelerator 14 to a beam outlet window 7 disposed at a more downstream position than the beam scanning apparatus 5a, 5b, and that transports the charged particle beam exiting from the accelerator 14 to the irradiation apparatus.

摘要翻译： 获得了粒径减小的粒子束治疗系统。 提供加速带电粒子束的加速器14; 具有用于利用带电粒子束进行扫描并将带电粒子束照射到照射对象上的光束扫描装置5a，5b的照射装置; 以及具有用于确保从加速器14延伸到设置在比光束扫描装置5a，5b的更下游位置处的光束出射窗口7的真空区域或气体区域的管道的光束传送装置15，并且传送带电 粒子束从加速器14离开到照射装置。

公开(公告)号：US08389952B2

公开(公告)日：2013-03-05

申请号：US13322201

申请日：2011-04-13

申请人： Takaaki Iwata ,  Yuehu Pu

发明人： Takaaki Iwata ,  Yuehu Pu

IPC分类号： H01J3/26 ,  H01J1/50 ,  A61N5/00

CPC分类号： G21K1/093 ,  A61N5/1043 ,  A61N2005/1087

摘要： There is provided a particle beam irradiation apparatus in which two or more pairs of scanning electromagnets are utilized so that scanning of a charged particle beam can be performed with a high accuracy and with a high flexibility in the speed, from a low speed to a high speed. In a particle beam irradiation apparatus that scans an incident charged particle beam on X-direction and Y-direction (two-direction) desired orbits perpendicular to the travelling direction of the charged particle beam and irradiates the charged particle beam onto an irradiation subject, there are provided two or more pairs of scanning electromagnets that scan a charged particle beam in the two directions; the desired orbit is given by time-series desired orbit data in which desired irradiation positions corresponding to time are determined; and command values for respective scanning electromagnets in the two or more pairs of scanning electromagnets are generated based on plural pieces of data obtained by frequency-separating the time-series desired orbit data.

摘要翻译： 提供了一种使用两对或更多对扫描电磁体的粒子束照射装置，从而能够以高精度和高速度地从低速到高的灵活性进行带电粒子束的扫描 速度。 在沿着与带电粒子束的行进方向垂直的X方向和Y方向（双向）期望的轨道扫描入射带电粒子束的粒子束照射装置中，将带电粒子束照射到照射对象上， 设置两对或更多对在两个方向扫描带电粒子束的扫描电磁体对; 期望的轨道由时间序列期望的轨道数据给出，其中确定对应于时间的期望的照射位置; 并且基于通过对时间序列期望的轨道数据进行频率分离而获得的多条数据，生成两对以上的扫描电磁体对的各扫描电磁体的指令值。

公开(公告)号：US20120132826A1

公开(公告)日：2012-05-31

申请号：US13322201

申请日：2011-04-13

申请人： Takaaki Iwata ,  Yuehu Pu

发明人： Takaaki Iwata ,  Yuehu Pu

IPC分类号： H01J3/26

CPC分类号： G21K1/093 ,  A61N5/1043 ,  A61N2005/1087

摘要： There is provided a particle beam irradiation apparatus in which two or more pairs of scanning electromagnets are utilized so that scanning of a charged particle beam can be performed with a high accuracy and with a high flexibility in the speed, from a low speed to a high speed. In a particle beam irradiation apparatus that scans an incident charged particle beam on X-direction and Y-direction (two-direction) desired orbits perpendicular to the travelling direction of the charged particle beam and irradiates the charged particle beam onto an irradiation subject, there are provided two or more pairs of scanning electromagnets that scan a charged particle beam in the two directions; the desired orbit is given by time-series desired orbit data in which desired irradiation positions corresponding to time are determined; and command values for respective scanning electromagnets in the two or more pairs of scanning electromagnets are generated based on plural pieces of data obtained by frequency-separating the time-series desired orbit data.

摘要翻译： 提供了一种使用两对或更多对扫描电磁体的粒子束照射装置，从而能够以高精度和高速度地从低速到高的灵活性进行带电粒子束的扫描 速度。 在沿着与带电粒子束的行进方向垂直的X方向和Y方向（双向）期望的轨道扫描入射带电粒子束的粒子束照射装置中，将带电粒子束照射到照射对象上， 设置两对或更多对在两个方向扫描带电粒子束的扫描电磁体对; 期望的轨道由时间序列期望的轨道数据给出，其中确定对应于时间的期望的照射位置; 并且基于通过对时间序列期望的轨道数据进行频率分离而获得的多条数据，生成两对以上的扫描电磁体对的各扫描电磁体的指令值。